Gibco

Human IL-6 Recombinant Protein, PeproTech®

Human IL-6 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human IL-6 Protein (200-06-20UG) in Functional

Bioassay analysis of Human IL-6 Recombinant Protein, PeproTech® (Product # 200-06-1MG).

Product Image Gallery

Product Details

200-06-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 5 publications 5 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 598 publications 598 publications

Competition Assay (CA)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 65 publications 65 publications

Product Specifications

Species

Human

Published species

Bacteria, Bovine, Chicken, Dog, Hamster, Human, Mouse, Non-human primate, Rat, Virus

Expression System

E. coli

Amino acid sequence

PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM

Molecular weight

20.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to stimulate the proliferation of mouse B9 cells.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Cell metabolism

Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A

200-06 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.

Tue May 02 00:00:00 EDT 2023

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.

Cell death & disease

Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M

200-06 was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.

Tue Apr 04 00:00:00 EDT 2023

Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.

Communications biology

Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H

200-06 was used in In vitro experiments to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.

Sat Apr 29 00:00:00 EDT 2023

Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.

International journal of biological sciences

Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z

200-06 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.

Tue Nov 07 00:00:00 EST 2023

Bach2 in CD4⁺ T cells from SLE patients modulates B-cell differentiation and IgG production.

European journal of immunology

Long D,Yang B,Yang M,Xiong F,Zhu X,Tan Y,Wu H

200-06 was used in Flow cytometry/Cell sorting to assess Bach2 levels, bisulfite sequencing PCR was used to measure the methylation level, and silencing by electroporation and stimulation with a cytokine concentration gradient were used to investigate the effect of Bach2 on T cells.

Sat Apr 01 00:00:00 EDT 2023

Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.

The Journal of clinical investigation

Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG

200-06 was used in In vitro experiments to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.

Thu Jun 01 00:00:00 EDT 2023

P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.

The Journal of experimental medicine

He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG

200-06 was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."

Mon Jan 03 00:00:00 EST 2022

The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.

Leukemia

Stavast CJ,van Zuijen I,Karkoulia E,Özçelik A,van Hoven-Beijen A,Leon LG,Voerman JSA,Janssen GMC,van Veelen PA,Burocziova M,Brouwer RWW,van IJcken WFJ,Maas A,Bindels EM,van der Velden VHJ,Schliehe C,Katsikis PD,Alberich-Jorda M,Erkeland SJ

200-06 was used in Cell Culture to investigate miRNA-139 in acute myeloid leukemia.

Tue Mar 01 00:00:00 EST 2022

Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.

Cancer immunology research

Gil Del Alcazar CR,Trinh A,Alečković M,Rojas Jimenez E,Harper NW,Oliphant MUJ,Xie S,Krop ED,Lulseged B,Murphy KC,Keenan TE,Van Allen EM,Tolaney SM,Freeman GJ,Dillon DA,Muthuswamy SK,Polyak K

200-06 was used in Tissue/organ culture to address how there are no good murine models of estrogen receptor-positive (ER+) breast cancer and demonstrate that Nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats recapitulate the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.

Fri Jun 03 00:00:00 EDT 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

200-06 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

200-06 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling.

Cancer science

Wang Q,Chen Y,Xie Y,Yang D,Sun Y,Yuan Y,Chen H,Zhang Y,Huang K,Zheng L

Sun May 01 00:00:00 EDT 2022

Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models.

Frontiers in oncology

Canals Hernaez D,Hughes MR,Li Y,Mainero Rocca I,Dean P,Brassard J,Bell EM,Samudio I,Mes-Masson AM,Narimatsu Y,Clausen H,Blixt O,Roskelley CD,McNagny KM

200-06 was used in Sample Preparation (FC/FACS) to use an array of glycosylation defective cell lines to define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.

Sat Jul 16 00:00:00 EDT 2022

A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.

RNA (New York, N.Y.)

Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF

200-06 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.

Thu Sep 01 00:00:00 EDT 2022

Highly sensitive interleukin 6 detection by employing commercially ready liposomes in an LFA format.

Analytical and bioanalytical chemistry

Rink S,Kaiser B,Steiner MS,Duerkop A,Baeumner AJ

200-06 was used in Immuno-assay to demonstrate how liposomes can significantly improve the LOD of traditional gold nanoparticle (AuNP)-based assays while fully supporting a ready-to-use system for commercial application.

Fri Apr 01 00:00:00 EDT 2022

Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells.

mBio

Zuniga M,Gomes C,Chen Z,Martinez C,Devlin JC,Loke P,Rodriguez A

200-06 was used in Sample Preparation (FC/FACS) to investigate TNF-α regulation of cerebral malaria infection across the blood-brain barrier.

Wed Oct 26 00:00:00 EDT 2022

Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.

Frontiers in immunology

Wang H,Xie L,Song X,Wang J,Li X,Lin Z,Su T,Liang B,Huang D

200-06 was used in Cell Culture to explore whether exogenous purines are responsible for increased xanthine oxidoreductase expression and activity.

Thu Mar 03 00:00:00 EST 2022

Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.

Nature communications

Igarashi N,Miyata K,Loo TM,Chiba M,Hanyu A,Nishio M,Kawasaki H,Zheng H,Toyokuni S,Kon S,Moriyama K,Fujita Y,Takahashi A

200-06 was used in Competition Assay to provide evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.

Mon Jul 18 00:00:00 EDT 2022

JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.

JCI insight

Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA

200-06 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.

Wed Jun 08 00:00:00 EDT 2022

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.

JID innovations : skin science from molecules to population health

Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH

200-06 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.

Sat Jan 01 00:00:00 EST 2022

A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells.

Cell discovery

Karpf L,Trichot C,Faucheux L,Legbre I,Grandclaudon M,Lahoute C,Mattoo H,Pasquier B,Soumelis V

Tue Jan 04 00:00:00 EST 2022

Indirubin-3'-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma.

EBioMedicine

Yu Z,Wei X,Liu L,Sun H,Fang T,Wang L,Li Y,Sui W,Wang K,He Y,Zhao Y,Huang W,An G,Meng F,Huang C,Yu T,Anderson KC,Cheng T,Qiu L,Hao M

200-06 was used in Cell Culture to study the effects of Indirubin-3'-monoxime (I3MO), one of the derivatives of Indirubin, in the treatment of multiple myeloma (MM).

Fri Apr 01 00:00:00 EDT 2022

Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis.

Communications biology

Wang Y,Huo T,Tseng YJ,Dang L,Yu Z,Yu W,Foulks Z,Murdaugh RL,Ludtke SJ,Nakada D,Wang Z

Thu Jan 20 00:00:00 EST 2022

Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress.

Cell death & disease

Al Haq AT,Tseng HY,Chen LM,Wang CC,Hsu HL

Tue Jan 11 00:00:00 EST 2022

Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress.

Cell death & disease

Al Haq AT,Tseng HY,Chen LM,Wang CC,Hsu HL

Tue Jan 11 00:00:00 EST 2022

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.

Life science alliance

Schneider MM,Emmenegger M,Xu CK,Condado Morales I,Meisl G,Turelli P,Zografou C,Zimmermann MR,Frey BM,Fiedler S,Denninger V,Jacquat RP,Madrigal L,Ilsley A,Kosmoliaptsis V,Fiegler H,Trono D,Knowles TP,Aguzzi A

Tue Feb 01 00:00:00 EST 2022

Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.

Viruses

Cruz-Lorenzo E,Ramirez NP,Lee J,Pandhe S,Wang L,Hernandez-Doria J,Spivak AM,Planelles V,Petersen T,Jain MK,Martinez ED,D'Orso I

200-06 was used in Cell Culture to suggest that manipulation of redox-sensitive pathways could be exploited to alter the course of HIV-1 latency, thus rendering host cells responsive to help achieve a sterilizing cure.

Tue Oct 18 00:00:00 EDT 2022

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.

Cellular and molecular gastroenterology and hepatology

Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR

200-06 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.

Mon Apr 04 00:00:00 EDT 2022

Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs.

STAR protocols

Dannenmann B,Skokowa J

200-06 was used in Cell Culture to provide protocol for generation of HPCs from iPSCs followed by HPC expansion on Sl/Sl feeder cells expressing FLT3L.

Fri Jun 17 00:00:00 EDT 2022

SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer.

American journal of cancer research

Xie SY,Shi DB,Ouyang Y,Lin F,Chen XY,Jiang TC,Xia W,Guo L,Lin HX

200-06 was used in In vitro experiments to indicate that SHMT2 plays a critical role in regulating breast cancer growth through MAPK, and VEGF signaling pathways.

Tue Aug 16 00:00:00 EDT 2022

Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.

Cell discovery

Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L

200-06 was used in Cell Culture to demonstrate that interferon-mediated cell cycle control underlies the clinical efficacy of glucocorticoids.

Tue May 10 00:00:00 EDT 2022

Central role of Prominin-1 in lipid rafts during liver regeneration.

Nature communications

Bahn MS,Yu DM,Lee M,Jo SJ,Lee JW,Kim HC,Lee H,Kim HL,Kim A,Hong JH,Kim JS,Koo SH,Lee JS,Ko YG

200-06 was used in In vitro experiments to reveal that Prominin-1 interacts with the interleukin-6 signal transducer glycoprotein 130, confining it to lipid rafts so that STAT3 signaling by IL-6 is effectively activated.

Thu Oct 20 00:00:00 EDT 2022

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.

Nature medicine

Ogishi M,Yang R,Aytekin C,Langlais D,Bourgey M,Khan T,Ali FA,Rahman M,Delmonte OM,Chrabieh M,Zhang P,Gruber C,Pelham SJ,Spaan AN,Rosain J,Lei WT,Drutman S,Hellmann MD,Callahan MK,Adamow M,Wong P,Wolchok JD,Rao G,Ma CS,Nakajima Y,Yaguchi T,Chamoto K,Williams SC,Emile JF,Rozenberg F,Glickman MS,Rapaport F,Kerner G,Allington G,Tezcan I,Cagdas D,Hosnut FO,Dogu F,Ikinciogullari A,Rao VK,Kainulainen L,Béziat V,Bustamante J,Vilarinho S,Lifton RP,Boisson B,Abel L,Bogunovic D,Marr N,Notarangelo LD,Tangye SG,Honjo T,Gros P,Boisson-Dupuis S,Casanova JL

200-06 was used in Sample Preparation (FC/FACS) to highlight the indispensable role of human PD-1 in governing both antimycobacterial immunity and self-tolerance, while identifying potentially actionable molecular targets for the diagnostic and therapeutic management of TB and autoimmunity in patients on PD-1 blockade.

Wed Sep 01 00:00:00 EDT 2021

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

Cell

Mills RJ,Humphrey SJ,Fortuna PRJ,Lor M,Foster SR,Quaife-Ryan GA,Johnston RL,Dumenil T,Bishop C,Rudraraju R,Rawle DJ,Le T,Zhao W,Lee L,Mackenzie-Kludas C,Mehdiabadi NR,Halliday C,Gilham D,Fu L,Nicholls SJ,Johansson J,Sweeney M,Wong NCW,Kulikowski E,Sokolowski KA,Tse BWC,Devilée L,Voges HK,Reynolds LT,Krumeich S,Mathieson E,Abu-Bonsrah D,Karavendzas K,Griffen B,Titmarsh D,Elliott DA,McMahon J,Suhrbier A,Subbarao K,Porrello ER,Smyth MJ,Engwerda CR,MacDonald KPA,Bald T,James DE,Hudson JE

Thu Apr 15 00:00:00 EDT 2021

Spatially organized multicellular immune hubs in human colorectal cancer.

