Product References
Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.
Cell death & disease
Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M
200-01B was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.
Tue Apr 04 00:00:00 EDT 2023
The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion.
PLoS pathogens
Wang S,Moreau F,Chadee K
200-01B was used in In vitro experiments to investigate pro-inflammatory cytokine secretion following Entamoeba histolytica infection.
Tue Mar 01 00:00:00 EST 2022
Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration.
Oxidative medicine and cellular longevity
Li Y,Wu X,Li J,Du L,Wang X,Cao J,Li H,Huo Z,Li G,Pan D,Xu H,Xu B
Fri Mar 04 00:00:00 EST 2022
Anti-apoptotic effects of human gingival mesenchymal stromal cells on polymorphonuclear leucocytes.
Oral diseases
Blufstein A,Behm C,Kubin B,Gahn J,Moritz A,Rausch-Fan X,Andrukhov O
Fri Apr 01 00:00:00 EDT 2022
Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells.
mBio
Zuniga M,Gomes C,Chen Z,Martinez C,Devlin JC,Loke P,Rodriguez A
200-01B was used in Sample Preparation (FC/FACS) to investigate TNF-α regulation of cerebral malaria infection across the blood-brain barrier.
Wed Oct 26 00:00:00 EDT 2022
Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.
Frontiers in immunology
Wang H,Xie L,Song X,Wang J,Li X,Lin Z,Su T,Liang B,Huang D
200-01B was used in Cell Culture to explore whether exogenous purines are responsible for increased xanthine oxidoreductase expression and activity.
Thu Mar 03 00:00:00 EST 2022
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.
Cell reports
Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ
200-01B was used in In vitro on human Huh7 cells
Tue Jan 25 00:00:00 EST 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
200-01B was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 EDT 2022
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.
JID innovations : skin science from molecules to population health
Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH
200-01B was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.
Sat Jan 01 00:00:00 EST 2022
Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer.
Cancers
Baram T,Oren N,Erlichman N,Meshel T,Ben-Baruch A
200-01B was used in In vitro experiments to suggest that in addition to its immune-suppressive activities, PD-L1 may promote disease course in TNBC by inhibiting the protective effects of sTNFR1 and sTNFR2.
Tue Jul 19 00:00:00 EDT 2022
TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1.
Aging cell
Kandhaya-Pillai R,Yang X,Tchkonia T,Martin GM,Kirkland JL,Oshima J
200-01B was used in In vitro experiments to find exposure of human umbilical vein endothelial cells (HUVECs) to the inflammatory cytokines, TNF-α + IFN-γ or a cocktail of TNF-α + IFN-γ + IL-6, increased expression of ACE2/DPP4, accentuated the pro-inflammatory senescence-associated secretory phenotype (SASP), and decreased cellular proliferative capacity, consistent with progression towards a cellular senescence-like state.
Wed Jun 01 00:00:00 EDT 2022
A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells.
Cell discovery
Karpf L,Trichot C,Faucheux L,Legbre I,Grandclaudon M,Lahoute C,Mattoo H,Pasquier B,Soumelis V
Tue Jan 04 00:00:00 EST 2022
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.
Viruses
Cruz-Lorenzo E,Ramirez NP,Lee J,Pandhe S,Wang L,Hernandez-Doria J,Spivak AM,Planelles V,Petersen T,Jain MK,Martinez ED,D'Orso I
200-01B was used in Cell Culture to suggest that manipulation of redox-sensitive pathways could be exploited to alter the course of HIV-1 latency, thus rendering host cells responsive to help achieve a sterilizing cure.
Tue Oct 18 00:00:00 EDT 2022
Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.
Cellular and molecular gastroenterology and hepatology
Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR
200-01B was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.
Mon Apr 04 00:00:00 EDT 2022
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia.
Life science alliance
Amatngalim GD,Rodenburg LW,Aalbers BL,Raeven HH,Aarts EM,Sarhane D,Spelier S,Lefferts JW,Silva IA,Nijenhuis W,Vrendenbarg S,Kruisselbrink E,Brunsveld JE,van Drunen CM,Michel S,de Winter-de Groot KM,Heijerman HG,Kapitein LC,Amaral MD,van der Ent CK,Beekman JM
200-01B was used in Cell Culture to define organoid culture conditions, with the growth factor/cytokine combination neuregulin-1lt;igt;βlt;/igt; and interleukin-1lt;igt;βlt;/igt;, which enabled consistent detection of CFTR modulator responses in nasal-airway organoid cultures from subjects with cystic fibrosis.
Wed Aug 03 00:00:00 EDT 2022
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell
Mills RJ,Humphrey SJ,Fortuna PRJ,Lor M,Foster SR,Quaife-Ryan GA,Johnston RL,Dumenil T,Bishop C,Rudraraju R,Rawle DJ,Le T,Zhao W,Lee L,Mackenzie-Kludas C,Mehdiabadi NR,Halliday C,Gilham D,Fu L,Nicholls SJ,Johansson J,Sweeney M,Wong NCW,Kulikowski E,Sokolowski KA,Tse BWC,Devilée L,Voges HK,Reynolds LT,Krumeich S,Mathieson E,Abu-Bonsrah D,Karavendzas K,Griffen B,Titmarsh D,Elliott DA,McMahon J,Suhrbier A,Subbarao K,Porrello ER,Smyth MJ,Engwerda CR,MacDonald KPA,Bald T,James DE,Hudson JE
Thu Apr 15 00:00:00 EDT 2021
Spatially organized multicellular immune hubs in human colorectal cancer.
Cell
Pelka K,Hofree M,Chen JH,Sarkizova S,Pirl JD,Jorgji V,Bejnood A,Dionne D,Ge WH,Xu KH,Chao SX,Zollinger DR,Lieb DJ,Reeves JW,Fuhrman CA,Hoang ML,Delorey T,Nguyen LT,Waldman J,Klapholz M,Wakiro I,Cohen O,Albers J,Smillie CS,Cuoco MS,Wu J,Su MJ,Yeung J,Vijaykumar B,Magnuson AM,Asinovski N,Moll T,Goder-Reiser MN,Applebaum AS,Brais LK,DelloStritto LK,Denning SL,Phillips ST,Hill EK,Meehan JK,Frederick DT,Sharova T,Kanodia A,Todres EZ,Jané-Valbuena J,Biton M,Izar B,Lambden CD,Clancy TE,Bleday R,Melnitchouk N,Irani J,Kunitake H,Berger DL,Srivastava A,Hornick JL,Ogino S,Rotem A,Vigneau S,Johnson BE,Corcoran RB,Sharpe AH,Kuchroo VK,Ng K,Giannakis M,Nieman LT,Boland GM,Aguirre AJ,Anderson AC,Rozenblatt-Rosen O,Regev A,Hacohen N
Thu Sep 02 00:00:00 EDT 2021
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Nature neuroscience
Wenzel J,Lampe J,Müller-Fielitz H,Schuster R,Zille M,Müller K,Krohn M,Körbelin J,Zhang L,Özorhan Ü,Neve V,Wagner JUG,Bojkova D,Shumliakivska M,Jiang Y,Fähnrich A,Ott F,Sencio V,Robil C,Pfefferle S,Sauve F,Coêlho CFF,Franz J,Spiecker F,Lembrich B,Binder S,Feller N,König P,Busch H,Collin L,Villaseñor R,Jöhren O,Altmeppen HC,Pasparakis M,Dimmeler S,Cinatl J,Püschel K,Zelic M,Ofengeim D,Stadelmann C,Trottein F,Nogueiras R,Hilgenfeld R,Glatzel M,Prevot V,Schwaninger M
Mon Nov 01 00:00:00 EDT 2021
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Nature neuroscience
Wenzel J,Lampe J,Müller-Fielitz H,Schuster R,Zille M,Müller K,Krohn M,Körbelin J,Zhang L,Özorhan Ü,Neve V,Wagner JUG,Bojkova D,Shumliakivska M,Jiang Y,Fähnrich A,Ott F,Sencio V,Robil C,Pfefferle S,Sauve F,Coêlho CFF,Franz J,Spiecker F,Lembrich B,Binder S,Feller N,König P,Busch H,Collin L,Villaseñor R,Jöhren O,Altmeppen HC,Pasparakis M,Dimmeler S,Cinatl J,Püschel K,Zelic M,Ofengeim D,Stadelmann C,Trottein F,Nogueiras R,Hilgenfeld R,Glatzel M,Prevot V,Schwaninger M
Mon Nov 01 00:00:00 EDT 2021
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.
Cell stem cell
Wang T,Pine AR,Kotini AG,Yuan H,Zamparo L,Starczynowski DT,Leslie C,Papapetrou EP
200-01B was used in Sample Preparation (PCR) to identify cell-autonomous dysregulation of inflammatory signaling as an early and persistent event in leukemogenesis and a promising early therapeutic target.
Thu Jun 03 00:00:00 EDT 2021
Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.
Arthritis & rheumatology (Hoboken, N.J.)
Vecellio M,Chen L,Cohen CJ,Cortes A,Li Y,Bonham S,Selmi C,Brown MA,Fischer R,Knight JC,Wordsworth BP
Tue Jun 01 00:00:00 EDT 2021
The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion.
Proceedings of the National Academy of Sciences of the United States of America
Liu J,Jang JY,Pirooznia M,Liu S,Finkel T
Tue Jan 19 00:00:00 EST 2021
Identification of human immune cell subtypes most responsive to IL-1β-induced inflammatory signaling using mass cytometry.
Science signaling
Kothari H,Williams CM,McSkimming C,Drago F,Marshall MA,Garmey J,Vigneshwar M,Zunder ER,McNamara CA
Tue Mar 09 00:00:00 EST 2021
Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.
Glia
Muraleedharan A,Rotem-Dai N,Strominger I,Anto NP,Isakov N,Monsonego A,Livneh E
Mon Mar 01 00:00:00 EST 2021
Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress.
Brain pathology (Zurich, Switzerland)
Zimmer TS,Korotkov A,Zwakenberg S,Jansen FE,Zwartkruis FJT,Rensing NR,Wong M,Mühlebner A,van Vliet EA,Aronica E,Mills JD
Wed Sep 01 00:00:00 EDT 2021
Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.
Oxidative medicine and cellular longevity
Ma W,Wang Z,Zhao Y,Wang Q,Zhang Y,Lei P,Lu W,Yan S,Zhou J,Li X,Yu W,Zhong Y,Chen L,Zheng T
Mon Sep 13 00:00:00 EDT 2021
Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity.
Frontiers in cardiovascular medicine
Vreeken D,Bruikman CS,Stam W,Cox SML,Nagy Z,Zhang H,Postma RJ,van Zonneveld AJ,Hovingh GK,van Gils JM
200-01B was used in Cell Culture to conclude that PLXNA4 may well have a causal role in atherogenesis that deserves further investigation.
Sun May 23 00:00:00 EDT 2021
Proinflammatory Features of Stem Cell-like Memory T Cells from Human Patients with Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Lee YJ,Park EH,Park JW,Jung KC,Lee EB
Thu Jul 15 00:00:00 EDT 2021
Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.
Stem cells international
Lee Y,Park YS,Choi NY,Kim YI,Koh YG
Tue Jul 27 00:00:00 EDT 2021
Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition.
American journal of physiology. Gastrointestinal and liver physiology
Her JY,Lee Y,Kim SJ,Heo G,Choo J,Kim Y,Howe C,Rhee SH,Yu HS,Chung HY,Pothoulakis C,Im E
Fri Jan 01 00:00:00 EST 2021
Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell.
Mediators of inflammation
Tien PT,Lin CH,Chen CS,Chang CY,Ku H,Gan D,Tsai YY,Chen JJ,Lin HJ,Wan L
Thu Mar 31 00:00:00 EDT 2022
Baicalin promotes chondrocyte viability and the synthesis of extracellular matrix through TGF-β/Smad3 pathway in chondrocytes.
American journal of translational research
Wang P,Liu J,Zhang S,Zhu P,Xiong X,Yu C,Li A,Liu Z
200-01B was used in Cell Culture to study how Baicalin (BA) neutralizes IL-1β-induced downregulation of chondrocyte viability and extracellular matrix (ECM) secretion, including Aggrecan (ACAN) and type II collagen (Col2α).
Sat Oct 16 00:00:00 EDT 2021
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion
Cunningham S,Hackstein H
Tue Jun 01 00:00:00 EDT 2021
Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.
Cell adhesion & migration
Roncato F,Regev O,Yadav SK,Alon R
200-01B was used in In vitro experiments on Human derman blood endothelial cells.
Wed Dec 01 00:00:00 EST 2021
Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF-κB and PI3K/AKT Pathways.
Evidence-based complementary and alternative medicine : eCAM
Chen GY,Chen JQ,Liu XY,Xu Y,Luo J,Wang YF,Zhou TL,Yan ZR,Zhou L,Tao QW
Tue May 18 00:00:00 EDT 2021
Shen Shuai II Recipe Attenuates Renal Interstitial Fibrosis by Improving Hypoxia via the IL-1β/c-Myc Pathway.
Evidence-based complementary and alternative medicine : eCAM
Yang L,Wang M,Zhou Y,Yang J,Ye C,Wang C
Sun Apr 24 00:00:00 EDT 2022
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 EDT 2021
Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response.
Communications biology
Enchéry F,Dumont C,Iampietro M,Pelissier R,Aurine N,Bloyet LM,Carbonnelle C,Mathieu C,Journo C,Gerlier D,Horvat B
Tue Nov 16 00:00:00 EST 2021
Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3.
Cell reports
Sun Y,Zhou Y,Shi Y,Zhang Y,Liu K,Liang R,Sun P,Chang X,Tang W,Zhang Y,Li J,Wang S,Zhu Y,Han X
Tue Jan 05 00:00:00 EST 2021
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
eLife
Arts JJ,Mahlandt EK,Grönloh ML,Schimmel L,Noordstra I,Gordon E,van Steen AC,Tol S,Walzog B,van Rijssel J,Nolte MA,Postma M,Khuon S,Heddleston JM,Wait E,Chew TL,Winter M,Montanez E,Goedhart J,van Buul JD
200-01B was used in In vitro experiments to discover a new mechanism that uses local induced junctional membrane protrusions to facilitate/steer the leukocyte escape/exit from inflamed vessel walls.
