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Product Details
RP-87981
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human CD200, amino acids Met1-Gly232 (Accession # NP_005935.4) with a C-terminal His-tag
Tag
His-tag
Molecular weight
40-45 kDa
Class
Recombinant
Type
Protein
Purity
>98% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Activity
Immobilized CD200 Protein, Human, Recombinant (His Tag) at 2 µg/mL (100 µL/well) can bind CD200R Protein, Human, Recombinant (His and hFc Tag), the EC50 is 5-28 ng/mL.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
Reconstituted with sterile deionized water to 0.25 mg/mL.
Concentration is measured by UV.
Target Information
CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody MRC OX-2; CD200; CD200 antigen; OX-2 membrane glycoprotein
Gene Aliases: CD200; MOX1; MOX2; MRC; My033; OX-2
UniProt ID: (Human) P41217
Entrez Gene ID: (Human) 4345
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