Cell

Pelka K,Hofree M,Chen JH,Sarkizova S,Pirl JD,Jorgji V,Bejnood A,Dionne D,Ge WH,Xu KH,Chao SX,Zollinger DR,Lieb DJ,Reeves JW,Fuhrman CA,Hoang ML,Delorey T,Nguyen LT,Waldman J,Klapholz M,Wakiro I,Cohen O,Albers J,Smillie CS,Cuoco MS,Wu J,Su MJ,Yeung J,Vijaykumar B,Magnuson AM,Asinovski N,Moll T,Goder-Reiser MN,Applebaum AS,Brais LK,DelloStritto LK,Denning SL,Phillips ST,Hill EK,Meehan JK,Frederick DT,Sharova T,Kanodia A,Todres EZ,Jané-Valbuena J,Biton M,Izar B,Lambden CD,Clancy TE,Bleday R,Melnitchouk N,Irani J,Kunitake H,Berger DL,Srivastava A,Hornick JL,Ogino S,Rotem A,Vigneau S,Johnson BE,Corcoran RB,Sharpe AH,Kuchroo VK,Ng K,Giannakis M,Nieman LT,Boland GM,Aguirre AJ,Anderson AC,Rozenblatt-Rosen O,Regev A,Hacohen N

Thu Sep 02 00:00:00 EDT 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

200-06 was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.

Tue Jan 12 00:00:00 EST 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

200-06 was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.

Tue Jan 12 00:00:00 EST 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

200-06 was used in Cell Culture to show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.

Tue Jan 12 00:00:00 EST 2021

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.

Nature genetics

Yun H,Narayan N,Vohra S,Giotopoulos G,Mupo A,Madrigal P,Sasca D,Lara-Astiaso D,Horton SJ,Agrawal-Singh S,Meduri E,Basheer F,Marando L,Gozdecka M,Dovey OM,Castillo-Venzor A,Wang X,Gallipoli P,Müller-Tidow C,Osborne CS,Vassiliou GS,Huntly BJP

Fri Oct 01 00:00:00 EDT 2021

N⁶-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

Cancer cell

Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG

200-06 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.

Mon Jul 12 00:00:00 EDT 2021

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.

Cancer discovery

Montefiori LE,Bendig S,Gu Z,Chen X,Pölönen P,Ma X,Murison A,Zeng A,Garcia-Prat L,Dickerson K,Iacobucci I,Abdelhamed S,Hiltenbrand R,Mead PE,Mehr CM,Xu B,Cheng Z,Chang TC,Westover T,Ma J,Stengel A,Kimura S,Qu C,Valentine MB,Rashkovan M,Luger S,Litzow MR,Rowe JM,den Boer ML,Wang V,Yin J,Kornblau SM,Hunger SP,Loh ML,Pui CH,Yang W,Crews KR,Roberts KG,Yang JJ,Relling MV,Evans WE,Stock W,Paietta EM,Ferrando AA,Zhang J,Kern W,Haferlach T,Wu G,Dick JE,Klco JM,Haferlach C,Mullighan CG

200-06 was used in In vitro experiments to identify oncogenic deregulation of BCL11B driven by diverse structural alterations, including de novo superenhancer generation, as the driving feature of a subset of lineage-ambiguous leukemias that transcend current diagnostic boundaries.

Mon Nov 01 00:00:00 EDT 2021

MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.

Cell stem cell

Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD

200-06 was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.

Thu Jan 07 00:00:00 EST 2021

Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.

Cell stem cell

Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S

Thu Mar 04 00:00:00 EST 2021

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.

Molecular cell

Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM

200-06 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.

Thu Jul 01 00:00:00 EDT 2021

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.

Science translational medicine

Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N

Wed Jun 16 00:00:00 EDT 2021

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome.

The Journal of experimental medicine

Stackowicz J,Gaudenzio N,Serhan N,Conde E,Godon O,Marichal T,Starkl P,Balbino B,Roers A,Bruhns P,Jönsson F,Moguelet P,Georgin-Lavialle S,Broderick L,Hoffman HM,Galli SJ,Reber LL

Mon Oct 04 00:00:00 EDT 2021

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

Mon Feb 01 00:00:00 EST 2021

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.

Arthritis & rheumatology (Hoboken, N.J.)

Vecellio M,Chen L,Cohen CJ,Cortes A,Li Y,Bonham S,Selmi C,Brown MA,Fischer R,Knight JC,Wordsworth BP

Tue Jun 01 00:00:00 EDT 2021

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

EMBO molecular medicine

Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P

Fri Mar 05 00:00:00 EST 2021

Modeling genetic epileptic encephalopathies using brain organoids.

EMBO molecular medicine

Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI

Mon Aug 09 00:00:00 EDT 2021

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.

Leukemia

Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM

Mon Nov 01 00:00:00 EDT 2021

Reducing TGF-β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34⁺ cells by inhibiting AhR signalling.

Cell proliferation

Zhu X,Sun Q,Tan WS,Cai H

Mon Mar 01 00:00:00 EST 2021

Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.

Stem cells translational medicine

Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H

Tue Jun 01 00:00:00 EDT 2021

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.

Blood advances

Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG

Tue Dec 14 00:00:00 EST 2021

Proinflammatory Features of Stem Cell-like Memory T Cells from Human Patients with Rheumatoid Arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Lee YJ,Park EH,Park JW,Jung KC,Lee EB

Thu Jul 15 00:00:00 EDT 2021

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Xie B,Khoyratty TE,Abu-Shah E,F Cespedes P,MacLean AJ,Pirgova G,Hu Z,Ahmed AA,Dustin ML,Udalova IA,Arnon TI

Thu Apr 01 00:00:00 EDT 2021

Scaffold compound L971 exhibits anti-inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways.

Journal of cellular and molecular medicine

Li M,Yan Y,Zhang X,Zhang Y,Xu X,Zhang L,Lu L,Wang J,Zhang Y,Song Q,Zhao C

Thu May 20 00:00:00 EDT 2021

Bortezomib suppresses self-renewal and leukemogenesis of leukemia stem cell by NF-ĸB-dependent inhibition of CDK6 in MLL-rearranged myeloid leukemia.

Journal of cellular and molecular medicine

Zhou B,Qin Y,Zhou J,Ruan J,Xiong F,Dong J,Huang X,Yu Z,Gao S

Mon Mar 01 00:00:00 EST 2021

Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell.

Mediators of inflammation

Tien PT,Lin CH,Chen CS,Chang CY,Ku H,Gan D,Tsai YY,Chen JJ,Lin HJ,Wan L

Thu Mar 31 00:00:00 EDT 2022

IL6R is a target of miR-197 in human keratinocytes.

Experimental dermatology

Masalha M,Gur-Wahnon D,Meningher T,Ben-Dov IZ,Kassem R,Sidi Y,Avni D

Sun Aug 01 00:00:00 EDT 2021

Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.

Transfusion

Cunningham S,Hackstein H

Tue Jun 01 00:00:00 EDT 2021

Single nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy.

Molecular biology reports

Tang H,Fang H,Guo W,Cao S,Guo D,Zhang H,Gao J,Zhang S

200-06 was used in Sample Preparation (FC/FACS) to investigate the function of IL-6 SNPs on ischemia-reperfusion injury prevention.

Mon Feb 01 00:00:00 EST 2021

Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer.

Cancer communications (London, England)

Yang S,He X,Zhao J,Wang D,Guo S,Gao T,Wang G,Jin C,Yan Z,Wang N,Wang Y,Zhao Y,Xing J,Huang Q

Sun Aug 01 00:00:00 EDT 2021

Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling.

Cell death & disease

Zhong B,Cheng B,Huang X,Xiao Q,Niu Z,Chen YF,Yu Q,Wang W,Wu XJ

Mon Dec 20 00:00:00 EST 2021

Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling.

Cell death & disease

Zhong B,Cheng B,Huang X,Xiao Q,Niu Z,Chen YF,Yu Q,Wang W,Wu XJ

Mon Dec 20 00:00:00 EST 2021

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.

Nature communications

Biavasco R,Lettera E,Giannetti K,Gilioli D,Beretta S,Conti A,Scala S,Cesana D,Gallina P,Norelli M,Basso-Ricci L,Bondanza A,Cavalli G,Ponzoni M,Dagna L,Doglioni C,Aiuti A,Merelli I,Di Micco R,Montini E

Tue Jul 27 00:00:00 EDT 2021

Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.

Nature communications

Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M

Fri May 21 00:00:00 EDT 2021

SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody.

Vaccines

Jugler C,Sun H,Chen Q

Sat Nov 20 00:00:00 EST 2021

PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cai C,Gu S,Yu Y,Zhu Y,Zhang H,Yuan B,Shen L,Yang B,Feng XH

Sat May 01 00:00:00 EDT 2021

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.

iScience

Zee BM,Poels KE,Yao CH,Kawabata KC,Wu G,Duy C,Jacobus WD,Senior E,Endress JE,Jambhekar A,Lovitch SB,Ma J,Dhall A,Harris IS,Blanco MA,Sykes DB,Licht JD,Weinstock DM,Melnick A,Haigis MC,Michor F,Shi Y

Fri Jun 25 00:00:00 EDT 2021

Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector.

Molecular therapy. Methods & clinical development

Dahl M,Smith EMK,Warsi S,Rothe M,Ferraz MJ,Aerts JMFG,Golipour A,Harper C,Pfeifer R,Pizzurro D,Schambach A,Mason C,Karlsson S

Fri Mar 12 00:00:00 EST 2021

Dyshomeostatic modulation of Ca²⁺-activated K⁺ channels in a human neuronal model of KCNQ2 encephalopathy.

eLife

Simkin D,Marshall KA,Vanoye CG,Desai RR,Bustos BI,Piyevsky BN,Ortega JA,Forrest M,Robertson GL,Penzes P,Laux LC,Lubbe SJ,Millichap JJ,George AL,Kiskinis E

200-06 was used in Cell Culture to measure the functional properties of differentiated excitatory neurons in an induced pluripotent stem cell (iPSCs) and gene editing established disease model.

Fri Feb 05 00:00:00 EST 2021

Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.

ImmunoHorizons

Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD

200-06 was used in Cell Culture to investigate correlations between cytokine expression and mortality.

Wed Jul 21 00:00:00 EDT 2021

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.

STAR protocols

Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD

200-06 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.

Fri Dec 17 00:00:00 EST 2021

Directly reprogrammed natural killer cells for cancer immunotherapy.

Nature biomedical engineering

Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS

Mon Nov 01 00:00:00 EDT 2021

Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.

Nature communications

Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT

Thu Oct 28 00:00:00 EDT 2021

Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.

Scientific reports

Estrada A,Rodriguez AC,Rodriguez G,Grant AH,Ayala-Marin YM,Arrieta AJ,Kirken RA

Fri Aug 20 00:00:00 EDT 2021

A two-herb formula inhibits hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes.

Scientific reports

Chen YJ,Liu YX,Wu JY,Li CY,Tang MM,Bai L,Fu XQ,Li JK,Chou JY,Yin CL,Wang YP,Bai JX,Wu Y,Wang XQ,Yu ZL

Tue Feb 16 00:00:00 EST 2021

Methylation of dual-specificity phosphatase 4 controls cell differentiation.

Cell reports

Su H,Jiang M,Senevirathne C,Aluri S,Zhang T,Guo H,Xavier-Ferrucio J,Jin S,Tran NT,Liu SM,Sun CW,Zhu Y,Zhao Q,Chen Y,Cable L,Shen Y,Liu J,Qu CK,Han X,Klug CA,Bhatia R,Chen Y,Nimer SD,Zheng YG,Iancu-Rubin C,Jin J,Deng H,Krause DS,Xiang J,Verma A,Luo M,Zhao X

Tue Jul 27 00:00:00 EDT 2021

Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.

Cell death & disease

Zhang W,Yin G,Zhao H,Ling H,Xie Z,Xiao C,Chen Y,Lin Y,Jiang T,Jin S,Wang J,Yang X

Wed Jan 20 00:00:00 EST 2021

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms.

Scientific reports

Wang Y,Mohseni M,Grauel A,Diez JE,Guan W,Liang S,Choi JE,Pu M,Chen D,Laszewski T,Schwartz S,Gu J,Mansur L,Burks T,Brodeur L,Velazquez R,Kovats S,Pant B,Buruzula G,Deng E,Chen JT,Sari-Sarraf F,Dornelas C,Varadarajan M,Yu H,Liu C,Lim J,Hao HX,Jiang X,Malamas A,LaMarche MJ,Geyer FC,McLaughlin M,Costa C,Wagner J,Ruddy D,Jayaraman P,Kirkpatrick ND,Zhang P,Iartchouk O,Aardalen K,Cremasco V,Dranoff G,Engelman JA,Silver S,Wang H,Hastings WD,Goldoni S

Thu Jan 14 00:00:00 EST 2021

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.