Wed Aug 25 00:00:00 EDT 2021
Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis.
Cancers
Masselli E,Carubbi C,Pozzi G,Percesepe A,Campanelli R,Villani L,Gobbi G,Bonomini S,Roti G,Rosti V,Massa M,Barosi G,Vitale M
200-01B was used in In vitro experiments to conclude that the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.
Sat May 22 00:00:00 EDT 2021
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.
Nature communications
Tombor LS,John D,Glaser SF,Luxán G,Forte E,Furtado M,Rosenthal N,Baumgarten N,Schulz MH,Wittig J,Rogg EM,Manavski Y,Fischer A,Muhly-Reinholz M,Klee K,Looso M,Selignow C,Acker T,Bibli SI,Fleming I,Patrick R,Harvey RP,Abplanalp WT,Dimmeler S
Fri Jan 29 00:00:00 EST 2021
MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade.
Scientific reports
Tanimura A,Nakazato A,Tanaka N
Wed Feb 17 00:00:00 EST 2021
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics.
Nature communications
Wilhelm M,Zolg DP,Graber M,Gessulat S,Schmidt T,Schnatbaum K,Schwencke-Westphal C,Seifert P,de Andrade Krätzig N,Zerweck J,Knaute T,Bräunlein E,Samaras P,Lautenbacher L,Klaeger S,Wenschuh H,Rad R,Delanghe B,Huhmer A,Carr SA,Clauser KR,Krackhardt AM,Reimer U,Kuster B
Mon Jun 07 00:00:00 EDT 2021
Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells.
Stem cell reports
Schäfer R,Spohn G,Bechtel M,Bojkova D,Baer PC,Kuçi S,Seifried E,Ciesek S,Cinatl J
Tue Mar 09 00:00:00 EST 2021
Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.
PLoS neglected tropical diseases
Bedoui Y,Septembre-Malaterre A,Giry C,Jaffar-Bandjee MC,Selambarom J,Guiraud P,Gasque P
200-01B was used in Cell Culture to report novel histological and in vitro data arguing for a plausible role of a COX-2-mediated inflammatory response post-chikungunya virus (CHIKV).
Mon Feb 01 00:00:00 EST 2021
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
ImmunoHorizons
Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD
200-01B was used in Cell Culture to investigate correlations between cytokine expression and mortality.
Wed Jul 21 00:00:00 EDT 2021
Arthritis flares mediated by tissue-resident memory T cells in the joint.
Cell reports
Chang MH,Levescot A,Nelson-Maney N,Blaustein RB,Winden KD,Morris A,Wactor A,Balu S,Grieshaber-Bouyer R,Wei K,Henderson LA,Iwakura Y,Clark RA,Rao DA,Fuhlbrigge RC,Nigrovic PA
Tue Oct 26 00:00:00 EDT 2021
Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.
Cell death & disease
Egea V,Kessenbrock K,Lawson D,Bartelt A,Weber C,Ries C
Thu May 20 00:00:00 EDT 2021
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Cell death & disease
Zhang W,Yin G,Zhao H,Ling H,Xie Z,Xiao C,Chen Y,Lin Y,Jiang T,Jin S,Wang J,Yang X
Wed Jan 20 00:00:00 EST 2021
Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis.
Cell death & disease
Hou M,Zhang Y,Zhou X,Liu T,Yang H,Chen X,He F,Zhu X
Thu May 13 00:00:00 EDT 2021
Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.
Cells
Morein D,Rubinstein-Achiasaf L,Brayer H,Dorot O,Pichinuk E,Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Ben-Baruch A
200-01B was used in Cell Culture to demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype which promotes a prometastatic cascade.
Mon May 31 00:00:00 EDT 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
200-01B was used in Cell Culture to investigate BET as a target in cancer.
Wed Jul 21 00:00:00 EDT 2021
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Nature communications
Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q
200-01B was used in Cell Culture to investigate BET as a target in cancer.
Wed Jul 21 00:00:00 EDT 2021
Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.
Scientific reports
Noda K,Dufner B,Ito H,Yoshida K,Balboni G,Straub RH
Wed Sep 15 00:00:00 EDT 2021
Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells.
Scientific reports
Calandria JM,Bhattacharjee S,Maness NJ,Kautzmann MI,Asatryan A,Gordon WC,Do KV,Jun B,Mukherjee PK,Petasis NA,Bazan NG
Thu Jun 10 00:00:00 EDT 2021
Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.
Nature communications
Fisher AL,Sangkhae V,Balušíková K,Palaskas NJ,Ganz T,Nemeth E
Tue Jun 29 00:00:00 EDT 2021
JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules.
iScience
Jankowski J,Lee HK,Wilflingseder J,Hennighausen L
Fri Aug 20 00:00:00 EDT 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 EDT 2021
Senescence-associated hyper-activation to inflammatory stimuli in vitro.
Aging
Budamagunta V,Manohar-Sindhu S,Yang Y,He Y,Traktuev DO,Foster TC,Zhou D
200-01B was used in Cell Culture to suggest that SnCs may play an important role in the age-related increases in the susceptibility to developing an exacerbated inflammatory response and highlight the potential to use senotherapeutics to ameliorate the severity of various devastating inflammatory conditions in the elderly.
Tue Aug 10 00:00:00 EDT 2021
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
Thu Apr 16 00:00:00 EDT 2020
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Cell
Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR
Thu May 28 00:00:00 EDT 2020
Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses.
Immunity
Zhou R,To KK,Wong YC,Liu L,Zhou B,Li X,Huang H,Mo Y,Luk TY,Lau TT,Yeung P,Chan WM,Wu AK,Lung KC,Tsang OT,Leung WS,Hung IF,Yuen KY,Chen Z
Tue Oct 13 00:00:00 EDT 2020
Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses.
Immunity
Zhou R,To KK,Wong YC,Liu L,Zhou B,Li X,Huang H,Mo Y,Luk TY,Lau TT,Yeung P,Chan WM,Wu AK,Lung KC,Tsang OT,Leung WS,Hung IF,Yuen KY,Chen Z
Tue Oct 13 00:00:00 EDT 2020
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.
The Journal of clinical investigation
Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y
Thu Oct 01 00:00:00 EDT 2020
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.
The Journal of clinical investigation
Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y
Thu Oct 01 00:00:00 EDT 2020
C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.
The Journal of clinical investigation
N'diaye M,Brauner S,Flytzani S,Kular L,Warnecke A,Adzemovic MZ,Piket E,Min JH,Edwards W,Mela F,Choi HY,Magg V,James T,Linden M,Reichardt HM,Daws MR,van Horssen J,Kockum I,Harris RA,Olsson T,Guerreiro-Cacais AO,Jagodic M
Mon Feb 03 00:00:00 EST 2020
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Proceedings of the National Academy of Sciences of the United States of America
Cribbs AP,Terlecki-Zaniewicz S,Philpott M,Baardman J,Ahern D,Lindow M,Obad S,Oerum H,Sampey B,Mander PK,Penn H,Wordsworth P,Bowness P,de Winther M,Prinjha RK,Feldmann M,Oppermann U
Tue Mar 17 00:00:00 EDT 2020
microRNA-132 is overexpressed in glia in temporal lobe epilepsy and reduces the expression of pro-epileptogenic factors in human cultured astrocytes.
Glia
Korotkov A,Broekaart DWM,Banchaewa L,Pustjens B,van Scheppingen J,Anink JJ,Baayen JC,Idema S,Gorter JA,van Vliet EA,Aronica E
Wed Jan 01 00:00:00 EST 2020
Presence, function, and regulation of IL-17F-expressing human CD4+ T cells.
European journal of immunology
Burns LA,Maroof A,Marshall D,Steel KJA,Lalnunhlimi S,Cole S,Catrina A,Kirkham B,Taams LS
Wed Apr 01 00:00:00 EDT 2020
Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Troullinaki M,Chen LS,Witt A,Pyrina I,Phieler J,Kourtzelis I,Chmelar J,Sprott D,Gercken B,Koutsilieris M,Chavakis T,Chatzigeorgiou A
Sat Feb 01 00:00:00 EST 2020
Pharmacological activation of ERβ by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tao Y,Yue M,Lv C,Yun X,Qiao S,Fang Y,Wei Z,Xia Y,Dai Y
Sat Feb 01 00:00:00 EST 2020
Inflammatory-sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang R,Xu C,Zhong H,Hu B,Wei L,Liu N,Zhang Y,Shi Q,Wang C,Qi M,Gu Y,Shen X,Tian Y,Liu Y,Cao P,Chen H,Yuan W
Sun Mar 01 00:00:00 EST 2020
Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wei L,Cao P,Xu C,Zhong H,Wang X,Bai M,Hu B,Wang R,Liu N,Tian Y,Chen H,Li J,Yuan W
Tue Dec 01 00:00:00 EST 2020
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.
Journal of immunology (Baltimore, Md. : 1950)
Taylor S,Whitfield M,Barratt J,Didangelos A
Thu Oct 15 00:00:00 EDT 2020
Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β.
Journal of cellular and molecular medicine
Hsueh YJ,Meir YJ,Lai JY,Chen HC,Ma DH,Huang CC,Lu TT,Cheng CM,Wu WC
Mon Jun 01 00:00:00 EDT 2020
Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β.
Journal of cellular and molecular medicine
Hsueh YJ,Meir YJ,Lai JY,Chen HC,Ma DH,Huang CC,Lu TT,Cheng CM,Wu WC
Mon Jun 01 00:00:00 EDT 2020
Interleukin-1β augments the angiogenesis of endothelial progenitor cells in an NF-κB/CXCR7-dependent manner.
Journal of cellular and molecular medicine
Fan X,He L,Dai Q,He J,Chen X,Dai X,Zhang C,Sun D,Meng X,Sun S,Huang J,Chen J,Lin L,Chen L,Tan Y,Yan X
Fri May 01 00:00:00 EDT 2020
A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.
Journal of cellular and molecular medicine
Bachmann M,Lamprecht L,Gonther S,Pfeilschifter J,Mühl H
Tue Sep 01 00:00:00 EDT 2020
Chondroprotective and anti-inflammatory effects of amurensin H by regulating TLR4/Syk/NF-κB signals.
Journal of cellular and molecular medicine
Ma P,Yue L,Yang H,Fan Y,Bai J,Li S,Yuan J,Zhang Z,Yao C,Lin M,Hou Q
Wed Jan 01 00:00:00 EST 2020
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Journal of cellular and molecular medicine
Wang X,Chen Z,Fan X,Li W,Qu J,Dong C,Wang Z,Ji Z,Li Y
Wed Jan 01 00:00:00 EST 2020
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
Journal of cell science
Mc Fie M,Koneva L,Collins I,Coveney CR,Clube AM,Chanalaris A,Vincent TL,Bezbradica JS,Sansom SN,Wann AKT
200-01B was used in Cell Culture to study how IFT88 depletion affects specific cytokine-regulated behaviours, changing cytosolic NFκB translocation dynamics but leaving MAPK signalling unaffected.
Wed Jul 08 00:00:00 EDT 2020
Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome.
International immunology
Niitsuma S,Kudo H,Kikuchi A,Hayashi T,Kumakura S,Kobayashi S,Okuyama Y,Kumagai N,Niihori T,Aoki Y,So T,Funayama R,Nakayama K,Shirota M,Kondo S,Kagami S,Tsukaguchi H,Iijima K,Kure S,Ishii N
200-01B was used in Cell Culture to investigate causative genes in steroid-sensitive nephrotic syndrome.
Sun Apr 12 00:00:00 EDT 2020
Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing.
Scientific reports
Shin JU,Abaci HE,Herron L,Guo Z,Sallee B,Pappalardo A,Jackow J,Wang EHC,Doucet Y,Christiano AM
Thu Mar 05 00:00:00 EST 2020
Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome.
Scientific reports
Romacho T,Valencia I,Ramos-González M,Vallejo S,López-Esteban M,Lorenzo O,Cannata P,Romero A,San Hipólito-Luengo A,Gómez-Cerezo JF,Peiró C,Sánchez-Ferrer CF
Wed Mar 25 00:00:00 EDT 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature communications
Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R
Thu Nov 05 00:00:00 EST 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.
Nature communications
Stoll L,Rodríguez-Trejo A,Guay C,Brozzi F,Bayazit MB,Gattesco S,Menoud V,Sobel J,Marques AC,Venø MT,Esguerra JLS,Barghouth M,Suleiman M,Marselli L,Kjems J,Eliasson L,Renström E,Bouzakri K,Pinget M,Marchetti P,Regazzi R
Thu Nov 05 00:00:00 EST 2020
Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights.
Cancers
Povo-Retana A,Mojena M,Stremtan AB,Fernández-García VB,Gómez-Sáez A,Nuevo-Tapioles C,Molina-Guijarro JM,Avendaño-Ortiz J,Cuezva JM,López-Collazo E,Martínez-Leal JF,Boscá L
200-01B was used in In vitro experiments to study the effect of trabectedin and lurbinectedin on human macrophage cell viability and function.
Tue Oct 20 00:00:00 EDT 2020
Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis.
PloS one
Baeza-Raja B,Goodyear A,Liu X,Lam K,Yamamoto L,Li Y,Dodson GS,Takeuchi T,Kisseleva T,Brenner DA,Dabbagh K
200-01B was used in Cell Culture to report that P2RX7 is expressed by infiltrating monocytes and resident Kupffer cells in livers from NASH-affected individuals.
Fri Aug 21 00:00:00 EDT 2020
Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis.
The Journal of biological chemistry
Stafford JD,Shaheen ZR,Yeo CT,Corbett JA
Fri Dec 04 00:00:00 EST 2020
The location of sensing determines the pancreatic β-cell response to the viral mimetic dsRNA.
The Journal of biological chemistry
Shaheen ZR,Stafford JD,Voss MG,Oleson BJ,Stancill JS,Corbett JA
Fri Feb 21 00:00:00 EST 2020
SIRT1 directly activates autophagy in human chondrocytes.
Cell death discovery
Sacitharan PK,Bou-Gharios G,Edwards JR
Tue Sep 26 00:00:00 EDT 2023
κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis.
Nature communications
Beel S,Kolloch L,Apken LH,Jürgens L,Bolle A,Sudhof N,Ghosh S,Wardelmann E,Meisterernst M,Steinestel K,Oeckinghaus A
Wed Jul 08 00:00:00 EDT 2020
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.
