Product References
A critical bioenergetic switch is regulated by IGF2 during murine cartilage development.
Communications biology
Hollander JM,Li L,Rawal M,Wang SK,Shu Y,Zhang M,Nielsen HC,Rosen CJ,Zeng L
100-12 was used in In vitro experiments to provide critical evidence of preference for a bioenergetic pathway in different stages of chondrocytes and highlight its importance as a fundamental mechanism in skeletal development.
Fri Nov 11 00:00:00 EST 2022
Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage.
Cellular and molecular life sciences : CMLS
Deng H,Gao Y,Trappetti V,Hertig D,Karatkevich D,Losmanova T,Urzi C,Ge H,Geest GA,Bruggmann R,Djonov V,Nuoffer JM,Vermathen P,Zamboni N,Riether C,Ochsenbein A,Peng RW,Kocher GJ,Schmid RA,Dorn P,Marti TM
100-12 was used in In vitro experiments to show that LDHB is essential for the maintenance of mitochondrial metabolism, especially nucleotide metabolism, demonstrating that LDHB is crucial for the survival and proliferation of NSCLC tumor-initiating cells and tumorigenesis.
Mon Jul 25 00:00:00 EDT 2022
The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.
Cancer letters
Catalano R,Giardino E,Treppiedi D,Mangili F,Morelli V,Elli FM,Serban AL,Luconi M,Mannelli M,Spada A,Arosio M,Mantovani G,Peverelli E
100-12 was used in Immunoprecipitation to test the involvement of cytoskeleton actin-binding protein filamin A in regulating IGF1R and IR responsiveness to both insulin-like growth factor 2 (IGF2) and inhibitors in adrenocortical carcinomas.
Thu Jan 28 00:00:00 EST 2021
Cell sheet technology: Influence of culture conditions on in vitro-cultivated corneal stromal tissue for regenerative therapies of the ocular surface.
Journal of biomedical materials research. Part B, Applied biomaterials
Hasenzahl M,Müsken M,Mertsch S,Schrader S,Reichl S
Fri Oct 01 00:00:00 EDT 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
100-12 was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.
Fri May 21 00:00:00 EDT 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
100-12 was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.
Fri May 21 00:00:00 EDT 2021
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
100-12 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 EST 2020
Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids.
Frontiers in bioengineering and biotechnology
Gentile SD,Kourouklis AP,Ryoo H,Underhill GH
100-12 was used in Cell Culture to propose that this liver progenitor cell culture system represents an approach for controlling the presentation of microenvironmental cues internalized within 3D spheroidal aggregate cultures.
Mon Sep 28 00:00:00 EDT 2020
Significant polyomic and functional upregulation of the PAPP-A/IGFBP-4/5/IGF-1 axis in chronic rhinosinusitis with nasal polyps.
International forum of allergy & rhinology
Mueller SK,Nocera AL,Workman A,Libermann T,Dillon ST,Stegmann A,Wurm J,Iro H,Wendler O,Bleier BS
Wed Apr 01 00:00:00 EDT 2020
TFEB regulates murine liver cell fate during development and regeneration.
Nature communications
Pastore N,Huynh T,Herz NJ,Calcagni' A,Klisch TJ,Brunetti L,Kim KH,De Giorgi M,Hurley A,Carissimo A,Mutarelli M,Aleksieva N,D'Orsi L,Lagor WR,Moore DD,Settembre C,Finegold MJ,Forbes SJ,Ballabio A
Mon May 18 00:00:00 EDT 2020
Fate and functional roles of Prominin 1+ cells in liver injury and cancer.
Scientific reports
Wu R,Pan S,Chen Y,Nakano Y,Li M,Balog S,Tsukamoto H
Tue Nov 10 00:00:00 EST 2020
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.
Cell death and differentiation
Battistelli C,Sabarese G,Santangelo L,Montaldo C,Gonzalez FJ,Tripodi M,Cicchini C
Wed May 01 00:00:00 EDT 2019
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Journal of immunology (Baltimore, Md. : 1950)
Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM
Fri Feb 15 00:00:00 EST 2019
Insulin-like growth factor 2 promotes the adipogenesis of hemangioma-derived stem cells.
Experimental and therapeutic medicine
Zhang K,Wang F,Huang J,Lou Y,Xie J,Li H,Cao D,Huang X
100-12 was used in In vitro experiments to indicate that IGF-2 is able to accelerate adipogenesis, and the propranolol-induced promotion of dysregulated adipogenesis may be mediated by the IGF-2 via IGF-1R and PI3K pathways.
Fri Mar 01 00:00:00 EST 2019
YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation.
