Product References
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Cell metabolism
Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A
300-31 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.
Tue May 02 00:00:00 EDT 2023
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.
Nature protocols
Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H
300-31 was used in In vitro experiments to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.
Fri Sep 01 00:00:00 EDT 2023
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
eLife
Jairaman A,McQuade A,Granzotto A,Kang YJ,Chadarevian JP,Gandhi S,Parker I,Smith I,Cho H,Sensi SL,Othy S,Blurton-Jones M,Cahalan MD
300-31 was used in In vitro experiments to show that loss of TREM2 confers a defect in microglial Ca2+ response to purinergic signals, suggesting a window of Ca2+ signaling for optimal microglial motility.
Tue Feb 22 00:00:00 EST 2022
Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.
Frontiers in immunology
Wallach T,Raden M,Hinkelmann L,Brehm M,Rabsch D,Weidling H,Krüger C,Kettenmann H,Backofen R,Lehnardt S
300-31 was used in In vitro experiments to determine TLR7 and TLR8 as key sensors of SARS-CoV-2-derived ssRNAs and may deepen our understanding of the mechanisms how this virus triggers, but also modulates an inflammatory response through innate immune signaling.
Tue Jan 31 00:00:00 EST 2023
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Brain : a journal of neurology
Magusali N,Graham AC,Piers TM,Panichnantakul P,Yaman U,Shoai M,Reynolds RH,Botia JA,Brookes KJ,Guetta-Baranes T,Bellou E,Bayram S,Sokolova D,Ryten M,Sala Frigerio C,Escott-Price V,Morgan K,Pocock JM,Hardy J,Salih DA
Fri Dec 31 00:00:00 EST 2021
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies.
Nature communications
De Groof TWM,Bergkamp ND,Heukers R,Giap T,Bebelman MP,Goeij-de Haas R,Piersma SR,Jimenez CR,Garcia KC,Ploegh HL,Siderius M,Smit MJ
Fri Jul 16 00:00:00 EDT 2021
Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
The Journal of experimental medicine
Liu T,Zhu B,Liu Y,Zhang X,Yin J,Li X,Jiang L,Hodges AP,Rosenthal SB,Zhou L,Yancey J,McQuade A,Blurton-Jones M,Tanzi RE,Huang TY,Xu H
Mon Dec 07 00:00:00 EST 2020
A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.
Stem cell reports
Grubman A,Vandekolk TH,Schröder J,Sun G,Hatwell-Humble J,Chan J,Oksanen M,Lehtonen S,Hunt C,Koistinaho JE,Nilsson SK,Haynes JM,Pouton CW,Polo JM
Tue Jun 09 00:00:00 EDT 2020
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Molecular systems biology
Morshed N,Ralvenius WT,Nott A,Watson LA,Rodriguez FH,Akay LA,Joughin BA,Pao PC,Penney J,LaRocque L,Mastroeni D,Tsai LH,White FM
Tue Dec 01 00:00:00 EST 2020
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Fluids and barriers of the CNS
Curtaz CJ,Schmitt C,Herbert SL,Feldheim J,Schlegel N,Gosselet F,Hagemann C,Roewer N,Meybohm P,Wöckel A,Burek M
300-31 was used in In vitro experiments to demonstrate that the CD34+ cell-derived human in vitro blood-brain barrier model can be used as a tool to study the molecular mechanisms underlying cerebrovascular pathologies.
Wed Apr 22 00:00:00 EDT 2020
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing.
Cell reports
Knupp A,Mishra S,Martinez R,Braggin JE,Szabo M,Kinoshita C,Hailey DW,Small SA,Jayadev S,Young JE
300-31 was used in Cell Culture to validate defects in neuronal endosomal trafficking following the depletion of the SORL1.
Tue Jun 02 00:00:00 EDT 2020
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Neuron
Hasselmann J,Coburn MA,England W,Figueroa Velez DX,Kiani Shabestari S,Tu CH,McQuade A,Kolahdouzan M,Echeverria K,Claes C,Nakayama T,Azevedo R,Coufal NG,Han CZ,Cummings BJ,Davtyan H,Glass CK,Healy LM,Gandhi SP,Spitale RC,Blurton-Jones M
Wed Sep 25 00:00:00 EDT 2019
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 EDT 2019
Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response.
Nature communications
Pokharel SM,Shil NK,Gc JB,Colburn ZT,Tsai SY,Segovia JA,Chang TH,Bandyopadhyay S,Natesan S,Jones JCR,Bose S
Mon Apr 01 00:00:00 EDT 2019
The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.
Oncogene
Heukers R,Fan TS,de Wit RH,van Senten JR,De Groof TWM,Bebelman MP,Lagerweij T,Vieira J,de Munnik SM,Smits-de Vries L,van Offenbeek J,Rahbar A,van Hoorick D,Söderberg-Naucler C,Würdinger T,Leurs R,Siderius M,Vischer HF,Smit MJ
Sun Jul 01 00:00:00 EDT 2018
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Scientific reports
Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S
Fri Apr 20 00:00:00 EDT 2018
Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets.
Journal of cellular physiology
Buskermolen JK,Roffel S,Gibbs S
Wed Nov 01 00:00:00 EDT 2017
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.