Nature communications
Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD
200-01B was used in In vitro experiments to investigate immunity in patients with inherited salt-losing tubulopathies (SLT).
Mon Aug 31 00:00:00 EDT 2020
Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.
Cells
Mandelli GE,Missale F,Bresciani D,Gatta LB,Scapini P,Caveggion E,Roca E,Bugatti M,Monti M,Cristinelli L,Belotti S,Simeone C,Calza S,Melocchi L,Vermi W
200-01B was used in In vitro experiments to explore the density and clinical significance of CD66b+ tumor-associated-neutrophils (TAN) and CD3+ T cells.
Sat Jan 25 00:00:00 EST 2020
β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.
Pharmacology research & perspectives
Tanaka S,Imaeda A,Matsumoto K,Maeda M,Obana M,Fujio Y
Wed Apr 01 00:00:00 EDT 2020
β2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.
Pharmacology research & perspectives
Tanaka S,Imaeda A,Matsumoto K,Maeda M,Obana M,Fujio Y
Wed Apr 01 00:00:00 EDT 2020
Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis.
Cell death discovery
Tsuji G,Hashimoto-Hachiya A,Yen VH,Takemura M,Yumine A,Furue K,Furue M,Nakahara T
Tue Sep 26 00:00:00 EDT 2023
TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells.
Cells
Cambria E,Arlt MJE,Wandel S,Krupkova O,Hitzl W,Passini FS,Hausmann ON,Snedeker JG,Ferguson SJ,Wuertz-Kozak K
200-01B was used in In vitro experiments to investigate potential pharmacological targets to treat degenerative disc disease and low back pain.
Tue Jul 21 00:00:00 EDT 2020
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.
Cell reports
Yan J,Pandey SP,Barnes BJ,Turner JR,Abraham C
200-01B was used in In vitro experiments to identify a previously undefined key role for T cell-intrinsic IRF5. In mice, IRF5 in CD4+ T cells promotes Th1- and Th17-associated cytokines and decreases Th2-associated cytokines.
Tue Jun 30 00:00:00 EDT 2020
Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity.
Scientific reports
Sousa C,Leitão AJ,Neves BM,Judas F,Cavaleiro C,Mendes AF
Wed Apr 29 00:00:00 EDT 2020
Metabolic alterations in Parkinson's disease astrocytes.
Scientific reports
Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š
Wed Sep 02 00:00:00 EDT 2020
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Scientific reports
Ingvarsen SZ,Gårdsvoll H,van Putten S,Nørregaard KS,Krigslund O,Meilstrup JA,Tran C,Jürgensen HJ,Melander MC,Nielsen CH,Kjaer A,Bugge TH,Engelholm LH,Behrendt N
Thu Nov 05 00:00:00 EST 2020
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
The Journal of biological chemistry
Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z
Fri Mar 27 00:00:00 EDT 2020
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
The Journal of biological chemistry
Zhang J,Xu M,Zhou W,Li D,Zhang H,Chen Y,Ning L,Zhang Y,Li S,Yu M,Chen Y,Zeng H,Cen L,Zhou T,Zhou X,Lu C,Yu C,Li Y,Sun J,Kong X,Shen Z
Fri Mar 27 00:00:00 EDT 2020
IL-17F induces inflammation, dysfunction and cell death in mouse islets.
Scientific reports
Catterall T,Fynch S,Kay TWH,Thomas HE,Sutherland APR
Tue Aug 04 00:00:00 EDT 2020
A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.
Cell
Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V
Thu Oct 03 00:00:00 EDT 2019
A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.
Cell
Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V
Thu Oct 03 00:00:00 EDT 2019
Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.
Immunity
Schwartz DM,Farley TK,Richoz N,Yao C,Shih HY,Petermann F,Zhang Y,Sun HW,Hayes E,Mikami Y,Jiang K,Davis FP,Kanno Y,Milner JD,Siegel R,Laurence A,Meylan F,O'Shea JJ
Tue Jan 15 00:00:00 EST 2019
Germline mutations in the transcription factor IKZF5 cause thrombocytopenia.
Blood
Lentaigne C,Greene D,Sivapalaratnam S,Favier R,Seyres D,Thys C,Grassi L,Mangles S,Sibson K,Stubbs M,Burden F,Bordet JC,Armari-Alla C,Erber W,Farrow S,Gleadall N,Gomez K,Megy K,Papadia S,Penkett CJ,Sims MC,Stefanucci L,Stephens JC,Read RJ,Stirrups KE,Ouwehand WH,Laffan MA,Frontini M,Freson K,Turro E
Thu Dec 05 00:00:00 EST 2019
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
The Journal of experimental medicine
Spencer S,Köstel Bal S,Egner W,Lango Allen H,Raza SI,Ma CA,Gürel M,Zhang Y,Sun G,Sabroe RA,Greene D,Rae W,Shahin T,Kania K,Ardy RC,Thian M,Staples E,Pecchia-Bekkum A,Worrall WPM,Stephens J,Brown M,Tuna S,York M,Shackley F,Kerrin D,Sargur R,Condliffe A,Tipu HN,Kuehn HS,Rosenzweig SD,Turro E,Tavaré S,Thrasher AJ,Jodrell DI,Smith KGC,Boztug K,Milner JD,Thaventhiran JED
Mon Sep 02 00:00:00 EDT 2019
An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.
Cancer research
Carter BZ,Mak PY,Wang X,Tao W,Ruvolo V,Mak D,Mu H,Burks JK,Andreeff M
200-01B was used in Cell Culture to conclude that the antiapoptotic protein ARC promotes AML aggressiveness by enabling detrimental cross-talk with bone marrow mesenchymal stromal cells.
Fri Mar 15 00:00:00 EDT 2019
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Proceedings of the National Academy of Sciences of the United States of America
Lu Y,Stuart JH,Talbot-Cooper C,Agrawal-Singh S,Huntly B,Smid AI,Snowden JS,Dupont L,Smith GL
Tue Jun 11 00:00:00 EDT 2019
NF-κB activation is a turn on for vaccinia virus phosphoprotein A49 to turn off NF-κB activation.
Proceedings of the National Academy of Sciences of the United States of America
Neidel S,Ren H,Torres AA,Smith GL
Tue Mar 19 00:00:00 EDT 2019
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.
Aging cell
Martini H,Iacovoni JS,Maggiorani D,Dutaur M,Marsal DJ,Roncalli J,Itier R,Dambrin C,Pizzinat N,Mialet-Perez J,Cussac D,Parini A,Lefevre L,Douin-Echinard V
Tue Oct 01 00:00:00 EDT 2019
The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation.
Aging cell
Romero A,San Hipólito-Luengo Á,Villalobos LA,Vallejo S,Valencia I,Michalska P,Pajuelo-Lozano N,Sánchez-Pérez I,León R,Bartha JL,Sanz MJ,Erusalimsky JD,Sánchez-Ferrer CF,Romacho T,Peiró C
Sat Jun 01 00:00:00 EDT 2019
Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.
British journal of cancer
Chen Q,Wang J,Zhang Q,Zhang J,Lou Y,Yang J,Chen Y,Wei T,Zhang J,Fu Q,Ye M,Zhang X,Dang X,Liang T,Bai X
Tue Oct 01 00:00:00 EDT 2019
CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.
Osteoarthritis and cartilage
Seidl CI,Fulga TA,Murphy CL
200-01B was used in In vitro experiments to investigate CRISPR editing of chondrocytes.
Tue Jan 01 00:00:00 EST 2019
RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.
Oncogenesis
Waters MR,Gupta AS,Mockenhaupt K,Brown LN,Biswas DD,Kordula T
Wed May 29 00:00:00 EDT 2019
USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.
Journal of immunology (Baltimore, Md. : 1950)
Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB
200-01B was used in In vitro experiments to investigate ubiquitination of TAK1.
Mon Jul 01 00:00:00 EDT 2019
Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.
Journal of periodontal research
Janjić K,Schellner A,Engenhart A,Kernstock K,Schädl B,Moritz A,Agis H
Tue Oct 01 00:00:00 EDT 2019
Activity of two hyaluronan preparations on primary human oral fibroblasts.
Journal of periodontal research
Asparuhova MB,Kiryak D,Eliezer M,Mihov D,Sculean A
Fri Feb 01 00:00:00 EST 2019
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.
Nature communications
Pereira BI,Devine OP,Vukmanovic-Stejic M,Chambers ES,Subramanian P,Patel N,Virasami A,Sebire NJ,Kinsler V,Valdovinos A,LeSaux CJ,Passos JF,Antoniou A,Rustin MHA,Campisi J,Akbar AN
Mon Jun 03 00:00:00 EDT 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 EDT 2019
Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells.
Scientific reports
Shokri MR,Bozorgmehr M,Ghanavatinejad A,Falak R,Aleahmad M,Kazemnejad S,Shokri F,Zarnani AH
Wed Jul 10 00:00:00 EDT 2019
The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis.
Scientific reports
Dimou P,Wright RD,Budge KL,Midgley A,Satchell SC,Peak M,Beresford MW
Thu Jun 06 00:00:00 EDT 2019
A network-centric approach to drugging TNF-induced NF-κB signaling.
Nature communications
Pabon NA,Zhang Q,Cruz JA,Schipper DL,Camacho CJ,Lee REC
Tue Feb 26 00:00:00 EST 2019
A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta.
Scientific reports
McClellan A,Evans R,Sze C,Kan S,Paterson Y,Guest D
Tue Feb 26 00:00:00 EST 2019
Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.
Cell death & disease
Derada Troletti C,Fontijn RD,Gowing E,Charabati M,van Het Hof B,Didouh I,van der Pol SMA,Geerts D,Prat A,van Horssen J,Kooij G,de Vries HE
Fri Jan 18 00:00:00 EST 2019
Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer.
Frontiers in immunology
Liubomirski Y,Lerrer S,Meshel T,Rubinstein-Achiasaf L,Morein D,Wiemann S,Körner C,Ben-Baruch A
200-01B was used in Sample Preparation (ELISA) to study the impact of tumor-stroma-inflammation networks on pro-metastatic phenotypes in triple-negative breast cancer (TNBC) to identify a novel tumor-stroma-inflammation networks that may promote TNBC aggressiveness by increasing the pro-malignancy potential of the TME and of the tumor cells themselves, and reveal key roles for CXCL8 in mediating these metastasis-promoting activities.
Mon Aug 10 00:00:00 EDT 2020
NOD1 modulates decidual stromal cell function to maintain pregnancy in the early trimester.
Cell biochemistry and function
Zhang Y,Zhang Y,Li C,Fu S,Yang C,Song Y,Liu M,Wang Z,Liang P,Zhang J
200-01B was used in Cell Culture to indicate that RPL may be associated with NOD1 aberrant expression in DSCs, which plays a significant role in maintaining pregnancy via infection control and regulation of immune responses that might affect the pregnancy outcome.
Tue Oct 01 00:00:00 EDT 2019
IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.
The Journal of biological chemistry
Magoro T,Dandekar A,Jennelle LT,Bajaj R,Lipkowitz G,Angelucci AR,Bessong PO,Hahn YS
Fri Oct 04 00:00:00 EDT 2019
HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β.
Oncotarget
Tawara K,Scott H,Emathinger J,Wolf C,LaJoie D,Hedeen D,Bond L,Montgomery P,Jorcyk C
200-01B was used in In vitro experiments to study how interleukin-6 (IL-6), oncostatin M (OSM), and interleukin-1 beta (IL-1β) cytokines are interrelated in expression to suggest a rationale for a breast cancer treatment regime that simultaneously suppresses multiple targets, as these cytokines possess many overlapping functions that increase metastasis and worsen patient survival.
Tue Mar 12 00:00:00 EDT 2019
M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling.
Frontiers in immunology
Zong Z,Zou J,Mao R,Ma C,Li N,Wang J,Wang X,Zhou H,Zhang L,Shi Y
200-01B was used in In vitro experiments to demonstrate that M1 macrophages induced expression of PD-L1 in HCC cells, supporting the pro-tumor role of M1 macrophages.
Wed Oct 14 00:00:00 EDT 2020
The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation.
Cell death & disease
Fu H,Alabdullah M,Großmann J,Spieler F,Abdosh R,Lutz V,Kalies K,Knöpp K,Rieckmann M,Koch S,Noutsias M,Pilowski C,Dutzmann J,Sedding D,Hüttelmaier S,Umezawa K,Werdan K,Loppnow H
Thu Nov 21 00:00:00 EST 2019
Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease.
Scientific reports
Dosh RH,Jordan-Mahy N,Sammon C,Le Maitre CL
Tue Feb 12 00:00:00 EST 2019
Identification of stably expressed housekeeping miRNAs in endothelial cells and macrophages in an inflammatory setting.
Scientific reports
Link F,Krohn K,Schumann J
Wed Sep 04 00:00:00 EDT 2019
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Cell reports
Huang C,Hedl M,Ranjan K,Abraham C
200-01B was used in Cell Culture to investigate that, if, upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors.
Tue Dec 24 00:00:00 EST 2019
Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages.
PloS one
Jumeau C,Awad F,Assrawi E,Cobret L,Duquesnoy P,Giurgea I,Valeyre D,Grateau G,Amselem S,Bernaudin JF,Karabina SA
200-01B was used in In vitro experiments to investigate serum amyloid A expression by monocytes.
Fri Jan 24 00:00:00 EST 2020
The N-Acetyl Phenylalanine Glucosamine Derivative Attenuates the Inflammatory/Catabolic Environment in a Chondrocyte-Synoviocyte Co-Culture System.
Scientific reports
Pagani S,Minguzzi M,Sicuro L,Veronesi F,Santi S,Scotto D'Abusco A,Fini M,Borzì RM
Thu Sep 19 00:00:00 EDT 2019
Vitamin D Switches BAF Complexes to Protect β Cells.
Cell
Wei Z,Yoshihara E,He N,Hah N,Fan W,Pinto AFM,Huddy T,Wang Y,Ross B,Estepa G,Dai Y,Ding N,Sherman MH,Fang S,Zhao X,Liddle C,Atkins AR,Yu RT,Downes M,Evans RM
Thu May 17 00:00:00 EDT 2018
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
Thu Oct 04 00:00:00 EDT 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.
