Product References
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
300-08 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 EDT 2022
Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling.
Journal of breast cancer
Luo A,Meng M,Wang G,Han R,Zhang Y,Jing X,Zhao L,Gu S,Zhao X
300-08 was used in Sample Preparation (FC/FACS) to conclude that CCL3 promoted the growth of breast cancer cells, and MDSCs recruited by CCL3 interacted with these cells and then activated the PI3K-Akt-mTOR pathway, which led to EMT and promoted the migration and invasion of the cells.
Wed Apr 01 00:00:00 EDT 2020
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
The Journal of clinical investigation
Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC
Mon Jul 15 00:00:00 EDT 2019
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 EDT 2019
Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt.
Scientific reports
Dang T,Liou GY
Wed May 16 00:00:00 EDT 2018
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Scientific reports
Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S
Fri Apr 20 00:00:00 EDT 2018
CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration.
Scientific reports
Fox JM,Kausar F,Day A,Osborne M,Hussain K,Mueller A,Lin J,Tsuchiya T,Kanegasaki S,Pease JE
Thu Jun 21 00:00:00 EDT 2018
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 EDT 2017
Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
Nature communications
Singh TP,Zhang HH,Borek I,Wolf P,Hedrick MN,Singh SP,Kelsall BL,Clausen BE,Farber JM
Fri Dec 16 00:00:00 EST 2016
Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).
The Journal of biological chemistry
Karlshøj S,Amarandi RM,Larsen O,Daugvilaite V,Steen A,Brvar M,Pui A,Frimurer TM,Ulven T,Rosenkilde MM
Fri Dec 23 00:00:00 EST 2016
Leukemia propagating cells rebuild an evolving niche in response to therapy.
Cancer cell
Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL
Mon Jun 16 00:00:00 EDT 2014
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.
Blood
Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ
Thu Mar 06 00:00:00 EST 2014
Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Epaulard O,Adam L,Poux C,Zurawski G,Salabert N,Rosenbaum P,Dereuddre-Bosquet N,Zurawski S,Flamar AL,Oh S,Romain G,Chapon C,Banchereau J,Lévy Y,Le Grand R,Martinon F
Mon Sep 01 00:00:00 EDT 2014
Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1.
Journal of immunology (Baltimore, Md. : 1950)
Bednar F,Song C,Bardi G,Cornwell W,Rogers TJ
Sun Jun 01 00:00:00 EDT 2014
Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis.
Frontiers in pharmacology
Lee R,Perry B,Heywood J,Reese C,Bonner M,Hatfield CM,Silver RM,Visconti RP,Hoffman S,Tourkina E
300-08 was used in Immunohistochemistry-immunofluorescence to suggest that low monocyte caveolin-1 promotes fibrosis by enhancing the recruitment of fibrocytes and their progenitors into affected tissue.
Thu Jun 26 00:00:00 EDT 2014
Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.
The Journal of biological chemistry
Jin J,Colin P,Staropoli I,Lima-Fernandes E,Ferret C,Demir A,Rogée S,Hartley O,Randriamampita C,Scott MG,Marullo S,Sauvonnet N,Arenzana-Seisdedos F,Lagane B,Brelot A
Fri Jul 04 00:00:00 EDT 2014
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood
Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T
Thu May 16 00:00:00 EDT 2013
Adam8 limits the development of allergic airway inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Knolle MD,Nakajima T,Hergrueter A,Gupta K,Polverino F,Craig VJ,Fyfe SE,Zahid M,Permaul P,Cernadas M,Montano G,Tesfaigzi Y,Sholl L,Kobzik L,Israel E,Owen CA
Sat Jun 15 00:00:00 EDT 2013
Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.
The Journal of biological chemistry
Steen A,Thiele S,Guo D,Hansen LS,Frimurer TM,Rosenkilde MM
Fri May 03 00:00:00 EDT 2013
Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function.
The Journal of biological chemistry
Blanchetot C,Verzijl D,Mujić-Delić A,Bosch L,Rem L,Leurs R,Verrips CT,Saunders M,de Haard H,Smit MJ
Fri Aug 30 00:00:00 EDT 2013
Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.
Blood
Struyf S,Salogni L,Burdick MD,Vandercappellen J,Gouwy M,Noppen S,Proost P,Opdenakker G,Parmentier M,Gerard C,Sozzani S,Strieter RM,Van Damme J
Thu Jan 13 00:00:00 EST 2011
Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines.
Virology journal
Bolton MJ,Garry RF
Mon Jan 31 00:00:00 EST 2011
Host chemokines bind to Staphylococcus aureus and stimulate protein A release.
The Journal of biological chemistry
Yung SC,Parenti D,Murphy PM
Fri Feb 18 00:00:00 EST 2011
Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.
