Product References
Adaptation of Human iPSC-Derived Macrophages Toward an Alveolar Macrophage-Like Phenotype Post-Intra-Pulmonary Transfer into Murine Models.
Methods in molecular biology (Clifton, N.J.)
Hetzel M,Gensch I,Ackermann M,Lachmann N
200-03 was used in In vitro experiments to introduce the use of human-induced pluripotent stem cell (iPSC)-derived primitive macrophages, which can be further matured towards an AM-like phenotype upon intra-pulmonary transfer into mice.
Tue Aug 29 00:00:00 EDT 2023
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
200-03 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Cell metabolism
Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A
200-03 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.
Tue May 02 00:00:00 EDT 2023
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.
The Journal of cell biology
Pellegrino E,Aylan B,Bussi C,Fearns A,Bernard EM,Athanasiadi N,Santucci P,Botella L,Gutierrez MG
200-03 was used in In vitro experiments to find peroxisomes increased ROS levels during Mtb WT infection.
Mon Dec 04 00:00:00 EST 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
200-03 was used in In vitro experiments to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 EDT 2023
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
200-03 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 EDT 2023
Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.
The Journal of clinical investigation
Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG
200-03 was used in In vitro experiments to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.
Thu Jun 01 00:00:00 EDT 2023
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
200-03 was used in Sample Preparation (FC/FACS) to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.
Mon Jan 24 00:00:00 EST 2022
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M
200-03 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.
Thu Sep 01 00:00:00 EDT 2022
Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors.
Nature protocols
Ackermann M,Rafiei Hashtchin A,Manstein F,Carvalho Oliveira M,Kempf H,Zweigerdt R,Lachmann N
Tue Feb 01 00:00:00 EST 2022
Disease-associated mutations in topoisomerase IIβ result in defective NK cells.
The Journal of allergy and clinical immunology
Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS
200-03 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.
Wed Jun 01 00:00:00 EDT 2022
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
Leukemia
Stavast CJ,van Zuijen I,Karkoulia E,Özçelik A,van Hoven-Beijen A,Leon LG,Voerman JSA,Janssen GMC,van Veelen PA,Burocziova M,Brouwer RWW,van IJcken WFJ,Maas A,Bindels EM,van der Velden VHJ,Schliehe C,Katsikis PD,Alberich-Jorda M,Erkeland SJ
200-03 was used in Cell Culture to investigate miRNA-139 in acute myeloid leukemia.
Tue Mar 01 00:00:00 EST 2022
Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.
Heart rhythm
Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ
200-03 was used in Cell Culture to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.
Sun May 01 00:00:00 EDT 2022
Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models.
Frontiers in oncology
Canals Hernaez D,Hughes MR,Li Y,Mainero Rocca I,Dean P,Brassard J,Bell EM,Samudio I,Mes-Masson AM,Narimatsu Y,Clausen H,Blixt O,Roskelley CD,McNagny KM
200-03 was used in Sample Preparation (FC/FACS) to use an array of glycosylation defective cell lines to define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.
Sat Jul 16 00:00:00 EDT 2022
Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells.
Biomedicines
Murugesan G,Davidson L,Jannetti L,Crocker PR,Weigle B
200-03 was used in Cell Culture to generate and culture embroyoid bodies (iPSCs). Polarised to either M1 or M2, the macrophages were subjected to quantitative proteomic analysis gaining further insight into their functionalities.
Sun Jan 23 00:00:00 EST 2022
A topological refactoring design strategy yields highly stable granulopoietic proteins.
Nature communications
Skokowa J,Hernandez Alvarez B,Coles M,Ritter M,Nasri M,Haaf J,Aghaallaei N,Xu Y,Mir P,Krahl AC,Rogers KW,Maksymenko K,Bajoghli B,Welte K,Lupas AN,Müller P,ElGamacy M
200-03 was used in Cell Culture to optimize protein folding based on nano molar activity for protein therapeutics.
Thu May 26 00:00:00 EDT 2022
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.
mBio
Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG
200-03 was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.
Tue Apr 26 00:00:00 EDT 2022
Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis.
Communications biology
Wang Y,Huo T,Tseng YJ,Dang L,Yu Z,Yu W,Foulks Z,Murdaugh RL,Ludtke SJ,Nakada D,Wang Z
Thu Jan 20 00:00:00 EST 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
200-03 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 EDT 2022
Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs.
STAR protocols
Dannenmann B,Skokowa J
200-03 was used in Cell Culture to provide protocol for generation of HPCs from iPSCs followed by HPC expansion on Sl/Sl feeder cells expressing FLT3L.
Fri Jun 17 00:00:00 EDT 2022
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters.
iScience
van Gils N,Verhagen HJMP,Broux M,Martiáñez T,Denkers F,Vermue E,Rutten A,Csikós T,Demeyer S,Çil M,Al M,Cools J,Janssen JJWM,Ossenkoppele GJ,Menezes RX,Smit L
200-03 was used in Cell Culture to reveal plasticity of anthracycline resistance in AML cells and highlight the potential of transcriptional reprogramming by epigenetic-based therapeutics to target chemotherapy-resistant AML cells.
Fri Sep 16 00:00:00 EDT 2022
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cancer cell
Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG
200-03 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.
Mon Jul 12 00:00:00 EDT 2021
M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity.
Signal transduction and targeted therapy
Zhao HY,Zhang YY,Xing T,Tang SQ,Wen Q,Lyu ZS,Lv M,Wang Y,Xu LP,Zhang XH,Kong Y,Huang XJ
Fri Jun 18 00:00:00 EDT 2021
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.
Cell stem cell
Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S
Thu Mar 04 00:00:00 EST 2021
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Cell stem cell
Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE
Thu May 06 00:00:00 EDT 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
200-03 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 EDT 2021
JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML.
The Journal of experimental medicine
Dagher T,Maslah N,Edmond V,Cassinat B,Vainchenker W,Giraudier S,Pasquier F,Verger E,Niwa-Kawakita M,Lallemand-Breitenbach V,Plo I,Kiladjian JJ,Villeval JL,de Thé H
Mon Feb 01 00:00:00 EST 2021
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine
Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ
Mon Feb 01 00:00:00 EST 2021
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
The Journal of experimental medicine
Le Coz C,Nguyen DN,Su C,Nolan BE,Albrecht AV,Xhani S,Sun D,Demaree B,Pillarisetti P,Khanna C,Wright F,Chen PA,Yoon S,Stiegler AL,Maurer K,Garifallou JP,Rymaszewski A,Kroft SH,Olson TS,Seif AE,Wertheim G,Grant SFA,Vo LT,Puck JM,Sullivan KE,Routes JM,Zakharova V,Shcherbina A,Mukhina A,Rudy NL,Hurst ACE,Atkinson TP,Boggon TJ,Hakonarson H,Abate AR,Hajjar J,Nicholas SK,Lupski JR,Verbsky J,Chinn IK,Gonzalez MV,Wells AD,Marson A,Poon GMK,Romberg N
Mon Jul 05 00:00:00 EDT 2021
Modeling genetic epileptic encephalopathies using brain organoids.
EMBO molecular medicine
Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI
Mon Aug 09 00:00:00 EDT 2021
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Developmental cell
Ma Y,Liu S,Gao J,Chen C,Zhang X,Yuan H,Chen Z,Yin X,Sun C,Mao Y,Zhou F,Shao Y,Liu Q,Xu J,Cheng L,Yu D,Li P,Yi P,He J,Geng G,Guo Q,Si Y,Zhao H,Li H,Banes GL,Liu H,Nakamura Y,Kurita R,Huang Y,Wang X,Wang F,Fang G,Engel JD,Shi L,Zhang YE,Yu J
200-03 was used in Sample Preparation (FC/FACS) to investigate pseudogene phenotypic effects.
Mon Feb 22 00:00:00 EST 2021
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem cells translational medicine
Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H
Tue Jun 01 00:00:00 EDT 2021
Engraftment characterization of risk-stratified AML in NSGS mice.
Blood advances
Díaz de la Guardia R,Velasco-Hernandez T,Gutiérrez-Agüera F,Roca-Ho H,Molina O,Nombela-Arrieta C,Bataller A,Fuster JL,Anguita E,Vives S,Zamora L,Nomdedeu J,Gómez-Casares MT,Ramírez-Orellana M,Lapillonne H,Ramos-Mejia V,Rodríguez-Manzaneque JC,Bueno C,Lopez-Millan B,Menéndez P
Tue Dec 14 00:00:00 EST 2021
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency.
Blood advances
Zoccolillo M,Brigida I,Barzaghi F,Scala S,Hernández RJ,Basso-Ricci L,Colantuoni M,Pettinato E,Sergi LS,Milardi G,Capasso P,Lombardo A,Gregori S,Sanvito F,Schena F,Cesaro S,Conti F,Pession A,Benedetti F,Gattorno M,Lee PY,Naldini L,Cicalese MP,Aiuti A,Mortellaro A
Tue Aug 24 00:00:00 EDT 2021
Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.
Stem cells (Dayton, Ohio)
Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS
Wed Dec 01 00:00:00 EST 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Xie B,Khoyratty TE,Abu-Shah E,F Cespedes P,MacLean AJ,Pirgova G,Hu Z,Ahmed AA,Dustin ML,Udalova IA,Arnon TI
Thu Apr 01 00:00:00 EDT 2021
Bortezomib suppresses self-renewal and leukemogenesis of leukemia stem cell by NF-ĸB-dependent inhibition of CDK6 in MLL-rearranged myeloid leukemia.
Journal of cellular and molecular medicine
Zhou B,Qin Y,Zhou J,Ruan J,Xiong F,Dong J,Huang X,Yu Z,Gao S
Mon Mar 01 00:00:00 EST 2021
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.
Stem cells international
Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS
Tue Jun 08 00:00:00 EDT 2021
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Cell reports
Simeoni F,Romero-Camarero I,Camera F,Amaral FMR,Sinclair OJ,Papachristou EK,Spencer GJ,Lie-A-Ling M,Lacaud G,Wiseman DH,Carroll JS,Somervaille TCP
Tue Sep 21 00:00:00 EDT 2021
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.
Science advances
Trizzino M,Zucco A,Deliard S,Wang F,Barbieri E,Veglia F,Gabrilovich D,Gardini A
Fri Jan 01 00:00:00 EST 2021
Stem-cell-derived human microglia transplanted into mouse brain to study human disease.