Nature communications

Boutin J,Rosier J,Cappellen D,Prat F,Toutain J,Pennamen P,Bouron J,Rooryck C,Merlio JP,Lamrissi-Garcia I,Cullot G,Amintas S,Guyonnet-Duperat V,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,Bedel A

Fri Aug 13 00:00:00 EDT 2021

In vitro expansion of fetal liver hematopoietic stem cells.

Scientific reports

Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V

Fri Jun 04 00:00:00 EDT 2021

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.

Scientific reports

Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS

Fri Mar 05 00:00:00 EST 2021

SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.

Cell reports

Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II

200-06 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.

Tue Feb 16 00:00:00 EST 2021

Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors.

The Journal of biological chemistry

Qin L,Cao X,Kaneko T,Voss C,Liu X,Wang G,Li SS

200-06 was used in In vitro experiments to report here that growth factor-induced epithelial cell migration is critically dependent on the crosstalk of two molecular switches, namely phosphorylation switch (P-switch) and transcriptional switch (T-switch).

Fri Oct 01 00:00:00 EDT 2021

CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data.

Nature communications

Amit I,Iancu O,Levy-Jurgenson A,Kurgan G,McNeill MS,Rettig GR,Allen D,Breier D,Ben Haim N,Wang Y,Anavy L,Hendel A,Yakhini Z

Mon May 24 00:00:00 EDT 2021

Higher PGD₂ production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis.

Scientific reports

Mishima S,Kashiwakura JI,Toyoshima S,Sasaki-Sakamoto T,Sano Y,Nakanishi K,Matsumoto K,Okayama Y

Thu Mar 11 00:00:00 EST 2021

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.

Communications biology

Lee HK,Jung O,Hennighausen L

Wed Jun 02 00:00:00 EDT 2021

The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.

Nature communications

Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R

Wed Jan 20 00:00:00 EST 2021

Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.

Nature communications

Georgolopoulos G,Psatha N,Iwata M,Nishida A,Som T,Yiangou M,Stamatoyannopoulos JA,Vierstra J

Tue Nov 23 00:00:00 EST 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Nature communications

Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM

Mon Mar 01 00:00:00 EST 2021

JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules.

iScience

Jankowski J,Lee HK,Wilflingseder J,Hennighausen L

Fri Aug 20 00:00:00 EDT 2021

Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.

Stem cell research & therapy

Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N

200-06 was used in Cell Culture to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.

Tue Sep 28 00:00:00 EDT 2021

Trilobolide-6-O-isobutyrate suppresses hepatocellular carcinoma tumorigenesis through inhibition of IL-6/STAT3 signaling pathway.

Phytotherapy research : PTR

Zhou XQ,Mao XM,Fan R,Li SY,Shang J,Zhang T,Li RH,Li HQ,Hui Y,Chen WH,Wang ZX,Shen DY

200-06 was used in In vitro experiments to indicate that TBB inhibited the STAT3 pathway activation by directly interacting with the TYR 640/657 sites of the STAT3 protein and decreasing the level of p-STAT3.

Fri Oct 01 00:00:00 EDT 2021

Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production.

Science advances

Tao P,Wang S,Ozen S,Lee PY,Zhang J,Wang J,Han H,Yang Z,Fang R,Tsai WL,Yang H,Sag E,Topaloglu R,Aksentijevich I,Yu X,Zhou Q

200-06 was used in In vitro experiments to reveal an important role of linear ubiquitination in the regulation of proteasome function and suggest a link in the pathogenesis of proteasome-associated autoinflammatory syndromes and OTULIN deficiency.

Fri Nov 19 00:00:00 EST 2021

Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production.

Science advances

Tao P,Wang S,Ozen S,Lee PY,Zhang J,Wang J,Han H,Yang Z,Fang R,Tsai WL,Yang H,Sag E,Topaloglu R,Aksentijevich I,Yu X,Zhou Q

Fri Nov 19 00:00:00 EST 2021

Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide.

Scientific reports

Ueno T,Yamamoto Y,Kawasaki K

Wed Mar 24 00:00:00 EDT 2021

The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.

Frontiers in immunology

Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E

200-06 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.

Mon Dec 27 00:00:00 EST 2021

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.

Nature

Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S

Tue Sep 01 00:00:00 EDT 2020

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

Cell

Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR

Thu May 28 00:00:00 EDT 2020

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nature genetics

Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC

200-06 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).

Wed Apr 01 00:00:00 EDT 2020

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J

200-06 was used in In vitro experiments to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.

Mon Jul 13 00:00:00 EDT 2020

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Cancer cell

Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C

Mon May 11 00:00:00 EDT 2020

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.

Blood

Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR

Thu Jan 02 00:00:00 EST 2020

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell stem cell

Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

200-06 was used in Cell Culture to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.

Thu Jul 02 00:00:00 EDT 2020

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.

Cell stem cell

Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A

200-06 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.

Thu Nov 05 00:00:00 EST 2020

Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections.

The Journal of clinical investigation

Suzuki T,Sato Y,Sano K,Arashiro T,Katano H,Nakajima N,Shimojima M,Kataoka M,Takahashi K,Wada Y,Morikawa S,Fukushi S,Yoshikawa T,Saijo M,Hasegawa H

Mon Feb 03 00:00:00 EST 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.

The Journal of clinical investigation

Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q

Wed Jul 01 00:00:00 EDT 2020

Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.

Allergy

Le Floc'h A,Allinne J,Nagashima K,Scott G,Birchard D,Asrat S,Bai Y,Lim WK,Martin J,Huang T,Potocky TB,Kim JH,Rafique A,Papadopoulos NJ,Stahl N,Yancopoulos GD,Murphy AJ,Sleeman MA,Orengo JM

Fri May 01 00:00:00 EDT 2020

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.

Developmental cell

Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE

200-06 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.

Mon Oct 26 00:00:00 EDT 2020

Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.

Proceedings of the National Academy of Sciences of the United States of America

Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ

Tue May 19 00:00:00 EDT 2020

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.

Proceedings of the National Academy of Sciences of the United States of America

Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A

Tue Jul 28 00:00:00 EDT 2020

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.

Proceedings of the National Academy of Sciences of the United States of America

Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F

Tue Feb 11 00:00:00 EST 2020

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.

Proceedings of the National Academy of Sciences of the United States of America

Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F

Tue Feb 11 00:00:00 EST 2020

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Cribbs AP,Terlecki-Zaniewicz S,Philpott M,Baardman J,Ahern D,Lindow M,Obad S,Oerum H,Sampey B,Mander PK,Penn H,Wordsworth P,Bowness P,de Winther M,Prinjha RK,Feldmann M,Oppermann U

Tue Mar 17 00:00:00 EDT 2020

Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.

Aging cell

Shang D,Sun D,Shi C,Xu J,Shen M,Hu X,Liu H,Tu Z

Fri May 01 00:00:00 EDT 2020

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.

Oncogene

Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA

Wed Apr 01 00:00:00 EDT 2020

Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34⁺ cells via inhibition of senescence.

Stem cells translational medicine

Li X,Ma X,Chen Y,Peng D,Wang H,Chen S,Xiao Y,Li L,Zhou H,Cheng F,Gao Y,Chang J,Cheng T,Liu L

Tue Dec 01 00:00:00 EST 2020

IQGAP1 restrains T-cell cosignaling mediated by OX40.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T

Wed Jan 01 00:00:00 EST 2020

Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6.

Experimental neurology

Jia C,Keasey MP,Malone HM,Lovins C,Hagg T

200-06 was used in In vivo experiments to show that Vitronectin leaks from the bloodstream into the injury site and neighboring subventricular zone following ischemic stroke in adult mice.

Wed Jan 01 00:00:00 EST 2020

Inhibition of IRE1/JNK pathway in HK-2 cells subjected to hypoxia-reoxygenation attenuates mesangial cells-derived extracellular matrix production.

Journal of cellular and molecular medicine

Liang Y,Liang L,Liu Z,Wang Y,Dong X,Qu L,Gou R,Wang Y,Wang Q,Liu Z,Tang L

Sun Nov 01 00:00:00 EDT 2020

Targeting STAT3 enhances NDV-induced immunogenic cell death in prostate cancer cells.

Journal of cellular and molecular medicine

Wang X,Shao X,Gu L,Jiang K,Wang S,Chen J,Fang J,Guo X,Yuan M,Shi J,Ding C,Meng S,Xu Q

Wed Apr 01 00:00:00 EDT 2020

Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.

Journal of cellular and molecular medicine

Chiu CZ,Wang BW,Yu YJ,Shyu KG

Sat Feb 01 00:00:00 EST 2020

Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice.

Journal of cellular and molecular medicine

Shi W,Ma H,Liu T,Yan D,Luo P,Zhai M,Tao J,Huo S,Guo J,Li C,Lin J,Zhang C,Li S,Lv J,Lin L

Wed Apr 01 00:00:00 EDT 2020

Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice.

Journal of cellular and molecular medicine

Shi W,Ma H,Liu T,Yan D,Luo P,Zhai M,Tao J,Huo S,Guo J,Li C,Lin J,Zhang C,Li S,Lv J,Lin L

Wed Apr 01 00:00:00 EDT 2020

Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform.

Clinical and translational science

Guan X,Wang L,Wang H,Wang H,Dai W,Jiang Y

Sun Nov 01 00:00:00 EDT 2020

MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities.

Journal of immunotoxicology

Lafleur MA,Werner J,Fort M,Lobenhofer EK,Balazs M,Goyos A

200-06 was used in Sample Preparation (FC/FACS) to investigate the use of assessing MRGPRX2 activation in engineered cells in screening for mast cell degranulation for peptide-based therapeutics.

Tue Dec 01 00:00:00 EST 2020

Stat-3 signaling promotes cell proliferation and metastasis of gastric cancer through PDCD4 downregulation.

The Kaohsiung journal of medical sciences

Yang YL,Liu P,Li D,Yang Q,Li B,Jiang XJ

Wed Apr 01 00:00:00 EDT 2020

Expression of keratins 8, 18, and 19 in epithelia of atrophic oral lichen planus.

European journal of oral sciences

Schreurs O,Karatsaidis A,Balta MG,Grung B,Hals EKB,Schenck K

Sat Feb 01 00:00:00 EST 2020

Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing.

Scientific reports

Shin JU,Abaci HE,Herron L,Guo Z,Sallee B,Pappalardo A,Jackow J,Wang EHC,Doucet Y,Christiano AM

Thu Mar 05 00:00:00 EST 2020

Phosphoregulated orthogonal signal transduction in mammalian cells.

Nature communications

Scheller L,Schmollack M,Bertschi A,Mansouri M,Saxena P,Fussenegger M

Thu Jun 18 00:00:00 EDT 2020

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming.

Cell reports

Yan P,Liu Z,Song M,Wu Z,Xu W,Li K,Ji Q,Wang S,Liu X,Yan K,Esteban CR,Ci W,Belmonte JCI,Xie W,Ren J,Zhang W,Sun Q,Qu J,Liu GH

200-06 was used in Sample Preparation (FC/FACS) to study the homeostasis of DNA:RNA hybrid regulation of chromatin and genome organization by characterizing R-loops, DNA methylation, histone modifications, and chromatin accessibility in pluripotent cells and their lineage-differentiated derivatives.

Tue Jul 07 00:00:00 EDT 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

200-06 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 EST 2020

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.

Stem cell reports

Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM

Tue Feb 11 00:00:00 EST 2020

Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation.

FASEB bioAdvances

Aki A,Tanaka K,Nagaoka N,Kimura T,Baba D,Onodera Y,Wada T,Maeda H,Nakanishi T,Agatsuma T,Komai T

Sat Aug 01 00:00:00 EDT 2020

Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.

Nature communications

Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD

Mon Aug 31 00:00:00 EDT 2020

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.

Molecular systems biology

Oberhuber M,Pecoraro M,Rusz M,Oberhuber G,Wieselberg M,Haslinger P,Gurnhofer E,Schlederer M,Limberger T,Lagger S,Pencik J,Kodajova P,Högler S,Stockmaier G,Grund-Gröschke S,Aberger F,Bolis M,Theurillat JP,Wiebringhaus R,Weiss T,Haitel A,Brehme M,Wadsak W,Griss J,Mohr T,Hofer A,Jäger A,Pollheimer J,Egger G,Koellensperger G,Mann M,Hantusch B,Kenner L

Wed Apr 01 00:00:00 EDT 2020

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics.

