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Product Details
A33353
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
1-498
Tag
GST-tag
Molecular weight
82.7 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris HCl, pH 7.5, with 0.25mM DTT, 25% glycerol, 0.1mM PMSF, 0.1mM EDTA, 150mM NaCl, 10mM glutathione
Contains
no preservative
Storage conditions
-80° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CDKL5 recombinant human protein (1-498) was expressed in insect cells.
CDKL5 recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z'-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
Target Information
CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin dependent kinase 5 transcript; Cyclin-dependent kinase-like 5; RP1-245G19.3; serine/threonine kinase 9; Serine/threonine-protein kinase 9
Gene Aliases: CDKL5; CFAP247; EIEE2; ISSX; STK9
UniProt ID: (Human) O76039
Entrez Gene ID: (Human) 6792
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