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Product Details
PEP-0228
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human Caspase-5.
PEP-0228 can be used as a blocking peptide with polyclonal antibody PA5-20110.
Target Information
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1-b and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1-b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP-5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; Caspase-5; ICE(rel)-III; Protease ICH-3; Protease TY; TY protease
Gene Aliases: CASP5; ICE(rel)III; ICEREL-III; ICH-3; ICH3
UniProt ID: (Human) Q0QVY8
Entrez Gene ID: (Human) 838
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