Science immunology

Alshetaiwi H,Pervolarakis N,McIntyre LL,Ma D,Nguyen Q,Rath JA,Nee K,Hernandez G,Evans K,Torosian L,Silva A,Walsh C,Kessenbrock K

200-06 was used in Sample Preparation (FC/FACS) to establish the MDSC-specific gene signature and identify CD84 as a surface marker for improved detection and enrichment of MDSCs in breast cancers.

Fri Feb 21 00:00:00 EST 2020

Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.

Cell death & disease

Luo B,Zhan Y,Luo M,Dong H,Liu J,Lin Y,Zhang J,Wang G,Verhoeyen E,Zhang Y,Zhang H

Thu Nov 12 00:00:00 EST 2020

Interleukin-6 signaling requires only few IL-6 molecules: Relation to physiological concentrations of extracellular IL-6.

Immunity, inflammation and disease

Hansen MB

Mon Jun 01 00:00:00 EDT 2020

Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.

Cells

Mandelli GE,Missale F,Bresciani D,Gatta LB,Scapini P,Caveggion E,Roca E,Bugatti M,Monti M,Cristinelli L,Belotti S,Simeone C,Calza S,Melocchi L,Vermi W

200-06 was used in In vitro experiments to explore the density and clinical significance of CD66b+ tumor-associated-neutrophils (TAN) and CD3+ T cells.

Sat Jan 25 00:00:00 EST 2020

Mast Cell Activation Test (MAT).

Methods in molecular biology (Clifton, N.J.)

Bahri R,Bulfone-Paus S

200-06 was used in In vitro experiments to describe the use of the mast cell activation test (MAT) that makes use of human primary MCs generated from peripheral blood progenitors, sensitized overnight with patients' sera and activated with allergens.

Fri Feb 26 00:00:00 EST 2021

Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System.

Molecular therapy. Methods & clinical development

Shapiro J,Iancu O,Jacobi AM,McNeill MS,Turk R,Rettig GR,Amit I,Tovin-Recht A,Yakhini Z,Behlke MA,Hendel A

Fri Jun 12 00:00:00 EDT 2020

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.

Cell reports

Niederkorn M,Hueneman K,Choi K,Varney ME,Romano L,Pujato MA,Greis KD,Inoue JI,Meetei R,Starczynowski DT

200-06 was used in Cell Culture to study how forkhead-associated domain B (TIFAB) regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity using a combination of proteomic and genetic approaches to uncover a function of TIFAB as an effector of USP15 activity and rheostat of p53 signaling in stressed and malignant hematopoietic stem/progenitor cells (HSPCs).

Tue Feb 25 00:00:00 EST 2020

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.

Nature communications

Barbier V,Erbani J,Fiveash C,Davies JM,Tay J,Tallack MR,Lowe J,Magnani JL,Pattabiraman DR,Perkins AC,Lisle J,Rasko JEJ,Levesque JP,Winkler IG

Mon Apr 27 00:00:00 EDT 2020

STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model.

Cells

Kim BH,Lee H,Park CG,Jeong AJ,Lee SH,Noh KH,Park JB,Lee CG,Paek SH,Kim H,Ye SK

200-06 was used in Cell Culture to demonstrate the therapeutic efficacy of ODZ10117 in glioblastoma by targeting STAT3.

Sun Mar 15 00:00:00 EDT 2020

Human blood vessel organoids as a model of diabetic vasculopathy.

Nature

Wimmer RA,Leopoldi A,Aichinger M,Wick N,Hantusch B,Novatchkova M,Taubenschmid J,Hämmerle M,Esk C,Bagley JA,Lindenhofer D,Chen G,Boehm M,Agu CA,Yang F,Fu B,Zuber J,Knoblich JA,Kerjaschki D,Penninger JM

Tue Jan 01 00:00:00 EST 2019

A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.

Cell

Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V

200-06 was used in Sample Prep to describe an integrative approach involving protein-level measurement of multiple communication signals coupled to output responses in receiving cells and mathematical modeling to uncover input-output relationships and interactions between signals.

Thu Oct 03 00:00:00 EDT 2019

A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.

Cell

Grandclaudon M,Perrot-Dockès M,Trichot C,Karpf L,Abouzid O,Chauvin C,Sirven P,Abou-Jaoudé W,Berger F,Hupé P,Thieffry D,Sansonnet L,Chiquet J,Lévy-Leduc C,Soumelis V

Thu Oct 03 00:00:00 EDT 2019

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.

Immunity

Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

Tue Aug 20 00:00:00 EDT 2019

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.

Immunity

Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H

Tue Nov 19 00:00:00 EST 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

Cancer cell

Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH

Mon Aug 12 00:00:00 EDT 2019

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells.

Blood

Hu T,Morita K,Hill MC,Jiang Y,Kitano A,Saito Y,Wang F,Mao X,Hoegenauer KA,Morishita K,Martin JF,Futreal PA,Takahashi K,Nakada D

Thu Aug 15 00:00:00 EDT 2019

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.

Blood

Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S

Thu Jul 11 00:00:00 EDT 2019

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

The Journal of clinical investigation

Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC

Mon Jul 15 00:00:00 EDT 2019

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.

The Journal of clinical investigation

Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C

Fri Mar 01 00:00:00 EST 2019

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.

Science translational medicine

Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM

200-06 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.

Wed Oct 30 00:00:00 EDT 2019

CD97 is a critical regulator of acute myeloid leukemia stem cell function.

The Journal of experimental medicine

Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY

Mon Oct 07 00:00:00 EDT 2019

CD97 is a critical regulator of acute myeloid leukemia stem cell function.

The Journal of experimental medicine

Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY

Mon Oct 07 00:00:00 EDT 2019

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.

The Journal of experimental medicine

Spencer S,Köstel Bal S,Egner W,Lango Allen H,Raza SI,Ma CA,Gürel M,Zhang Y,Sun G,Sabroe RA,Greene D,Rae W,Shahin T,Kania K,Ardy RC,Thian M,Staples E,Pecchia-Bekkum A,Worrall WPM,Stephens J,Brown M,Tuna S,York M,Shackley F,Kerrin D,Sargur R,Condliffe A,Tipu HN,Kuehn HS,Rosenzweig SD,Turro E,Tavaré S,Thrasher AJ,Jodrell DI,Smith KGC,Boztug K,Milner JD,Thaventhiran JED

Mon Sep 02 00:00:00 EDT 2019

EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation.

Leukemia

Herviou L,Jourdan M,Martinez AM,Cavalli G,Moreaux J

Thu Aug 01 00:00:00 EDT 2019

Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity.

Experimental & molecular medicine

Kim DH,Park HJ,Park HS,Lee JU,Ko C,Gye MC,Choi JM

Mon Apr 15 00:00:00 EDT 2019

Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells.

Cell proliferation

Sheng Y,Ji Z,Zhao H,Wang J,Cheng C,Xu W,Wang X,He Y,Liu K,Li L,Voeltzel T,Maguer-Satta V,Gao WQ,Zhu HH

Mon Jul 01 00:00:00 EDT 2019

Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34⁺ Cells Using Gas-Permeable Surfaces.

Stem cells translational medicine

Martinez AF,Miller WM

Mon Jul 01 00:00:00 EDT 2019

Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.

Antioxidants & redox signaling

Halvarsson C,Rörby E,Eliasson P,Lang S,Soneji S,Jönsson JI

200-06 was used in Cell Culture to investigate if HIF-1α protects hematopoietic stem cells against ROS.

Sat Jul 20 00:00:00 EDT 2019

EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production.

PLoS pathogens

Luo Z,Su R,Wang W,Liang Y,Zeng X,Shereen MA,Bashir N,Zhang Q,Zhao L,Wu K,Liu Y,Wu J

200-06 was used in In vivo experiments to investigate the role of mechanisms of Toll-like receptor 7 during human Enterovirus 71 infection.

Fri Nov 01 00:00:00 EDT 2019

Progranulin sustains STAT3 hyper-activation and oncogenic function in colorectal cancer cells.

Molecular oncology

Laudisi F,Cherubini F,Di Grazia A,Dinallo V,Di Fusco D,Franzè E,Ortenzi A,Salvatori I,Scaricamazza S,Monteleone I,Sakamoto N,Monteleone G,Stolfi C

Tue Oct 01 00:00:00 EDT 2019

Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.

Oncogenesis

Chen CH,Bhasin S,Khanna P,Joshi M,Joslin PM,Saxena R,Amin S,Liu S,Sindhu S,Walker SR,Catalano P,Frank DA,Alper SL,Bhasin M,Bhatt RS

Fri Feb 22 00:00:00 EST 2019

Tumor necrosis factor receptor modulator spermatogenesis-associated protein 2 is a novel predictor of outcome in ovarian cancer.

Cancer science

Wieser V,Tsibulak I,Degasper C,Welponer H,Leitner K,Parson W,Zeimet AG,Marth C,Fiegl H

Fri Mar 01 00:00:00 EST 2019

Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.

Cancer science

Harada K,Ihara F,Takami M,Kamata T,Mise N,Yoshizawa H,Hishiki T,Saito T,Terui K,Nakata M,Komatsu S,Ikeuchi T,Nakayama T,Yoshida H,Motohashi S

Fri Mar 01 00:00:00 EST 2019

Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.

Stem cells (Dayton, Ohio)

Lomova A,Clark DN,Campo-Fernandez B,Flores-Bjurström C,Kaufman ML,Fitz-Gibbon S,Wang X,Miyahira EY,Brown D,DeWitt MA,Corn JE,Hollis RP,Romero Z,Kohn DB

Fri Feb 01 00:00:00 EST 2019

Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.

Stem cells (Dayton, Ohio)

Shan J,Shen J,Wu M,Zhou H,Feng J,Yao C,Yang Z,Ma Q,Luo Y,Wang Y,Qian C

Fri Nov 01 00:00:00 EDT 2019

Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Journal of immunology (Baltimore, Md. : 1950)

Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM

Fri Feb 15 00:00:00 EST 2019

Xanthatin inhibits STAT3 and NF-κB signalling by covalently binding to JAK and IKK kinases.

Journal of cellular and molecular medicine

Liu M,Xiao CQ,Sun MW,Tan MJ,Hu LH,Yu Q

Sat Jun 01 00:00:00 EDT 2019

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.

Cell reports

Aho ER,Wang J,Gogliotti RD,Howard GC,Phan J,Acharya P,Macdonald JD,Cheng K,Lorey SL,Lu B,Wenzel S,Foshage AM,Alvarado J,Wang F,Shaw JG,Zhao B,Weissmiller AM,Thomas LR,Vakoc CR,Hall MD,Hiebert SW,Liu Q,Stauffer SR,Fesik SW,Tansey WP

200-06 was used in Cell Culture to identify WIN site inhibitors and demonstrate that the WIN site links WDR5 to chromatin at a small cohort of loci, including a specific subset of ribosome protein genes.

Tue Mar 12 00:00:00 EDT 2019

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8⁺ T cell inhibition.

Nature communications

Pereira BI,Devine OP,Vukmanovic-Stejic M,Chambers ES,Subramanian P,Patel N,Virasami A,Sebire NJ,Kinsler V,Valdovinos A,LeSaux CJ,Passos JF,Antoniou A,Rustin MHA,Campisi J,Akbar AN

Mon Jun 03 00:00:00 EDT 2019

Gene correction for SCID-X1 in long-term hematopoietic stem cells.

Nature communications

Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH

200-06 was used in In vitro experiments to evaluate the use of SCID-X1 in targeting the cDNA in human long-term hematopoietic stem cells.

Tue Apr 09 00:00:00 EDT 2019

The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis.

Scientific reports

Dimou P,Wright RD,Budge KL,Midgley A,Satchell SC,Peak M,Beresford MW

Thu Jun 06 00:00:00 EDT 2019

Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59.

Cell death & disease

Zhang R,Liu Q,Peng J,Wang M,Gao X,Liao Q,Zhao Y

Mon Nov 04 00:00:00 EST 2019

A comprehensive single cell transcriptional landscape of human hematopoietic progenitors.