Nature protocols
Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R
200-03 was used in In vitro experiments to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.
Mon Feb 01 00:00:00 EST 2021
Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis.
Cancers
Masselli E,Carubbi C,Pozzi G,Percesepe A,Campanelli R,Villani L,Gobbi G,Bonomini S,Roti G,Rosti V,Massa M,Barosi G,Vitale M
200-03 was used in In vitro experiments to conclude that the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.
Sat May 22 00:00:00 EDT 2021
Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.
Nature communications
Zhang X,Luo M,Dastagir SR,Nixon M,Khamhoung A,Schmidt A,Lee A,Subbiah N,McLaughlin DC,Moore CL,Gribble M,Bayhi N,Amin V,Pepi R,Pawar S,Lyford TJ,Soman V,Mellen J,Carpenter CL,Turka LA,Wickham TJ,Chen TF
Tue May 11 00:00:00 EDT 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
200-03 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 EST 2021
Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy.
eLife
Simkin D,Marshall KA,Vanoye CG,Desai RR,Bustos BI,Piyevsky BN,Ortega JA,Forrest M,Robertson GL,Penzes P,Laux LC,Lubbe SJ,Millichap JJ,George AL,Kiskinis E
200-03 was used in Cell Culture to measure the functional properties of differentiated excitatory neurons in an induced pluripotent stem cell (iPSCs) and gene editing established disease model.
Fri Feb 05 00:00:00 EST 2021
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination.
eLife
Choi J,Lysakovskaia K,Stik G,Demel C,Söding J,Tian TV,Graf T,Cramer P
200-03 was used in In vitro experiments to investigate enhancer cooperation during transdifferentiation of human leukemia B-cells to macrophages.
Fri Mar 26 00:00:00 EDT 2021
Directly reprogrammed natural killer cells for cancer immunotherapy.
Nature biomedical engineering
Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS
Mon Nov 01 00:00:00 EDT 2021
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells.
Blood cancer discovery
Mian SA,Abarrategi A,Kong KL,Rouault-Pierre K,Wood H,Oedekoven CA,Smith AE,Batsivari A,Ariza-McNaughton L,Johnson P,Snoeks T,Mufti GJ,Bonnet D
200-03 was used in Cell Culture to show that human microenvironment but not mouse is essential to MDS-SCs homing and engraftment.
Mon Mar 01 00:00:00 EST 2021
Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.
Nature communications
Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL
Fri Mar 12 00:00:00 EST 2021
CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.
Nature communications
Boutin J,Rosier J,Cappellen D,Prat F,Toutain J,Pennamen P,Bouron J,Rooryck C,Merlio JP,Lamrissi-Garcia I,Cullot G,Amintas S,Guyonnet-Duperat V,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,Bedel A
Fri Aug 13 00:00:00 EDT 2021
SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.
Cell reports
Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II
200-03 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.
Tue Feb 16 00:00:00 EST 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
200-03 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 EST 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
Wed Jan 20 00:00:00 EST 2021
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.
Nature communications
Georgolopoulos G,Psatha N,Iwata M,Nishida A,Som T,Yiangou M,Stamatoyannopoulos JA,Vierstra J
Tue Nov 23 00:00:00 EST 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Nature communications
Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM
Mon Mar 01 00:00:00 EST 2021
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
iScience
de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG
Fri Aug 20 00:00:00 EDT 2021
Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.
Stem cell research & therapy
Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N
200-03 was used in In vitro experiments to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.
Tue Sep 28 00:00:00 EDT 2021
The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia.
Molecular & cellular proteomics : MCP
Thomé CH,Ferreira GA,Pereira-Martins DA,Augusto Dos Santos G,Almeida-Silveira DR,Weinhäuser I,Antônio de Souza G,Houtsma R,Schuringa JJ,Rego EM,Faça VM
Mon Mar 21 00:00:00 EDT 2022
An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1.
Scientific reports
Wegner J,Zillinger T,Schlee-Guimaraes TM,Bartok E,Schlee M
Thu Jul 22 00:00:00 EDT 2021
Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.
Scientific reports
Hofmans M,Lammens T,Depreter B,Wu Y,Erlacher M,Caye A,Cavé H,Flotho C,de Haas V,Niemeyer CM,Stary J,Van Nieuwerburgh F,Deforce D,Van Loocke W,Van Vlierberghe P,Philippé J,De Moerloose B
Tue Feb 02 00:00:00 EST 2021
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Scientific reports
Wang X,Negrou E,Maloney MT,Bondar VV,Andrews SV,Montalban M,Llapashtica C,Maciuca R,Nguyen H,Solanoy H,Arguello A,Przybyla L,Moerke NJ,Huntwork-Rodriguez S,Henry AG
Fri Jun 18 00:00:00 EDT 2021
The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.
Frontiers in immunology
Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E
200-03 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.
Mon Dec 27 00:00:00 EST 2021
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 EDT 2020
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Nature genetics
Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC
200-03 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).
Wed Apr 01 00:00:00 EDT 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
Mon Jul 13 00:00:00 EDT 2020
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
Cancer discovery
Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A
200-03 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.
Tue Dec 01 00:00:00 EST 2020
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.
Blood
Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR
Thu Jan 02 00:00:00 EST 2020
Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.
Blood
Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG
Thu Aug 27 00:00:00 EDT 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 EST 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
200-03 was used in Cell Culture to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
200-03 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 EST 2020
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Cell stem cell
Jones CL,Stevens BM,Pollyea DA,Culp-Hill R,Reisz JA,Nemkov T,Gehrke S,Gamboni F,Krug A,Winters A,Pei S,Gustafson A,Ye H,Inguva A,Amaya M,Minhajuddin M,Abbott D,Becker MW,DeGregori J,Smith CA,D'Alessandro A,Jordan CT
200-03 was used in Tissue/organ culture to demonstrate that elevated nicotinamide metabolism is both the mechanistic basis for ven/aza resistance and a metabolic vulnerability of R/R LSCs.
Thu Nov 05 00:00:00 EST 2020
Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption.
The Journal of clinical investigation
Mitchell JL,Takata H,Muir R,Colby DJ,Kroon E,Crowell TA,Sacdalan C,Pinyakorn S,Puttamaswin S,Benjapornpong K,Trichavaroj R,Tressler RL,Fox L,Polonis VR,Bolton DL,Maldarelli F,Lewin SR,Haddad EK,Phanuphak P,Robb ML,Michael NL,de Souza M,Phanuphak N,Ananworanich J,Trautmann L
Mon Jun 01 00:00:00 EDT 2020
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia.
The Journal of clinical investigation
Waclawiczek A,Hamilton A,Rouault-Pierre K,Abarrategi A,Albornoz MG,Miraki-Moud F,Bah N,Gribben J,Fitzgibbon J,Taussig D,Bonnet D
Mon Jun 01 00:00:00 EDT 2020
A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia.
The Journal of clinical investigation
Williams MS,Amaral FM,Simeoni F,Somervaille TC
Mon Mar 02 00:00:00 EST 2020
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
Nugent AA,Lin K,van Lengerich B,Lianoglou S,Przybyla L,Davis SS,Llapashtica C,Wang J,Kim DJ,Xia D,Lucas A,Baskaran S,Haddick PCG,Lenser M,Earr TK,Shi J,Dugas JC,Andreone BJ,Logan T,Solanoy HO,Chen H,Srivastava A,Poda SB,Sanchez PE,Watts RJ,Sandmann T,Astarita G,Lewcock JW,Monroe KM,Di Paolo G
Wed Mar 04 00:00:00 EST 2020
Real-Time NMR Spectroscopy for Studying Metabolism.
Angewandte Chemie (International ed. in English)
Alshamleh I,Krause N,Richter C,Kurrle N,Serve H,Günther UL,Schwalbe H
Mon Feb 03 00:00:00 EST 2020
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
EMBO molecular medicine
Di Matteo F,Pipicelli F,Kyrousi C,Tovecci I,Penna E,Crispino M,Chambery A,Russo R,Ayo-Martin AC,Giordano M,Hoffmann A,Ciusani E,Canafoglia L,Götz M,Di Giaimo R,Cappello S
Mon Jun 08 00:00:00 EDT 2020
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.
Developmental cell
Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE
200-03 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.
Mon Oct 26 00:00:00 EDT 2020
Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.
Proceedings of the National Academy of Sciences of the United States of America
Huang P,Zhao Y,Zhong J,Zhang X,Liu Q,Qiu X,Chen S,Yan H,Hillyer C,Mohandas N,Pan X,Xu X
Tue Jun 09 00:00:00 EDT 2020
Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America
Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ
Tue May 19 00:00:00 EDT 2020
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Proceedings of the National Academy of Sciences of the United States of America
Qiao X,van der Zanden SY,Wander DPA,Borràs DM,Song JY,Li X,van Duikeren S,van Gils N,Rutten A,van Herwaarden T,van Tellingen O,Giacomelli E,Bellin M,Orlova V,Tertoolen LGJ,Gerhardt S,Akkermans JJ,Bakker JM,Zuur CL,Pang B,Smits AM,Mummery CL,Smit L,Arens R,Li J,Overkleeft HS,Neefjes J
Tue Jun 30 00:00:00 EDT 2020
Design of novel granulopoietic proteins by topological rescaffolding.
PLoS biology
Hernandez Alvarez B,Skokowa J,Coles M,Mir P,Nasri M,Maksymenko K,Weidmann L,Rogers KW,Welte K,Lupas AN,Müller P,ElGamacy M
200-03 was used in Cell Culture to propose an approach to develop highly active therapeutic leads purely based on computational design.
Tue Dec 01 00:00:00 EST 2020
Design of novel granulopoietic proteins by topological rescaffolding.
PLoS biology
Hernandez Alvarez B,Skokowa J,Coles M,Mir P,Nasri M,Maksymenko K,Weidmann L,Rogers KW,Welte K,Lupas AN,Müller P,ElGamacy M
200-03 was used in Cell Culture to propose an approach to develop highly active therapeutic leads purely based on computational design.
Tue Dec 01 00:00:00 EST 2020
ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.
Oncogene
Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA
Wed Apr 01 00:00:00 EDT 2020
Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia.
British journal of haematology
Zabkiewicz J,Lazenby M,Edwards G,Bygrave CA,Omidvar N,Zhuang L,Knapper S,Guy C,Hills RK,Burnett AK,Alvares CL
Thu Oct 01 00:00:00 EDT 2020
Regulation of ABO blood group antigen expression by miR-331-3p and miR-1908-5p during hematopoietic stem cell differentiation.
