Product References
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.
Nature communications
Meyrath M,Szpakowska M,Zeiner J,Massotte L,Merz MP,Benkel T,Simon K,Ohnmacht J,Turner JD,Krüger R,Seutin V,Ollert M,Kostenis E,Chevigné A
Fri Jun 19 00:00:00 EDT 2020
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes.
Cell chemical biology
White CW,Caspar B,Vanyai HK,Pfleger KDG,Hill SJ
300-46 was used in In vitro experiments to show that genetically encoded luminescent biosensors can be used to investigate numerous aspects of receptor function at native expression levels.
Thu May 21 00:00:00 EDT 2020
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
The Journal of biological chemistry
Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S
Fri Jul 19 00:00:00 EDT 2019
Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo.
Nature communications
Tulic MK,Cavazza E,Cheli Y,Jacquel A,Luci C,Cardot-Leccia N,Hadhiri-Bzioueche H,Abbe P,Gesson M,Sormani L,Regazzetti C,Beranger GE,Lereverend C,Pons C,Khemis A,Ballotti R,Bertolotto C,Rocchi S,Passeron T
Thu May 16 00:00:00 EDT 2019
Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3-mediated chemokine scavenging.
The Journal of biological chemistry
Montpas N,St-Onge G,Nama N,Rhainds D,Benredjem B,Girard M,Hickson G,Pons V,Heveker N
Fri Jan 19 00:00:00 EST 2018
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Scientific reports
Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S
Fri Apr 20 00:00:00 EDT 2018
Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets.
Journal of cellular physiology
Buskermolen JK,Roffel S,Gibbs S
Wed Nov 01 00:00:00 EDT 2017
Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling.
International journal of molecular sciences
Metzemaekers M,Mortier A,Janssens R,Boff D,Vanbrabant L,Lamoen N,Van Damme J,Teixeira MM,De Meester I,Amaral FA,Proost P
Thu Jul 13 00:00:00 EDT 2017
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Scientific reports
Zhang Y,Wu Y,Qi H,Xiao J,Gong H,Zhang Y,Xu E,Li S,Ma D,Wang Y,Li W,Shen H
Wed Nov 08 00:00:00 EST 2017
Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.
The Journal of biological chemistry
Benredjem B,Girard M,Rhainds D,St-Onge G,Heveker N
Fri Jan 06 00:00:00 EST 2017
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 EDT 2017
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
Wed Jun 01 00:00:00 EDT 2016
Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Wendt E,White GE,Ferry H,Huhn M,Greaves DR,Keshav S
Sun May 01 00:00:00 EDT 2016
CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.
British journal of pharmacology
Nedjai B,Viney JM,Li H,Hull C,Anderson CA,Horie T,Horuk R,Vaidehi N,Pease JE
Wed Apr 01 00:00:00 EDT 2015
The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice.
The Journal of biological chemistry
Vanheule V,Janssens R,Boff D,Kitic N,Berghmans N,Ronsse I,Kungl AJ,Amaral FA,Teixeira MM,Van Damme J,Proost P,Mortier A
Fri Aug 28 00:00:00 EDT 2015
CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells.
Molecular cancer research : MCR
Choi YH,Burdick MD,Strieter BA,Mehrad B,Strieter RM
300-46 was used in In vitro experiments to indicate that CXCR4, not CXCR7, expression engages CXCL12 to mediate NSCLC metastatic behavior.
Wed Jan 01 00:00:00 EST 2014
Chemokine cooperativity is caused by competitive glycosaminoglycan binding.
Journal of immunology (Baltimore, Md. : 1950)
Verkaar F,van Offenbeek J,van der Lee MMC,van Lith LHCJ,Watts AO,Rops ALWMM,Aguilar DC,Ziarek JJ,van der Vlag J,Handel TM,Volkman BF,Proudfoot AEI,Vischer HF,Zaman GJR,Smit MJ
Tue Apr 15 00:00:00 EDT 2014
Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function.
The Journal of biological chemistry
Blanchetot C,Verzijl D,Mujić-Delić A,Bosch L,Rem L,Leurs R,Verrips CT,Saunders M,de Haard H,Smit MJ
Fri Aug 30 00:00:00 EDT 2013
Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3.
British journal of pharmacology
Nedjai B,Li H,Stroke IL,Wise EL,Webb ML,Merritt JR,Henderson I,Klon AE,Cole AG,Horuk R,Vaidehi N,Pease JE
Fri Jun 01 00:00:00 EDT 2012
Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).