Nature communications

Pellin D,Loperfido M,Baricordi C,Wolock SL,Montepeloso A,Weinberg OK,Biffi A,Klein AM,Biasco L

Mon Jun 03 00:00:00 EDT 2019

Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.

Cell death & disease

Zhong B,Shi D,Wu F,Wang S,Hu H,Cheng C,Qing X,Huang X,Luo X,Zhang Z,Shao Z

Wed Sep 18 00:00:00 EDT 2019

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.

Nature communications

Martínez-García JJ,Martínez-Banaclocha H,Angosto-Bazarra D,de Torre-Minguela C,Baroja-Mazo A,Alarcón-Vila C,Martínez-Alarcón L,Amores-Iniesta J,Martín-Sánchez F,Ercole GA,Martínez CM,González-Lisorge A,Fernández-Pacheco J,Martínez-Gil P,Adriouch S,Koch-Nolte F,Luján J,Acosta-Villegas F,Parrilla P,García-Palenciano C,Pelegrin P

Thu Jun 20 00:00:00 EDT 2019

Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.

The Journal of biological chemistry

Dupont L,Du L,Poulter M,Choi S,McIntosh M,Reeves MB

Fri Aug 30 00:00:00 EDT 2019

IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.

The Journal of biological chemistry

Magoro T,Dandekar A,Jennelle LT,Bajaj R,Lipkowitz G,Angelucci AR,Bessong PO,Hahn YS

Fri Oct 04 00:00:00 EDT 2019

STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes.

Scientific reports

Edsbäcker E,Serviss JT,Kolosenko I,Palm-Apergi C,De Milito A,Tamm KP

Thu Jan 24 00:00:00 EST 2019

Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis.

The Journal of biological chemistry

Ko J,Mills T,Huang J,Chen NY,Mertens TCJ,Collum SD,Lee G,Xiang Y,Han L,Zhou Y,Lee CG,Elias JA,Jyothula SSK,Rajagopal K,Karmouty-Quintana H,Blackburn MR

Fri Oct 25 00:00:00 EDT 2019

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.

Cell reports

Huang C,Hedl M,Ranjan K,Abraham C

200-06 was used in Cell Culture to investigate that, if, upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors.

Tue Dec 24 00:00:00 EST 2019

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.

Cancers

White CL,Jayasekara WSN,Picard D,Chen J,Watkins DN,Cain JE,Remke M,Gough DJ

200-06 was used in Cell Culture to identify a sex-specific role for the transcription factor Signal Transducer and Activator of Transcription 3 in the Sonic Hedgehog medulloblastoma subgroup.

Fri Nov 01 00:00:00 EDT 2019

Expansion, isolation and first characterization of bovine Th17 lymphocytes.

Scientific reports

Cunha P,Vern YL,Gitton C,Germon P,Foucras G,Rainard P

Wed Nov 06 00:00:00 EST 2019

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

Nature communications

Papaioannou D,Petri A,Dovey OM,Terreri S,Wang E,Collins FA,Woodward LA,Walker AE,Nicolet D,Pepe F,Kumchala P,Bill M,Walker CJ,Karunasiri M,Mrózek K,Gardner ML,Camilotto V,Zitzer N,Cooper JL,Cai X,Rong-Mullins X,Kohlschmidt J,Archer KJ,Freitas MA,Zheng Y,Lee RJ,Aifantis I,Vassiliou G,Singh G,Kauppinen S,Bloomfield CD,Dorrance AM,Garzon R

Mon Nov 25 00:00:00 EST 2019

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.

Cell death & disease

Zhang R,Qi F,Zhao F,Li G,Shao S,Zhang X,Yuan L,Feng Y

Wed Mar 20 00:00:00 EDT 2019

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer.

Cell death & disease

Zhang R,Qi F,Zhao F,Li G,Shao S,Zhang X,Yuan L,Feng Y

Wed Mar 20 00:00:00 EDT 2019

Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.

Nature communications

Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T

Fri Dec 06 00:00:00 EST 2019

Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages.

PloS one

Jumeau C,Awad F,Assrawi E,Cobret L,Duquesnoy P,Giurgea I,Valeyre D,Grateau G,Amselem S,Bernaudin JF,Karabina SA

200-06 was used in In vitro experiments to investigate serum amyloid A expression by monocytes.

Fri Jan 24 00:00:00 EST 2020

MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway.

Cell death & disease

Zou H,Chen Q,Zhang A,Wang S,Wu H,Yuan Y,Wang S,Yu J,Luo M,Wen X,Cui W,Fu W,Yu R,Chen L,Zhang M,Lan H,Zhang X,Xie Q,Jin G,Xu C

Fri Feb 15 00:00:00 EST 2019

Regulation of embryonic haematopoietic multipotency by EZH1.

Nature

Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ

Thu Jan 25 00:00:00 EST 2018

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

200-06 was used in In vitro experiments to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.

Thu Oct 04 00:00:00 EDT 2018

Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.

Cell

Wroblewska A,Dhainaut M,Ben-Zvi B,Rose SA,Park ES,Amir ED,Bektesevic A,Baccarini A,Merad M,Rahman AH,Brown BD

Thu Nov 01 00:00:00 EDT 2018

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Cell

Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH

200-06 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.

Thu Jun 28 00:00:00 EDT 2018

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m⁶A/MYC/CEBPA Signaling.

Cell

Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J

Thu Jan 11 00:00:00 EST 2018

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Cell

Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y

200-06 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.

Thu Sep 20 00:00:00 EDT 2018

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell

Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

Thu Jan 25 00:00:00 EST 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Cell

Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S

Thu May 31 00:00:00 EDT 2018

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Cancer cell

Yamauchi T,Masuda T,Canver MC,Seiler M,Semba Y,Shboul M,Al-Raqad M,Maeda M,Schoonenberg VAC,Cole MA,Macias-Trevino C,Ishikawa Y,Yao Q,Nakano M,Arai F,Orkin SH,Reversade B,Buonamici S,Pinello L,Akashi K,Bauer DE,Maeda T

Mon Mar 12 00:00:00 EDT 2018

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer cell

Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH

Mon Jan 08 00:00:00 EST 2018

Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.

Blood

Li Y,Jin C,Bai H,Gao Y,Sun S,Chen L,Qin L,Liu PP,Cheng L,Wang QF

Thu Jan 11 00:00:00 EST 2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Cell stem cell

Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A

200-06 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.

Thu Dec 06 00:00:00 EST 2018

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.

Cell stem cell

Duarte D,Hawkins ED,Akinduro O,Ang H,De Filippo K,Kong IY,Haltalli M,Ruivo N,Straszkowski L,Vervoort SJ,McLean C,Weber TS,Khorshed R,Pirillo C,Wei A,Ramasamy SK,Kusumbe AP,Duffy K,Adams RH,Purton LE,Carlin LM,Lo Celso C

200-06 was used in Cell Culture to suggest that preventing degradation of the endosteal vasculature may improve current paradigms for treating acute myeloid leukemia.

Thu Jan 04 00:00:00 EST 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 EST 2018

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.

The Journal of clinical investigation

Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J

Tue May 01 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

The Journal of clinical investigation

Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q

Fri Jun 01 00:00:00 EDT 2018

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.

The Journal of clinical investigation

Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC

Mon Dec 03 00:00:00 EST 2018

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

The Journal of clinical investigation

Shastri A,Choudhary G,Teixeira M,Gordon-Mitchell S,Ramachandra N,Bernard L,Bhattacharyya S,Lopez R,Pradhan K,Giricz O,Ravipati G,Wong LF,Cole S,Bhagat TD,Feld J,Dhar Y,Bartenstein M,Thiruthuvanathan VJ,Wickrema A,Ye BH,Frank DA,Pellagatti A,Boultwood J,Zhou T,Kim Y,MacLeod AR,Epling-Burnette PK,Ye M,McCoon P,Woessner R,Steidl U,Will B,Verma A

Mon Dec 03 00:00:00 EST 2018

PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature.

The Journal of clinical investigation

Corrigan DJ,Luchsinger LL,Justino de Almeida M,Williams LJ,Strikoudis A,Snoeck HW

Wed Aug 01 00:00:00 EDT 2018

Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.

The Journal of experimental medicine

Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW

Mon Mar 05 00:00:00 EST 2018

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies.

Clinical cancer research : an official journal of the American Association for Cancer Research

L'Italien L,Orozco O,Abrams T,Cantagallo L,Connor A,Desai J,Ebersbach H,Gelderblom H,Hoffmaster K,Lees E,Maacke H,Schleyer S,Skegro D,Lee-Hoeflich ST

200-06 was used in In vitro experiments to identifying potential mitigation strategies in hypersensitivity reactions.

Sun Jul 15 00:00:00 EDT 2018

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.

Leukemia

Mingay M,Chaturvedi A,Bilenky M,Cao Q,Jackson L,Hui T,Moksa M,Heravi-Moussavi A,Humphries RK,Heuser M,Hirst M

Mon Jan 01 00:00:00 EST 2018

Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.

Experimental & molecular medicine

Choi HJ,Chung TW,Choi HJ,Han JH,Choi JH,Kim CH,Ha KT

Wed Dec 12 00:00:00 EST 2018

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.

Science signaling

Jones DS,Jenney AP,Joughin BA,Sorger PK,Lauffenburger DA

200-06 was used in In vitro experiments to investigate signaling pathways in rheumatoid arthritis.

Tue Mar 06 00:00:00 EST 2018

Interleukin-6 and Interferon-α Signaling via JAK1-STAT Differentially Regulate Oncolytic versus Cytoprotective Antiviral States.

Frontiers in immunology

Danziger O,Pupko T,Bacharach E,Ehrlich M

200-06 was used in Sample Preparation (FC/FACS) to investigate the effects of JAK-STAT signaling on tumor development and therapy efficacy.

Thu Feb 28 00:00:00 EST 2019

Lymphatic exosomes promote dendritic cell migration along guidance cues.

The Journal of cell biology

Brown M,Johnson LA,Leone DA,Majek P,Vaahtomeri K,Senfter D,Bukosza N,Schachner H,Asfour G,Langer B,Hauschild R,Parapatics K,Hong YK,Bennett KL,Kain R,Detmar M,Sixt M,Jackson DG,Kerjaschki D

Mon Jun 04 00:00:00 EDT 2018

Quality-Quantity Control Culture Enhances Vasculogenesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells.

Stem cells translational medicine

Tanaka R,Masuda H,Fujimura S,Ito-Hirano R,Arita K,Kakinuma Y,Hagiwara H,Kado M,Hayashi A,Mita T,Ogawa T,Watada H,Mizuno H,Sawada N,Asahara T

Tue May 01 00:00:00 EDT 2018

Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia.

Blood advances

Jalali S,Price-Troska T,Paludo J,Villasboas J,Kim HJ,Yang ZZ,Novak AJ,Ansell SM

Tue Aug 14 00:00:00 EDT 2018

Inhibition of IL-6-JAK/Stat3 signaling in castration-resistant prostate cancer cells enhances the NK cell-mediated cytotoxicity via alteration of PD-L1/NKG2D ligand levels.

Molecular oncology

Xu L,Chen X,Shen M,Yang DR,Fang L,Weng G,Tsai Y,Keng PC,Chen Y,Lee SO

200-06 was used in In vitro experiments to investigate whether IL-6 signaling affects the susceptibility of castration resistant prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells.

Thu Mar 01 00:00:00 EST 2018

Single Cell Resolution of Human Hematoendothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium.

Stem cells (Dayton, Ohio)

Angelos MG,Abrahante JE,Blum RH,Kaufman DS

Thu Feb 01 00:00:00 EST 2018

Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.

Journal of immunology (Baltimore, Md. : 1950)

Otsuka Y,Watanabe E,Shinya E,Okura S,Saeki H,Geijtenbeek TBH,Takahashi H

Thu Nov 15 00:00:00 EST 2018

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Journal of immunology (Baltimore, Md. : 1950)

Hecht I,Toporik A,Podojil JR,Vaknin I,Cojocaru G,Oren A,Aizman E,Liang SC,Leung L,Dicken Y,Novik A,Marbach-Bar N,Elmesmari A,Tange C,Gilmour A,McIntyre D,Kurowska-Stolarska M,McNamee K,Leitner J,Greenwald S,Dassa L,Levine Z,Steinberger P,Williams RO,Miller SD,McInnes IB,Neria E,Rotman G

Thu Mar 15 00:00:00 EDT 2018

Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells.