Cell death & disease
Noce V,Battistelli C,Cozzolino AM,Consalvi V,Cicchini C,Strippoli R,Tripodi M,Marchetti A,Amicone L
Thu Oct 10 00:00:00 EDT 2019
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Nature communications
Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP
Tue Jul 02 00:00:00 EDT 2019
A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies.
The Journal of biological chemistry
Peeß C,Scholz C,Casagolda D,Düfel H,Gerg M,Kowalewsky F,Bocola M,von Proff L,Goller S,Klöppel-Swarlik H,Hoppe A,Schräml M
Fri Sep 06 00:00:00 EDT 2019
A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies.
The Journal of biological chemistry
Peeß C,Scholz C,Casagolda D,Düfel H,Gerg M,Kowalewsky F,Bocola M,von Proff L,Goller S,Klöppel-Swarlik H,Hoppe A,Schräml M
Fri Sep 06 00:00:00 EDT 2019
Circuit Design Features of a Stable Two-Cell System.
Cell
Zhou X,Franklin RA,Adler M,Jacox JB,Bailis W,Shyer JA,Flavell RA,Mayo A,Alon U,Medzhitov R
100-12 was used in In vitro experiments to illustrate principles of cell circuit design and provide a quantitative perspective on cell interactions.
Thu Feb 08 00:00:00 EST 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
100-12 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Stem cells in middle ear cholesteatoma contribute to its pathogenesis.
Scientific reports
Nagel J,Wöllner S,Schürmann M,Brotzmann V,Müller J,Greiner JF,Goon P,Kaltschmidt B,Kaltschmidt C,Sudhoff H
Wed Apr 18 00:00:00 EDT 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 EDT 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 EDT 2018
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
Cell death & disease
Melguizo-Sanchis D,Xu Y,Taheem D,Yu M,Tilgner K,Barta T,Gassner K,Anyfantis G,Wan T,Elango R,Alharthi S,El-Harouni AA,Przyborski S,Adam S,Saretzki G,Samarasinghe S,Armstrong L,Lako M
Fri Jan 26 00:00:00 EST 2018
Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA.
Nucleic acids research
Park KS,Mitra A,Rahat B,Kim K,Pfeifer K
100-12 was used in Cell Culture to investigate the role of Igf2 and H19 in Beckwith Wiedemann Syndrome development in mice.
Fri Dec 15 00:00:00 EST 2017
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.
Nature communications
Rosner M,Pham HTT,Moriggl R,Hengstschläger M
Tue Sep 19 00:00:00 EDT 2017
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.
Nature communications
Rosner M,Pham HTT,Moriggl R,Hengstschläger M
Tue Sep 19 00:00:00 EDT 2017
Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
The Journal of experimental medicine
Holmfeldt P,Ganuza M,Marathe H,He B,Hall T,Kang G,Moen J,Pardieck J,Saulsberry AC,Cico A,Gaut L,McGoldrick D,Finkelstein D,Tan K,McKinney-Freeman S
Mon Mar 07 00:00:00 EST 2016
Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.
Hepatology (Baltimore, Md.)
Yi J,Lu L,Yanger K,Wang W,Sohn BH,Stanger BZ,Zhang M,Martin JF,Ajani JA,Chen J,Lee JS,Song S,Johnson RL
100-12 was used in Cell Culture to study the role of Hippo signalling pathway kinases, large tumour suppressor homologues 1 and 2, during mouse liver development.
Tue Nov 01 00:00:00 EDT 2016
Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America
Kodama T,Newberg JY,Kodama M,Rangel R,Yoshihara K,Tien JC,Parsons PH,Wu H,Finegold MJ,Copeland NG,Jenkins NA
Tue Jun 14 00:00:00 EDT 2016
ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
Nature communications
Yamaguchi T,Lu C,Ida L,Yanagisawa K,Usukura J,Cheng J,Hotta N,Shimada Y,Isomura H,Suzuki M,Fujimoto T,Takahashi T
Mon Jan 04 00:00:00 EST 2016
Combinatorial microenvironmental regulation of liver progenitor differentiation by Notch ligands, TGFβ, and extracellular matrix.
Scientific reports
Kaylan KB,Ermilova V,Yada RC,Underhill GH
Wed Mar 30 00:00:00 EDT 2016
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nature communications
Gamrekelashvili J,Giagnorio R,Jussofie J,Soehnlein O,Duchene J,Briseño CG,Ramasamy SK,Krishnasamy K,Limbourg A,Kapanadze T,Ishifune C,Hinkel R,Radtke F,Strobl LJ,Zimber-Strobl U,Napp LC,Bauersachs J,Haller H,Yasutomo K,Kupatt C,Murphy KM,Adams RH,Weber C,Limbourg FP
Wed Aug 31 00:00:00 EDT 2016
A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells.
