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Recombinant Human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions. The calculated molecular weight of Recombinant Human GASP-1 is 59.9 kDa.
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Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-beta binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain.
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Protein Aliases: GASP-1; Growth and differentiation factor-associated serum protein 1; multivalent protease inhibitor protein; WAP four-disulfide core domain 20B; WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein; WAP, FS, Ig, two KU and NTR module related protein; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; WFIKKN-related protein
Gene Aliases: GASP-1; GASP1; hGASP-1; UNQ9235/PRO31996; WFDC20B; WFIKKN2; WFIKKNRP
UniProt ID: (Human) Q8TEU8
Entrez Gene ID: (Human) 124857
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