Gibco

Human CTGF (CCN2) Recombinant Protein, PeproTech®

Product Details

120-19-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

View 1 publication 1 publication

In vitro Assay (IV)

View 19 publications 19 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Chicken, Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

GKKCIRTPKI SKPIKFELSG CTSMKTYRAK FCGVCTDGRC CTPHRTTTLP VEFKCPDGEV MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA

Molecular weight

11 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human CTGF is an 11.0 kDa protein consisting of 97 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway.

Cell proliferation

Wu Z,Zhou C,Yuan Q,Zhang D,Xie J,Zou S

Mon Mar 01 00:00:00 EST 2021

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.

iScience

Chen X,Zhang Y,Qian W,Han L,Li W,Duan W,Wu Z,Wang Z,Ma Q

120-19 was used in Control to uncover that high Arl4c expression is associated with cell proliferation, drug resistance, and PSC activation, suggesting its vitality in pancreatic cancer progression.

Fri Dec 17 00:00:00 EST 2021

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.

The Journal of clinical investigation

Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C

Fri Mar 01 00:00:00 EST 2019

Exosomes from tendon stem cells promote injury tendon healing through balancing synthesis and degradation of the tendon extracellular matrix.

Journal of cellular and molecular medicine

Wang Y,He G,Guo Y,Tang H,Shi Y,Bian X,Zhu M,Kang X,Zhou M,Lyu J,Yang M,Mu M,Lai F,Lu K,Chen W,Zhou B,Zhang J,Tang K

Thu Aug 01 00:00:00 EDT 2019

TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.

Scientific reports

Kanda A,Noda K,Hirose I,Ishida S

Thu Jan 24 00:00:00 EST 2019

Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.

The Journal of biological chemistry

Sato-Matsubara M,Matsubara T,Daikoku A,Okina Y,Longato L,Rombouts K,Thuy LTT,Adachi J,Tomonaga T,Ikeda K,Yoshizato K,Pinzani M,Kawada N

Fri Nov 17 00:00:00 EST 2017

Tenomodulin highly expressing MSCs as a better cell source for tendon injury healing.

Oncotarget

Hou Y,Ni M,Lin S,Sun Y,Lin W,Liu Y,Wang H,He W,Li G,Xu L

120-19 was used in Cell Culture to generate the Tenomodulin (Tnmd) promoter-driven GFP expression lentiviral plasmid to show that Tnmd could be used as an ideal cell surface marker to select cells with higher tenogenic differentiation ability from BMSCs, and GDF7 was indispensable for tenogenesis of MSCs.

Fri Sep 29 00:00:00 EDT 2017

Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop.

Scientific reports

Kechagia JZ,Ezra DG,Burton MJ,Bailly M

Mon Jun 20 00:00:00 EDT 2016

Priming with ligands secreted by human stromal progenitor cells promotes grafts of cardiac stem/progenitor cells after myocardial infarction.

Stem cells (Dayton, Ohio)

Iso Y,Rao KS,Poole CN,Zaman AK,Curril I,Sobel BE,Kajstura J,Anversa P,Spees JL

Sat Mar 01 00:00:00 EST 2014

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

Proceedings of the National Academy of Sciences of the United States of America

Ren S,Johnson BG,Kida Y,Ip C,Davidson KC,Lin SL,Kobayashi A,Lang RA,Hadjantonakis AK,Moon RT,Duffield JS

Tue Jan 22 00:00:00 EST 2013

CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3β signaling pathway.

Journal of cell communication and signaling

Moe IT,Pham TA,Hagelin EM,Ahmed MS,Attramadal H

Fri Mar 01 00:00:00 EST 2013

CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis.

PloS one

Hall-Glenn F,De Young RA,Huang BL,van Handel B,Hofmann JJ,Chen TT,Choi A,Ong JR,Benya PD,Mikkola H,Iruela-Arispe ML,Lyons KM

Fri Jun 29 00:00:00 EDT 2012

CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway.

PloS one

Liu SC,Hsu CJ,Chen HT,Tsou HK,Chuang SM,Tang CH

Tue May 21 00:00:00 EDT 2013

Increased fibroblast functionality on CNN2-loaded titania nanotubes.

International journal of nanomedicine

Wei H,Wu S,Feng Z,Zhou W,Dong Y,Wu G,Bai S,Zhao Y

Tue Jun 19 00:00:00 EDT 2012

CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8/Svneo cell adhesion and network formation.

Human reproduction (Oxford, England)

Waddell JM,Evans J,Jabbour HN,Denison FC

Sat Jan 01 00:00:00 EST 2011

Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.

PloS one

Lorda-Diez CI,Montero JA,Diaz-Mendoza MJ,Garcia-Porrero JA,Hurle JM

Fri Jun 08 00:00:00 EDT 2012

Gene bionetwork analysis of ovarian primordial follicle development.

PloS one

Nilsson EE,Savenkova MI,Schindler R,Zhang B,Schadt EE,Skinner MK

Fri Jul 16 00:00:00 EDT 2010

Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors.

BMC cancer

Hamm CA,Stevens JW,Xie H,Vanin EF,Morcuende JA,Abdulkawy H,Seftor EA,Sredni ST,Bischof JM,Wang D,Malchenko S,Bonaldo Mde F,Casavant TL,Hendrix MJ,Soares MB

Wed Sep 01 00:00:00 EDT 2010

Induction of ovarian primordial follicle assembly by connective tissue growth factor CTGF.

PloS one

Schindler R,Nilsson E,Skinner MK

Fri Sep 24 00:00:00 EDT 2010

Connective tissue growth factor enhances osteoblastogenesis in vitro.

The Journal of biological chemistry

Smerdel-Ramoya A,Zanotti S,Deregowski V,Canalis E

Fri Aug 15 00:00:00 EDT 2008

Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.

Cancer research

Kikuchi R,Tsuda H,Kanai Y,Kasamatsu T,Sengoku K,Hirohashi S,Inazawa J,Imoto I

Wed Aug 01 00:00:00 EDT 2007

Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development.

American journal of physiology. Gastrointestinal and liver physiology

Kidd M,Modlin IM,Eick GN,Camp RL,Mane SM

Mon Jan 01 00:00:00 EST 2007

Bioinformatics

Protein Aliases: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; H-CTGF; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839

Human CTGF (CCN2) Recombinant Protein, PeproTech®

Product Details

120-19-20UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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