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Human Galectin-1 Recombinant Protein, PeproTech®

Human Galectin-1 Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Human Galectin-1 Protein (450-39-50UG) in Functional

Bioassay analysis of Human Galectin-1 Recombinant Protein, PeproTech® (Product # 450-39-1MG).

Product Image Gallery

Product Details

450-39-50UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 7 publications 7 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species

Human

Published species

Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD

Molecular weight

14.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obtained at 250 ug/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Galectin-1 belongs to a large family of carbohydrate-binding proteins called lectins. Galectin-1can be either monomeric or homodimeric and is found in a wide variety of cells and tissue types. Galectin-1 can control cell growth, proliferation, induce apoptosis of activated T cells while it can also modulate cytokine secretion or inhibit pro-inflammatory cytokine production. Galectin-1 plays an important role in acute and chronic inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.

Cancer science

Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K

Mon Feb 01 00:00:00 EST 2021

Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.

Cancer science

Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K

Mon Feb 01 00:00:00 EST 2021

Pharmacological treatment with galectin-1 protects against renal ischaemia-reperfusion injury.

Scientific reports

Carlos CP,Silva AA,Gil CD,Oliani SM

Fri Jun 22 00:00:00 EDT 2018

Pharmacological treatment with galectin-1 protects against renal ischaemia-reperfusion injury.

Scientific reports

Carlos CP,Silva AA,Gil CD,Oliani SM

Fri Jun 22 00:00:00 EDT 2018

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.

Nature communications

Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

Wed Aug 22 00:00:00 EDT 2018

Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans.

Nature communications

Giovannone N,Liang J,Antonopoulos A,Geddes Sweeney J,King SL,Pochebit SM,Bhattacharyya N,Lee GS,Dell A,Widlund HR,Haslam SM,Dimitroff CJ

Fri Aug 17 00:00:00 EDT 2018

Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

White MJ,Roife D,Gomer RH

Sat Aug 15 00:00:00 EDT 2015

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.

Proceedings of the National Academy of Sciences of the United States of America

Freitag N,Tirado-González I,Barrientos G,Herse F,Thijssen VL,Weedon-Fekjær SM,Schulz H,Wallukat G,Klapp BF,Nevers T,Sharma S,Staff AC,Dechend R,Blois SM

Tue Jul 09 00:00:00 EDT 2013

Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ye Y,Yan S,Jiang G,Zhou L,Xie H,Xie X,Yu X,Ding Y,Tian J,Dai Y,Zheng S

Fri Mar 01 00:00:00 EST 2013

HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation.

Placenta

Liu X,Gu W,Li X

450-39 was used in Cell Culture to demonstrate that human leucocyte antigen-G is able to regulate JEG-3 cell invasion by influencing STAT3 activation, which may underlie the implantation defects accompanying HLA-G hypo-expression in pre-eclampsia.

Fri Nov 01 00:00:00 EDT 2013

Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma.

Blood

Cedeno-Laurent F,Watanabe R,Teague JE,Kupper TS,Clark RA,Dimitroff CJ

Thu Apr 12 00:00:00 EDT 2012

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

Blood

Garín MI,Chu CC,Golshayan D,Cernuda-Morollón E,Wait R,Lechler RI

Thu Mar 01 00:00:00 EST 2007

Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells.

Journal of immunology (Baltimore, Md. : 1950)

Perone MJ,Larregina AT,Shufesky WJ,Papworth GD,Sullivan ML,Zahorchak AF,Stolz DB,Baum LG,Watkins SC,Thomson AW,Morelli AE

Thu Jun 15 00:00:00 EDT 2006

Bioinformatics

Protein Aliases: 14 kDa laminin-binding protein; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; beta-galactoside-binding protein 14kDa; DKFZp686E23103; Gal-1; Galaptin; Galectin-1; Galectin1; H-Galectin-1; HBL; HLBP14; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; lectin, galactoside binding soluble 1; lectin, galactoside-binding, soluble, 1; pm12; Putative MAPK-activating protein PM12; S-Lac lectin 1

Human Galectin-1 Recombinant Protein, PeproTech®

Human Galectin-1 Protein (450-39-50UG) in Functional

Product Details

450-39-50UG

Western Blot (WB)

Flow Cytometry (Flow)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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