Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 15 amino acids near the carboxy terminus of human ERRF2.
PEP-1577 can be used as a blocking peptide with polyclonal antibody PA5-34534. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.
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Protein Aliases: ER-related factor; Estrogen receptor-related factor; RP11-5P18.4; Steroid receptor-associated and regulated protein; Steroid receptor-regulated protein
Gene Aliases: C1orf64; ERRF; SRARP; SSPR
UniProt ID: (Human) Q8NEQ6
Entrez Gene ID: (Human) 149563
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