Journal of immunology (Baltimore, Md. : 1950)

Paupert J,Espinosa E,Cenac N,Robert V,Laharrague P,Evrard SM,Casteilla L,Lorsignol A,Cousin B

Sat Dec 15 00:00:00 EST 2018

The classic signalling and trans-signalling of interleukin-6 are both injurious in podocyte under high glucose exposure.

Journal of cellular and molecular medicine

Lei CT,Su H,Ye C,Tang H,Gao P,Wan C,He FF,Wang YM,Zhang C

Mon Jan 01 00:00:00 EST 2018

Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling.

Oncology reports

Zhang X,Lu H,Hong W,Liu L,Wang S,Zhou M,Chen B,Bai Y

200-06 was used in In vitro experiments to study the molecular mechanisms of drug‚resistance and the methods of effective intervention by investigating the effect of tyrphostin B42, also called AG490, on histone deacetylase (HDAC) inhibitor trichostatin A (TSA)‚induced resistance in pancreatic cancer cells (PCCs).

Sun Apr 01 00:00:00 EDT 2018

STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas.

Nature communications

Pan YR,Chen CC,Chan YT,Wang HJ,Chien FT,Chen YL,Liu JL,Yang MH

Wed Sep 12 00:00:00 EDT 2018

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.

Stem cell reports

Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J

Tue Feb 13 00:00:00 EST 2018

TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.

Nature communications

Zhang HX,Xu ZS,Lin H,Li M,Xia T,Cui K,Wang SY,Li Y,Shu HB,Wang YY

Fri Aug 24 00:00:00 EDT 2018

G3BP1 promotes tumor progression and metastasis through IL-6/G3BP1/STAT3 signaling axis in renal cell carcinomas.

Cell death & disease

Wang Y,Fu D,Chen Y,Su J,Wang Y,Li X,Zhai W,Niu Y,Yue D,Geng H

Tue May 01 00:00:00 EDT 2018

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.

Cell reports

Osorio FG,Rosendahl Huber A,Oka R,Verheul M,Patel SH,Hasaart K,de la Fonteijne L,Varela I,Camargo FD,van Boxtel R

200-06 was used in Sample Preparation (FC/FACS) to perform genomic analysis of the mutation accumulation of HSPCs.

Tue Nov 27 00:00:00 EST 2018

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.

Scientific reports

Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S

Tue Apr 03 00:00:00 EDT 2018

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature communications

Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II

Tue May 08 00:00:00 EDT 2018

A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.

Nature communications

Sumide K,Matsuoka Y,Kawamura H,Nakatsuka R,Fujioka T,Asano H,Takihara Y,Sonoda Y

Wed Jun 06 00:00:00 EDT 2018

Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis.

Scientific reports

Di Domenico EG,Cavallo I,Bordignon V,Prignano G,Sperduti I,Gurtner A,Trento E,Toma L,Pimpinelli F,Capitanio B,Ensoli F

Thu Jun 28 00:00:00 EDT 2018

Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts.

Scientific reports

Pearson MJ,Bik MA,Ospelt C,Naylor AJ,Wehmeyer C,Jones SW,Buckley CD,Gay S,Filer A,Lord JM

Mon Aug 27 00:00:00 EDT 2018

Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.

The Journal of biological chemistry

Razidlo GL,Burton KM,McNiven MA

Fri Jul 13 00:00:00 EDT 2018

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.

Nature communications

Hsieh WC,Hsu TS,Chang YJ,Lai MZ

Wed Jan 31 00:00:00 EST 2018

Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition.

Nature communications

Jiao J,Zhang R,Li Z,Yin Y,Fang X,Ding X,Cai Y,Yang S,Mu H,Zong D,Chen Y,Zhang Y,Zou J,Shao J,Huang Z

Wed Jun 27 00:00:00 EDT 2018

Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons.

Scientific reports

DeRosa BA,El Hokayem J,Artimovich E,Garcia-Serje C,Phillips AW,Van Booven D,Nestor JE,Wang L,Cuccaro ML,Vance JM,Pericak-Vance MA,Cukier HN,Nestor MW,Dykxhoorn DM

Wed May 30 00:00:00 EDT 2018

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.

Nature communications

Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q

Thu Feb 08 00:00:00 EST 2018

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.

Nature communications

Sheng C,Jungverdorben J,Wiethoff H,Lin Q,Flitsch LJ,Eckert D,Hebisch M,Fischer J,Kesavan J,Weykopf B,Schneider L,Holtkamp D,Beck H,Till A,Wüllner U,Ziller MJ,Wagner W,Peitz M,Brüstle O

Tue Oct 02 00:00:00 EDT 2018

Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity.

Scientific reports

Al-Maskari M,Care MA,Robinson E,Cocco M,Tooze RM,Doody GM

Tue Sep 25 00:00:00 EDT 2018

Reconstruction of complex single-cell trajectories using CellRouter.

Nature communications

Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ

Thu Mar 01 00:00:00 EST 2018

Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.

Scientific reports

Biechonski S,Olender L,Zipin-Roitman A,Yassin M,Aqaqe N,Marcu-Malina V,Rall-Scharpf M,Trottier M,Meyn MS,Wiesmüller L,Beider K,Raz Y,Grisaru D,Nagler A,Milyavsky M

Tue Apr 17 00:00:00 EDT 2018

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.

Stem cell reports

Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P

Tue Oct 09 00:00:00 EDT 2018

Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia.

Scientific reports

Nemoto M,Hattori H,Maeda N,Akita N,Muramatsu H,Moritani S,Kawasaki T,Maejima M,Ode H,Hachiya A,Sugiura W,Yokomaku Y,Horibe K,Iwatani Y

Thu May 03 00:00:00 EDT 2018

Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Nature communications

Latham SL,Ehmke N,Reinke PYA,Taft MH,Eicke D,Reindl T,Stenzel W,Lyons MJ,Friez MJ,Lee JA,Hecker R,Frühwald MC,Becker K,Neuhann TM,Horn D,Schrock E,Niehaus I,Sarnow K,Grützmann K,Gawehn L,Klink B,Rump A,Chaponnier C,Figueiredo C,Knöfler R,Manstein DJ,Di Donato N

Fri Oct 12 00:00:00 EDT 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 EDT 2018

TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells.

Scientific reports

Yen J,Fiorino M,Liu Y,Paula S,Clarkson S,Quinn L,Tschantz WR,Klock H,Guo N,Russ C,Yu VWC,Mickanin C,Stevenson SC,Lee C,Yang Y

Fri Nov 02 00:00:00 EDT 2018

Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes.

Cell death & disease

Li Z,Li SP,Li RY,Zhu H,Liu X,Guo XL,Mu LL,Cai JJ,Bai F,Chen GQ,Hong DL

Tue May 01 00:00:00 EDT 2018

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.

Nature communications

Hyrenius-Wittsten A,Pilheden M,Sturesson H,Hansson J,Walsh MP,Song G,Kazi JU,Liu J,Ramakrishan R,Garcia-Ruiz C,Nance S,Gupta P,Zhang J,Rönnstrand L,Hultquist A,Downing JR,Lindkvist-Petersson K,Paulsson K,Järås M,Gruber TA,Ma J,Hagström-Andersson AK

Wed May 02 00:00:00 EDT 2018

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.

Nature communications

Shiozawa Y,Malcovati L,Gallì A,Sato-Otsubo A,Kataoka K,Sato Y,Watatani Y,Suzuki H,Yoshizato T,Yoshida K,Sanada M,Makishima H,Shiraishi Y,Chiba K,Hellström-Lindberg E,Miyano S,Ogawa S,Cazzola M

Fri Sep 07 00:00:00 EDT 2018

GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.

Scientific reports

Khanna P,Lee JS,Sereemaspun A,Lee H,Baeg GH

Fri Jun 22 00:00:00 EDT 2018

Regulation of IL-22BP in psoriasis.

Scientific reports

Voglis S,Moos S,Kloos L,Wanke F,Zayoud M,Pelczar P,Giannou AD,Pezer S,Albers M,Luessi F,Huber S,Schäkel K,Kurschus FC

Fri Mar 23 00:00:00 EDT 2018

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.

Cell death & disease

Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H

Tue Sep 11 00:00:00 EDT 2018

Inhibitory effects of isocryptotanshinone on gastric cancer.

Scientific reports

Chen ZM,Huang L,Li MM,Meng L,Ying SC,Xu AM

Mon Jun 18 00:00:00 EDT 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.

Nature communications

Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

Fri Jul 27 00:00:00 EDT 2018

JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway.

The Journal of biological chemistry

Wang W,Li F,Xu Y,Wei J,Zhang Y,Yang H,Gao B,Yu G,Fang D

Fri Jul 13 00:00:00 EDT 2018

Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G₁ arrest independent of DRD2.

The Journal of biological chemistry

Tegowski M,Fan C,Baldwin AS

Fri Oct 12 00:00:00 EDT 2018

Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.

Nature communications

Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W

Tue Sep 25 00:00:00 EDT 2018

Primary Cilia Are Dysfunctional in Obese Adipose-Derived Mesenchymal Stem Cells.

Stem cell reports

Ritter A,Friemel A,Kreis NN,Hoock SC,Roth S,Kielland-Kaisen U,Brüggmann D,Solbach C,Louwen F,Yuan J

Tue Feb 13 00:00:00 EST 2018

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

Cell

Cantor JR,Abu-Remaileh M,Kanarek N,Freinkman E,Gao X,Louissaint A,Lewis CA,Sabatini DM

Thu Apr 06 00:00:00 EDT 2017

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Cell

Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC

200-06 was used in Cell Culture to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.

Thu Mar 09 00:00:00 EST 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell

Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T

Mon Apr 10 00:00:00 EDT 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell

Mon Apr 10 00:00:00 EDT 2017

MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes Prostate Cancer Metastasis by Engaging Tumor-Stromal Cell Interactions.

Cancer cell

Wu JB,Yin L,Shi C,Li Q,Duan P,Huang JM,Liu C,Wang F,Lewis M,Wang Y,Lin TP,Pan CC,Posadas EM,Zhau HE,Chung LWK

Mon Mar 13 00:00:00 EDT 2017

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.

Gastroenterology

Endo S,Nakata K,Ohuchida K,Takesue S,Nakayama H,Abe T,Koikawa K,Okumura T,Sada M,Horioka K,Zheng B,Mizuuchi Y,Iwamoto C,Murata M,Moriyama T,Miyasaka Y,Ohtsuka T,Mizumoto K,Oda Y,Hashizume M,Nakamura M

200-06 was used in Cell Culture to study whether autophagy activates pancreatic stellate cells (PSCs), which promotes development of the tumor stroma and growth of pancreatic tumors in mice.

Mon May 01 00:00:00 EDT 2017

JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.

Blood

Karjalainen R,Pemovska T,Popa M,Liu M,Javarappa KK,Majumder MM,Yadav B,Tamborero D,Tang J,Bychkov D,Kontro M,Parsons A,Suvela M,Mayoral Safont M,Porkka K,Aittokallio T,Kallioniemi O,McCormack E,Gjertsen BT,Wennerberg K,Knowles J,Heckman CA

Thu Aug 10 00:00:00 EDT 2017

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

Blood

Ishizawa J,Sugihara E,Kuninaka S,Mogushi K,Kojima K,Benton CB,Zhao R,Chachad D,Hashimoto N,Jacamo RO,Qiu Y,Yoo SY,Okamoto S,Andreeff M,Kornblau SM,Saya H

Thu Apr 06 00:00:00 EDT 2017

Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells.

Blood

Angelos MG,Ruh PN,Webber BR,Blum RH,Ryan CD,Bendzick L,Shim S,Yingst AM,Tufa DM,Verneris MR,Kaufman DS

Thu Jun 29 00:00:00 EDT 2017

KIT signaling is dispensable for human mast cell progenitor development.

Blood

Dahlin JS,Ekoff M,Grootens J,Löf L,Amini RM,Hagberg H,Ungerstedt JS,Olsson-Strömberg U,Nilsson G

Thu Oct 19 00:00:00 EDT 2017

Molecular convergence in ex vivo models of Diamond-Blackfan anemia.