Stem cells (Dayton, Ohio)
Kronstein-Wiedemann R,Nowakowska P,Milanov P,Gubbe K,Seifried E,Bugert P,Chavakis T,Tonn T
Thu Oct 01 00:00:00 EDT 2020
EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dong XM,Zhao K,Zheng WW,Xu CW,Zhang MJ,Yin RH,Gao R,Tang LJ,Liu JF,Chen H,Zhan YQ,Yu M,Ge CH,Gao HY,Li X,Luo T,Ning HM,Yang XM,Li CY
Mon Jun 01 00:00:00 EDT 2020
Triggering of the cGAS-STING Pathway in Human Plasmacytoid Dendritic Cells Inhibits TLR9-Mediated IFN Production.
Journal of immunology (Baltimore, Md. : 1950)
Deb P,Dai J,Singh S,Kalyoussef E,Fitzgerald-Bocarsly P
Wed Jul 01 00:00:00 EDT 2020
Increased number and activation of peripheral basophils in adult-onset minimal change disease.
Journal of cellular and molecular medicine
Han H,Xu YZ,Liao S,Xiao H,Chen X,Lu X,Wang S,Yang C,Liu HF,Pan Q
Wed Jul 01 00:00:00 EDT 2020
Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform.
Clinical and translational science
Guan X,Wang L,Wang H,Wang H,Dai W,Jiang Y
Sun Nov 01 00:00:00 EDT 2020
Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response.
The Kaohsiung journal of medical sciences
Liu CH,Chou CT,Chen CH,Chen CH,Yang SY,Ko YA,Wu YT,Wang CC,Liu FC,Yue CT,Hung SC,Tzeng IS,Tsai WC,Lin KI
Mon Jun 01 00:00:00 EDT 2020
Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome.
Nature communications
Rai R,Romito M,Rivers E,Turchiano G,Blattner G,Vetharoy W,Ladon D,Andrieux G,Zhang F,Zinicola M,Leon-Rico D,Santilli G,Thrasher AJ,Cavazza A
Wed Aug 12 00:00:00 EDT 2020
Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.
Communications biology
Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S
Fri Dec 18 00:00:00 EST 2020
Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.
Stem cell reports
Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A
Tue Jan 14 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
200-03 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
200-03 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.
Stem cell reports
Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM
Tue Feb 11 00:00:00 EST 2020
DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
Cell death & disease
Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA
Fri Aug 14 00:00:00 EDT 2020
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nature communications
Zhang Y,Guo Y,Gough SM,Zhang J,Vann KR,Li K,Cai L,Shi X,Aplan PD,Wang GG,Kutateladze TG
Fri Jul 03 00:00:00 EDT 2020
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells.
Clinical & translational immunology
Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ
Fri Apr 15 00:00:00 EDT 2022
The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Nature communications
Agarwal S,Vierbuchen T,Ghosh S,Chan J,Jiang Z,Kandasamy RK,Ricci E,Fitzgerald KA
Fri Dec 11 00:00:00 EST 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
200-03 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
Mast Cell Activation Test (MAT).
Methods in molecular biology (Clifton, N.J.)
Bahri R,Bulfone-Paus S
200-03 was used in In vitro experiments to describe the use of the mast cell activation test (MAT) that makes use of human primary MCs generated from peripheral blood progenitors, sensitized overnight with patients' sera and activated with allergens.
Fri Feb 26 00:00:00 EST 2021
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
Nature communications
Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M
Fri Jan 10 00:00:00 EST 2020
Human mast cells exhibit an individualized pattern of antimicrobial responses.
Immunity, inflammation and disease
Garcia-Rodriguez KM,Bahri R,Sattentau C,Roberts IS,Goenka A,Bulfone-Paus S
Mon Jun 01 00:00:00 EDT 2020
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.
Nature communications
Herster F,Bittner Z,Archer NK,Dickhöfer S,Eisel D,Eigenbrod T,Knorpp T,Schneiderhan-Marra N,Löffler MW,Kalbacher H,Vierbuchen T,Heine H,Miller LS,Hartl D,Freund L,Schäkel K,Heister M,Ghoreschi K,Weber ANR
Wed Jan 08 00:00:00 EST 2020
The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
Immunity
Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG
Tue Aug 20 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
Mon Apr 15 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
Mon Apr 15 00:00:00 EDT 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 EDT 2019
PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.
Blood
Hu T,Morita K,Hill MC,Jiang Y,Kitano A,Saito Y,Wang F,Mao X,Hoegenauer KA,Morishita K,Martin JF,Futreal PA,Takahashi K,Nakada D
Thu Aug 15 00:00:00 EDT 2019
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.
Blood
Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S
Thu Jul 11 00:00:00 EDT 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
200-03 was used in In vitro experiments to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 EDT 2019
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Science translational medicine
Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM
200-03 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.
Wed Oct 30 00:00:00 EDT 2019
Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs.
Autophagy
Rodrigo R,Mendis N,Ibrahim M,Ma C,Kreinin E,Roma A,Berg S,Blay J,Spagnuolo PA
200-03 was used in Cell Culture to investigate the mitochondria-specific changes that occur in leukemia cells after knockdown of BNIP3L/Nix or SQSTM1/p62.
Wed May 01 00:00:00 EDT 2019
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.
Leukemia
Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P
Mon Jul 01 00:00:00 EDT 2019
Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34+ Cells Using Gas-Permeable Surfaces.
Stem cells translational medicine
Martinez AF,Miller WM
Mon Jul 01 00:00:00 EDT 2019
Diminished secretion and function of IL-29 is associated with impaired IFN-α response of neonatal plasmacytoid dendritic cells.
Journal of leukocyte biology
Wisgrill L,Wessely I,Netzl A,Pummer L,Sadeghi K,Spittler A,Berger A,Förster-Waldl E
Fri Nov 01 00:00:00 EDT 2019
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.
Stem cells (Dayton, Ohio)
Lomova A,Clark DN,Campo-Fernandez B,Flores-Bjurström C,Kaufman ML,Fitz-Gibbon S,Wang X,Miyahira EY,Brown D,DeWitt MA,Corn JE,Hollis RP,Romero Z,Kohn DB
Fri Feb 01 00:00:00 EST 2019
Efficient gene correction of an aberrant splice site in β-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides.
Journal of cellular and molecular medicine
Xiong Z,Xie Y,Yang Y,Xue Y,Wang D,Lin S,Chen D,Lu D,He L,Song B,Yang Y,Sun X
Sun Dec 01 00:00:00 EST 2019
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell reports
Aho ER,Wang J,Gogliotti RD,Howard GC,Phan J,Acharya P,Macdonald JD,Cheng K,Lorey SL,Lu B,Wenzel S,Foshage AM,Alvarado J,Wang F,Shaw JG,Zhao B,Weissmiller AM,Thomas LR,Vakoc CR,Hall MD,Hiebert SW,Liu Q,Stauffer SR,Fesik SW,Tansey WP
200-03 was used in Cell Culture to identify WIN site inhibitors and demonstrate that the WIN site links WDR5 to chromatin at a small cohort of loci, including a specific subset of ribosome protein genes.
Tue Mar 12 00:00:00 EDT 2019
CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners.
Stem cell reports
He L,Beghi F,Baral V,Dépond M,Zhang Y,Joulin V,Rueda BR,Gonin P,Foudi A,Wittner M,Louache F
Tue Aug 13 00:00:00 EDT 2019
Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages.
Nature communications
Bencheikh L,Diop MK,Rivière J,Imanci A,Pierron G,Souquere S,Naimo A,Morabito M,Dussiot M,De Leeuw F,Lobry C,Solary E,Droin N
Fri Apr 26 00:00:00 EDT 2019
Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis.
Cell reports
Ludwig LS,Lareau CA,Bao EL,Nandakumar SK,Muus C,Ulirsch JC,Chowdhary K,Buenrostro JD,Mohandas N,An X,Aryee MJ,Regev A,Sankaran VG
200-03 was used in Cell Culture to apply deep transcriptomic and accessible chromatin profiling to characterize a faithful ex vivo human erythroid differentiation system from hematopoietic stem and progenitor cells.
Tue Jun 11 00:00:00 EDT 2019
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
Scientific reports
Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL
Thu Nov 14 00:00:00 EST 2019
A comprehensive single cell transcriptional landscape of human hematopoietic progenitors.
Nature communications
Pellin D,Loperfido M,Baricordi C,Wolock SL,Montepeloso A,Weinberg OK,Biffi A,Klein AM,Biasco L
Mon Jun 03 00:00:00 EDT 2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 EST 2019
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Nature communications
Papaioannou D,Petri A,Dovey OM,Terreri S,Wang E,Collins FA,Woodward LA,Walker AE,Nicolet D,Pepe F,Kumchala P,Bill M,Walker CJ,Karunasiri M,Mrózek K,Gardner ML,Camilotto V,Zitzer N,Cooper JL,Cai X,Rong-Mullins X,Kohlschmidt J,Archer KJ,Freitas MA,Zheng Y,Lee RJ,Aifantis I,Vassiliou G,Singh G,Kauppinen S,Bloomfield CD,Dorrance AM,Garzon R
Mon Nov 25 00:00:00 EST 2019
Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo.
Stem cell reports
Easterbrook J,Rybtsov S,Gordon-Keylock S,Ivanovs A,Taoudi S,Anderson RA,Medvinsky A
Tue May 14 00:00:00 EDT 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 EST 2019
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Nature medicine
Johnson DC,Taabazuing CY,Okondo MC,Chui AJ,Rao SD,Brown FC,Reed C,Peguero E,de Stanchina E,Kentsis A,Bachovchin DA
200-03 was used in Cell Culture to identify an activator of CARD8 in human cells and indicate that its activation by small-molecule DPP8/9 inhibitors represents a new potential therapeutic strategy for AML.
Wed Aug 01 00:00:00 EDT 2018
Regulation of embryonic haematopoietic multipotency by EZH1.
Nature
Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ
Thu Jan 25 00:00:00 EST 2018
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.
