Product References
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Cell metabolism
Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A
200-34 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.
Tue May 02 00:00:00 EDT 2023
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Communications biology
Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H
200-34 was used in In vitro experiments to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.
Sat Apr 29 00:00:00 EDT 2023
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.
Nature protocols
Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H
200-34 was used in Cell Culture to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.
Fri Sep 01 00:00:00 EDT 2023
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.
Nature protocols
Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H
200-34 was used in Cell Culture to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.
Fri Sep 01 00:00:00 EDT 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
200-34 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 EDT 2023
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M
200-34 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.
Thu Sep 01 00:00:00 EDT 2022
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Cellular and molecular life sciences : CMLS
Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC
200-34 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.
Wed Jul 27 00:00:00 EDT 2022
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
eLife
Jairaman A,McQuade A,Granzotto A,Kang YJ,Chadarevian JP,Gandhi S,Parker I,Smith I,Cho H,Sensi SL,Othy S,Blurton-Jones M,Cahalan MD
200-34 was used in In vitro experiments to show that loss of TREM2 confers a defect in microglial Ca2+ response to purinergic signals, suggesting a window of Ca2+ signaling for optimal microglial motility.
Tue Feb 22 00:00:00 EST 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
200-34 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 EDT 2022
Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.
Frontiers in immunology
Wallach T,Raden M,Hinkelmann L,Brehm M,Rabsch D,Weidling H,Krüger C,Kettenmann H,Backofen R,Lehnardt S
200-34 was used in In vitro experiments to determine TLR7 and TLR8 as key sensors of SARS-CoV-2-derived ssRNAs and may deepen our understanding of the mechanisms how this virus triggers, but also modulates an inflammatory response through innate immune signaling.
Tue Jan 31 00:00:00 EST 2023
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Brain : a journal of neurology
Magusali N,Graham AC,Piers TM,Panichnantakul P,Yaman U,Shoai M,Reynolds RH,Botia JA,Brookes KJ,Guetta-Baranes T,Bellou E,Bayram S,Sokolova D,Ryten M,Sala Frigerio C,Escott-Price V,Morgan K,Pocock JM,Hardy J,Salih DA
Fri Dec 31 00:00:00 EST 2021
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
Glia
Parajuli B,Saito H,Shinozaki Y,Shigetomi E,Miwa H,Yoneda S,Tanimura M,Omachi S,Asaki T,Takahashi K,Fujita M,Nakashima K,Koizumi S
Fri Oct 01 00:00:00 EDT 2021
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.
Translational psychiatry
Sheridan SD,Thanos JM,De Guzman RM,McCrea LT,Horng JE,Fu T,Sellgren CM,Perlis RH,Edlow AG
Fri Mar 19 00:00:00 EDT 2021
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Nature communications
Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B
Wed Sep 01 00:00:00 EDT 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
200-34 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 EST 2021
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
Cell stem cell
Popova G,Soliman SS,Kim CN,Keefe MG,Hennick KM,Jain S,Li T,Tejera D,Shin D,Chhun BB,McGinnis CS,Speir M,Gartner ZJ,Mehta SB,Haeussler M,Hengen KB,Ransohoff RR,Piao X,Nowakowski TJ
200-34 was used in Cell Culture to compare human microglia states across culture models, including cultured primary and pluripotent stem cell-derived microglia.
Thu Dec 02 00:00:00 EST 2021
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
iScience
Morozzi G,Rothen J,Toussaint G,De Lange K,Westritschnig K,Doelemeyer A,Ueberschlag VP,Kahle P,Lambert C,Obrecht M,Beckmann N,Ritter V,Panesar M,Stauffer D,Garnier I,Mueller M,Guerini D,Keller CG,Knehr J,Roma G,Bidinosti M,Brachat S,Morvan F,Fornaro M
200-34 was used in In vitro experiments to investigate relationship between peripheral nerve injury and inflammation.
Fri Dec 17 00:00:00 EST 2021
Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
The Journal of experimental medicine
Liu T,Zhu B,Liu Y,Zhang X,Yin J,Li X,Jiang L,Hodges AP,Rosenthal SB,Zhou L,Yancey J,McQuade A,Blurton-Jones M,Tanzi RE,Huang TY,Xu H
Mon Dec 07 00:00:00 EST 2020
ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.
The EMBO journal
Muliyil S,Levet C,Düsterhöft S,Dulloo I,Cowley SA,Freeman M
Tue Sep 01 00:00:00 EDT 2020
Direct kinetic fingerprinting and digital counting of single protein molecules.