Blood

O'Brien KA,Farrar JE,Vlachos A,Anderson SM,Tsujiura CA,Lichtenberg J,Blanc L,Atsidaftos E,Elkahloun A,An X,Ellis SR,Lipton JM,Bodine DM

Thu Jun 08 00:00:00 EDT 2017

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.

The Journal of clinical investigation

Wang S,Liang K,Hu Q,Li P,Song J,Yang Y,Yao J,Mangala LS,Li C,Yang W,Park PK,Hawke DH,Zhou J,Zhou Y,Xia W,Hung MC,Marks JR,Gallick GE,Lopez-Berestein G,Flores ER,Sood AK,Huang S,Yu D,Yang L,Lin C

Fri Dec 01 00:00:00 EST 2017

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.

The Journal of clinical investigation

Wang S,Liang K,Hu Q,Li P,Song J,Yang Y,Yao J,Mangala LS,Li C,Yang W,Park PK,Hawke DH,Zhou J,Zhou Y,Xia W,Hung MC,Marks JR,Gallick GE,Lopez-Berestein G,Flores ER,Sood AK,Huang S,Yu D,Yang L,Lin C

Fri Dec 01 00:00:00 EST 2017

Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.

The Journal of experimental medicine

Nandin IS,Fong C,Deantonio C,Torreno-Pina JA,Pecetta S,Maldonado P,Gasparrini F,Ordovas-Montanes J,Kazer SW,Kjaer S,Borley DW,Nair U,Coleman JA,Lingwood D,Shalek AK,Meffre E,Poignard P,Burton DR,Batista FD

Mon Sep 04 00:00:00 EDT 2017

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

The Journal of experimental medicine

Lyons JJ,Liu Y,Ma CA,Yu X,O'Connell MP,Lawrence MG,Zhang Y,Karpe K,Zhao M,Siegel AM,Stone KD,Nelson C,Jones N,DiMaggio T,Darnell DN,Mendoza-Caamal E,Orozco L,Hughes JD,McElwee J,Hohman RJ,Frischmeyer-Guerrerio PA,Rothenberg ME,Freeman AF,Holland SM,Milner JD

Mon Mar 06 00:00:00 EST 2017

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients.

The Journal of experimental medicine

Zhang Y,Ma CA,Lawrence MG,Break TJ,O'Connell MP,Lyons JJ,López DB,Barber JS,Zhao Y,Barber DL,Freeman AF,Holland SM,Lionakis MS,Milner JD

Mon Sep 04 00:00:00 EDT 2017

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.

The Journal of experimental medicine

Pattarini L,Trichot C,Bogiatzi S,Grandclaudon M,Meller S,Keuylian Z,Durand M,Volpe E,Madonna S,Cavani A,Chiricozzi A,Romanelli M,Hori T,Hovnanian A,Homey B,Soumelis V

Mon May 01 00:00:00 EDT 2017

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

The Journal of experimental medicine

Schwerd T,Twigg SRF,Aschenbrenner D,Manrique S,Miller KA,Taylor IB,Capitani M,McGowan SJ,Sweeney E,Weber A,Chen L,Bowness P,Riordan A,Cant A,Freeman AF,Milner JD,Holland SM,Frede N,Müller M,Schmidt-Arras D,Grimbacher B,Wall SA,Jones EY,Wilkie AOM,Uhlig HH

Mon Sep 04 00:00:00 EDT 2017

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy

Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y

200-06 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.

Thu May 04 00:00:00 EDT 2017

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.

Oncogene

Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW

Thu Jul 13 00:00:00 EDT 2017

Safety and Efficacy of Megakaryocytes Induced from Hematopoietic Stem Cells in Murine and Nonhuman Primate Models.

Stem cells translational medicine

Guan X,Qin M,Zhang Y,Wang Y,Shen B,Ren Z,Ding X,Dai W,Jiang Y

Wed Mar 01 00:00:00 EST 2017

Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice.

Journal of lipid research

Yang P,Xiao Y,Luo X,Zhao Y,Zhao L,Wang Y,Wu T,Wei L,Chen Y

Sat Jul 01 00:00:00 EDT 2017

Growth-induced stress enhances epithelial-mesenchymal transition induced by IL-6 in clear cell renal cell carcinoma via the Akt/GSK-3β/β-catenin signaling pathway.

Oncogenesis

Chen Q,Yang D,Zong H,Zhu L,Wang L,Wang X,Zhu X,Song X,Wang J

Mon Aug 28 00:00:00 EDT 2017

Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.

Journal of immunology (Baltimore, Md. : 1950)

McCurdy S,Baumer Y,Toulmin E,Lee BH,Boisvert WA

Wed Nov 15 00:00:00 EST 2017

Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition.

Journal of immunology (Baltimore, Md. : 1950)

Arumugakani G,Stephenson SJ,Newton DJ,Rawstron A,Emery P,Doody GM,McGonagle D,Tooze RM

Thu Jun 15 00:00:00 EDT 2017

A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Montoya MM,Maul J,Singh PB,Pua HH,Dahlström F,Wu N,Huang X,Ansel KM,Baumjohann D

Sat Jul 15 00:00:00 EDT 2017

Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Akoto C,Davies DE,Swindle EJ

Wed Mar 01 00:00:00 EST 2017

Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis.

Journal of cellular and molecular medicine

Peng KY,Liu YH,Li YW,Yen BL,Yen ML

Tue Aug 01 00:00:00 EDT 2017

Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.

Journal of cellular and molecular medicine

Darvin P,Joung YH,Kang DY,Sp N,Byun HJ,Hwang TS,Sasidharakurup H,Lee CH,Cho KH,Park KD,Lee HK,Yang YM

Sat Apr 01 00:00:00 EDT 2017

Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34⁺ cells.

Cell cycle (Georgetown, Tex.)

Dhenge A,Limbkar K,Melinkeri S,Kale VP,Limaye L

200-06 was used in Cell Culture to examine the role of poly-unsaturated fatty acids in platelet production.

Fri May 19 00:00:00 EDT 2017

KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.

Nature communications

Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

Fri Nov 10 00:00:00 EST 2017

Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.

PloS one

Eitas TK,Stepp WH,Sjeklocha L,Long CV,Riley C,Callahan J,Sanchez Y,Gough P,Knowlin L,van Duin D,Ortiz-Pujols S,Jones SW,Maile R,Hong Z,Berger S,Cairns BA

200-06 was used in Sample Preparation (ELISA) to describe a novel aspect of NRF2 activation that may contribute to the beneficial effects of NRF2 agonists during disease.

Wed Oct 18 00:00:00 EDT 2017

Novel STAT binding elements mediate IL-6 regulation of MMP-1 and MMP-3.

Scientific reports

Cutler SJ,Doecke JD,Ghazawi I,Yang J,Griffiths LR,Spring KJ,Ralph SJ,Mellick AS

Thu Aug 17 00:00:00 EDT 2017

Inflammation-mediated SOD-2 upregulation contributes to epithelial-mesenchymal transition and migration of tumor cells in aflatoxin G₁-induced lung adenocarcinoma.

Scientific reports

Yi L,Shen H,Zhao M,Shao P,Liu C,Cui J,Wang J,Wang C,Guo N,Kang L,Lv P,Xing L,Zhang X

Fri Aug 11 00:00:00 EDT 2017

miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment.

Scientific reports

Mayer U,Benditz A,Grässel S

Mon Oct 16 00:00:00 EDT 2017

Interleukin-6-dependent growth in a newly established plasmablastic lymphoma cell line and its therapeutic targets.

Scientific reports

Mine S,Hishima T,Suganuma A,Fukumoto H,Sato Y,Kataoka M,Sekizuka T,Kuroda M,Suzuki T,Hasegawa H,Fukayama M,Katano H

Thu Aug 31 00:00:00 EDT 2017

Butyrate and propionate inhibit antigen-specific CD8⁺ T cell activation by suppressing IL-12 production by antigen-presenting cells.

Scientific reports

Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A

Mon Nov 06 00:00:00 EST 2017

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells.

Nature communications

Malik S,Sadhu S,Elesela S,Pandey RP,Chawla AS,Sharma D,Panda L,Rathore D,Ghosh B,Ahuja V,Awasthi A

Mon Oct 09 00:00:00 EDT 2017

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.

Scientific reports

Zitti B,Molfetta R,Fionda C,Quatrini L,Stabile H,Lecce M,de Turris V,Ricciardi MR,Petrucci MT,Cippitelli M,Gismondi A,Santoni A,Paolini R

200-06 was used in Cell Culture to study the role of ubiquitin and ubiquitin-like modifiers in the regulation of ligand expression in tumour cells.

Tue Sep 05 00:00:00 EDT 2017

Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes.

Scientific reports

Wiśnik E,Płoszaj T,Robaszkiewicz A

Fri Aug 25 00:00:00 EDT 2017

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.

Stem cell reports

Di Tullio A,Passaro D,Rouault-Pierre K,Purewal S,Bonnet D

Tue Jul 11 00:00:00 EDT 2017

Increased expression of Siglec-9 in chronic obstructive pulmonary disease.

Scientific reports

Zeng Z,Li M,Wang M,Wu X,Li Q,Ning Q,Zhao J,Xu Y,Xie J

Thu Aug 31 00:00:00 EDT 2017

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

Stem cell reports

Tripathi P,Rodriguez-Muela N,Klim JR,de Boer AS,Agrawal S,Sandoe J,Lopes CS,Ogliari KS,Williams LA,Shear M,Rubin LL,Eggan K,Zhou Q

Tue Aug 08 00:00:00 EDT 2017

Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3.

Scientific reports

He H,Kuriyan AE,Su CW,Mahabole M,Zhang Y,Zhu YT,Flynn HW,Parel JM,Tseng SC

200-06 was used in Cell Culture to investigate heavy chain-hyaluronic acid/pentraxin 3 inhibition of proliferative vitreoretinopathy.

Thu Mar 02 00:00:00 EST 2017

Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.

Scientific reports

Chen J,Adamiak W,Huang G,Atasoy U,Rostami A,Yu S

Fri Dec 08 00:00:00 EST 2017

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.

Scientific reports

Mori R,Wauman J,Icardi L,Van der Heyden J,De Cauwer L,Peelman F,De Bosscher K,Tavernier J

Tue Nov 21 00:00:00 EST 2017

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell stem cell

Kotini AG,Chang CJ,Chow A,Yuan H,Ho TC,Wang T,Vora S,Solovyov A,Husser C,Olszewska M,Teruya-Feldstein J,Perumal D,Klimek VM,Spyridonidis A,Rampal RK,Silverman L,Reddy EP,Papaemmanuil E,Parekh S,Greenbaum BD,Leslie CS,Kharas MG,Papapetrou EP

200-06 was used in Cell Culture to provide insight into the cellular events demarcating the initiation and progression of myeloid transformation and a new platform for testing genetic and pharmacological interventions.

Thu Mar 02 00:00:00 EST 2017

CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.

Cancer medicine

Ueshima C,Kataoka TR,Takei Y,Hirata M,Sugimoto A,Hirokawa M,Okayama Y,Blumberg RS,Haga H

Sat Apr 01 00:00:00 EDT 2017

Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.

ACS biomaterials science & engineering

Liu FD,Pishesha N,Poon Z,Kaushik T,Van Vliet KJ

200-06 was used in Cell Culture to leverage cell-material interactions in vitro to induce human bone marrow-derived MSCs to preferentially secrete factors that are beneficial to hematopoietic cell proliferation.

Mon Dec 11 00:00:00 EST 2017

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.

Nature biotechnology

Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR

200-06 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.

Tue Nov 01 00:00:00 EDT 2016

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Cell

Sykes DB,Kfoury YS,Mercier FE,Wawer MJ,Law JM,Haynes MK,Lewis TA,Schajnovitz A,Jain E,Lee D,Meyer H,Pierce KA,Tolliday NJ,Waller A,Ferrara SJ,Eheim AL,Stoeckigt D,Maxcy KL,Cobert JM,Bachand J,Szekely BA,Mukherjee S,Sklar LA,Kotz JD,Clish CB,Sadreyev RI,Clemons PA,Janzer A,Schreiber SL,Scadden DT

200-06 was used in Cell Culture to investigate the role of HoxA9 on the regulation of dihydroorotate dehydrogenase in acute myeloid leukemia models.