Immunity
Bando JK,Gilfillan S,Song C,McDonald KG,Huang SC,Newberry RD,Kobayashi Y,Allan DSJ,Carlyle JR,Cella M,Colonna M
Tue Jun 19 00:00:00 EDT 2018
Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection.
Cell host & microbe
Johnson JS,Lucas SY,Amon LM,Skelton S,Nazitto R,Carbonetti S,Sather DN,Littman DR,Aderem A
200-01B was used in Cell Culture to study how dendritic cells (DCs) detect HIV-1 in distinct phases, before and after virus integration in response to reverse transcription.
Wed Mar 14 00:00:00 EDT 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 EDT 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 EDT 2018
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.
The Journal of experimental medicine
Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F
Mon May 07 00:00:00 EDT 2018
Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.
Clinical cancer research : an official journal of the American Association for Cancer Research
L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST
200-01B was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.
Sun Jul 15 00:00:00 EDT 2018
Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.
Experimental & molecular medicine
Choi HJ,Chung TW,Choi HJ,Han JH,Choi JH,Kim CH,Ha KT
Wed Dec 12 00:00:00 EST 2018
Lymphatic exosomes promote dendritic cell migration along guidance cues.
The Journal of cell biology
Brown M,Johnson LA,Leone DA,Majek P,Vaahtomeri K,Senfter D,Bukosza N,Schachner H,Asfour G,Langer B,Hauschild R,Parapatics K,Hong YK,Bennett KL,Kain R,Detmar M,Sixt M,Jackson DG,Kerjaschki D
Mon Jun 04 00:00:00 EDT 2018
Immune Assisted Tissue Engineering via Incorporation of Macrophages in Cell-Laden Hydrogels Under Cytokine Stimulation.
Frontiers in bioengineering and biotechnology
Barthes J,Dollinger C,Muller CB,Liivas U,Dupret-Bories A,Knopf-Marques H,Vrana NE
200-01B was used in Enzyme-linked immunosorbent assay to demonstrate that incorporation of macrophages in a resident macrophage function and their phenotype control have significant effects on the maturation and cytokine microenvironment of 3-D multiple cell type-laden hydrogels, which can be harnessed for better integration of implantable systems and for more physiologically relevant in vitro tissue models with an immune component.
Thu Oct 01 00:00:00 EDT 2020
BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation.
Journal of cellular and molecular medicine
Pardali E,Makowski LM,Leffers M,Borgscheiper A,Waltenberger J
Thu Nov 01 00:00:00 EDT 2018
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery.
SLAS discovery : advancing life sciences R & D
Young J,Margaron Y,Fernandes M,Duchemin-Pelletier E,Michaud J,Flaender M,Lorintiu O,Degot S,Poydenot P
200-01B was used in In vitro experiments to investigate MyoScreen treatment of muscle atrophy and disease.
Sat Sep 01 00:00:00 EDT 2018
Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue.
Scientific reports
Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J
Mon Aug 27 00:00:00 EDT 2018
Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.
Cell death & disease
Chen J,Xie JJ,Jin MY,Gu YT,Wu CC,Guo WJ,Yan YZ,Zhang ZJ,Wang JL,Zhang XL,Lin Y,Sun JL,Zhu GH,Wang XY,Wu YS
Fri Jan 19 00:00:00 EST 2018
Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis.
Scientific reports
Di Domenico EG,Cavallo I,Bordignon V,Prignano G,Sperduti I,Gurtner A,Trento E,Toma L,Pimpinelli F,Capitanio B,Ensoli F
Thu Jun 28 00:00:00 EDT 2018
GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis.
Cell death & disease
Jia W,Wu W,Yang D,Xiao C,Huang M,Long F,Su Z,Qin M,Liu X,Zhu YZ
Tue May 01 00:00:00 EDT 2018
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
Nature communications
Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q
Thu Feb 08 00:00:00 EST 2018
IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.
Scientific reports
Ahsan F,Maertzdorf J,Guhlich-Bornhof U,Kaufmann SHE,Moura-Alves P
Wed Jan 24 00:00:00 EST 2018
IL-1β- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans.
Scientific reports
Moratal C,Raffort J,Arrighi N,Rekima S,Schaub S,Dechesne CA,Chinetti G,Dani C
Mon Nov 19 00:00:00 EST 2018
A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.
Nature communications
Petersen A,Princ A,Korus G,Ellinghaus A,Leemhuis H,Herrera A,Klaumünzer A,Schreivogel S,Woloszyk A,Schmidt-Bleek K,Geissler S,Heschel I,Duda GN
Thu Oct 25 00:00:00 EDT 2018
Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.
Scientific reports
Beaudry-Richard A,Nadeau-Vallée M,Prairie É,Maurice N,Heckel É,Nezhady M,Pundir S,Madaan A,Boudreault A,Hou X,Quiniou C,Sierra EM,Beaulac A,Lodygensky G,Robertson SA,Keelan J,Adams Waldorf KM,Olson DM,Rivera JC,Lubell WD,Joyal JS,Bouchard JF,Chemtob S
Wed Aug 08 00:00:00 EDT 2018
Regulation of IL-22BP in psoriasis.
Scientific reports
Voglis S,Moos S,Kloos L,Wanke F,Zayoud M,Pelczar P,Giannou AD,Pezer S,Albers M,Luessi F,Huber S,Schäkel K,Kurschus FC
Fri Mar 23 00:00:00 EDT 2018
A Pilot Study To Investigate the Immune-Modulatory Effects of Fasting in Steroid-Naive Mild Asthmatics.
Journal of immunology (Baltimore, Md. : 1950)
Han K,Nguyen A,Traba J,Yao X,Kaler M,Huffstutler RD,Levine SJ,Sack MN
Sat Sep 01 00:00:00 EDT 2018
Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells.
Scientific reports
Martin-Gallausiaux C,Béguet-Crespel F,Marinelli L,Jamet A,Ledue F,Blottière HM,Lapaque N
Wed Jun 27 00:00:00 EDT 2018
Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses.
PLoS neglected tropical diseases
Bedoui Y,Giry C,Jaffar-Bandjee MC,Selambarom J,Guiraud P,Gasque P
200-01B was used in In vitro experiments to argue for a beneficial effect of MTX to treat CIR post-CHIKV given that it does not critically impact the antiviral, the proinflammatory and the bone tissue remodeling responses of synovial cells.
Wed Aug 01 00:00:00 EDT 2018
PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.
The Journal of experimental medicine
Zhang Y,Ma CA,Lawrence MG,Break TJ,O'Connell MP,Lyons JJ,López DB,Barber JS,Zhao Y,Barber DL,Freeman AF,Holland SM,Lionakis MS,Milner JD
Mon Sep 04 00:00:00 EDT 2017
TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.
The Journal of experimental medicine
Pattarini L,Trichot C,Bogiatzi S,Grandclaudon M,Meller S,Keuylian Z,Durand M,Volpe E,Madonna S,Cavani A,Chiricozzi A,Romanelli M,Hori T,Hovnanian A,Homey B,Soumelis V
Mon May 01 00:00:00 EDT 2017
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
The Journal of experimental medicine
Young HL,Rowling EJ,Bugatti M,Giurisato E,Luheshi N,Arozarena I,Acosta JC,Kamarashev J,Frederick DT,Cooper ZA,Reuben A,Gil J,Flaherty KT,Wargo JA,Vermi W,Smith MP,Wellbrock C,Hurlstone A
Mon Jun 05 00:00:00 EDT 2017
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.
The Journal of experimental medicine
Pierce RW,Merola J,Lavik JP,Kluger MS,Huttner A,Khokha MK,Pober JS
Mon Dec 04 00:00:00 EST 2017
S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.
The Journal of experimental medicine
Weichand B,Popp R,Dziumbla S,Mora J,Strack E,Elwakeel E,Frank AC,Scholich K,Pierre S,Syed SN,Olesch C,Ringleb J,Ören B,Döring C,Savai R,Jung M,von Knethen A,Levkau B,Fleming I,Weigert A,Brüne B
Mon Sep 04 00:00:00 EDT 2017
TRPM2-mediated rise in mitochondrial Zn2+ promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.
Cell death and differentiation
Li F,Munsey TS,Sivaprasadarao A
Fri Dec 01 00:00:00 EST 2017
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
European journal of immunology
Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E
Fri Sep 01 00:00:00 EDT 2017
Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction.
Journal of immunology (Baltimore, Md. : 1950)
Brien ME,Duval C,Palacios J,Boufaied I,Hudon-Thibeault AA,Nadeau-Vallée M,Vaillancourt C,Sibley CP,Abrahams VM,Jones RL,Girard S
Sun Jan 01 00:00:00 EST 2017
Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Nadeau-Vallée M,Chin PY,Belarbi L,Brien MÈ,Pundir S,Berryer MH,Beaudry-Richard A,Madaan A,Sharkey DJ,Lupien-Meilleur A,Hou X,Quiniou C,Beaulac A,Boufaied I,Boudreault A,Carbonaro A,Doan ND,Joyal JS,Lubell WD,Olson DM,Robertson SA,Girard S,Chemtob S
200-01B was used in Enzyme-linked immunosorbent assay to develop treatment for drugs targeting preterm birth-associated utero foetal inflammation.
Wed Mar 01 00:00:00 EST 2017
Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Nadeau-Vallée M,Chin PY,Belarbi L,Brien MÈ,Pundir S,Berryer MH,Beaudry-Richard A,Madaan A,Sharkey DJ,Lupien-Meilleur A,Hou X,Quiniou C,Beaulac A,Boufaied I,Boudreault A,Carbonaro A,Doan ND,Joyal JS,Lubell WD,Olson DM,Robertson SA,Girard S,Chemtob S
200-01B was used in Enzyme-linked immunosorbent assay to develop treatment for drugs targeting preterm birth-associated utero foetal inflammation.
Wed Mar 01 00:00:00 EST 2017
A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Montoya MM,Maul J,Singh PB,Pua HH,Dahlström F,Wu N,Huang X,Ansel KM,Baumjohann D
Sat Jul 15 00:00:00 EDT 2017
IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.
Journal of immunology (Baltimore, Md. : 1950)
Victor AR,Nalin AP,Dong W,McClory S,Wei M,Mao C,Kladney RD,Youssef Y,Chan WK,Briercheck EL,Hughes T,Scoville SD,Pitarresi JR,Chen C,Manz S,Wu LC,Zhang J,Ostrowski MC,Freud AG,Leone GW,Caligiuri MA,Yu J
Sun Oct 01 00:00:00 EDT 2017
Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway.
Journal of cellular and molecular medicine
Wang Z,Huang J,Zhou S,Luo F,Xu W,Wang Q,Tan Q,Chen L,Wang J,Chen H,Chen L,Xie Y,Du X
Fri Dec 01 00:00:00 EST 2017
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.
Bioscience reports
Kehlen A,Haegele M,Böhme L,Cynis H,Hoffmann T,Demuth HU
200-01B was used in In vitro experiments to suggest that QC-catalysed N-terminal pGlu formation of CX3CL1 is important for the stability or the interaction with its receptor and opens new insights into the function of QC in inflammation.
Thu Aug 31 00:00:00 EDT 2017
Induction of antimicrobial peptides secretion by IL-1β enhances human amniotic membrane for regenerative medicine.
Scientific reports
Tehrani FA,Modaresifar K,Azizian S,Niknejad H
Tue Dec 05 00:00:00 EST 2017
IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration.
Scientific reports
Wang S,Liu C,Sun Z,Yan P,Liang H,Huang K,Li C,Tian J
Fri Jun 23 00:00:00 EDT 2017
Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment.
Scientific reports
Mills JD,Iyer AM,van Scheppingen J,Bongaarts A,Anink JJ,Janssen B,Zimmer TS,Spliet WG,van Rijen PC,Jansen FE,Feucht M,Hainfellner JA,Krsek P,Zamecnik J,Kotulska K,Jozwiak S,Jansen A,Lagae L,Curatolo P,Kwiatkowski DJ,Pasterkamp RJ,Senthilkumar K,von Oerthel L,Hoekman MF,Gorter JA,Crino PB,Mühlebner A,Scicluna BP,Aronica E
Mon Aug 14 00:00:00 EDT 2017
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.
The Journal of biological chemistry
Majkowska I,Shitomi Y,Ito N,Gray NS,Itoh Y
Fri Apr 21 00:00:00 EDT 2017
miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.
Scientific reports
Mayer U,Benditz A,Grässel S
Mon Oct 16 00:00:00 EDT 2017
Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.
Nature communications
Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A
Mon Oct 09 00:00:00 EDT 2017
Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis.
Scientific reports
Gibson AL,Hui Mingalone CK,Foote AT,Uchimura T,Zhang M,Zeng L
Mon Feb 06 00:00:00 EST 2017
Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis.
Scientific reports
Gibson AL,Hui Mingalone CK,Foote AT,Uchimura T,Zhang M,Zeng L
Mon Feb 06 00:00:00 EST 2017
Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes.
BMC musculoskeletal disorders
Hansen AK,Figenschau Y,Zubiaurre-Martinez I
200-01B was used in Cell Culture to study whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1).
Mon Nov 06 00:00:00 EST 2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Stem cell reports
Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q
Tue Aug 08 00:00:00 EDT 2017
Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium.
Scientific reports
Terenzi R,Manetti M,Rosa I,Romano E,Galluccio F,Guiducci S,Ibba-Manneschi L,Matucci-Cerinic M
Mon Oct 16 00:00:00 EDT 2017
Heparanase and macrophage interplay in the onset of liver fibrosis.
Scientific reports
Secchi MF,Crescenzi M,Masola V,Russo FP,Floreani A,Onisto M
Thu Nov 02 00:00:00 EDT 2017
Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
The Journal of experimental medicine
Wang Y,Ma CS,Ling Y,Bousfiha A,Camcioglu Y,Jacquot S,Payne K,Crestani E,Roncagalli R,Belkadi A,Kerner G,Lorenzo L,Deswarte C,Chrabieh M,Patin E,Vincent QB,Müller-Fleckenstein I,Fleckenstein B,Ailal F,Quintana-Murci L,Fraitag S,Alyanakian MA,Leruez-Ville M,Picard C,Puel A,Bustamante J,Boisson-Dupuis S,Malissen M,Malissen B,Abel L,Hovnanian A,Notarangelo LD,Jouanguy E,Tangye SG,Béziat V,Casanova JL
Mon Oct 17 00:00:00 EDT 2016
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.
