Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 15 amino acids near the amino terminus of human CaBP7.
PEP-1115 can be used as a blocking peptide with polyclonal antibody PA5-21001.
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
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Protein Aliases: CaBP7; Calcium-binding protein 7; calneuron 2; Calneuron II; Calneuron-2
Gene Aliases: CABP7; CALN2
UniProt ID: (Human) Q86V35
Entrez Gene ID: (Human) 164633
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