The Journal of biological chemistry
Xiao H,Bid HK,Jou D,Wu X,Yu W,Li C,Houghton PJ,Lin J
Fri Feb 06 00:00:00 EST 2015
Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.
Cell death & disease
Grassi G,Di Caprio G,Santangelo L,Fimia GM,Cozzolino AM,Komatsu M,Ippolito G,Tripodi M,Alonzi T
Thu Sep 10 00:00:00 EDT 2015
Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs.
Proceedings of the National Academy of Sciences of the United States of America
Park CY,Kim J,Kweon J,Son JS,Lee JS,Yoo JE,Cho SR,Kim JH,Kim JS,Kim DW
Tue Jun 24 00:00:00 EDT 2014
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.
Blood
Holmfeldt P,Pardieck J,Saulsberry AC,Nandakumar SK,Finkelstein D,Gray JT,Persons DA,McKinney-Freeman S
Thu Oct 24 00:00:00 EDT 2013
CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.
Blood
Gekas C,Graf T
Thu May 30 00:00:00 EDT 2013
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators.
Journal of neuroinflammation
Suh HS,Zhao ML,Derico L,Choi N,Lee SC
100-12 was used in Cell Culture to suggest that chronic neuroinflammation and upregulation of proinflammatory cytokines could lead to neurodegeneration by suppressing the production of microglia-derived neuronal growth factors, such as IGF1.
Tue Mar 12 00:00:00 EDT 2013
Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.
The Journal of biological chemistry
Leenders JJ,Wijnen WJ,Hiller M,van der Made I,Lentink V,van Leeuwen REW,Herias V,Pokharel S,Heymans S,de Windt LJ,Høydal MA,Pinto YM,Creemers EE
Fri Aug 27 00:00:00 EDT 2010
Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.
Blood
Zhao H,Pestina TI,Nasimuzzaman M,Mehta P,Hargrove PW,Persons DA
Thu Jun 04 00:00:00 EDT 2009
Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.
Molecular therapy : the journal of the American Society of Gene Therapy
Pestina TI,Hargrove PW,Jay D,Gray JT,Boyd KM,Persons DA
Sun Feb 01 00:00:00 EST 2009
Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma.
The Journal of clinical endocrinology and metabolism
Barlaskar FM,Spalding AC,Heaton JH,Kuick R,Kim AC,Thomas DG,Giordano TJ,Ben-Josef E,Hammer GD
Thu Jan 01 00:00:00 EST 2009
A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A
Thu Jan 01 00:00:00 EST 2009
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.
Blood
Takayama N,Nishikii H,Usui J,Tsukui H,Sawaguchi A,Hiroyama T,Eto K,Nakauchi H
Sun Jun 01 00:00:00 EDT 2008
Isolation and characterization of a murine resident liver stem cell.
Cell death and differentiation
Conigliaro A,Colletti M,Cicchini C,Guerra MT,Manfredini R,Zini R,Bordoni V,Siepi F,Leopizzi M,Tripodi M,Amicone L
Tue Jan 01 00:00:00 EST 2008
TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling.
Experimental cell research
Cicchini C,Laudadio I,Citarella F,Corazzari M,Steindler C,Conigliaro A,Fantoni A,Amicone L,Tripodi M
Tue Jan 01 00:00:00 EST 2008
Micromechanical control of cell-cell interactions.
Proceedings of the National Academy of Sciences of the United States of America
Hui EE,Bhatia SN
Tue Apr 03 00:00:00 EDT 2007
Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.
Journal of immunology (Baltimore, Md. : 1950)
Hartnell A,Heinemann A,Conroy DM,Wait R,Sturm GJ,Caversaccio M,Jose PJ,Williams TJ
Mon Nov 15 00:00:00 EST 2004
Cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in inflammatory breast carcinoma.
Oncogene
Alpaugh ML,Tomlinson JS,Kasraeian S,Barsky SH
Thu May 16 00:00:00 EDT 2002
Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue.
Proceedings of the National Academy of Sciences of the United States of America
Savchenko A,Kraft TW,Molokanova E,Kramer RH
Tue May 08 00:00:00 EDT 2001
Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells.
Cancer research
Goetzl EJ,Dolezalova H,Kong Y,Zeng L
Wed Sep 15 00:00:00 EDT 1999
Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells.
Cancer research
Goetzl EJ,Dolezalova H,Kong Y,Zeng L
Wed Sep 15 00:00:00 EDT 1999
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
Cancer research
Goetzl EJ,Dolezalova H,Kong Y,Hu YL,Jaffe RB,Kalli KR,Conover CA
Fri Oct 15 00:00:00 EDT 1999
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
Cancer research
Goetzl EJ,Dolezalova H,Kong Y,Hu YL,Jaffe RB,Kalli KR,Conover CA
Fri Oct 15 00:00:00 EDT 1999