The Journal of biological chemistry
Thiele S,Steen A,Jensen PC,Mokrosinski J,Frimurer TM,Rosenkilde MM
Fri Oct 28 00:00:00 EDT 2011
PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
PLoS pathogens
Hanley TM,Blay Puryear W,Gummuluru S,Viglianti GA
Thu Jul 01 00:00:00 EDT 2010
Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients.
Arthritis research & therapy
Rodríguez-Bayona B,Ramos-Amaya A,Pérez-Venegas JJ,Rodríguez C,Brieva JA
Wed Nov 24 00:00:00 EST 2010
Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.
Journal of immunology (Baltimore, Md. : 1950)
Quintero PA,Knolle MD,Cala LF,Zhuang Y,Owen CA
Mon Feb 01 00:00:00 EST 2010
Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.
Journal of immunology (Baltimore, Md. : 1950)
Rius C,Abu-Taha M,Hermenegildo C,Piqueras L,Cerda-Nicolas JM,Issekutz AC,Estañ L,Cortijo J,Morcillo EJ,Orallo F,Sanz MJ
Wed Sep 15 00:00:00 EDT 2010
Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.
Journal of immunology (Baltimore, Md. : 1950)
Rius C,Abu-Taha M,Hermenegildo C,Piqueras L,Cerda-Nicolas JM,Issekutz AC,Estañ L,Cortijo J,Morcillo EJ,Orallo F,Sanz MJ
Wed Sep 15 00:00:00 EDT 2010
CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Carbone T,Nasorri F,Pennino D,Eyerich K,Foerster S,Cifaldi L,Traidl-Hoffman C,Behrendt H,Cavani A
Fri Jan 15 00:00:00 EST 2010
Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients.
Journal of immunology (Baltimore, Md. : 1950)
Madigan J,Freeman DJ,Menzies F,Forrow S,Nelson SM,Young A,Sharkey A,Moffett A,Graham GJ,Greer IA,Rot A,Nibbs RJ
Mon Mar 15 00:00:00 EDT 2010
Dynamic interaction networks in a hierarchically organized tissue.
Molecular systems biology
Kirouac DC,Ito C,Csaszar E,Roch A,Yu M,Sykes EA,Bader GD,Zandstra PW
Tue Oct 05 00:00:00 EDT 2010
Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14.
Blood
Salogni L,Musso T,Bosisio D,Mirolo M,Jala VR,Haribabu B,Locati M,Sozzani S
Thu Jun 04 00:00:00 EDT 2009
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
Journal of immunology (Baltimore, Md. : 1950)
Abu-Taha M,Rius C,Hermenegildo C,Noguera I,Cerda-Nicolas JM,Issekutz AC,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ
Wed Jul 15 00:00:00 EDT 2009
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.
Journal of neurotrauma
Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ
Wed Apr 01 00:00:00 EDT 2009
Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.
Journal of bacteriology
Bryan JD,Shelver DW
Sun Mar 01 00:00:00 EST 2009
Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence.
The Journal of biological chemistry
Savino B,Borroni EM,Torres NM,Proost P,Struyf S,Mortier A,Mantovani A,Locati M,Bonecchi R
Fri Sep 18 00:00:00 EDT 2009
Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Vassiliou EK,Kesler OM,Tadros JH,Ganea D
Wed Oct 01 00:00:00 EDT 2008
A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.
Blood
Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ
Sat Sep 15 00:00:00 EDT 2007
CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.
Arteriosclerosis, thrombosis, and vascular biology
Abu Nabah YN,Losada M,Estellés R,Mateo T,Company C,Piqueras L,Lopez-Gines C,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ
Thu Nov 01 00:00:00 EDT 2007
CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.
Arteriosclerosis, thrombosis, and vascular biology
Abu Nabah YN,Losada M,Estellés R,Mateo T,Company C,Piqueras L,Lopez-Gines C,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ
Thu Nov 01 00:00:00 EDT 2007
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 EDT 2007
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence.
The Journal of experimental medicine
Yurchenko E,Tritt M,Hay V,Shevach EM,Belkaid Y,Piccirillo CA
Mon Oct 30 00:00:00 EST 2006
CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M
Wed Nov 01 00:00:00 EST 2006
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.
The European respiratory journal
Pilette C,Francis JN,Till SJ,Durham SR
Tue Jun 01 00:00:00 EDT 2004
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.
The European respiratory journal
Pilette C,Francis JN,Till SJ,Durham SR
Tue Jun 01 00:00:00 EDT 2004
Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas.
Blood
Trentin L,Cabrelle A,Facco M,Carollo D,Miorin M,Tosoni A,Pizzo P,Binotto G,Nicolardi L,Zambello R,Adami F,Agostini C,Semenzato G
Thu Jul 15 00:00:00 EDT 2004
Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP
Thu Jan 15 00:00:00 EST 2004
Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology
Toh K,Kukita T,Wu Z,Kukita A,Sandra F,Tang QY,Nomiyama H,Iijima T
Wed Sep 01 00:00:00 EDT 2004
Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.
