Product References
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Nature communications
Nagata K,Hojo H,Chang SH,Okada H,Yano F,Chijimatsu R,Omata Y,Mori D,Makii Y,Kawata M,Kaneko T,Iwanaga Y,Nakamoto H,Maenohara Y,Tachibana N,Ishikura H,Higuchi J,Taniguchi Y,Ohba S,Chung UI,Tanaka S,Saito T
AF-200-01B was used in Tissue/organ culture to study the role of runt-related transcription factor (Runx)2 and Runx3 for osteoarthritis development in vivo and in vitro to show that Runx3 protects adult articular cartilage through extracellular matrix protein production under normal conditions, while Runx2 exerts both catabolic and anabolic effects under the inflammatory condition.
Wed Oct 19 00:00:00 EDT 2022
Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients.
Cancer immunology research
Lulu AM,Cummings KL,Jeffery ED,Myers PT,Underwood D,Lacy RM,Chianese-Bullock KA,Slingluff CL,Modesitt SC,Engelhard VH
AF-200-01B was used in In vitro experiments to suggest that the immunogens generating most phosphopeptide-specific immune memory are rare infectious agents or incipient cancer cells with distinct phosphoproteome dysregulations, and that repetitive immunogenic exposures occur in individual donors.
Mon Nov 01 00:00:00 EDT 2021
Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells.
Scientific reports
Liang YH,Wu JM,Teng JW,Hung E,Wang HS
Mon Jul 19 00:00:00 EDT 2021
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.
Nature communications
Weng RR,Lu HH,Lin CT,Fan CC,Lin RS,Huang TC,Lin SY,Huang YJ,Juan YH,Wu YC,Hung ZC,Liu C,Lin XH,Hsieh WC,Chiu TY,Liao JC,Chiu YL,Chen SY,Yu CJ,Tsai HC
Mon Apr 12 00:00:00 EDT 2021
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.
Translational psychiatry
Szabo A,Akkouh IA,Vandenberghe M,Osete JR,Hughes T,Heine V,Smeland OB,Glover JC,Andreassen OA,Djurovic S
Fri Oct 29 00:00:00 EDT 2021
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Cell death & disease
Liu H,Zhu Y,Gao Y,Qi D,Zhao L,Zhao L,Liu C,Tao T,Zhou C,Sun X,Guo F,Xiao J
Tue Feb 18 00:00:00 EST 2020
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.
Scientific reports
Hyvärinen T,Hagman S,Ristola M,Sukki L,Veijula K,Kreutzer J,Kallio P,Narkilahti S
Fri Nov 15 00:00:00 EST 2019
Helicobacter pylori-induced exosomal MET educates tumour-associated macrophages to promote gastric cancer progression.
Journal of cellular and molecular medicine
Che Y,Geng B,Xu Y,Miao X,Chen L,Mu X,Pan J,Zhang C,Zhao T,Wang C,Li X,Wen H,Liu Z,You Q
AF-200-01B was used in In vitro experiments to investigate exosome-mediated communication between Helicobacter pylori-infected gastric cancer cells and macrophages, focusing on the transfer of activated mesenchymal-epithelial transition factor.
Thu Nov 01 00:00:00 EDT 2018
Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis.
Scientific reports
Murahashi Y,Yano F,Kobayashi H,Makii Y,Iba K,Yamashita T,Tanaka S,Saito T
Wed Nov 07 00:00:00 EST 2018
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.
Scientific reports
Wu X,Liu W,Duan Z,Gao Y,Li S,Wang K,Song Y,Shao Z,Yang S,Yang C
Wed Jul 27 00:00:00 EDT 2016
Aldo-keto reductase 1C1 induced by interleukin-1β mediates the invasive potential and drug resistance of metastatic bladder cancer cells.
Scientific reports
Matsumoto R,Tsuda M,Yoshida K,Tanino M,Kimura T,Nishihara H,Abe T,Shinohara N,Nonomura K,Tanaka S
Tue Oct 04 00:00:00 EDT 2016
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H
Tue Jan 15 00:00:00 EST 2013
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.
PLoS pathogens
Mansur DS,Maluquer de Motes C,Unterholzner L,Sumner RP,Ferguson BJ,Ren H,Strnadova P,Bowie AG,Smith GL
Fri Feb 01 00:00:00 EST 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 EST 2013
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
PloS one
Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T
Fri Sep 06 00:00:00 EDT 2013
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.
The Journal of biological chemistry
Humphrey RK,Yu SM,Bellary A,Gonuguntla S,Yebra M,Jhala US
Fri Jan 25 00:00:00 EST 2013
Mast cells play a protumorigenic role in primary cutaneous lymphoma.