Cell
Khajuria RK,Munschauer M,Ulirsch JC,Fiorini C,Ludwig LS,McFarland SK,Abdulhay NJ,Specht H,Keshishian H,Mani DR,Jovanovic M,Ellis SR,Fulco CP,Engreitz JM,Schütz S,Lian J,Gripp KW,Weinberg OK,Pinkus GS,Gehrke L,Regev A,Lander ES,Gazda HT,Lee WY,Panse VG,Carr SA,Sankaran VG
Thu Mar 22 00:00:00 EDT 2018
Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.
Cell
Brumbaugh J,Di Stefano B,Wang X,Borkent M,Forouzmand E,Clowers KJ,Ji F,Schwarz BA,Kalocsay M,Elledge SJ,Chen Y,Sadreyev RI,Gygi SP,Hu G,Shi Y,Hochedlinger K
Thu Jan 11 00:00:00 EST 2018
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Cell
Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH
200-03 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.
Thu Jun 28 00:00:00 EDT 2018
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Cell
Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J
Thu Jan 11 00:00:00 EST 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
200-03 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.
Thu Sep 20 00:00:00 EDT 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 EDT 2018
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Cancer cell
Jones CL,Stevens BM,D'Alessandro A,Reisz JA,Culp-Hill R,Nemkov T,Pei S,Khan N,Adane B,Ye H,Krug A,Reinhold D,Smith C,DeGregori J,Pollyea DA,Jordan CT
Mon Nov 12 00:00:00 EST 2018
Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.
Blood
Li Y,Jin C,Bai H,Gao Y,Sun S,Chen L,Qin L,Liu PP,Cheng L,Wang QF
Thu Jan 11 00:00:00 EST 2018
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Cell stem cell
Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A
200-03 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.
Thu Dec 06 00:00:00 EST 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Mon Apr 02 00:00:00 EDT 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Mon Apr 02 00:00:00 EDT 2018
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
The Journal of clinical investigation
Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J
Tue May 01 00:00:00 EDT 2018
Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.
The Journal of clinical investigation
Shastri A,Choudhary G,Teixeira M,Gordon-Mitchell S,Ramachandra N,Bernard L,Bhattacharyya S,Lopez R,Pradhan K,Giricz O,Ravipati G,Wong LF,Cole S,Bhagat TD,Feld J,Dhar Y,Bartenstein M,Thiruthuvanathan VJ,Wickrema A,Ye BH,Frank DA,Pellagatti A,Boultwood J,Zhou T,Kim Y,MacLeod AR,Epling-Burnette PK,Ye M,McCoon P,Woessner R,Steidl U,Will B,Verma A
Mon Dec 03 00:00:00 EST 2018
PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.
The Journal of clinical investigation
Corrigan DJ,Luchsinger LL,Justino de Almeida M,Williams LJ,Strikoudis A,Snoeck HW
Wed Aug 01 00:00:00 EDT 2018
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.
Molecular cell
Chen L,Chen JY,Huang YJ,Gu Y,Qiu J,Qian H,Shao C,Zhang X,Hu J,Li H,He S,Zhou Y,Abdel-Wahab O,Zhang DE,Fu XD
200-03 was used in Cell Culture to study the importance of the augmented R-loop as a unifying mechanism for myelodysplastic syndromes induced by high-risk splicing factor mutations.
Thu Feb 01 00:00:00 EST 2018
Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
The Journal of experimental medicine
Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A
Mon Feb 05 00:00:00 EST 2018
Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.
Clinical cancer research : an official journal of the American Association for Cancer Research
L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST
200-03 was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.
Sun Jul 15 00:00:00 EDT 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
200-03 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 EST 2018
X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.
Molecular oncology
Zhou J,Lu X,Tan TZ,Chng WJ
Mon Jan 01 00:00:00 EST 2018
Single Cell Resolution of Human Hematoendothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium.
Stem cells (Dayton, Ohio)
Angelos MG,Abrahante JE,Blum RH,Kaufman DS
Thu Feb 01 00:00:00 EST 2018
Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.
Journal of immunology (Baltimore, Md. : 1950)
Paupert J,Espinosa E,Cenac N,Robert V,Laharrague P,Evrard SM,Casteilla L,Lorsignol A,Cousin B
Sat Dec 15 00:00:00 EST 2018
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.
Stem cell reports
Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J
Tue Feb 13 00:00:00 EST 2018
Serotonin receptor type 1B constitutes a therapeutic target for MDS and CMML.
Scientific reports
Banús-Mulet A,Etxabe A,Cornet-Masana JM,Torrente MÁ,Lara-Castillo MC,Palomo L,Nomdedeu M,Díaz-Beyá M,Solé F,Nomdedeu B,Esteve J,Risueño RM
Mon Sep 17 00:00:00 EDT 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.
Nature communications
Sumide K,Matsuoka Y,Kawamura H,Nakatsuka R,Fujioka T,Asano H,Takihara Y,Sonoda Y
Wed Jun 06 00:00:00 EDT 2018
Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin.
Nature communications
Haun F,Neumann S,Peintner L,Wieland K,Habicht J,Schwan C,Østevold K,Koczorowska MM,Biniossek M,Kist M,Busch H,Boerries M,Davis RJ,Maurer U,Schilling O,Aktories K,Borner C
Thu Aug 30 00:00:00 EDT 2018
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
Nature communications
Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR
Thu Aug 30 00:00:00 EDT 2018
Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.
Nature communications
Stevens BM,Khan N,D'Alessandro A,Nemkov T,Winters A,Jones CL,Zhang W,Pollyea DA,Jordan CT
Wed Sep 12 00:00:00 EDT 2018
Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.
Scientific reports
Eicke D,Baigger A,Schulze K,Latham SL,Halloin C,Zweigerdt R,Guzman CA,Blasczyk R,Figueiredo C
Thu Jul 05 00:00:00 EDT 2018
Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs.
Nature communications
Pellefigues C,Dema B,Lamri Y,Saidoune F,Chavarot N,Lohéac C,Pacreau E,Dussiot M,Bidault C,Marquet F,Jablonski M,Chemouny JM,Jouan F,Dossier A,Chauveheid MP,Gobert D,Papo T,Karasuyama H,Sacré K,Daugas E,Charles N
Tue Feb 20 00:00:00 EST 2018
Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs.
Nature communications
Pellefigues C,Dema B,Lamri Y,Saidoune F,Chavarot N,Lohéac C,Pacreau E,Dussiot M,Bidault C,Marquet F,Jablonski M,Chemouny JM,Jouan F,Dossier A,Chauveheid MP,Gobert D,Papo T,Karasuyama H,Sacré K,Daugas E,Charles N
Tue Feb 20 00:00:00 EST 2018
Reconstruction of complex single-cell trajectories using CellRouter.
Nature communications
Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ
Thu Mar 01 00:00:00 EST 2018
Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.
Stem cell reports
Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P
Tue Oct 09 00:00:00 EDT 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 EDT 2018
IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils.
Cell death & disease
Zellweger F,Buschor P,Hobi G,Brigger D,Dahinden CA,Villiger PM,Eggel A
Tue May 01 00:00:00 EDT 2018
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.
Nature communications
Shiozawa Y,Malcovati L,Gallì A,Sato-Otsubo A,Kataoka K,Sato Y,Watatani Y,Suzuki H,Yoshizato T,Yoshida K,Sanada M,Makishima H,Shiraishi Y,Chiba K,Hellström-Lindberg E,Miyano S,Ogawa S,Cazzola M
Fri Sep 07 00:00:00 EDT 2018
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Nature communications
Skucha A,Ebner J,Schmöllerl J,Roth M,Eder T,César-Razquin A,Stukalov A,Vittori S,Muhar M,Lu B,Aichinger M,Jude J,Müller AC,Győrffy B,Vakoc CR,Valent P,Bennett KL,Zuber J,Superti-Furga G,Grebien F
Fri May 18 00:00:00 EDT 2018
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
Cell death & disease
Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H
Tue Sep 11 00:00:00 EDT 2018
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.
Cell death & disease
Schubert F,Rapp J,Brauns-Schubert P,Schlicher L,Stock K,Wissler M,Weiß M,Charvet C,Borner C,Maurer U
Tue May 01 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
Nature communications
Ackermann M,Kempf H,Hetzel M,Hesse C,Hashtchin AR,Brinkert K,Schott JW,Haake K,Kühnel MP,Glage S,Figueiredo C,Jonigk D,Sewald K,Schambach A,Wronski S,Moritz T,Martin U,Zweigerdt R,Munder A,Lachmann N
Fri Nov 30 00:00:00 EST 2018
Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Nature communications
Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W
Tue Sep 25 00:00:00 EDT 2018
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Nature
Raffel S,Falcone M,Kneisel N,Hansson J,Wang W,Lutz C,Bullinger L,Poschet G,Nonnenmacher Y,Barnert A,Bahr C,Zeisberger P,Przybylla A,Sohn M,Tönjes M,Erez A,Adler L,Jensen P,Scholl C,Fröhling S,Cocciardi S,Wuchter P,Thiede C,Flörcken A,Westermann J,Ehninger G,Lichter P,Hiller K,Hell R,Herrmann C,Ho AD,Krijgsveld J,Radlwimmer B,Trumpp A
Thu Nov 16 00:00:00 EST 2017
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
Cell
Kim AR,Ulirsch JC,Wilmes S,Unal E,Moraga I,Karakukcu M,Yuan D,Kazerounian S,Abdulhay NJ,King DS,Gupta N,Gabriel SB,Lander ES,Patiroglu T,Ozcan A,Ozdemir MA,Garcia KC,Piehler J,Gazda HT,Klein DE,Sankaran VG
200-03 was used in In vitro experiments to demonstrate how variation in a single cytokine can lead to biased downstream signaling and can thereby cause human disease.
Thu Mar 09 00:00:00 EST 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
Thu Sep 07 00:00:00 EDT 2017
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Cell
Gaidt MM,Ebert TS,Chauhan D,Ramshorn K,Pinci F,Zuber S,O'Duill F,Schmid-Burgk JL,Hoss F,Buhmann R,Wittmann G,Latz E,Subklewe M,Hornung V
Thu Nov 16 00:00:00 EST 2017
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Cell
Spencer DH,Russler-Germain DA,Ketkar S,Helton NM,Lamprecht TL,Fulton RS,Fronick CC,O'Laughlin M,Heath SE,Shinawi M,Westervelt P,Payton JE,Wartman LD,Welch JS,Wilson RK,Walter MJ,Link DC,DiPersio JF,Ley TJ
Thu Feb 23 00:00:00 EST 2017
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Cell
Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC
200-03 was used in Cell Culture to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.