The Journal of biological chemistry
Hirata T,Furukawa Y,Yang BG,Hieshima K,Fukuda M,Kannagi R,Yoshie O,Miyasaka M
Fri Dec 10 00:00:00 EST 2004
Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.
The Journal of biological chemistry
Alvarez Arias D,Navenot JM,Zhang WB,Broach J,Peiper SC
Fri Sep 19 00:00:00 EDT 2003
Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.
American journal of respiratory and critical care medicine
Bryan SA,Jose PJ,Topping JR,Wilhelm R,Soderberg C,Kertesz D,Barnes PJ,Williams TJ,Hansel TT,Sabroe I
Sat Jun 15 00:00:00 EDT 2002
CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor.
Blood
Honczarenko M,Le Y,Glodek AM,Majka M,Campbell JJ,Ratajczak MZ,Silberstein LE
Tue Oct 01 00:00:00 EDT 2002
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.
The Journal of biological chemistry
Tiffany HL,Lavigne MC,Cui YH,Wang JM,Leto TL,Gao JL,Murphy PM
Fri Jun 29 00:00:00 EDT 2001
CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.
Nature immunology
Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A
Sat Jul 01 00:00:00 EDT 2000
The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro.
Stem cells (Dayton, Ohio)
Majka M,Ratajczak J,Lee B,Honczarenko M,Douglas R,Kowalska MA,Silberstein L,Gewirtz AM,Ratajczak MZ
Mon Jun 26 00:00:00 EDT 2000
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
The Journal of biological chemistry
Sabroe I,Peck MJ,Van Keulen BJ,Jorritsma A,Simmons G,Clapham PR,Williams TJ,Pease JE
Fri Aug 25 00:00:00 EDT 2000
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
The Journal of biological chemistry
Sabroe I,Peck MJ,Van Keulen BJ,Jorritsma A,Simmons G,Clapham PR,Williams TJ,Pease JE
Fri Aug 25 00:00:00 EDT 2000
Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.
Journal of immunology (Baltimore, Md. : 1950)
Sabroe I,Hartnell A,Jopling LA,Bel S,Ponath PD,Pease JE,Collins PD,Williams TJ
Mon Mar 01 00:00:00 EST 1999
Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.
The Journal of biological chemistry
Oppermann M,Mack M,Proudfoot AE,Olbrich H
Fri Mar 26 00:00:00 EST 1999
Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3.
The Journal of biological chemistry
Kitaura M,Suzuki N,Imai T,Takagi S,Suzuki R,Nakajima T,Hirai K,Nomiyama H,Yoshie O
Fri Sep 24 00:00:00 EDT 1999
Chemokines and the arrest of lymphocytes rolling under flow conditions.
Science (New York, N.Y.)
Campbell JJ,Hedrick J,Zlotnik A,Siani MA,Thompson DA,Butcher EC
Fri Jan 16 00:00:00 EST 1998
Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: withdrawal of chemokines from the environment of cytomegalovirus-infected cells.
The Journal of experimental medicine
Bodaghi B,Jones TR,Zipeto D,Vita C,Sun L,Laurent L,Arenzana-Seisdedos F,Virelizier JL,Michelson S
Mon Sep 07 00:00:00 EDT 1998
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains.
The American journal of pathology
Xia MQ,Qin SX,Wu LJ,Mackay CR,Hyman BT
Wed Jul 01 00:00:00 EDT 1998
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains.
The American journal of pathology
Xia MQ,Qin SX,Wu LJ,Mackay CR,Hyman BT
Wed Jul 01 00:00:00 EDT 1998
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
Journal of immunology (Baltimore, Md. : 1950)
Wang JM,Ueda H,Howard OM,Grimm MC,Chertov O,Gong X,Gong W,Resau JH,Broder CC,Evans G,Arthur LO,Ruscetti FW,Oppenheim JJ
Thu Oct 15 00:00:00 EDT 1998
Type I IFNs enhance the terminal differentiation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Luft T,Pang KC,Thomas E,Hertzog P,Hart DN,Trapani J,Cebon J
Sat Aug 15 00:00:00 EDT 1998
Identification of single C motif-1/lymphotactin receptor XCR1.
The Journal of biological chemistry
Yoshida T,Imai T,Kakizaki M,Nishimura M,Takagi S,Yoshie O
Fri Jun 26 00:00:00 EDT 1998
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
The Journal of experimental medicine
Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM
Mon Jul 07 00:00:00 EDT 1997
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
The Journal of experimental medicine
Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM
Mon Jul 07 00:00:00 EDT 1997
