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This peptide corresponds to 17 amino acids near the amino terminus of human CCDC134.
PEP-0894 can be used as a blocking peptide with polyclonal antibody PA5-20780.
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.
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Protein Aliases: Coiled-coil domain-containing protein 134; dJ821D11.3
Gene Aliases: CCDC134
UniProt ID: (Human) Q9H6E4
Entrez Gene ID: (Human) 79879
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