Thu Mar 09 00:00:00 EST 2017
Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells.
Blood
Angelos MG,Ruh PN,Webber BR,Blum RH,Ryan CD,Bendzick L,Shim S,Yingst AM,Tufa DM,Verneris MR,Kaufman DS
Thu Jun 29 00:00:00 EDT 2017
KIT signaling is dispensable for human mast cell progenitor development.
Blood
Dahlin JS,Ekoff M,Grootens J,Löf L,Amini RM,Hagberg H,Ungerstedt JS,Olsson-Strömberg U,Nilsson G
Thu Oct 19 00:00:00 EDT 2017
Molecular convergence in ex vivo models of Diamond-Blackfan anemia.
Blood
O'Brien KA,Farrar JE,Vlachos A,Anderson SM,Tsujiura CA,Lichtenberg J,Blanc L,Atsidaftos E,Elkahloun A,An X,Ellis SR,Lipton JM,Bodine DM
Thu Jun 08 00:00:00 EDT 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
200-03 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.
Thu May 04 00:00:00 EDT 2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Stem cells translational medicine
Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP
Wed Mar 01 00:00:00 EST 2017
Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Akoto C,Davies DE,Swindle EJ
Wed Mar 01 00:00:00 EST 2017
Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells.
Cell cycle (Georgetown, Tex.)
Dhenge A,Limbkar K,Melinkeri S,Kale VP,Limaye L
200-03 was used in Cell Culture to examine the role of poly-unsaturated fatty acids in platelet production.
Fri May 19 00:00:00 EDT 2017
A potential bioactive hard-stock fat replacer comprised of a molecular gel.
Food science & nutrition
Rogers MA,Spagnuolo PA,Wang TM,Angka L
Mon May 01 00:00:00 EDT 2017
KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.
Nature communications
Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J
Fri Nov 10 00:00:00 EST 2017
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.
Nature communications
Di Tullio A,Rouault-Pierre K,Abarrategi A,Mian S,Grey W,Gribben J,Stewart A,Blackwood E,Bonnet D
Wed Nov 22 00:00:00 EST 2017
Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.
Scientific reports
Zitti B,Molfetta R,Fionda C,Quatrini L,Stabile H,Lecce M,de Turris V,Ricciardi MR,Petrucci MT,Cippitelli M,Gismondi A,Santoni A,Paolini R
200-03 was used in Cell Culture to study the role of ubiquitin and ubiquitin-like modifiers in the regulation of ligand expression in tumour cells.
Tue Sep 05 00:00:00 EDT 2017
Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes.
Scientific reports
Wiśnik E,Płoszaj T,Robaszkiewicz A
Fri Aug 25 00:00:00 EDT 2017
CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.
Cancer medicine
Ueshima C,Kataoka TR,Takei Y,Hirata M,Sugimoto A,Hirokawa M,Okayama Y,Blumberg RS,Haga H
Sat Apr 01 00:00:00 EDT 2017
High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing.
Scientific reports
Guzniczak E,Mohammad Zadeh M,Dempsey F,Jimenez M,Bock H,Whyte G,Willoughby N,Bridle H
Tue Oct 31 00:00:00 EDT 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 EST 2017
Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.
ACS biomaterials science & engineering
Liu FD,Pishesha N,Poon Z,Kaushik T,Van Vliet KJ
200-03 was used in Cell Culture to leverage cell-material interactions in vitro to induce human bone marrow-derived MSCs to preferentially secrete factors that are beneficial to hematopoietic cell proliferation.
Mon Dec 11 00:00:00 EST 2017
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
200-03 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 EDT 2016
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Cell
Sykes DB,Kfoury YS,Mercier FE,Wawer MJ,Law JM,Haynes MK,Lewis TA,Schajnovitz A,Jain E,Lee D,Meyer H,Pierce KA,Tolliday NJ,Waller A,Ferrara SJ,Eheim AL,Stoeckigt D,Maxcy KL,Cobert JM,Bachand J,Szekely BA,Mukherjee S,Sklar LA,Kotz JD,Clish CB,Sadreyev RI,Clemons PA,Janzer A,Schreiber SL,Scadden DT
200-03 was used in Cell Culture to investigate the role of HoxA9 on the regulation of dihydroorotate dehydrogenase in acute myeloid leukemia models.
Thu Sep 22 00:00:00 EDT 2016
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Blood
Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G
Thu May 26 00:00:00 EDT 2016
Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.
Blood
Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J
Thu Jan 28 00:00:00 EST 2016
Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion.
Blood
Chesnais V,Renneville A,Toma A,Lambert J,Passet M,Dumont F,Chevret S,Lejeune J,Raimbault A,Stamatoullas A,Rose C,Beyne-Rauzy O,Delaunay J,Solary E,Fenaux P,Dreyfus F,Preudhomme C,Kosmider O,Fontenay M
Thu Feb 11 00:00:00 EST 2016
MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.
The Journal of clinical investigation
Zhu N,Chen M,Eng R,DeJong J,Sinha AU,Rahnamay NF,Koche R,Al-Shahrour F,Minehart JC,Chen CW,Deshpande AJ,Xu H,Chu SH,Ebert BL,Roeder RG,Armstrong SA
Tue Mar 01 00:00:00 EST 2016
Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.
The Journal of clinical investigation
Brendel C,Guda S,Renella R,Bauer DE,Canver MC,Kim YJ,Heeney MM,Klatt D,Fogel J,Milsom MD,Orkin SH,Gregory RI,Williams DA
Mon Oct 03 00:00:00 EDT 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 EST 2016
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.
The Journal of clinical investigation
Jin Y,Zhou J,Xu F,Jin B,Cui L,Wang Y,Du X,Li J,Li P,Ren R,Pan J
Mon Oct 03 00:00:00 EDT 2016
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 EDT 2016
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.
The Journal of experimental medicine
Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG
Mon Nov 14 00:00:00 EST 2016
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J
Tue Oct 25 00:00:00 EDT 2016
Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.
Stem cells (Dayton, Ohio)
Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL
Wed Jun 01 00:00:00 EDT 2016
Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.
Stem cells (Dayton, Ohio)
Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL
Wed Jun 01 00:00:00 EDT 2016
Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation.
Stem cells (Dayton, Ohio)
Hoffmann D,Göhring G,Heuser M,Ganser A,Schambach A,Morgan MA
Tue Mar 01 00:00:00 EST 2016
Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β.
Journal of immunology (Baltimore, Md. : 1950)
Suurmond J,Habets KL,Dorjée AL,Huizinga TW,Toes RE
Thu Dec 01 00:00:00 EST 2016
Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Pazdrak K,Straub C,Maroto R,Stafford S,White WI,Calhoun WJ,Kurosky A
Tue Nov 15 00:00:00 EST 2016
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Cell cycle (Georgetown, Tex.)
Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A
200-03 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.
Mon May 02 00:00:00 EDT 2016
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Stem cell reports
D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II
Tue Feb 09 00:00:00 EST 2016
BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.
Cell death & disease
Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R
Thu Apr 07 00:00:00 EDT 2016
Acetylation of C/EBPα inhibits its granulopoietic function.
Nature communications
Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG
Wed Mar 23 00:00:00 EDT 2016
Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.
Scientific reports
Lombardo G,Dentelli P,Togliatto G,Rosso A,Gili M,Gallo S,Deregibus MC,Camussi G,Brizzi MF
Mon May 09 00:00:00 EDT 2016
Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.
Stem cell reports
Saxena S,Rönn RE,Guibentif C,Moraghebi R,Woods NB
Tue May 10 00:00:00 EDT 2016
The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice.
Scientific reports
Ou Z,Niu X,He W,Chen Y,Song B,Xian Y,Fan D,Tang D,Sun X
Thu Sep 01 00:00:00 EDT 2016
Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.
Nature communications
Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP
Thu Oct 20 00:00:00 EDT 2016
A Newly Defined and Xeno-Free Culture Medium Supports Every-Other-Day Medium Replacement in the Generation and Long-Term Cultivation of Human Pluripotent Stem Cells.
PloS one
Ahmadian Baghbaderani B,Tian X,Scotty Cadet J,Shah K,Walde A,Tran H,Kovarcik DP,Clarke D,Fellner T
200-03 was used in Cell Culture to show that the medium plays an integral role in establishing a cGMP-compliant process for the manufacturing of hiPSCs that can be used for generation of clinically relevant cell types for cell replacement therapy applications.
Fri Aug 04 00:00:00 EDT 2017
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Scientific reports
Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H
Wed May 18 00:00:00 EDT 2016
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Scientific reports
Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H
Wed May 18 00:00:00 EDT 2016
ASXL1 plays an important role in erythropoiesis.
Scientific reports
Shi H,Yamamoto S,Sheng M,Bai J,Zhang P,Chen R,Chen S,Shi L,Abdel-Wahab O,Xu M,Zhou Y,Yang FC
Wed Jun 29 00:00:00 EDT 2016
Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials.
Scientific reports
Jeon OH,Panicker LM,Lu Q,Chae JJ,Feldman RA,Elisseeff JH
Thu May 26 00:00:00 EDT 2016
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Cancer cell
Borkin D,He S,Miao H,Kempinska K,Pollock J,Chase J,Purohit T,Malik B,Zhao T,Wang J,Wen B,Zong H,Jones M,Danet-Desnoyers G,Guzman ML,Talpaz M,Bixby DL,Sun D,Hess JL,Muntean AG,Maillard I,Cierpicki T,Grembecka J
Mon Apr 13 00:00:00 EDT 2015
Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
Blood
Sinha S,Thomas D,Yu L,Gentles AJ,Jung N,Corces-Zimmerman MR,Chan SM,Reinisch A,Feinberg AP,Dill DL,Majeti R
Thu Jan 08 00:00:00 EST 2015
MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.
Blood
Buechele C,Breese EH,Schneidawind D,Lin CH,Jeong J,Duque-Afonso J,Wong SH,Smith KS,Negrin RS,Porteus M,Cleary ML
Thu Oct 01 00:00:00 EDT 2015
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
The Journal of clinical investigation
Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA
Mon Aug 03 00:00:00 EDT 2015
CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
The Journal of experimental medicine
Mende N,Kuchen EE,Lesche M,Grinenko T,Kokkaliaris KD,Hanenberg H,Lindemann D,Dahl A,Platz A,Höfer T,Calegari F,Waskow C
Mon Jul 27 00:00:00 EDT 2015
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.