Bioscience reports
Kehlen A,Haegele M,Böhme L,Cynis H,Hoffmann T,Demuth HU
300-31 was used in In vitro experiments to suggest that QC-catalysed N-terminal pGlu formation of CX3CL1 is important for the stability or the interaction with its receptor and opens new insights into the function of QC in inflammation.
Thu Aug 31 00:00:00 EDT 2017
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 EDT 2017
Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Ridderstad Wollberg A,Ericsson-Dahlstrand A,Juréus A,Ekerot P,Simon S,Nilsson M,Wiklund SJ,Berg AL,Ferm M,Sunnemark D,Johansson R
Tue Apr 08 00:00:00 EDT 2014
CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration.
Journal of immunology (Baltimore, Md. : 1950)
Zhang J,Xiao Z,Qu C,Cui W,Wang X,Du J
Sat Nov 15 00:00:00 EST 2014
CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies.
PloS one
Zieger M,Ahnelt PK,Uhrin P
300-31 was used in Western Blotting to investigate CX3CL1 expression in retinal degeneration.
Thu Mar 17 00:00:00 EDT 2016
CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice.
Blood
Jacquelin S,Licata F,Dorgham K,Hermand P,Poupel L,Guyon E,Deterre P,Hume DA,Combadière C,Boissonnas A
Thu Aug 01 00:00:00 EDT 2013
US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells.
PloS one
Miller WE,Zagorski WA,Brenneman JD,Avery D,Miller JL,O'Connor CM
Wed May 22 00:00:00 EDT 2013
US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells.
PloS one
Miller WE,Zagorski WA,Brenneman JD,Avery D,Miller JL,O'Connor CM
Wed May 22 00:00:00 EDT 2013
Host chemokines bind to Staphylococcus aureus and stimulate protein A release.
The Journal of biological chemistry
Yung SC,Parenti D,Murphy PM
Fri Feb 18 00:00:00 EST 2011
ATP secreted by endothelial cells blocks CX₃CL 1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y₁₁ receptor activation.
Blood
Gorini S,Callegari G,Romagnoli G,Mammi C,Mavilio D,Rosano G,Fini M,Di Virgilio F,Gulinelli S,Falzoni S,Cavani A,Ferrari D,la Sala A
Thu Nov 25 00:00:00 EST 2010
Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.
Journal of immunology (Baltimore, Md. : 1950)
Nakayama T,Watanabe Y,Oiso N,Higuchi T,Shigeta A,Mizuguchi N,Katou F,Hashimoto K,Kawada A,Yoshie O
Wed Dec 01 00:00:00 EST 2010
Eotaxin-3/CC chemokine ligand 26 is a functional ligand for CX3CR1.
Journal of immunology (Baltimore, Md. : 1950)
Nakayama T,Watanabe Y,Oiso N,Higuchi T,Shigeta A,Mizuguchi N,Katou F,Hashimoto K,Kawada A,Yoshie O
Wed Dec 01 00:00:00 EST 2010
CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Carbone T,Nasorri F,Pennino D,Eyerich K,Foerster S,Cifaldi L,Traidl-Hoffman C,Behrendt H,Cavani A
Fri Jan 15 00:00:00 EST 2010
Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma.
Journal of immunology (Baltimore, Md. : 1950)
Clements D,Markwick LJ,Puri N,Johnson SR
Sun Aug 01 00:00:00 EDT 2010
Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.
Molecular pain
Chen T,Koga K,Li XY,Zhuo M
Fri Apr 09 00:00:00 EDT 2010
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.
Nature medicine
Koenen RR,von Hundelshausen P,Nesmelova IV,Zernecke A,Liehn EA,Sarabi A,Kramp BK,Piccinini AM,Paludan SR,Kowalska MA,Kungl AJ,Hackeng TM,Mayo KH,Weber C
Thu Jan 01 00:00:00 EST 2009
Human cytomegalovirus paralyzes macrophage motility through down-regulation of chemokine receptors, reorganization of the cytoskeleton, and release of macrophage migration inhibitory factor.
Journal of immunology (Baltimore, Md. : 1950)
Frascaroli G,Varani S,Blankenhorn N,Pretsch R,Bacher M,Leng L,Bucala R,Landini MP,Mertens T
Thu Jan 01 00:00:00 EST 2009
SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
PloS one
Egesten A,Olin AI,Linge HM,Yadav M,Mörgelin M,Karlsson A,Collin M
Mon Jun 15 00:00:00 EDT 2009
Structure and function of A41, a vaccinia virus chemokine binding protein.
PLoS pathogens
Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM
Tue Jan 01 00:00:00 EST 2008
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 EDT 2007
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.
The Journal of biological chemistry
Tiffany HL,Lavigne MC,Cui YH,Wang JM,Leto TL,Gao JL,Murphy PM
Fri Jun 29 00:00:00 EDT 2001
Chemokines and the arrest of lymphocytes rolling under flow conditions.
Science (New York, N.Y.)
Campbell JJ,Hedrick J,Zlotnik A,Siani MA,Thompson DA,Butcher EC
Fri Jan 16 00:00:00 EST 1998
