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Product Details
PEP-0937
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human IA-1.
PEP-0937 can be used as a blocking peptide with polyclonal antibody PA5-20823.
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: insulinoma associated 1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1
Gene Aliases: IA-1; IA1; INSM1
UniProt ID: (Human) Q01101
Entrez Gene ID: (Human) 3642
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