Proceedings of the National Academy of Sciences of the United States of America
McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R
Tue Mar 31 00:00:00 EDT 2015
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.
British journal of haematology
Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J
Sun Nov 01 00:00:00 EDT 2015
A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.
Stem cells translational medicine
Chou BK,Gu H,Gao Y,Dowey SN,Wang Y,Shi J,Li Y,Ye Z,Cheng T,Cheng L
200-03 was used in In vitro experiments to derive human induced pluripotent stem cells from blood mononuclear cells under clinically compliant culture conditions.
Wed Apr 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
Molecular signature of erythroblast enucleation in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H
Sat Aug 01 00:00:00 EDT 2015
SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7.
Journal of immunology (Baltimore, Md. : 1950)
Guo H,Zhang J,Zhang X,Wang Y,Yu H,Yin X,Li J,Du P,Plumas J,Chaperot L,Chen J,Su L,Liu Y,Zhang L
Fri May 15 00:00:00 EDT 2015
The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.
Journal of immunology (Baltimore, Md. : 1950)
Pundir P,MacDonald CA,Kulka M
Tue Sep 15 00:00:00 EDT 2015
Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.
Molecular carcinogenesis
Fisser MC,Rommer A,Steinleitner K,Heller G,Herbst F,Wiese M,Glimm H,Sill H,Wieser R
Tue Dec 01 00:00:00 EST 2015
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem cell reports
Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC
Tue Dec 08 00:00:00 EST 2015
Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells.
Scientific reports
Lopes JP,Stylianou M,Nilsson G,Urban CF
Mon Jul 20 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.
Molecular therapy. Methods & clinical development
Prel A,Caval V,Gayon R,Ravassard P,Duthoit C,Payen E,Maouche-Chretien L,Creneguy A,Nguyen TH,Martin N,Piver E,Sevrain R,Lamouroux L,Leboulch P,Deschaseaux F,Bouillé P,Sensébé L,Pagès JC
Tue Nov 03 00:00:00 EST 2015
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.
Nature communications
Mian SA,Rouault-Pierre K,Smith AE,Seidl T,Pizzitola I,Kizilors A,Kulasekararaj AG,Bonnet D,Mufti GJ
Tue Dec 08 00:00:00 EST 2015
Rh D blood group conversion using transcription activator-like effector nucleases.
Nature communications
Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H
Tue Jun 16 00:00:00 EDT 2015
Construction of stable packaging cell lines for clinical lentiviral vector production.
Scientific reports
Sanber KS,Knight SB,Stephen SL,Bailey R,Escors D,Minshull J,Santilli G,Thrasher AJ,Collins MK,Takeuchi Y
Thu Mar 12 00:00:00 EDT 2015
Chemically defined generation of human cardiomyocytes.
Nature methods
Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC
Fri Aug 01 00:00:00 EDT 2014
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Blood
Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE
Thu Oct 02 00:00:00 EDT 2014
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.
Blood
Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK
Thu Feb 20 00:00:00 EST 2014
Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.
Blood
Lee WC,Malleret B,Lau YL,Mauduit M,Fong MY,Cho JS,Suwanarusk R,Zhang R,Albrecht L,Costa FT,Preiser P,McGready R,Renia L,Nosten F,Russell B
Thu May 01 00:00:00 EDT 2014
CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330.
Blood
Krupka C,Kufer P,Kischel R,Zugmaier G,Bögeholz J,Köhnke T,Lichtenegger FS,Schneider S,Metzeler KH,Fiegl M,Spiekermann K,Baeuerle PA,Hiddemann W,Riethmüller G,Subklewe M
Thu Jan 16 00:00:00 EST 2014
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
The Journal of clinical investigation
Velu CS,Chaubey A,Phelan JD,Horman SR,Wunderlich M,Guzman ML,Jegga AG,Zeleznik-Le NJ,Chen J,Mulloy JC,Cancelas JA,Jordan CT,Aronow BJ,Marcucci G,Bhat B,Gebelein B,Grimes HL
Wed Jan 01 00:00:00 EST 2014
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
The Journal of experimental medicine
Verma R,Su S,McCrann DJ,Green JM,Leu K,Young PR,Schatz PJ,Silva JC,Stokes MP,Wojchowski DM
Mon Aug 25 00:00:00 EDT 2014
BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.
The Journal of experimental medicine
Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE
Mon Apr 07 00:00:00 EDT 2014
The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.
Cell death and differentiation
Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW
Wed Jan 01 00:00:00 EST 2014
EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.
Stem cells (Dayton, Ohio)
Zheng WW,Dong XM,Yin RH,Xu FF,Ning HM,Zhang MJ,Xu CW,Yang Y,Ding YL,Wang ZD,Zhao WB,Tang LJ,Chen H,Wang XH,Zhan YQ,Yu M,Ge CH,Li CY,Yang XM
Fri Aug 01 00:00:00 EDT 2014
Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.
Stem cells (Dayton, Ohio)
Fernandez I,Ooi TP,Roy K
Wed Jan 01 00:00:00 EST 2014
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.
Stem cells (Dayton, Ohio)
Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM
Mon Dec 01 00:00:00 EST 2014
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.
The Journal of biological chemistry
Fujiwara T,Saitoh H,Inoue A,Kobayashi M,Okitsu Y,Katsuoka Y,Fukuhara N,Onishi Y,Ishizawa K,Ichinohasama R,Harigae H
Fri Mar 21 00:00:00 EDT 2014
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.
Blood
Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS
Thu Apr 04 00:00:00 EDT 2013
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
Blood
Harada Y,Inoue D,Ding Y,Imagawa J,Doki N,Matsui H,Yahata T,Matsushita H,Ando K,Sashida G,Iwama A,Kitamura T,Harada H
Thu Apr 25 00:00:00 EDT 2013
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.
Blood
Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A
Thu Nov 14 00:00:00 EST 2013
Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation.
Blood
Nuzzo F,Radu C,Baralle M,Spiezia L,Hackeng TM,Simioni P,Castoldi E
Thu Nov 28 00:00:00 EST 2013
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.
Blood
Kung Sutherland MS,Walter RB,Jeffrey SC,Burke PJ,Yu C,Kostner H,Stone I,Ryan MC,Sussman D,Lyon RP,Zeng W,Harrington KH,Klussman K,Westendorf L,Meyer D,Bernstein ID,Senter PD,Benjamin DR,Drachman JG,McEarchern JA
Thu Aug 22 00:00:00 EDT 2013
Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.
Blood
Merling RK,Sweeney CL,Choi U,De Ravin SS,Myers TG,Otaizo-Carrasquero F,Pan J,Linton G,Chen L,Koontz S,Theobald NL,Malech HL
Thu Apr 04 00:00:00 EDT 2013
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood
Nakajima-Takagi Y,Osawa M,Oshima M,Takagi H,Miyagi S,Endoh M,Endo TA,Takayama N,Eto K,Toyoda T,Koseki H,Nakauchi H,Iwama A
Thu Jan 17 00:00:00 EST 2013
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood
Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T
Thu May 16 00:00:00 EDT 2013
Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.
Blood
Laperrousaz B,Jeanpierre S,Sagorny K,Voeltzel T,Ramas S,Kaniewski B,Ffrench M,Salesse S,Nicolini FE,Maguer-Satta V
Thu Nov 28 00:00:00 EST 2013
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ
Thu Feb 28 00:00:00 EST 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 EDT 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine
Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I
Mon Feb 11 00:00:00 EST 2013
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy
Scaramuzza S,Biasco L,Ripamonti A,Castiello MC,Loperfido M,Draghici E,Hernandez RJ,Benedicenti F,Radrizzani M,Salomoni M,Ranzani M,Bartholomae CC,Vicenzi E,Finocchi A,Bredius R,Bosticardo M,Schmidt M,von Kalle C,Montini E,Biffi A,Roncarolo MG,Naldini L,Villa A,Aiuti A
Tue Jan 01 00:00:00 EST 2013
Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.
Molecular therapy. Nucleic acids
Centlivre M,Legrand N,Klamer S,Liu YP,Jasmijn von Eije K,Bohne M,Rijnstra ES,Weijer K,Blom B,Voermans C,Spits H,Berkhout B
Tue Sep 03 00:00:00 EDT 2013
TNF-α has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8.
Stem cells (Dayton, Ohio)
Mizrahi K,Stein J,Yaniv I,Kaplan O,Askenasy N
Tue Jan 01 00:00:00 EST 2013
β-Defensins activate human mast cells via Mas-related gene X2.
Journal of immunology (Baltimore, Md. : 1950)
Subramanian H,Gupta K,Lee D,Bayir AK,Ahn H,Ali H
Mon Jul 01 00:00:00 EDT 2013
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sat Jun 15 00:00:00 EDT 2013
Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.
Journal of immunology (Baltimore, Md. : 1950)
Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N
Sun Sep 15 00:00:00 EDT 2013
Cigarette smoke suppresses the surface expression of c-kit and FcεRI on mast cells.
Mediators of inflammation
Givi ME,Blokhuis BR,Da Silva CA,Adcock I,Garssen J,Folkerts G,Redegeld FA,Mortaz E
Mon Aug 19 00:00:00 EDT 2013
Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.
PloS one
Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X
Fri Jul 19 00:00:00 EDT 2013
Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.
PloS one
Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X
Fri Jul 19 00:00:00 EDT 2013
The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.
The Journal of biological chemistry
Chacón-Martínez CA,Kiessling N,Winterhoff M,Faix J,Müller-Reichert T,Jessberger R
Fri Oct 04 00:00:00 EDT 2013
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
PloS one
Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG
Thu Aug 08 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs.
PloS one
Szabo A,Gogolak P,Pazmandi K,Kis-Toth K,Riedl K,Wizel B,Lingnau K,Bacsi A,Rethi B,Rajnavolgyi E
Mon Dec 02 00:00:00 EST 2013
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
PloS one
Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L
Fri Jul 19 00:00:00 EDT 2013
A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.
PloS one
Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L
Fri Jul 19 00:00:00 EDT 2013
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.
Blood
Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D
Thu Oct 11 00:00:00 EDT 2012
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.
Blood
Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D
Thu Oct 11 00:00:00 EDT 2012
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.