The Journal of experimental medicine
Ma CS,Wong N,Rao G,Nguyen A,Avery DT,Payne K,Torpy J,O'Young P,Deenick E,Bustamante J,Puel A,Okada S,Kobayashi M,Martinez-Barricarte R,Elliott M,Sebnem Kilic S,El Baghdadi J,Minegishi Y,Bousfiha A,Robertson N,Hambleton S,Arkwright PD,French M,Blincoe AK,Hsu P,Campbell DE,Stormon MO,Wong M,Adelstein S,Fulcher DA,Cook MC,Stepensky P,Boztug K,Beier R,Ikincioğullari A,Ziegler JB,Gray P,Picard C,Boisson-Dupuis S,Phan TG,Grimbacher B,Warnatz K,Holland SM,Uzel G,Casanova JL,Tangye SG
Mon Jul 25 00:00:00 EDT 2016
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.
Proceedings of the National Academy of Sciences of the United States of America
Zhou Q,Yu X,Demirkaya E,Deuitch N,Stone D,Tsai WL,Kuehn HS,Wang H,Yang D,Park YH,Ombrello AK,Blake M,Romeo T,Remmers EF,Chae JJ,Mullikin JC,Güzel F,Milner JD,Boehm M,Rosenzweig SD,Gadina M,Welch SB,Özen S,Topaloglu R,Abinun M,Kastner DL,Aksentijevich I
Tue Sep 06 00:00:00 EDT 2016
Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America
Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC
Tue Aug 16 00:00:00 EDT 2016
SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes.
Experimental & molecular medicine
Ha YJ,Choi YS,Kang EH,Shin K,Kim TK,Song YW,Lee YJ
Fri Jun 24 00:00:00 EDT 2016
Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells.
Experimental & molecular medicine
Hong CY,Lee HJ,Choi NR,Jung SH,Vo MC,Hoang MD,Kim HJ,Lee JJ
Fri Aug 19 00:00:00 EDT 2016
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V
Sat Oct 01 00:00:00 EDT 2016
Uterotonic Neuromedin U Receptor 2 and Its Ligands Are Upregulated by Inflammation in Mice and Humans, and Elicit Preterm Birth.
Biology of reproduction
Nadeau-Vallée M,Boudreault A,Leimert K,Hou X,Obari D,Madaan A,Rouget R,Zhu T,Belarbi L,Brien MÈ,Beaudry-Richard A,Olson DM,Girard S,Chemtob S
200-01B was used in Cell Culture to study the expression and function of NmU-R2, NmU and NmS in gestational tissues.
Thu Sep 01 00:00:00 EDT 2016
Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation.
Scientific reports
Liu L,Sun Q,Bao R,Roth M,Zhong B,Lan X,Tian J,He Q,Li D,Sun J,Yang X,Lu S
Thu Feb 25 00:00:00 EST 2016
Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling.
Scientific reports
Chandrika G,Natesh K,Ranade D,Chugh A,Shastry P
Fri Mar 04 00:00:00 EST 2016
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
The Journal of biological chemistry
Doherty CM,Visse R,Dinakarpandian D,Strickland DK,Nagase H,Troeberg L
Fri Oct 14 00:00:00 EDT 2016
Isolation of highly enriched primary human microglia for functional studies.
Scientific reports
Rustenhoven J,Park TI,Schweder P,Scotter J,Correia J,Smith AM,Gibbons HM,Oldfield RL,Bergin PS,Mee EW,Faull RL,Curtis MA,Scott Graham E,Dragunow M
Mon Jan 18 00:00:00 EST 2016
Differential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration.
Scientific reports
Yang C,Cao P,Gao Y,Wu M,Lin Y,Tian Y,Yuan W
Thu Feb 25 00:00:00 EST 2016
Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.
Scientific reports
Lombardo G,Dentelli P,Togliatto G,Rosso A,Gili M,Gallo S,Deregibus MC,Camussi G,Brizzi MF
Mon May 09 00:00:00 EDT 2016
Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.
Scientific reports
Hu B,Shi C,Xu C,Cao P,Tian Y,Zhang Y,Deng L,Chen H,Yuan W
Mon Feb 15 00:00:00 EST 2016
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.
The Journal of biological chemistry
Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y
Fri Aug 26 00:00:00 EDT 2016
Nerve Growth Factor Is Regulated by Toll-Like Receptor 2 in Human Intervertebral Discs.
The Journal of biological chemistry
Krock E,Currie JB,Weber MH,Ouellet JA,Stone LS,Rosenzweig DH,Haglund L
Fri Feb 12 00:00:00 EST 2016
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
Scientific reports
Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C
Thu Mar 24 00:00:00 EDT 2016
A novel role for β2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells.
Scientific reports
Chiou SJ,Wang CC,Tseng YS,Lee YJ,Chen SC,Chou CH,Chuang LY,Hong YR,Lu CY,Chiu CC,Chignard M
Tue Aug 09 00:00:00 EDT 2016
The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.
Scientific reports
Villalvilla A,García-Martín A,Largo R,Gualillo O,Herrero-Beaumont G,Gómez R
Thu Jul 07 00:00:00 EDT 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 EST 2016
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Cell death & disease
Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G
Thu Sep 08 00:00:00 EDT 2016
Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease.
Scientific reports
Kumagai E,Mano Y,Yoshio S,Shoji H,Sugiyama M,Korenaga M,Ishida T,Arai T,Itokawa N,Atsukawa M,Hyogo H,Chayama K,Ohashi T,Ito K,Yoneda M,Kawaguchi T,Torimura T,Nozaki Y,Watanabe S,Mizokami M,Kanto T
Fri Oct 14 00:00:00 EDT 2016
A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis.
Scientific reports
Xu W,Xie Y,Wang Q,Wang X,Luo F,Zhou S,Wang Z,Huang J,Tan Q,Jin M,Qi H,Tang J,Chen L,Du X,Zhao C,Liang G,Chen L
Mon Apr 04 00:00:00 EDT 2016
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.
Scientific reports
Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M
Wed Nov 09 00:00:00 EST 2016
Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways.
Cell death & disease
Mao CY,Wang YG,Zhang X,Zheng XY,Tang TT,Lu EY
Thu Jul 14 00:00:00 EDT 2016
The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.
Molecular vision
Dardik R,Livnat T,Halpert G,Jawad S,Nisgav Y,Azar-Avivi S,Liu B,Nussenblatt RB,Weinberger D,Sredni B
Tue Nov 08 00:00:00 EST 2016
Endothelial-to-mesenchymal transition drives atherosclerosis progression.
The Journal of clinical investigation
Chen PY,Qin L,Baeyens N,Li G,Afolabi T,Budatha M,Tellides G,Schwartz MA,Simons M
Mon Oct 26 00:00:00 EDT 2015
Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.
The Journal of clinical investigation
Zhang Z,Cheng L,Zhao J,Li G,Zhang L,Chen W,Nie W,Reszka-Blanco NJ,Wang FS,Su L
Tue Sep 01 00:00:00 EDT 2015
STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.
The Journal of experimental medicine
Wilson RP,Ives ML,Rao G,Lau A,Payne K,Kobayashi M,Arkwright PD,Peake J,Wong M,Adelstein S,Smart JM,French MA,Fulcher DA,Picard C,Bustamante J,Boisson-Dupuis S,Gray P,Stepensky P,Warnatz K,Freeman AF,Rossjohn J,McCluskey J,Holland SM,Casanova JL,Uzel G,Ma CS,Tangye SG,Deenick EK
Mon Jun 01 00:00:00 EDT 2015
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.
Proceedings of the National Academy of Sciences of the United States of America
Hammitzsch A,Tallant C,Fedorov O,O'Mahony A,Brennan PE,Hay DA,Martinez FO,Al-Mossawi MH,de Wit J,Vecellio M,Wells C,Wordsworth P,Müller S,Knapp S,Bowness P
Tue Aug 25 00:00:00 EDT 2015
Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.
Proceedings of the National Academy of Sciences of the United States of America
De S,Zhou H,DeSantis D,Croniger CM,Li X,Stark GR
Tue Aug 04 00:00:00 EDT 2015
Crohn's disease-derived monocytes fail to induce Paneth cell defensins.
Proceedings of the National Academy of Sciences of the United States of America
Courth LF,Ostaff MJ,Mailänder-Sánchez D,Malek NP,Stange EF,Wehkamp J
Tue Nov 10 00:00:00 EST 2015
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.
Proceedings of the National Academy of Sciences of the United States of America
Schwartz MP,Hou Z,Propson NE,Zhang J,Engstrom CJ,Santos Costa V,Jiang P,Nguyen BK,Bolin JM,Daly W,Wang Y,Stewart R,Page CD,Murphy WL,Thomson JA
Tue Oct 06 00:00:00 EDT 2015
Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.
Mucosal immunology
Cobo ER,Kissoon-Singh V,Moreau F,Chadee K
Sun Nov 01 00:00:00 EDT 2015
Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.
Acta physiologica (Oxford, England)
Jean-Gilles L,Braitch M,Latif ML,Aram J,Fahey AJ,Edwards LJ,Robins RA,Tanasescu R,Tighe PJ,Gran B,Showe LC,Alexander SP,Chapman V,Kendall DA,Constantinescu CS
Fri May 01 00:00:00 EDT 2015
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.
Journal of lipid research
Benesch MG,Zhao YY,Curtis JM,McMullen TP,Brindley DN
Mon Jun 01 00:00:00 EDT 2015
Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.
Journal of leukocyte biology
De Buck M,Berghmans N,Pörtner N,Vanbrabant L,Cockx M,Struyf S,Opdenakker G,Proost P,Van Damme J,Gouwy M
Tue Dec 01 00:00:00 EST 2015
In Vivo Identification and Induction of Articular Cartilage Stem Cells by Inhibiting NF-κB Signaling in Osteoarthritis.
Stem cells (Dayton, Ohio)
Tong W,Geng Y,Huang Y,Shi Y,Xiang S,Zhang N,Qin L,Shi Q,Chen Q,Dai K,Zhang X
Thu Oct 01 00:00:00 EDT 2015
Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chadet S,Ivanes F,Benoist L,Salmon-Gandonnière C,Guibon R,Velge-Roussel F,Babuty D,Baron C,Roger S,Angoulvant D
Wed Jul 15 00:00:00 EDT 2015
Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
Journal of immunology (Baltimore, Md. : 1950)
Nadeau-Vallée M,Quiniou C,Palacios J,Hou X,Erfani A,Madaan A,Sanchez M,Leimert K,Boudreault A,Duhamel F,Rivera JC,Zhu T,Noueihed B,Robertson SA,Ni X,Olson DM,Lubell W,Girard S,Chemtob S
Thu Oct 01 00:00:00 EDT 2015
Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
Journal of immunology (Baltimore, Md. : 1950)
Nadeau-Vallée M,Quiniou C,Palacios J,Hou X,Erfani A,Madaan A,Sanchez M,Leimert K,Boudreault A,Duhamel F,Rivera JC,Zhu T,Noueihed B,Robertson SA,Ni X,Olson DM,Lubell W,Girard S,Chemtob S
Thu Oct 01 00:00:00 EDT 2015
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Journal of immunology (Baltimore, Md. : 1950)
Lourenco S,Teixeira VH,Kalber T,Jose RJ,Floto RA,Janes SM
Wed Apr 01 00:00:00 EDT 2015
Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry.
Journal of immunology (Baltimore, Md. : 1950)
Bushkin Y,Radford F,Pine R,Lardizabal A,Mangura BT,Gennaro ML,Tyagi S
Thu Jan 15 00:00:00 EST 2015
Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling.
Journal of immunology (Baltimore, Md. : 1950)
Larena M,Holmgren J,Lebens M,Terrinoni M,Lundgren A
Wed Apr 15 00:00:00 EDT 2015
Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.
Journal of immunology (Baltimore, Md. : 1950)
Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH
Thu Oct 15 00:00:00 EDT 2015
Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Takami M,Fujimaki K,Nishimura MI,Iwashima M
Tue Sep 15 00:00:00 EDT 2015
Allergenic Can f 1 and its human homologue Lcn-1 direct dendritic cells to induce divergent immune responses.
Journal of cellular and molecular medicine
Posch B,Irsara C,Gamper FS,Herrmann M,Bindreither D,Fuchs D,Reider N,Redl B,Heufler C
Thu Oct 01 00:00:00 EDT 2015
Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action.
CPT: pharmacometrics & systems pharmacology
Michailidou M,Melas IN,Messinis DE,Klamt S,Alexopoulos LG,Kolisis FN,Loutrari H
Mon Jun 01 00:00:00 EDT 2015
Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Thompson CL,Yasmin H,Varone A,Wiles A,Poole CA,Knight MM
Thu Oct 01 00:00:00 EDT 2015
Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.
Scientific reports
Liu J,Zhou F,Chen Q,Kang A,Lu M,Liu W,Zang X,Wang G,Zhang J
Tue Sep 01 00:00:00 EDT 2015
Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.
The Journal of biological chemistry
Burzynski LC,Humphry M,Bennett MR,Clarke MC
Fri Oct 09 00:00:00 EDT 2015
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.
Nature communications
Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M
Wed Nov 04 00:00:00 EST 2015
IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.
Nature communications
Wee ZN,Yatim SM,Kohlbauer VK,Feng M,Goh JY,Bao Y,Lee PL,Zhang S,Wang PP,Lim E,Tam WL,Cai Y,Ditzel HJ,Hoon DS,Tan EY,Yu Q
Tue Oct 27 00:00:00 EDT 2015
MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins.
The Journal of biological chemistry
Park H,Huang X,Lu C,Cairo MS,Zhou X
Fri Jan 30 00:00:00 EST 2015
IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.
Scientific reports
Mailer RK,Joly AL,Liu S,Elias S,Tegner J,Andersson J
Tue Oct 06 00:00:00 EDT 2015
The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Hou C,Meng F,Zhang Z,Kang Y,Chen W,Huang G,Fu M,Sheng P,Zhang Z,Liao W
200-01B was used in In vitro experiments to examine its role in chondrogenesis and osteoarthritic cartilage degeneration.