Blood
Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K
Thu Sep 06 00:00:00 EDT 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 EST 2012
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F
Tue Nov 06 00:00:00 EST 2012
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ
Tue Jun 19 00:00:00 EDT 2012
Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Fowler DW,Copier J,Wilson N,Dalgleish AG,Bodman-Smith MD
Sun Apr 01 00:00:00 EDT 2012
Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease.
Arthritis research & therapy
Sugita S,Kawazoe Y,Imai A,Yamada Y,Horie S,Mochizuki M
Tue May 01 00:00:00 EDT 2012
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM
Sat Dec 01 00:00:00 EST 2012
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
Journal of immunology (Baltimore, Md. : 1950)
Young A,Linehan E,Hams E,O'Hara Hall AC,McClurg A,Johnston JA,Hunter CA,Fallon PG,Fitzgerald DC
Sat Sep 01 00:00:00 EDT 2012
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.
The Biochemical journal
Whitehead MA,Bombardieri M,Pitzalis C,Vanhaesebroeck B
Tue May 01 00:00:00 EDT 2012
Characterization of the autocrine/paracrine function of vitamin D in human gingival fibroblasts and periodontal ligament cells.
PloS one
Liu K,Meng H,Hou J
Fri Jan 04 00:00:00 EST 2013
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 EST 2012
Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.
Journal of inflammation (London, England)
Klawitter M,Quero L,Klasen J,Gloess AN,Klopprogge B,Hausmann O,Boos N,Wuertz K
Tue Aug 21 00:00:00 EDT 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 EDT 2012
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
PloS one
Suh HS,Choi N,Tarassishin L,Lee SC
Tue Aug 07 00:00:00 EDT 2012
Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.
The Journal of biological chemistry
Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T
Fri Jul 20 00:00:00 EDT 2012
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
PloS one
Iyer A,Zurolo E,Prabowo A,Fluiter K,Spliet WG,van Rijen PC,Gorter JA,Aronica E
Tue Mar 05 00:00:00 EST 2013
Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion.
BMC biotechnology
Liu M,Huang Y,Hu L,Liu G,Hu X,Liu D,Yang X
Tue Sep 25 00:00:00 EDT 2012
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
PloS one
Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H
Fri Aug 03 00:00:00 EDT 2012
Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.
PloS one
Zhou J,Joplin DG,Cross JV,Templeton DJ
Thu Jun 20 00:00:00 EDT 2013
Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.
PloS one
Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR
Mon Jan 14 00:00:00 EST 2013
Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.
PloS one
Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR
Mon Jan 14 00:00:00 EST 2013
Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.
PloS one
Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR
Mon Jan 14 00:00:00 EST 2013
The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.
The Journal of biological chemistry
Keuylian Z,de Baaij JH,Gueguen M,Glorian M,Rouxel C,Merlet E,Lipskaia L,Blaise R,Mateo V,Limon I
Fri Jul 20 00:00:00 EDT 2012
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.
PloS one
Matta H,Gopalakrishnan R,Graham C,Tolani B,Khanna A,Yi H,Suo Y,Chaudhary PM
Wed Sep 19 00:00:00 EDT 2012
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
PLoS pathogens
Maluquer de Motes C,Cooray S,Ren H,Almeida GM,McGourty K,Bahar MW,Stuart DI,Grimes JM,Graham SC,Smith GL
Thu Dec 01 00:00:00 EST 2011
The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Ortner D,Grabher D,Hermann M,Kremmer E,Hofer S,Heufler C
Sat Oct 15 00:00:00 EDT 2011
Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.
PloS one
Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B
Tue Feb 14 00:00:00 EST 2012
ST2 and IL-33 in pregnancy and pre-eclampsia.
PloS one
Granne I,Southcombe JH,Snider JV,Tannetta DS,Child T,Redman CW,Sargent IL
Fri Feb 03 00:00:00 EST 2012
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.
BMC complementary and alternative medicine
Schwager J,Hoeller U,Wolfram S,Richard N
Thu Nov 03 00:00:00 EDT 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 EST 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 EST 2011
Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes.
PloS one
García-Arnandis I,Guillén MI,Gomar F,Castejón MA,Alcaraz MJ
Thu Mar 01 00:00:00 EST 2012
Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro.
PloS one
Mokhtari D,Li T,Lu T,Welsh N
Tue Feb 28 00:00:00 EST 2012
Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release.
PloS one
Davidson LB,Nessar R,Kempaiah P,Perkins DJ,Byrd TF
Mon May 21 00:00:00 EDT 2012
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway.
Journal of neuroinflammation
Tarassishin L,Suh HS,Lee SC
Fri Dec 30 00:00:00 EST 2011