Blood
Will B,Zhou L,Vogler TO,Ben-Neriah S,Schinke C,Tamari R,Yu Y,Bhagat TD,Bhattacharyya S,Barreyro L,Heuck C,Mo Y,Parekh S,McMahon C,Pellagatti A,Boultwood J,Montagna C,Silverman L,Maciejewski J,Greally JM,Ye BH,List AF,Steidl C,Steidl U,Verma A
Thu Sep 06 00:00:00 EDT 2012
Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells.
Blood
Gori JL,Chandrasekaran D,Kowalski JP,Adair JE,Beard BC,D'Souza SL,Kiem HP
Thu Sep 27 00:00:00 EDT 2012
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.
The Journal of clinical investigation
Cesana D,Sgualdino J,Rudilosso L,Merella S,Naldini L,Montini E
Tue May 01 00:00:00 EDT 2012
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
The Journal of experimental medicine
Thiollier C,Lopez CK,Gerby B,Ignacimouttou C,Poglio S,Duffourd Y,Guégan J,Rivera-Munoz P,Bluteau O,Mabialah V,Diop M,Wen Q,Petit A,Bauchet AL,Reinhardt D,Bornhauser B,Gautheret D,Lecluse Y,Landman-Parker J,Radford I,Vainchenker W,Dastugue N,de Botton S,Dessen P,Bourquin JP,Crispino JD,Ballerini P,Bernard OA,Pflumio F,Mercher T
Mon Oct 22 00:00:00 EDT 2012
Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.
Nature protocols
Dowey SN,Huang X,Chou BK,Ye Z,Cheng L
200-03 was used in Cell Culture to describe a detailed, validated protocol for effective generation of integration-free human induced pluripotent stem cells from blood mononuclear cells by plasmid vectors.
Thu Nov 01 00:00:00 EDT 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 EDT 2012
Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Skrzeczynska-Moncznik J,Wlodarczyk A,Zabieglo K,Kapinska-Mrowiecka M,Marewicz E,Dubin A,Potempa J,Cichy J
Wed Aug 15 00:00:00 EDT 2012
TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-α-mediated antitumor reactivity.
Journal of immunology (Baltimore, Md. : 1950)
Kalb ML,Glaser A,Stary G,Koszik F,Stingl G
Wed Feb 15 00:00:00 EST 2012
Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.
Allergy, asthma & immunology research
Kashiwakura J,Okayama Y,Furue M,Kabashima K,Shimada S,Ra C,Siraganian RP,Kawakami Y,Kawakami T
Thu Nov 01 00:00:00 EDT 2012
Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.
PloS one
Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H
Wed Dec 12 00:00:00 EST 2012
GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression.
The Journal of biological chemistry
Baba Y,Maeda K,Yashiro T,Inage E,Kasakura K,Suzuki R,Niyonsaba F,Hara M,Tanabe A,Ogawa H,Okumura K,Ohtsuka Y,Shimizu T,Nishiyama C
Fri Sep 21 00:00:00 EDT 2012
Interleukin-33 primes mast cells for activation by IgG immune complexes.
PloS one
Kaieda S,Wang JX,Shnayder R,Fishgal N,Hei H,Lee RT,Stevens RL,Nigrovic PA
Thu Apr 04 00:00:00 EDT 2013
Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.
PloS one
Ramos-Mejía V,Montes R,Bueno C,Ayllón V,Real PJ,Rodríguez R,Menendez P
Mon Aug 27 00:00:00 EDT 2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry
Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y
Fri Nov 23 00:00:00 EST 2012
Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.
PloS one
Vatolin S,Khan SN,Reu FJ
Tue Mar 12 00:00:00 EDT 2013
Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
The Journal of biological chemistry
Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z
Fri Aug 24 00:00:00 EDT 2012
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
PloS one
Li XH,Ha CT,Fu D,Xiao M
Thu May 09 00:00:00 EDT 2013
Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.
PloS one
Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A
Wed Jul 24 00:00:00 EDT 2013
HBsAg inhibits IFN-α production in plasmacytoid dendritic cells through TNF-α and IL-10 induction in monocytes.
PloS one
Shi B,Ren G,Hu Y,Wang S,Zhang Z,Yuan Z
Fri Feb 15 00:00:00 EST 2013
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 EDT 2011
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Cell
Grebien F,Hantschel O,Wojcik J,Kaupe I,Kovacic B,Wyrzucki AM,Gish GD,Cerny-Reiterer S,Koide A,Beug H,Pawson T,Valent P,Koide S,Superti-Furga G
Fri Oct 14 00:00:00 EDT 2011
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.
Cell
Bock C,Kiskinis E,Verstappen G,Gu H,Boulting G,Smith ZD,Ziller M,Croft GF,Amoroso MW,Oakley DH,Gnirke A,Eggan K,Meissner A
Fri Feb 04 00:00:00 EST 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.
Blood
Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R
Thu Apr 21 00:00:00 EDT 2011
Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.
Blood
Montes R,Ayllón V,Gutierrez-Aranda I,Prat I,Hernández-Lamas MC,Ponce L,Bresolin S,Te Kronnie G,Greaves M,Bueno C,Menendez P
Thu May 05 00:00:00 EDT 2011
BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
Blood
Sheng Z,Ma L,Sun JE,Zhu LJ,Green MR
Thu Sep 08 00:00:00 EDT 2011
Proof of principle for transfusion of in vitro-generated red blood cells.
Blood
Giarratana MC,Rouard H,Dumont A,Kiger L,Safeukui I,Le Pennec PY,François S,Trugnan G,Peyrard T,Marie T,Jolly S,Hebert N,Mazurier C,Mario N,Harmand L,Lapillonne H,Devaux JY,Douay L
Thu Nov 10 00:00:00 EST 2011
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Blood
Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ
Thu Mar 17 00:00:00 EDT 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 EST 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 EST 2011
TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.
Blood
Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW
Thu Dec 08 00:00:00 EST 2011
Sox6 enhances erythroid differentiation in human erythroid progenitors.
Blood
Cantù C,Ierardi R,Alborelli I,Fugazza C,Cassinelli L,Piconese S,Bosè F,Ottolenghi S,Ferrari G,Ronchi A
Thu Mar 31 00:00:00 EDT 2011
Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.
Blood
Hu K,Yu J,Suknuntha K,Tian S,Montgomery K,Choi KD,Stewart R,Thomson JA,Slukvin II
Thu Apr 07 00:00:00 EDT 2011
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.
Blood
Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B
Thu Aug 18 00:00:00 EDT 2011
The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.
Blood
Zhou J,Bi C,Cheong LL,Mahara S,Liu SC,Tay KG,Koh TL,Yu Q,Chng WJ
Thu Sep 08 00:00:00 EDT 2011
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood
Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F
Thu Mar 17 00:00:00 EDT 2011
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation.
The Journal of clinical investigation
Wu X,Gao H,Ke W,Giese RW,Zhu Z
Fri Jul 01 00:00:00 EDT 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
200-03 was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
200-03 was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Many putative endocrine disruptors inhibit prostaglandin synthesis.
Environmental health perspectives
Kristensen DM,Skalkam ML,Audouze K,Lesné L,Desdoits-Lethimonier C,Frederiksen H,Brunak S,Skakkebæk NE,Jégou B,Hansen JB,Junker S,Leffers H
Fri Apr 01 00:00:00 EDT 2011
Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Rådinger M,Smrž D,Metcalfe DD,Gilfillan AM
Thu Dec 01 00:00:00 EST 2011
Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils.
Journal of immunology (Baltimore, Md. : 1950)
Suzukawa M,Nagase H,Ogahara I,Han K,Tashimo H,Shibui A,Koketsu R,Nakae S,Yamaguchi M,Ohta K
Sun May 01 00:00:00 EDT 2011
Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation.
Cell transplantation
Ehnert S,Seeliger C,Vester H,Schmitt A,Saidy-Rad S,Lin J,Neumaier M,Gillen S,Kleeff J,Friess H,Burkhart J,Stöckle U,Nüssler AK
Thu Mar 08 00:00:00 EST 2012
PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy.
PloS one
Zhou J,Bi C,Chng WJ,Cheong LL,Liu SC,Mahara S,Tay KG,Zeng Q,Li J,Guo K,Tan CP,Yu H,Albert DH,Chen CS
Thu May 12 00:00:00 EDT 2011
Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.
PloS one
Mack AA,Kroboth S,Rajesh D,Wang WB
Mon Apr 02 00:00:00 EDT 2012
Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.
PloS one
Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P
Fri Feb 11 00:00:00 EST 2011
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 EST 2011
Comparative study of hematopoietic differentiation between human embryonic stem cell lines.
PloS one
Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A
Fri Oct 21 00:00:00 EDT 2011
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 EST 2011
Efficient feeder-free episomal reprogramming with small molecules.
PloS one
Yu J,Chau KF,Vodyanik MA,Jiang J,Jiang Y
Tue Mar 01 00:00:00 EST 2011
Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.
PloS one
Yu HC,Zhao HL,Wu ZK,Zhang JW
Tue Dec 06 00:00:00 EST 2011
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
The Journal of biological chemistry
Nishimura K,Sano M,Ohtaka M,Furuta B,Umemura Y,Nakajima Y,Ikehara Y,Kobayashi T,Segawa H,Takayasu S,Sato H,Motomura K,Uchida E,Kanayasu-Toyoda T,Asashima M,Nakauchi H,Yamaguchi T,Nakanishi M
Fri Feb 11 00:00:00 EST 2011
Congenital dyserythropoietic anemia type II: molecular analysis and expression of the SEC23B gene.
Orphanet journal of rare diseases
Punzo F,Bertoli-Avella AM,Scianguetta S,Della Ragione F,Casale M,Ronzoni L,Cappellini MD,Forni G,Oostra BA,Perrotta S
Fri Dec 30 00:00:00 EST 2011
Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.
The Journal of biological chemistry
Subramanian H,Gupta K,Guo Q,Price R,Ali H
Fri Dec 30 00:00:00 EST 2011
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia.
Nature
Cavazzana-Calvo M,Payen E,Negre O,Wang G,Hehir K,Fusil F,Down J,Denaro M,Brady T,Westerman K,Cavallesco R,Gillet-Legrand B,Caccavelli L,Sgarra R,Maouche-Chrétien L,Bernaudin F,Girot R,Dorazio R,Mulder GJ,Polack A,Bank A,Soulier J,Larghero J,Kabbara N,Dalle B,Gourmel B,Socie G,Chrétien S,Cartier N,Aubourg P,Fischer A,Cornetta K,Galacteros F,Beuzard Y,Gluckman E,Bushman F,Hacein-Bey-Abina S,Leboulch P
Thu Sep 16 00:00:00 EDT 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 EST 2010
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.