Mon May 16 00:00:00 EDT 2016
The Role of MicroRNA-381 in Chondrogenesis and Interleukin-1-β Induced Chondrocyte Responses.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Hou C,Meng F,Zhang Z,Kang Y,Chen W,Huang G,Fu M,Sheng P,Zhang Z,Liao W
200-01B was used in In vitro experiments to examine its role in chondrogenesis and osteoarthritic cartilage degeneration.
Mon May 16 00:00:00 EDT 2016
An anti-inflammatory role for C/EBPδ in human brain pericytes.
Scientific reports
Rustenhoven J,Scotter EL,Jansson D,Kho DT,Oldfield RL,Bergin PS,Mee EW,Faull RL,Curtis MA,Graham SE,Park TI,Dragunow M
Mon Jul 13 00:00:00 EDT 2015
Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis.
Scientific reports
Zhu H,Wan X,Li J,Han L,Bo X,Chen W,Lu C,Shen Z,Xu C,Chen L,Yu C,Xu G
Fri Jul 17 00:00:00 EDT 2015
Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.
The Journal of biological chemistry
Tsukuda S,Watashi K,Iwamoto M,Suzuki R,Aizaki H,Okada M,Sugiyama M,Kojima S,Tanaka Y,Mizokami M,Li J,Tong S,Wakita T
Fri Feb 27 00:00:00 EST 2015
TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance.
Oncoimmunology
Guerville F,Daburon S,Marlin R,Lartigue L,Loizon S,Pitard V,Couzi L,Moreau JF,Déchanet-Merville J,Faustin B
200-01B was used in In vitro experiments to investigate the relationship between inflammasome secreted by tumor cells and γδ cell immusurveillance.
Fri May 01 00:00:00 EDT 2015
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
Fri Aug 01 00:00:00 EDT 2014
IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Addi A,Mambole-Dema A,Brender C,Martin SR,Janzen J,Kjaer S,Smerdon SJ,Ley SC
Tue Jun 10 00:00:00 EDT 2014
EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells.
Proceedings of the National Academy of Sciences of the United States of America
De S,Dermawan JK,Stark GR
Tue Aug 12 00:00:00 EDT 2014
Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.
British journal of cancer
Nagasaki T,Hara M,Nakanishi H,Takahashi H,Sato M,Takeyama H
Tue Jan 21 00:00:00 EST 2014
Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response.
Stem cells (Dayton, Ohio)
De Kock J,Meuleman P,Raicevic G,Rodrigues RM,Branson S,Meganathan K,De Boe V,Sachinidis A,Leroux-Roels G,Vanhaecke T,Lagneaux L,Rogiers V,Najar M
Fri Aug 01 00:00:00 EDT 2014
Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mota C,Nunes-Silva V,Pires AR,Matoso P,Victorino RM,Sousa AE,Caramalho I
Mon Dec 15 00:00:00 EST 2014
Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Epaulard O,Adam L,Poux C,Zurawski G,Salabert N,Rosenbaum P,Dereuddre-Bosquet N,Zurawski S,Flamar AL,Oh S,Romain G,Chapon C,Banchereau J,Lévy Y,Le Grand R,Martinon F
Mon Sep 01 00:00:00 EDT 2014
Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Yu J,Wang Y,Yan F,Zhang P,Li H,Zhao H,Yan C,Yan F,Ren X
Mon Sep 01 00:00:00 EDT 2014
Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
Gu M,Ouyang C,Lin W,Zhang T,Cao X,Xia Z,Wang X
Sat Mar 15 00:00:00 EDT 2014
IL-2 phosphorylates STAT5 to drive IFN-γ production and activation of human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Herr F,Lemoine R,Gouilleux F,Meley D,Kazma I,Heraud A,Velge-Roussel F,Baron C,Lebranchu Y
Sun Jun 15 00:00:00 EDT 2014
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
Journal of immunology (Baltimore, Md. : 1950)
Dreymueller D,Martin C,Schumacher J,Groth E,Boehm JK,Reiss LK,Uhlig S,Ludwig A
Wed Jan 15 00:00:00 EST 2014
A negative feedback loop mediated by STAT3 limits human Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Purvis HA,Anderson AE,Young DA,Isaacs JD,Hilkens CM
Fri Aug 01 00:00:00 EDT 2014
Modulation of TNF-induced macrophage polarization by synovial fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Donlin LT,Jayatilleke A,Giannopoulou EG,Kalliolias GD,Ivashkiv LB
Mon Sep 01 00:00:00 EDT 2014
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
The Journal of biological chemistry
Zhang Y,Lei CQ,Hu YH,Xia T,Li M,Zhong B,Shu HB
Fri May 02 00:00:00 EDT 2014
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
The Journal of biological chemistry
Zhang Y,Lei CQ,Hu YH,Xia T,Li M,Zhong B,Shu HB
Fri May 02 00:00:00 EDT 2014
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX).
The Journal of biological chemistry
Ouyang C,Nie L,Gu M,Wu A,Han X,Wang X,Shao J,Xia Z
Fri Aug 29 00:00:00 EDT 2014
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
The Journal of biological chemistry
Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US
Fri Oct 24 00:00:00 EDT 2014
Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
The Journal of biological chemistry
Humphrey RK,Ray A,Gonuguntla S,Hao E,Jhala US
Fri Oct 24 00:00:00 EDT 2014
Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.
Nature communications
Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC
Wed Sep 03 00:00:00 EDT 2014
CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Tran CM,Schoepflin ZR,Markova DZ,Kepler CK,Anderson DG,Shapiro IM,Risbud MV
Fri Mar 14 00:00:00 EDT 2014
CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Tran CM,Schoepflin ZR,Markova DZ,Kepler CK,Anderson DG,Shapiro IM,Risbud MV
Fri Mar 14 00:00:00 EDT 2014
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
PloS one
Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP
200-01B was used in In vitro experiments to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.
Thu Oct 22 00:00:00 EDT 2015
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
PloS one
Zhang YY,Chen H,Sun C,Wang HZ,Liu ML,Li YY,Nie XL,Du MR,Li DJ,Zhang JP
200-01B was used in In vitro experiments to investigate the effects of NOD2 expression on the maternal-fetal relationship in normal decidual stromal cells.
Thu Oct 22 00:00:00 EDT 2015
Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells.
The Journal of biological chemistry
Oleson BJ,Broniowska KA,Schreiber KH,Tarakanova VL,Corbett JA
Fri Apr 18 00:00:00 EDT 2014
N-terminal hydrophobic amino acids of activating transcription factor 5 (ATF5) protein confer interleukin 1β (IL-1β)-induced stabilization.
The Journal of biological chemistry
Abe T,Kojima M,Akanuma S,Iwashita H,Yamazaki T,Okuyama R,Ichikawa K,Umemura M,Nakano H,Takahashi S,Takahashi Y
Fri Feb 14 00:00:00 EST 2014
The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.
BMC cancer
Leibovich-Rivkin T,Liubomirski Y,Meshel T,Abashidze A,Brisker D,Solomon H,Rotter V,Weil M,Ben-Baruch A
200-01B was used in Sample Preparation (ELISA) to determine the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.
Thu Mar 06 00:00:00 EST 2014
Interleukin-1β promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production.
Cell death & disease
Sun W,Depping R,Jelkmann W
Thu Jan 23 00:00:00 EST 2014
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
Scientific reports
Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ
Wed Apr 23 00:00:00 EDT 2014
Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.
Blood
Matta J,Baratin M,Chiche L,Forel JM,Cognet C,Thomas G,Farnarier C,Piperoglou C,Papazian L,Chaussabel D,Ugolini S,Vély F,Vivier E
Thu Jul 18 00:00:00 EDT 2013
Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.
The Journal of clinical investigation
Aziz A,Baxter EJ,Edwards C,Cheong CY,Ito M,Bench A,Kelley R,Silber Y,Beer PA,Chng K,Renfree MB,McEwen K,Gray D,Nangalia J,Mufti GJ,Hellstrom-Lindberg E,Kiladjian JJ,McMullin MF,Campbell PJ,Ferguson-Smith AC,Green AR
Wed May 01 00:00:00 EDT 2013
CXCL5 limits macrophage foam cell formation in atherosclerosis.
The Journal of clinical investigation
Rousselle A,Qadri F,Leukel L,Yilmaz R,Fontaine JF,Sihn G,Bader M,Ahluwalia A,Duchene J
Fri Mar 01 00:00:00 EST 2013
MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.
The Journal of experimental medicine
Long HM,Chagoury OL,Leese AM,Ryan GB,James E,Morton LT,Abbott RJ,Sabbah S,Kwok W,Rickinson AB
Mon May 06 00:00:00 EDT 2013
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.
The Journal of experimental medicine
Liu X,Li H,Zhong B,Blonska M,Gorjestani S,Yan M,Tian Q,Zhang DE,Lin X,Dong C
Mon Jul 29 00:00:00 EDT 2013
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H
Tue Jan 15 00:00:00 EST 2013
Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells.
PLoS pathogens
Chen Y,Hwang SL,Chan VS,Chung NP,Wang SR,Li Z,Ma J,Lin CW,Hsieh YJ,Chang KP,Kung SS,Wu YC,Chu CW,Tai HT,Gao GF,Zheng B,Yokoyama KK,Austyn JM,Lin CL
Tue Jan 01 00:00:00 EST 2013
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.
PLoS pathogens
Mansur DS,Maluquer de Motes C,Unterholzner L,Sumner RP,Ferguson BJ,Ren H,Strnadova P,Bowie AG,Smith GL
Fri Feb 01 00:00:00 EST 2013
Trp53 deficiency protects against acute intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Spehlmann ME,Manthey CF,Dann SM,Hanson E,Sandhu SS,Liu LY,Abdelmalak FK,Diamanti MA,Retzlaff K,Scheller J,Rose-John S,Greten FR,Wang JY,Eckmann L
Mon Jul 15 00:00:00 EDT 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 EST 2013
TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.
PloS one
Liu Y,Yu S,Li Z,Ma J,Zhang Y,Wang H,Yang B,Wu C
Tue Feb 18 00:00:00 EST 2014
Immunologic targeting of FOXP3 in inflammatory breast cancer cells.
PloS one
Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR
Tue Jul 09 00:00:00 EDT 2013
Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
PloS one
Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T
Fri Sep 06 00:00:00 EDT 2013
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.
The Journal of biological chemistry
Humphrey RK,Yu SM,Bellary A,Gonuguntla S,Yebra M,Jhala US
Fri Jan 25 00:00:00 EST 2013
Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage.
The Journal of biological chemistry
Yan D,Kc R,Chen D,Xiao G,Im HJ
Fri Nov 01 00:00:00 EDT 2013
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.
The Journal of biological chemistry
Ferreira E,Porter RM,Wehling N,O'Sullivan RP,Liu F,Boskey A,Estok DM,Harris MB,Vrahas MS,Evans CH,Wells JW
Fri Oct 11 00:00:00 EDT 2013
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Wang H,Tian Y,Wang J,Phillips KLE,Binch ALA,Dunn S,Cross A,Chiverton N,Zheng Z,Shapiro IM,Le Maitre CL,Risbud MV
Fri Jun 07 00:00:00 EDT 2013
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.
The Journal of biological chemistry
Wang H,Tian Y,Wang J,Phillips KLE,Binch ALA,Dunn S,Cross A,Chiverton N,Zheng Z,Shapiro IM,Le Maitre CL,Risbud MV
Fri Jun 07 00:00:00 EDT 2013
Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.
The Journal of biological chemistry
Ingvarsen S,Porse A,Erpicum C,Maertens L,Jürgensen HJ,Madsen DH,Melander MC,Gårdsvoll H,Høyer-Hansen G,Noel A,Holmbeck K,Engelholm LH,Behrendt N
Fri Apr 12 00:00:00 EDT 2013
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.
Nature
Landsberg J,Kohlmeyer J,Renn M,Bald T,Rogava M,Cron M,Fatho M,Lennerz V,Wölfel T,Hölzel M,Tüting T
Thu Oct 18 00:00:00 EDT 2012
Functional STAT3 deficiency compromises the generation of human T follicular helper cells.
Blood
Ma CS,Avery DT,Chan A,Batten M,Bustamante J,Boisson-Dupuis S,Arkwright PD,Kreins AY,Averbuch D,Engelhard D,Magdorf K,Kilic SS,Minegishi Y,Nonoyama S,French MA,Choo S,Smart JM,Peake J,Wong M,Gray P,Cook MC,Fulcher DA,Casanova JL,Deenick EK,Tangye SG
Thu Apr 26 00:00:00 EDT 2012
Mast cells play a protumorigenic role in primary cutaneous lymphoma.
Blood
Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K
Thu Sep 06 00:00:00 EDT 2012
Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function.
Blood
Dannull J,Schneider T,Lee WT,de Rosa N,Tyler DS,Pruitt SK
Thu Mar 29 00:00:00 EDT 2012
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.
The Journal of clinical investigation
Argaw AT,Asp L,Zhang J,Navrazhina K,Pham T,Mariani JN,Mahase S,Dutta DJ,Seto J,Kramer EG,Ferrara N,Sofroniew MV,John GR
Sun Jul 01 00:00:00 EDT 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 EST 2012
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F
Tue Nov 06 00:00:00 EST 2012
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ
Tue Jun 19 00:00:00 EDT 2012
Mycobacteria activate γδ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Fowler DW,Copier J,Wilson N,Dalgleish AG,Bodman-Smith MD
Sun Apr 01 00:00:00 EDT 2012
Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease.
Arthritis research & therapy
Sugita S,Kawazoe Y,Imai A,Yamada Y,Horie S,Mochizuki M
Tue May 01 00:00:00 EDT 2012
Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes.
Journal of immunology (Baltimore, Md. : 1950)
Sommaggio R,Cohnen A,Watzl C,Costa C
Thu Mar 01 00:00:00 EST 2012
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery LE,Wood AM,Qureshi OS,Hou TZ,Gardner D,Briggs Z,Kaur S,Raza K,Sansom DM
Sat Dec 01 00:00:00 EST 2012
Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Kuckleburg CJ,Tilkens SB,Santoso S,Newman PJ
Thu Mar 01 00:00:00 EST 2012
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.