Journal of immunology (Baltimore, Md. : 1950)
Bengsch B,Seigel B,Flecken T,Wolanski J,Blum HE,Thimme R
Fri Jun 01 00:00:00 EDT 2012
Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells.
PloS one
Liang YJ,Luo J,Lu Q,Zhou Y,Wu HW,Zheng D,Ren YY,Sun KY,Wang Y,Zhang ZS
Mon Feb 11 00:00:00 EST 2013
Ubiquitination of CXCR7 controls receptor trafficking.
PloS one
Canals M,Scholten DJ,de Munnik S,Han MK,Smit MJ,Leurs R
Fri Aug 03 00:00:00 EDT 2012
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
PloS one
Liberman J,Sartelet H,Flahaut M,Mühlethaler-Mottet A,Coulon A,Nyalendo C,Vassal G,Joseph JM,Gross N
Wed Jan 16 00:00:00 EST 2013
Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion.
Molecular cancer
Wu Q,Dhir R,Wells A
Wed Jan 11 00:00:00 EST 2012
Epigallocatechin-3-gallate reduces airway inflammation in mice through binding to proinflammatory chemokines and inhibiting inflammatory cell recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Qin S,Alcorn JF,Craigo JK,Tjoeng C,Tarwater PM,Kolls JK,Reinhart TA
Tue Mar 15 00:00:00 EDT 2011
Host chemokines bind to Staphylococcus aureus and stimulate protein A release.
The Journal of biological chemistry
Yung SC,Parenti D,Murphy PM
Fri Feb 18 00:00:00 EST 2011
CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.
The Journal of biological chemistry
Décaillot FM,Kazmi MA,Lin Y,Ray-Saha S,Sakmar TP,Sachdev P
Fri Sep 16 00:00:00 EDT 2011
Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection.
PLoS pathogens
Crawford MA,Burdick MD,Glomski IJ,Boyer AE,Barr JR,Mehrad B,Strieter RM,Hughes MA
Thu Nov 18 00:00:00 EST 2010
The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.
The Journal of biological chemistry
Lüttichau HR
Fri Mar 19 00:00:00 EDT 2010
m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate.
The Journal of biological chemistry
Leloup L,Shao H,Bae YH,Deasy B,Stolz D,Roy P,Wells A
Fri Oct 22 00:00:00 EDT 2010
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.
Journal of immunology (Baltimore, Md. : 1950)
Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N
Wed Jul 01 00:00:00 EDT 2009
SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
PloS one
Egesten A,Olin AI,Linge HM,Yadav M,Mörgelin M,Karlsson A,Collin M
Mon Jun 15 00:00:00 EDT 2009
Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Qin S,Sui Y,Soloff AC,Junecko BA,Kirschner DE,Murphey-Corb MA,Watkins SC,Tarwater PM,Pease JE,Barratt-Boyes SM,Reinhart TA
Tue Apr 15 00:00:00 EDT 2008
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Proceedings of the National Academy of Sciences of the United States of America
Miao Z,Luker KE,Summers BC,Berahovich R,Bhojani MS,Rehemtulla A,Kleer CG,Essner JJ,Nasevicius A,Luker GD,Howard MC,Schall TJ
Tue Oct 02 00:00:00 EDT 2007
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Proceedings of the National Academy of Sciences of the United States of America
Miao Z,Luker KE,Summers BC,Berahovich R,Bhojani MS,Rehemtulla A,Kleer CG,Essner JJ,Nasevicius A,Luker GD,Howard MC,Schall TJ
Tue Oct 02 00:00:00 EDT 2007
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.
Blood
Howard OM,Dong HF,Su SB,Caspi RR,Chen X,Plotz P,Oppenheim JJ
Wed Jun 01 00:00:00 EDT 2005
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.
Blood
Lord GM,Rao RM,Choe H,Sullivan BM,Lichtman AH,Luscinskas FW,Glimcher LH
Tue Nov 15 00:00:00 EST 2005
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor.
The Journal of biological chemistry
Rosenkilde MM,Gerlach LO,Jakobsen JS,Skerlj RT,Bridger GJ,Schwartz TW
Fri Jan 23 00:00:00 EST 2004
Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.
The Journal of biological chemistry
Colvin RA,Campanella GS,Sun J,Luster AD
Fri Jul 16 00:00:00 EDT 2004
Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease.
Circulation
Kao J,Kobashigawa J,Fishbein MC,MacLellan WR,Burdick MD,Belperio JA,Strieter RM
Tue Apr 22 00:00:00 EDT 2003