Proceedings of the National Academy of Sciences of the United States of America
Chatterjee T,Knappik A,Sandford E,Tewari M,Choi SW,Strong WB,Thrush EP,Oh KJ,Liu N,Walter NG,Johnson-Buck A
Tue Sep 15 00:00:00 EDT 2020
Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction.
Scientific reports
Nzou G,Wicks RT,VanOstrand NR,Mekky GA,Seale SA,El-Taibany A,Wicks EE,Nechtman CM,Marrotte EJ,Makani VS,Murphy SV,Seeds MC,Jackson JD,Atala AJ
Wed Jun 17 00:00:00 EDT 2020
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Molecular systems biology
Morshed N,Ralvenius WT,Nott A,Watson LA,Rodriguez FH,Akay LA,Joughin BA,Pao PC,Penney J,LaRocque L,Mastroeni D,Tsai LH,White FM
Tue Dec 01 00:00:00 EST 2020
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing.
Cell reports
Knupp A,Mishra S,Martinez R,Braggin JE,Szabo M,Kinoshita C,Hailey DW,Small SA,Jayadev S,Young JE
200-34 was used in Cell Culture to validate defects in neuronal endosomal trafficking following the depletion of the SORL1.
Tue Jun 02 00:00:00 EDT 2020
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Nature communications
Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M
Wed Oct 14 00:00:00 EDT 2020
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Neuron
Hasselmann J,Coburn MA,England W,Figueroa Velez DX,Kiani Shabestari S,Tu CH,McQuade A,Kolahdouzan M,Echeverria K,Claes C,Nakayama T,Azevedo R,Coufal NG,Han CZ,Cummings BJ,Davtyan H,Glass CK,Healy LM,Gandhi SP,Spitale RC,Blurton-Jones M
Wed Sep 25 00:00:00 EDT 2019
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.
Stem cell reports
Konttinen H,Cabral-da-Silva MEC,Ohtonen S,Wojciechowski S,Shakirzyanova A,Caligola S,Giugno R,Ishchenko Y,Hernández D,Fazaludeen MF,Eamen S,Budia MG,Fagerlund I,Scoyni F,Korhonen P,Huber N,Haapasalo A,Hewitt AW,Vickers J,Smith GC,Oksanen M,Graff C,Kanninen KM,Lehtonen S,Propson N,Schwartz MP,Pébay A,Koistinaho J,Ooi L,Malm T
Tue Oct 08 00:00:00 EDT 2019
Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed.
Nature biotechnology
Kveler K,Starosvetsky E,Ziv-Kenet A,Kalugny Y,Gorelik Y,Shalev-Malul G,Aizenbud-Reshef N,Dubovik T,Briller M,Campbell J,Rieckmann JC,Asbeh N,Rimar D,Meissner F,Wiser J,Shen-Orr SS
Wed Aug 01 00:00:00 EDT 2018
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron
Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH
Wed Jun 27 00:00:00 EDT 2018
Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling.
Scientific reports
Nzou G,Wicks RT,Wicks EE,Seale SA,Sane CH,Chen A,Murphy SV,Jackson JD,Atala AJ
Wed May 09 00:00:00 EDT 2018
Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.
Stem cell reports
Brownjohn PW,Smith J,Solanki R,Lohmann E,Houlden H,Hardy J,Dietmann S,Livesey FJ
Tue Apr 10 00:00:00 EDT 2018
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
Neuron
Abud EM,Ramirez RN,Martinez ES,Healy LM,Nguyen CHH,Newman SA,Yeromin AV,Scarfone VM,Marsh SE,Fimbres C,Caraway CA,Fote GM,Madany AM,Agrawal A,Kayed R,Gylys KH,Cahalan MD,Cummings BJ,Antel JP,Mortazavi A,Carson MJ,Poon WW,Blurton-Jones M
Wed Apr 19 00:00:00 EDT 2017
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.
Stem cell reports
Haenseler W,Sansom SN,Buchrieser J,Newey SE,Moore CS,Nicholls FJ,Chintawar S,Schnell C,Antel JP,Allen ND,Cader MZ,Wade-Martins R,James WS,Cowley SA
Tue Jun 06 00:00:00 EDT 2017
Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis.
Arthritis research & therapy
Hwang SJ,Choi B,Kang SS,Chang JH,Kim YG,Chung YH,Sohn DH,So MW,Lee CK,Robinson WH,Chang EJ
Fri Jan 20 00:00:00 EST 2012