Journal of immunology (Baltimore, Md. : 1950)
Young A,Linehan E,Hams E,O'Hara Hall AC,McClurg A,Johnston JA,Hunter CA,Fallon PG,Fitzgerald DC
Sat Sep 01 00:00:00 EDT 2012
Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β administration.
Neuropharmacology
Wilhelm CJ,Murphy-Crews A,Menasco DJ,Huckans MS,Loftis JM
200-01B was used in In vivo experiments to show that additional studies will be needed to determine whether CRF(1) antagonism is an effective treatment for cytokine-induced sickness.
Sun Jan 01 00:00:00 EST 2012
Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes.
Journal of cellular biochemistry
Yan D,Chen D,Im HJ
Sat Sep 01 00:00:00 EDT 2012
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.
The Biochemical journal
Whitehead MA,Bombardieri M,Pitzalis C,Vanhaesebroeck B
Tue May 01 00:00:00 EDT 2012
Characterization of the autocrine/paracrine function of vitamin D in human gingival fibroblasts and periodontal ligament cells.
PloS one
Liu K,Meng H,Hou J
Fri Jan 04 00:00:00 EST 2013
DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.
PloS one
Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H
Thu Nov 08 00:00:00 EST 2012
Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.
Journal of inflammation (London, England)
Klawitter M,Quero L,Klasen J,Gloess AN,Klopprogge B,Hausmann O,Boos N,Wuertz K
Tue Aug 21 00:00:00 EDT 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 EDT 2012
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
PloS one
Suh HS,Choi N,Tarassishin L,Lee SC
Tue Aug 07 00:00:00 EDT 2012
Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.
The Journal of biological chemistry
Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T
Fri Jul 20 00:00:00 EDT 2012
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.
PloS one
Iyer A,Zurolo E,Prabowo A,Fluiter K,Spliet WG,van Rijen PC,Gorter JA,Aronica E
Tue Mar 05 00:00:00 EST 2013
Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion.
BMC biotechnology
Liu M,Huang Y,Hu L,Liu G,Hu X,Liu D,Yang X
Tue Sep 25 00:00:00 EDT 2012
The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers.
BMC cancer
Wang J,Xu K,Wu J,Luo C,Li Y,Wu X,Gao H,Feng G,Yuan BZ
Fri Sep 21 00:00:00 EDT 2012
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
PloS one
Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H
Fri Aug 03 00:00:00 EDT 2012
Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.
PloS one
Zhou J,Joplin DG,Cross JV,Templeton DJ
Thu Jun 20 00:00:00 EDT 2013
Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.
PloS one
Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR
Mon Jan 14 00:00:00 EST 2013
Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.
PloS one
Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR
Mon Jan 14 00:00:00 EST 2013
Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes.
PloS one
Shih KS,Wang JH,Wu YW,Teng CM,Chen CC,Yang CR
Mon Jan 14 00:00:00 EST 2013
Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.
Cancers
Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A
200-01B was used in Cell Culture to use an unbiased model system to propose that inflammatory mediators of the tumor milieu have dominating roles over oncogenic modifications in dictating the expression of a pro-malignancy chemokine readout.
Fri Jan 20 00:00:00 EST 2012
Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations.
Cancers
Leibovich-Rivkin T,Buganim Y,Solomon H,Meshel T,Rotter V,Ben-Baruch A
200-01B was used in Cell Culture to use an unbiased model system to propose that inflammatory mediators of the tumor milieu have dominating roles over oncogenic modifications in dictating the expression of a pro-malignancy chemokine readout.
Fri Jan 20 00:00:00 EST 2012
The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.
The Journal of biological chemistry
Keuylian Z,de Baaij JH,Gueguen M,Glorian M,Rouxel C,Merlet E,Lipskaia L,Blaise R,Mateo V,Limon I
Fri Jul 20 00:00:00 EDT 2012
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.
PloS one
Matta H,Gopalakrishnan R,Graham C,Tolani B,Khanna A,Yi H,Suo Y,Chaudhary PM
Wed Sep 19 00:00:00 EDT 2012
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.
Annals of the rheumatic diseases
Valdes AM,De Wilde G,Doherty SA,Lories RJ,Vaughn FL,Laslett LL,Maciewicz RA,Soni A,Hart DJ,Zhang W,Muir KR,Dennison EM,Wheeler M,Leaverton P,Cooper C,Spector TD,Cicuttini FM,Chapman V,Jones G,Arden NK,Doherty M
Thu Sep 01 00:00:00 EDT 2011
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Blood
Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L
Thu Mar 03 00:00:00 EST 2011
A novel pro-lymphangiogenic function for Th17/IL-17.
Blood
Chauhan SK,Jin Y,Goyal S,Lee HS,Fuchsluger TA,Lee HK,Dana R
Thu Oct 27 00:00:00 EDT 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 EST 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
200-01B was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
200-01B was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
PLoS pathogens
Maluquer de Motes C,Cooray S,Ren H,Almeida GM,McGourty K,Bahar MW,Stuart DI,Grimes JM,Graham SC,Smith GL
Thu Dec 01 00:00:00 EST 2011
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.
PLoS pathogens
Eitz Ferrer P,Potthoff S,Kirschnek S,Gasteiger G,Kastenmüller W,Ludwig H,Paschen SA,Villunger A,Sutter G,Drexler I,Häcker G
Wed Jun 01 00:00:00 EDT 2011
Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee JH,Ulrich B,Cho J,Park J,Kim CH
Mon Aug 15 00:00:00 EDT 2011
Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Campbell IK,van Nieuwenhuijze A,Segura E,O'Donnell K,Coghill E,Hommel M,Gerondakis S,Villadangos JA,Wicks IP
Sun May 01 00:00:00 EDT 2011
Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.
Journal of immunology (Baltimore, Md. : 1950)
Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K
Tue Feb 01 00:00:00 EST 2011
IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.
Journal of immunology (Baltimore, Md. : 1950)
Pathak S,Goldofsky E,Vivas EX,Bonagura VR,Vambutas A
Tue Feb 01 00:00:00 EST 2011
The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Ortner D,Grabher D,Hermann M,Kremmer E,Hofer S,Heufler C
Sat Oct 15 00:00:00 EDT 2011
Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential.
Stem cells international
Auletta JJ,Zale EA,Welter JF,Solchaga LA
Thu Mar 03 00:00:00 EST 2011
A novel TLR3 inhibitor encoded by African swine fever virus (ASFV).
Archives of virology
de Oliveira VL,Almeida SC,Soares HR,Crespo A,Marshall-Clarke S,Parkhouse RM
Fri Apr 01 00:00:00 EDT 2011
Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.
PloS one
Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B
Tue Feb 14 00:00:00 EST 2012
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.
The Journal of biological chemistry
Benfield CT,Mansur DS,McCoy LE,Ferguson BJ,Bahar MW,Oldring AP,Grimes JM,Stuart DI,Graham SC,Smith GL
Fri Jun 10 00:00:00 EDT 2011
ST2 and IL-33 in pregnancy and pre-eclampsia.
PloS one
Granne I,Southcombe JH,Snider JV,Tannetta DS,Child T,Redman CW,Sargent IL
Fri Feb 03 00:00:00 EST 2012
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
PloS one
An H,Lu X,Liu D,Yarbrough WG
Mon Jan 24 00:00:00 EST 2011
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α.
BMC genomics
Wang Z,Bishop EP,Burke PA
Fri Feb 25 00:00:00 EST 2011
FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.
The Journal of biological chemistry
Hughes KJ,Meares GP,Hansen PA,Corbett JA
Fri Mar 11 00:00:00 EST 2011
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
Journal of neuroinflammation
Green JA,Dholakia S,Janczar K,Ong CW,Moores R,Fry J,Elkington PT,Roncaroli F,Friedland JS
Wed May 11 00:00:00 EDT 2011
Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1.
The Journal of biological chemistry
Lobito AA,Ramani SR,Tom I,Bazan JF,Luis E,Fairbrother WJ,Ouyang W,Gonzalez LC
Fri May 27 00:00:00 EDT 2011
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.
BMC complementary and alternative medicine
Schwager J,Hoeller U,Wolfram S,Richard N
Thu Nov 03 00:00:00 EDT 2011
The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes.
The Journal of biological chemistry
Lo Buono N,Parrotta R,Morone S,Bovino P,Nacci G,Ortolan E,Horenstein AL,Inzhutova A,Ferrero E,Funaro A
Fri May 27 00:00:00 EDT 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 EST 2011
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
The Journal of biological chemistry
Wang J,Markova D,Anderson DG,Zheng Z,Shapiro IM,Risbud MV
Fri Nov 18 00:00:00 EST 2011
Function of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.
The Journal of biological chemistry
de Lucas-Cerrillo AM,Maldifassi MC,Arnalich F,Renart J,Atienza G,Serantes R,Cruces J,Sánchez-Pacheco A,Andrés-Mateos E,Montiel C
Fri Jan 07 00:00:00 EST 2011
Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes.
PloS one
García-Arnandis I,Guillén MI,Gomar F,Castejón MA,Alcaraz MJ
Thu Mar 01 00:00:00 EST 2012
IκB kinase β regulates epithelium migration during corneal wound healing.
PloS one
Chen L,Meng Q,Kao W,Xia Y
Mon Jan 17 00:00:00 EST 2011
Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro.
PloS one
Mokhtari D,Li T,Lu T,Welsh N
Tue Feb 28 00:00:00 EST 2012
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
PloS one
Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S
Fri Apr 29 00:00:00 EDT 2011
Deactivation of STAT6 through serine 707 phosphorylation by JNK.
The Journal of biological chemistry
Shirakawa T,Kawazoe Y,Tsujikawa T,Jung D,Sato S,Uesugi M
Fri Feb 04 00:00:00 EST 2011
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.
Cell death & disease
Donadelli M,Dando I,Zaniboni T,Costanzo C,Dalla Pozza E,Scupoli MT,Scarpa A,Zappavigna S,Marra M,Abbruzzese A,Bifulco M,Caraglia M,Palmieri M
Thu Apr 28 00:00:00 EDT 2011
Mycobacterium abscessus glycopeptidolipid prevents respiratory epithelial TLR2 signaling as measured by HβD2 gene expression and IL-8 release.
PloS one
Davidson LB,Nessar R,Kempaiah P,Perkins DJ,Byrd TF
Mon May 21 00:00:00 EDT 2012
Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway.
Journal of neuroinflammation
Tarassishin L,Suh HS,Lee SC
Fri Dec 30 00:00:00 EST 2011
The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.
PloS one
Di Meglio P,Di Cesare A,Laggner U,Chu CC,Napolitano L,Villanova F,Tosi I,Capon F,Trembath RC,Peris K,Nestle FO
Tue Feb 22 00:00:00 EST 2011
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.
Immunity
Hughes T,Becknell B,Freud AG,McClory S,Briercheck E,Yu J,Mao C,Giovenzana C,Nuovo G,Wei L,Zhang X,Gavrilin MA,Wewers MD,Caligiuri MA
Fri Jun 25 00:00:00 EDT 2010
Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.
Immunity
Blanchet FP,Moris A,Nikolic DS,Lehmann M,Cardinaud S,Stalder R,Garcia E,Dinkins C,Leuba F,Wu L,Schwartz O,Deretic V,Piguet V
Fri May 28 00:00:00 EDT 2010
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood
Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K
Thu Aug 19 00:00:00 EDT 2010
Low-strength T-cell activation promotes Th17 responses.
Blood
Purvis HA,Stoop JN,Mann J,Woods S,Kozijn AE,Hambleton S,Robinson JH,Isaacs JD,Anderson AE,Hilkens CM
Thu Dec 02 00:00:00 EST 2010
Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Cella M,Otero K,Colonna M
Tue Jun 15 00:00:00 EDT 2010
An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells.
Human reproduction (Oxford, England)
King AE,Collins F,Klonisch T,Sallenave JM,Critchley HO,Saunders PT
Mon Feb 01 00:00:00 EST 2010
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes.
The international journal of biochemistry & cell biology
Ali S,Singh NN,Yildirim H,Ramji DP
Fri Jan 01 00:00:00 EST 2010
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.
Arthritis research & therapy
García-Arnandis I,Guillén MI,Gomar F,Pelletier JP,Martel-Pelletier J,Alcaraz MJ
Wed Jan 19 00:00:00 EST 2011
Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.
Journal of immunology (Baltimore, Md. : 1950)
Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J
Wed Dec 01 00:00:00 EST 2010
Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.
Journal of immunology (Baltimore, Md. : 1950)
Green JA,Elkington PT,Pennington CJ,Roncaroli F,Dholakia S,Moores RC,Bullen A,Porter JC,Agranoff D,Edwards DR,Friedland JS
Tue Jun 01 00:00:00 EDT 2010
Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.
Journal of immunology (Baltimore, Md. : 1950)
Kuang DM,Peng C,Zhao Q,Wu Y,Zhu LY,Wang J,Yin XY,Li L,Zheng L
Sun Aug 01 00:00:00 EDT 2010
The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.
Journal of immunology (Baltimore, Md. : 1950)
Thacker SG,Berthier CC,Mattinzoli D,Rastaldi MP,Kretzler M,Kaplan MJ
Fri Oct 01 00:00:00 EDT 2010
Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1.
Journal of immunology (Baltimore, Md. : 1950)
Gosset M,Pigenet A,Salvat C,Berenbaum F,Jacques C
Mon Nov 15 00:00:00 EST 2010
RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.
Journal of immunology (Baltimore, Md. : 1950)
Burgler S,Mantel PY,Bassin C,Ouaked N,Akdis CA,Schmidt-Weber CB
Tue Jun 01 00:00:00 EDT 2010
IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.
Journal of immunology (Baltimore, Md. : 1950)
Ho AW,Shen F,Conti HR,Patel N,Childs EE,Peterson AC,Hernández-Santos N,Kolls JK,Kane LP,Ouyang W,Gaffen SL
Thu Jul 15 00:00:00 EDT 2010
IL-17 immunity in human type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Honkanen J,Nieminen JK,Gao R,Luopajarvi K,Salo HM,Ilonen J,Knip M,Otonkoski T,Vaarala O
Sun Aug 01 00:00:00 EDT 2010
The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950)
Privratsky JR,Tourdot BE,Newman DK,Newman PJ
Mon Mar 15 00:00:00 EDT 2010
Short-time survival and engraftment of bone marrow stromal cells in an ectopic model of bone regeneration.
