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Product Details
RP-88001
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human CD3 delta, amino acids Met1-Ala105 (Accession # NP_000723.1) with a C-terminal Flag-tagged human IgG1 Fc region
Tag
DYKDDDDK-tag, Fc-tag
Molecular weight
47-51 kDa
Class
Recombinant
Type
Protein
Purity
>85% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Conjugate
Form
Lyophilized
Concentration
0.25 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (1000 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
CD3d is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The CD3d protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in the CD3d gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms of CD3d have been found. Other variants of CD3d may also exist, but the full-length nature of their transcripts have yet to be defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD3 antigen, delta subunit; CD3 delta; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); OKT3, delta chain; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain
Gene Aliases: CD3-DELTA; CD3D; IMD19; T3D
UniProt ID: (Human) P04234
Entrez Gene ID: (Human) 915
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