Blood
Jahrsdörfer B,Vollmer A,Blackwell SE,Maier J,Sontheimer K,Beyer T,Mandel B,Lunov O,Tron K,Nienhaus GU,Simmet T,Debatin KM,Weiner GJ,Fabricius D
Thu Feb 11 00:00:00 EST 2010
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.
Blood
Fauriat C,Ivarsson MA,Ljunggren HG,Malmberg KJ,Michaëlsson J
Thu Feb 11 00:00:00 EST 2010
The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.
Blood
Van Handel B,Prashad SL,Hassanzadeh-Kiabi N,Huang A,Magnusson M,Atanassova B,Chen A,Hamalainen EI,Mikkola HK
Thu Oct 28 00:00:00 EDT 2010
Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.
Blood
Flister MJ,Wilber A,Hall KL,Iwata C,Miyazono K,Nisato RE,Pepper MS,Zawieja DC,Ran S
Thu Jan 14 00:00:00 EST 2010
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood
Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K
Thu Aug 19 00:00:00 EDT 2010
W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.
Blood
Jansson L,Larsson J
Thu Jan 07 00:00:00 EST 2010
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.
Blood
Pratz KW,Sato T,Murphy KM,Stine A,Rajkhowa T,Levis M
Thu Feb 18 00:00:00 EST 2010
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.
Blood
Pratz KW,Sato T,Murphy KM,Stine A,Rajkhowa T,Levis M
Thu Feb 18 00:00:00 EST 2010
Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood
Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN
Thu Jul 08 00:00:00 EDT 2010
Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.
Blood
Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H
Thu Dec 02 00:00:00 EST 2010
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
The Journal of experimental medicine
Lauterbach H,Bathke B,Gilles S,Traidl-Hoffmann C,Luber CA,Fejer G,Freudenberg MA,Davey GM,Vremec D,Kallies A,Wu L,Shortman K,Chaplin P,Suter M,O'Keeffe M,Hochrein H
Mon Nov 22 00:00:00 EST 2010
Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Schuerwegh AJ,Ioan-Facsinay A,Dorjée AL,Roos J,Bajema IM,van der Voort EI,Huizinga TW,Toes RE
Tue Feb 09 00:00:00 EST 2010
Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response.
PLoS pathogens
Deal EM,Jaimes MC,Crawford SE,Estes MK,Greenberg HB
Thu Jun 03 00:00:00 EDT 2010
PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
PLoS pathogens
Hanley TM,Blay Puryear W,Gummuluru S,Viglianti GA
Thu Jul 01 00:00:00 EDT 2010
IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Macey MR,Sturgill JL,Morales JK,Falanga YT,Morales J,Norton SK,Yerram N,Shim H,Fernando J,Gifillan AM,Gomez G,Schwartz L,Oskeritzian C,Spiegel S,Conrad D,Ryan JJ
Sat May 01 00:00:00 EDT 2010
Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Rådinger M,Kuehn HS,Kim MS,Metcalfe DD,Gilfillan AM
Fri Jan 15 00:00:00 EST 2010
CXCR7 protein is not expressed on human or mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ
Mon Nov 01 00:00:00 EDT 2010
CXCR7 protein is not expressed on human or mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ
Mon Nov 01 00:00:00 EDT 2010
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes.
Journal of immunology (Baltimore, Md. : 1950)
Santer DM,Hall BE,George TC,Tangsombatvisit S,Liu CL,Arkwright PD,Elkon KB
Fri Oct 15 00:00:00 EDT 2010
Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement.
Journal of immunology (Baltimore, Md. : 1950)
Fabricius D,Neubauer M,Mandel B,Schütz C,Viardot A,Vollmer A,Jahrsdörfer B,Debatin KM
Fri Jan 15 00:00:00 EST 2010
Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Niyonsaba F,Ushio H,Hara M,Yokoi H,Tominaga M,Takamori K,Kajiwara N,Saito H,Nagaoka I,Ogawa H,Okumura K
Thu Apr 01 00:00:00 EDT 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 EDT 2010
Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.
The Journal of biological chemistry
Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ
Fri Jul 02 00:00:00 EDT 2010
In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.
PloS one
Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR
Fri Aug 27 00:00:00 EDT 2010
Hypoxia modulates human eosinophil function.
Clinical and molecular allergy : CMA
Nissim Ben Efraim AH,Eliashar R,Levi-Schaffer F
Mon Jul 19 00:00:00 EDT 2010
Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.
BMC systems biology
Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A
Wed Jun 16 00:00:00 EDT 2010
Mast cell survival and mediator secretion in response to hypoxia.
PloS one
Gulliksson M,Carvalho RF,Ullerås E,Nilsson G
Mon Aug 23 00:00:00 EDT 2010
ErythRED, a hESC line enabling identification of erythroid cells.
Nature methods
Hatzistavrou T,Micallef SJ,Ng ES,Vadolas J,Stanley EG,Elefanty AG
Tue Sep 01 00:00:00 EDT 2009
Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.
Blood
Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS
Thu Jun 11 00:00:00 EDT 2009
ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype.
Blood
Soriani A,Zingoni A,Cerboni C,Iannitto ML,Ricciardi MR,Di Gialleonardo V,Cippitelli M,Fionda C,Petrucci MT,Guarini A,Foà R,Santoni A
Thu Apr 09 00:00:00 EDT 2009
Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.
Blood
Will B,Kawahara M,Luciano JP,Bruns I,Parekh S,Erickson-Miller CL,Aivado MA,Verma A,Steidl U
Thu Oct 29 00:00:00 EDT 2009
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.
Blood
Ding Y,Harada Y,Imagawa J,Kimura A,Harada H
Thu Dec 10 00:00:00 EST 2009
Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation.
Blood
Gobbi G,Mirandola P,Carubbi C,Micheloni C,Malinverno C,Lunghi P,Bonati A,Vitale M
Thu Mar 26 00:00:00 EDT 2009
The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.
Blood
Oehler VG,Guthrie KA,Cummings CL,Sabo K,Wood BL,Gooley T,Yang T,Epping MT,Shou Y,Pogosova-Agadjanyan E,Ladne P,Stirewalt DL,Abkowitz JL,Radich JP
Thu Oct 08 00:00:00 EDT 2009
NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.
Blood
Starnes LM,Sorrentino A,Pelosi E,Ballarino M,Morsilli O,Biffoni M,Santoro S,Felli N,Castelli G,De Marchis ML,Mastroberardino G,Gabbianelli M,Fatica A,Bozzoni I,Nervi C,Peschle C
Thu Aug 27 00:00:00 EDT 2009
Role for MKL1 in megakaryocytic maturation.
Blood
Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS
Thu Mar 19 00:00:00 EDT 2009
NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner.
Blood
Cui YX,Kerby A,McDuff FK,Ye H,Turner SD
Thu May 21 00:00:00 EDT 2009
Generation of induced pluripotent stem cells from human blood.
Blood
Loh YH,Agarwal S,Park IH,Urbach A,Huo H,Heffner GC,Kim K,Miller JD,Ng K,Daley GQ
Thu May 28 00:00:00 EDT 2009
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.
Blood
Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR
Thu Apr 02 00:00:00 EDT 2009
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD
Thu Oct 01 00:00:00 EDT 2009
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
The Journal of clinical investigation
Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T
Sun Mar 01 00:00:00 EST 2009
Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y
Tue Sep 15 00:00:00 EDT 2009
Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Stem cells (Dayton, Ohio)
Tian X,Hexum MK,Penchev VR,Taylor RJ,Shultz LD,Kaufman DS
Sun Nov 01 00:00:00 EDT 2009
A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A
Thu Jan 01 00:00:00 EST 2009
IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Sundstrom JB,Hair GA,Ansari AA,Secor WE,Gilfillan AM,Metcalfe DD,Kirshenbaum AS
Fri May 15 00:00:00 EDT 2009
Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Kato A,Chustz RT,Ogasawara T,Kulka M,Saito H,Schleimer RP,Matsumoto K
Mon Jun 01 00:00:00 EDT 2009
The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.
Journal of immunology (Baltimore, Md. : 1950)
Boehmler AM,Drost A,Jaggy L,Seitz G,Wiesner T,Denzlinger C,Kanz L,Möhle R
Mon Jun 01 00:00:00 EDT 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 EDT 2009
Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.
PloS one
Das H,George JC,Joseph M,Das M,Abdulhameed N,Blitz A,Khan M,Sakthivel R,Mao HQ,Hoit BD,Kuppusamy P,Pompili VJ
Wed Oct 07 00:00:00 EDT 2009
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
PloS one
Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P
Wed Nov 18 00:00:00 EST 2009
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity.
The Journal of experimental medicine
Junttila IS,Mizukami K,Dickensheets H,Meier-Schellersheim M,Yamane H,Donnelly RP,Paul WE
Mon Oct 27 00:00:00 EDT 2008
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Su Z,Frye C,Bae KM,Kelley V,Vieweg J
Wed Oct 01 00:00:00 EDT 2008
Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia.
Stem cells (Dayton, Ohio)
Moshaver B,van Rhenen A,Kelder A,van der Pol M,Terwijn M,Bachas C,Westra AH,Ossenkoppele GJ,Zweegman S,Schuurhuis GJ
Mon Dec 01 00:00:00 EST 2008
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuehn HS,Swindle EJ,Kim MS,Beaven MA,Metcalfe DD,Gilfillan AM
Mon Dec 01 00:00:00 EST 2008
Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.
BMC immunology
Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A
Wed Oct 01 00:00:00 EDT 2008
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 EDT 2007
Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.
Blood
Della Chiesa M,Romagnani C,Thiel A,Moretta L,Moretta A
Fri Dec 01 00:00:00 EST 2006
Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells.
Proceedings of the National Academy of Sciences of the United States of America
Hsieh FH,Sharma P,Gibbons A,Goggans T,Erzurum SC,Haque SJ
Tue Oct 04 00:00:00 EDT 2005
Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.
Journal of immunology (Baltimore, Md. : 1950)
van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P
Tue Feb 15 00:00:00 EST 2005
Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.
Journal of immunology (Baltimore, Md. : 1950)
Hartnell A,Heinemann A,Conroy DM,Wait R,Sturm GJ,Caversaccio M,Jose PJ,Williams TJ
Mon Nov 15 00:00:00 EST 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