Tissue engineering. Part A
Giannoni P,Scaglione S,Daga A,Ilengo C,Cilli M,Quarto R
Mon Feb 01 00:00:00 EST 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 EDT 2010
Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.
The Journal of biological chemistry
Humphrey RK,Newcomb CJ,Yu SM,Hao E,Yu D,Krajewski S,Du K,Jhala US
Fri Jul 16 00:00:00 EDT 2010
Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.
The Journal of biological chemistry
Roell MK,Issafras H,Bauer RJ,Michelson KS,Mendoza N,Vanegas SI,Gross LM,Larsen PD,Bedinger DH,Bohmann DJ,Nonet GH,Liu N,Lee SR,Handa M,Kantak SS,Horwitz AH,Hunter JJ,Owyang AM,Mirza AM,Corbin JA,White ML
Fri Jul 02 00:00:00 EDT 2010
E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.
The Journal of biological chemistry
Sayama K,Yamamoto M,Shirakata Y,Hanakawa Y,Hirakawa S,Dai X,Tohyama M,Tokumaru S,Shin MS,Sakurai H,Akira S,Hashimoto K
Fri Sep 24 00:00:00 EDT 2010
Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway.
The Journal of biological chemistry
Vigetti D,Genasetti A,Karousou E,Viola M,Moretto P,Clerici M,Deleonibus S,De Luca G,Hascall VC,Passi A
Fri Aug 06 00:00:00 EDT 2010
Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.
Molecular pain
Chen T,Koga K,Li XY,Zhuo M
Fri Apr 09 00:00:00 EDT 2010
Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.
PloS one
Azcutia V,Abu-Taha M,Romacho T,Vázquez-Bella M,Matesanz N,Luscinskas FW,Rodríguez-Mañas L,Sanz MJ,Sánchez-Ferrer CF,Peiró C
Thu Apr 08 00:00:00 EDT 2010
Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.
PloS one
Ombetta JE,Thelier N,Dong CZ,Plocki S,Tsagris L,Rannou F,Massicot F,Djimdé A,El-Hayek E,Shi Y,Heymans F,Gresh N,Chauvet C
Tue Jun 01 00:00:00 EDT 2010
Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.
Journal of inflammation (London, England)
Jensen SS,Gad M
Tue Jul 27 00:00:00 EDT 2010
Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.
PloS one
Curnow SJ,Fairclough M,Schmutz C,Kissane S,Denniston AK,Nash K,Buckley CD,Lord JM,Salmon M
Thu Mar 18 00:00:00 EDT 2010
Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.
PloS one
Dibble CF,Horst JA,Malone MH,Park K,Temple B,Cheeseman H,Barbaro JR,Johnson GL,Bencharit S
Fri Jul 23 00:00:00 EDT 2010
Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.
The Journal of biological chemistry
Thoh M,Kumar P,Nagarajaram HA,Manna SK
Fri Feb 19 00:00:00 EST 2010
Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.
Molecular cancer
Valentine R,Dawson CW,Hu C,Shah KM,Owen TJ,Date KL,Maia SP,Shao J,Arrand JR,Young LS,O'Neil JD
Tue Jan 05 00:00:00 EST 2010
Cleavage of the NF-κB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae.
The Journal of biological chemistry
Christian J,Vier J,Paschen SA,Häcker G
Fri Dec 31 00:00:00 EST 2010
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.
The Journal of biological chemistry
Nakamura K,Kimple AJ,Siderovski DP,Johnson GL
Fri Jan 15 00:00:00 EST 2010
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.
PloS one
Fred RG,Bang-Berthelsen CH,Mandrup-Poulsen T,Grunnet LG,Welsh N
Wed May 26 00:00:00 EDT 2010
AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
The Journal of biological chemistry
Meares GP,Hughes KJ,Jaimes KF,Salvatori AS,Rhodes CJ,Corbett JA
Fri Jan 29 00:00:00 EST 2010
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.
Nature
Trompette A,Divanovic S,Visintin A,Blanchard C,Hegde RS,Madan R,Thorne PS,Wills-Karp M,Gioannini TL,Weiss JP,Karp CL
Thu Jan 29 00:00:00 EST 2009
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.
Immunity
Chung Y,Chang SH,Martinez GJ,Yang XO,Nurieva R,Kang HS,Ma L,Watowich SS,Jetten AM,Tian Q,Dong C
Fri Apr 17 00:00:00 EDT 2009
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.
Blood
Pecaric-Petkovic T,Didichenko SA,Kaempfer S,Spiegl N,Dahinden CA
Thu Feb 12 00:00:00 EST 2009
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome.
The Journal of experimental medicine
Minegishi Y,Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Karasuyama H
Mon Jun 08 00:00:00 EDT 2009
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation.
The Journal of experimental medicine
Haniffa M,Ginhoux F,Wang XN,Bigley V,Abel M,Dimmick I,Bullock S,Grisotto M,Booth T,Taub P,Hilkens C,Merad M,Collin M
Mon Feb 16 00:00:00 EST 2009
Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y
Tue Sep 15 00:00:00 EDT 2009
Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals.
Proceedings of the National Academy of Sciences of the United States of America
Bazzoni F,Rossato M,Fabbri M,Gaudiosi D,Mirolo M,Mori L,Tamassia N,Mantovani A,Cassatella MA,Locati M
Tue Mar 31 00:00:00 EDT 2009
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.
Proceedings of the National Academy of Sciences of the United States of America
Lu T,Jackson MW,Singhi AD,Kandel ES,Yang M,Zhang Y,Gudkov AV,Stark GR
Tue Sep 22 00:00:00 EDT 2009
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown.
Proceedings of the National Academy of Sciences of the United States of America
Argaw AT,Gurfein BT,Zhang Y,Zameer A,John GR
Tue Feb 10 00:00:00 EST 2009
Regulation of pentraxin-3 by antioxidants.
British journal of anaesthesia
Hill AL,Lowes DA,Webster NR,Sheth CC,Gow NA,Galley HF
Tue Dec 01 00:00:00 EST 2009
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.
The Journal of cell biology
Chong HC,Tan MJ,Philippe V,Tan SH,Tan CK,Ku CW,Goh YY,Wahli W,Michalik L,Tan NS
Mon Mar 23 00:00:00 EDT 2009
Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin.
PLoS pathogens
Bachman MA,Miller VL,Weiser JN
Thu Oct 01 00:00:00 EDT 2009
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.
PLoS pathogens
Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B
Sun Feb 01 00:00:00 EST 2009
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.
Immunology and cell biology
Ma CS,Suryani S,Avery DT,Chan A,Nanan R,Santner-Nanan B,Deenick EK,Tangye SG
Thu Jan 14 00:00:00 EST 2010
In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage.
Arthritis research & therapy
Pretzel D,Pohlers D,Weinert S,Kinne RW
Wed Sep 09 00:00:00 EDT 2009
Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H
Wed Jul 01 00:00:00 EDT 2009
MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.
Journal of immunology (Baltimore, Md. : 1950)
Qu C,Nguyen VA,Merad M,Randolph GJ
Sun Mar 15 00:00:00 EDT 2009
Developmental switch of the expression of ion channels in human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Zsiros E,Kis-Toth K,Hajdu P,Gaspar R,Bielanska J,Felipe A,Rajnavolgyi E,Panyi G
Thu Oct 01 00:00:00 EDT 2009
1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Széles L,Keresztes G,Töröcsik D,Balajthy Z,Krenács L,Póliska S,Steinmeyer A,Zuegel U,Pruenster M,Rot A,Nagy L
Sun Feb 15 00:00:00 EST 2009
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.
Journal of immunology (Baltimore, Md. : 1950)
Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N
Wed Jul 01 00:00:00 EDT 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 EDT 2009
IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.
Journal of immunology (Baltimore, Md. : 1950)
Chen WY,Chang MS
Wed Apr 15 00:00:00 EDT 2009
IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.
Journal of immunology (Baltimore, Md. : 1950)
Chen WY,Chang MS
Wed Apr 15 00:00:00 EDT 2009
Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.
Journal of immunology (Baltimore, Md. : 1950)
Kishuku M,Nishioka Y,Abe S,Kishi J,Ogino H,Aono Y,Azuma M,Kinoshita K,Batmunkh R,Makino H,Ranjan P,Minakuchi K,Sone S
Tue Dec 15 00:00:00 EST 2009
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.
Journal of neurotrauma
Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ
Wed Apr 01 00:00:00 EDT 2009
Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression.
The Journal of biological chemistry
Hughes KJ,Meares GP,Chambers KT,Corbett JA
Fri Oct 02 00:00:00 EDT 2009
Modulation of hyaluronan synthase activity in cellular membrane fractions.
The Journal of biological chemistry
Vigetti D,Genasetti A,Karousou E,Viola M,Clerici M,Bartolini B,Moretto P,De Luca G,Hascall VC,Passi A
Fri Oct 30 00:00:00 EDT 2009
Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.
PloS one
St-Onge M,Dumas A,Michaud A,Laflamme C,Dussault AA,Pouliot M
Thu May 14 00:00:00 EDT 2009
Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.
The Journal of biological chemistry
Nold-Petry CA,Nold MF,Nielsen JW,Bustamante A,Zepp JA,Storm KA,Hong JW,Kim SH,Dinarello CA
Fri Sep 18 00:00:00 EDT 2009
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Blood
Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA
Sat Nov 01 00:00:00 EDT 2008
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3.
The Journal of experimental medicine
Ma CS,Chew GY,Simpson N,Priyadarshi A,Wong M,Grimbacher B,Fulcher DA,Tangye SG,Cook MC
Mon Jul 07 00:00:00 EDT 2008
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America
Miyahara Y,Odunsi K,Chen W,Peng G,Matsuzaki J,Wang RF
Tue Oct 07 00:00:00 EDT 2008
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.
PLoS pathogens
Chen RA,Ryzhakov G,Cooray S,Randow F,Smith GL
Fri Feb 08 00:00:00 EST 2008
A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains.
Journal of immunology (Baltimore, Md. : 1950)
Parker LC,Prestwich EC,Ward JR,Smythe E,Berry A,Triantafilou M,Triantafilou K,Sabroe I
Wed Oct 15 00:00:00 EDT 2008
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Journal of immunology (Baltimore, Md. : 1950)
Hartl D,Krauss-Etschmann S,Koller B,Hordijk PL,Kuijpers TW,Hoffmann F,Hector A,Eber E,Marcos V,Bittmann I,Eickelberg O,Griese M,Roos D
Mon Dec 01 00:00:00 EST 2008
Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.
Journal of immunology (Baltimore, Md. : 1950)
Attur M,Al-Mussawir HE,Patel J,Kitay A,Dave M,Palmer G,Pillinger MH,Abramson SB
Wed Oct 01 00:00:00 EDT 2008
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.
Journal of immunology (Baltimore, Md. : 1950)
Aronoff DM,Hao Y,Chung J,Coleman N,Lewis C,Peres CM,Serezani CH,Chen GH,Flamand N,Brock TG,Peters-Golden M
Sun Jun 15 00:00:00 EDT 2008
Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.
Journal of immunology (Baltimore, Md. : 1950)
Ando T,Mimura K,Johansson CC,Hanson MG,Mougiakakos D,Larsson C,Martins da Palma T,Sakurai D,Norell H,Li M,Nishimura MI,Kiessling R
Mon Dec 15 00:00:00 EST 2008
B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
Journal of immunology (Baltimore, Md. : 1950)
Takagi R,Higashi T,Hashimoto K,Nakano K,Mizuno Y,Okazaki Y,Matsushita S
Tue Jul 01 00:00:00 EDT 2008
Leptin inhibits food-deprivation-induced increases in food intake and food hoarding.
American journal of physiology. Regulatory, integrative and comparative physiology
Keen-Rhinehart E,Bartness TJ
Mon Dec 01 00:00:00 EST 2008
Interferon-alpha controls IL-17 expression in vitro and in vivo.
Immunobiology
Moschen AR,Geiger S,Krehan I,Kaser A,Tilg H
Thu Feb 05 00:00:00 EST 2009
Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells.
BMC immunology
Weingart C,Nelson PJ,Krämer BK,Mack M
Wed Dec 10 00:00:00 EST 2008
Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.
BMC immunology
Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A
Wed Oct 01 00:00:00 EDT 2008
Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.
BMC immunology
Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD
Thu Aug 07 00:00:00 EDT 2008
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Blood
Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F
Wed Mar 01 00:00:00 EST 2006
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.
The Journal of clinical investigation
Wong PK,Egan PJ,Croker BA,O'Donnell K,Sims NA,Drake S,Kiu H,McManus EJ,Alexander WS,Roberts AW,Wicks IP
Thu Jun 01 00:00:00 EDT 2006
CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M
Wed Nov 01 00:00:00 EST 2006
Differential pattern of inflammatory molecule regulation in intestinal epithelial cells stimulated with IL-1.
Journal of immunology (Baltimore, Md. : 1950)
Yan SR,Joseph RR,Wang J,Stadnyk AW
Sun Oct 15 00:00:00 EDT 2006
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
Journal of immunology (Baltimore, Md. : 1950)
Eksteen B,Miles A,Curbishley SM,Tselepis C,Grant AJ,Walker LS,Adams DH
Sat Jul 01 00:00:00 EDT 2006
IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Schaefer TM,Wright JA,Pioli PA,Wira CR
Tue Nov 15 00:00:00 EST 2005
Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.
Journal of immunology (Baltimore, Md. : 1950)
Øynebråten I,Barois N,Hagelsteen K,Johansen FE,Bakke O,Haraldsen G
Sat Oct 15 00:00:00 EDT 2005
Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines.
Circulation
Nabah YN,Mateo T,Estellés R,Mata M,Zagorski J,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ
Tue Dec 07 00:00:00 EST 2004
Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form.
Blood
Sahni A,Guo M,Sahni SK,Francis CW
Thu Jul 15 00:00:00 EDT 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Maertzdorf J,Osterhaus AD,Verjans GM
Fri Nov 15 00:00:00 EST 2002
IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses.
Journal of immunology (Baltimore, Md. : 1950)
Olee T,Hashimoto S,Quach J,Lotz M
Fri Jan 15 00:00:00 EST 1999
