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Product Details
PEP-1111
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human ATG3.
PEP-1111 can be used as a blocking peptide with polyclonal antibody PA5-20997.
Target Information
ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2610016C12Rik; APG3-like; ATG3 autophagy related 3 homolog; Autophagy-related protein 3; DKFZp564M1178; FLJ22125; hApg3; MGC15201; Protein PC3-96; Ubiquitin-like-conjugating enzyme ATG3
Gene Aliases: APG3; APG3-LIKE; APG3L; ATG3; PC3-96
UniProt ID: (Human) Q9H6L9
Entrez Gene ID: (Human) 64422
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