Thu Sep 22 00:00:00 EDT 2016

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Cell metabolism

Kishton RJ,Barnes CE,Nichols AG,Cohen S,Gerriets VA,Siska PJ,Macintyre AN,Goraksha-Hicks P,de Cubas AA,Liu T,Warmoes MO,Abel ED,Yeoh AE,Gershon TR,Rathmell WK,Richards KL,Locasale JW,Rathmell JC

200-06 was used in Cell Culture to study to what extent the leukemic T cell populations are metabolically similar and if differences reveal T cell acute lymphoblastic leukemia (T-ALL) vulnerabilities.

Tue Apr 12 00:00:00 EDT 2016

IL-4 rescues surface IgM expression in chronic lymphocytic leukemia.

Blood

Guo B,Zhang L,Chiorazzi N,Rothstein TL

Thu Jul 28 00:00:00 EDT 2016

Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Blood

Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J

Thu Jan 28 00:00:00 EST 2016

MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.

The Journal of clinical investigation

Zhu N,Chen M,Eng R,DeJong J,Sinha AU,Rahnamay NF,Koche R,Al-Shahrour F,Minehart JC,Chen CW,Deshpande AJ,Xu H,Chu SH,Ebert BL,Roeder RG,Armstrong SA

Tue Mar 01 00:00:00 EST 2016

Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.

The Journal of clinical investigation

Sanges D,Simonte G,Di Vicino U,Romo N,Pinilla I,Nicolás M,Cosma MP

Mon Aug 01 00:00:00 EDT 2016

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.

The Journal of clinical investigation

Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J

Thu Dec 01 00:00:00 EST 2016

Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.

The Journal of clinical investigation

Jin Y,Zhou J,Xu F,Jin B,Cui L,Wang Y,Du X,Li J,Li P,Ren R,Pan J

Mon Oct 03 00:00:00 EDT 2016

Targeting MTHFD2 in acute myeloid leukemia.

The Journal of experimental medicine

Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K

Mon Jun 27 00:00:00 EDT 2016

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

The Journal of experimental medicine

Wang Y,Ma CS,Ling Y,Bousfiha A,Camcioglu Y,Jacquot S,Payne K,Crestani E,Roncagalli R,Belkadi A,Kerner G,Lorenzo L,Deswarte C,Chrabieh M,Patin E,Vincent QB,Müller-Fleckenstein I,Fleckenstein B,Ailal F,Quintana-Murci L,Fraitag S,Alyanakian MA,Leruez-Ville M,Picard C,Puel A,Bustamante J,Boisson-Dupuis S,Malissen M,Malissen B,Abel L,Hovnanian A,Notarangelo LD,Jouanguy E,Tangye SG,Béziat V,Casanova JL

Mon Oct 17 00:00:00 EDT 2016

Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.

The Journal of experimental medicine

Cheung KL,Jarrett R,Subramaniam S,Salimi M,Gutowska-Owsiak D,Chen YL,Hardman C,Xue L,Cerundolo V,Ogg G

Mon Oct 17 00:00:00 EDT 2016

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

The Journal of experimental medicine

Ma CS,Wong N,Rao G,Nguyen A,Avery DT,Payne K,Torpy J,O'Young P,Deenick E,Bustamante J,Puel A,Okada S,Kobayashi M,Martinez-Barricarte R,Elliott M,Sebnem Kilic S,El Baghdadi J,Minegishi Y,Bousfiha A,Robertson N,Hambleton S,Arkwright PD,French M,Blincoe AK,Hsu P,Campbell DE,Stormon MO,Wong M,Adelstein S,Fulcher DA,Cook MC,Stepensky P,Boztug K,Beier R,Ikincioğullari A,Ziegler JB,Gray P,Picard C,Boisson-Dupuis S,Phan TG,Grimbacher B,Warnatz K,Holland SM,Uzel G,Casanova JL,Tangye SG

Mon Jul 25 00:00:00 EDT 2016

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.

The Journal of experimental medicine

Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG

Mon Nov 14 00:00:00 EST 2016

miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America

Serr I,Fürst RW,Ott VB,Scherm MG,Nikolaev A,Gökmen F,Kälin S,Zillmer S,Bunk M,Weigmann B,Kunschke N,Loretz B,Lehr CM,Kirchner B,Haase B,Pfaffl M,Waisman A,Willis RA,Ziegler AG,Daniel C

Tue Oct 25 00:00:00 EDT 2016

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America

Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J

Tue Oct 25 00:00:00 EDT 2016

Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America

Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

Tue Aug 16 00:00:00 EDT 2016

Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis.

Stem cells (Dayton, Ohio)

Abbonante V,Di Buduo CA,Gruppi C,Malara A,Gianelli U,Celesti G,Anselmo A,Laghi L,Vercellino M,Visai L,Iurlo A,Moratti R,Barosi G,Rosti V,Balduini A

Fri Apr 01 00:00:00 EDT 2016

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.

Stem cells (Dayton, Ohio)

Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL

Wed Jun 01 00:00:00 EDT 2016

Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.

Stem cells (Dayton, Ohio)

Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL

Wed Jun 01 00:00:00 EDT 2016

Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.

Stem cells (Dayton, Ohio)

Tuccitto A,Tazzari M,Beretta V,Rini F,Miranda C,Greco A,Santinami M,Patuzzo R,Vergani B,Villa A,Manenti G,Cleris L,Giardiello D,Alison M,Rivoltini L,Castelli C,Perego M

Sat Oct 01 00:00:00 EDT 2016

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Journal of immunology (Baltimore, Md. : 1950)

Llibre A,López-Macías C,Marafioti T,Mehta H,Partridge A,Kanzig C,Rivellese F,Galson JD,Walker LJ,Milne P,Phillips RE,Kelly DF,Freeman GJ,El Shikh ME,Klenerman P,Willberg CB

Tue Mar 01 00:00:00 EST 2016

Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1β.

Journal of immunology (Baltimore, Md. : 1950)

Suurmond J,Habets KL,Dorjée AL,Huizinga TW,Toes RE

Thu Dec 01 00:00:00 EST 2016

Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Care MA,Stephenson SJ,Barnes NA,Fan I,Zougman A,El-Sherbiny YM,Vital EM,Westhead DR,Tooze RM,Doody GM

Mon Aug 15 00:00:00 EDT 2016

TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.

Journal of immunology (Baltimore, Md. : 1950)

Nagashima H,Okuyama Y,Hayashi T,Ishii N,So T

Sun May 15 00:00:00 EDT 2016

ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V

Sat Oct 01 00:00:00 EDT 2016

ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V

Sat Oct 01 00:00:00 EDT 2016

CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.

Cell cycle (Georgetown, Tex.)

Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A

200-06 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.

Mon May 02 00:00:00 EDT 2016

Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell.

Molecular carcinogenesis

Zhang J,Jia J,Zhao L,Li X,Xie Q,Chen X,Wang J,Lu F

Sun May 01 00:00:00 EDT 2016

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

Stem cell reports

D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II

Tue Feb 09 00:00:00 EST 2016

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.

Cell death & disease

Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R

Thu Apr 07 00:00:00 EDT 2016

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.

Nature communications

Grover A,Sanjuan-Pla A,Thongjuea S,Carrelha J,Giustacchini A,Gambardella A,Macaulay I,Mancini E,Luis TC,Mead A,Jacobsen SE,Nerlov C

Thu Mar 24 00:00:00 EDT 2016

Acetylation of C/EBPα inhibits its granulopoietic function.

Nature communications

Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG

Wed Mar 23 00:00:00 EDT 2016

RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.

Scientific reports

Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C

Thu Mar 24 00:00:00 EDT 2016

Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling.

Scientific reports

Liu F,Zhang W,Yang F,Feng T,Zhou M,Yu Y,Yu X,Zhao W,Yi F,Tang W,Lu Y

Tue Feb 16 00:00:00 EST 2016

The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice.

Scientific reports

Ou Z,Niu X,He W,Chen Y,Song B,Xian Y,Fan D,Tang D,Sun X

Thu Sep 01 00:00:00 EDT 2016

Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Nature communications

Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP

Thu Oct 20 00:00:00 EDT 2016

Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.

Cell death & disease

Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G

Thu Sep 08 00:00:00 EDT 2016

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports

Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H

Wed May 18 00:00:00 EDT 2016

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports

Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H

Wed May 18 00:00:00 EDT 2016

Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines.

Cancer prevention research (Philadelphia, Pa.)

Jin K,Su KK,Li T,Zhu XQ,Wang Q,Ge RS,Pan ZF,Wu BW,Ge LJ,Zhang YH,Wang YF,Shen GF,Zhu DY,Xiang CS,Li LJ,Lou YJ

200-06 was used in Cell Culture to study the relationship of aristolochic acid I and urothelial cancer in canines.

Fri Apr 01 00:00:00 EDT 2016

PGE₂ is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.

Scientific reports

Fujii S,Suzuki K,Kawamoto A,Ishibashi F,Nakata T,Murano T,Ito G,Shimizu H,Mizutani T,Oshima S,Tsuchiya K,Nakamura T,Araki A,Ohtsuka K,Okamoto R,Watanabe M

Wed Nov 09 00:00:00 EST 2016

The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.

Scientific reports

Chen JY,Lai YS,Tsai HJ,Kuo CC,Yen BL,Yeh SP,Sun HS,Hung WC

Wed Aug 31 00:00:00 EDT 2016

Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.

Cell research

Li P,Shan JX,Chen XH,Zhang D,Su LP,Huang XY,Yu BQ,Zhi QM,Li CL,Wang YQ,Tomei S,Cai Q,Ji J,Li JF,Chouchane L,Yu YY,Sun FZ,Xu ZH,Liu BY,Zhu ZG

Fri May 01 00:00:00 EDT 2015

T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.

Immunity

Cook KD,Shpargel KB,Starmer J,Whitfield-Larry F,Conley B,Allard DE,Rager JE,Fry RC,Davenport ML,Magnuson T,Whitmire JK,Su MA

Tue Oct 20 00:00:00 EDT 2015

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Cancer cell

Borkin D,He S,Miao H,Kempinska K,Pollock J,Chase J,Purohit T,Malik B,Zhao T,Wang J,Wen B,Zong H,Jones M,Danet-Desnoyers G,Guzman ML,Talpaz M,Bixby DL,Sun D,Hess JL,Muntean AG,Maillard I,Cierpicki T,Grembecka J

Mon Apr 13 00:00:00 EDT 2015

A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.

Blood

Belay E,Miller CP,Kortum AN,Torok-Storb B,Blau CA,Emery DW

Thu Feb 05 00:00:00 EST 2015

MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.

Blood

Buechele C,Breese EH,Schneidawind D,Lin CH,Jeong J,Duque-Afonso J,Wong SH,Smith KS,Negrin RS,Porteus M,Cleary ML

Thu Oct 01 00:00:00 EDT 2015

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.

The Journal of clinical investigation

Meldi K,Qin T,Buchi F,Droin N,Sotzen J,Micol JB,Selimoglu-Buet D,Masala E,Allione B,Gioia D,Poloni A,Lunghi M,Solary E,Abdel-Wahab O,Santini V,Figueroa ME

Fri May 01 00:00:00 EDT 2015

Coordinate expression of heme and globin is essential for effective erythropoiesis.

The Journal of clinical investigation

Doty RT,Phelps SR,Shadle C,Sanchez-Bonilla M,Keel SB,Abkowitz JL

Tue Dec 01 00:00:00 EST 2015

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

The Journal of clinical investigation

Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA

Mon Aug 03 00:00:00 EDT 2015

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.

The Journal of experimental medicine

Wilson RP,Ives ML,Rao G,Lau A,Payne K,Kobayashi M,Arkwright PD,Peake J,Wong M,Adelstein S,Smart JM,French MA,Fulcher DA,Picard C,Bustamante J,Boisson-Dupuis S,Gray P,Stepensky P,Warnatz K,Freeman AF,Rossjohn J,McCluskey J,Holland SM,Casanova JL,Uzel G,Ma CS,Tangye SG,Deenick EK

Mon Jun 01 00:00:00 EDT 2015

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Proceedings of the National Academy of Sciences of the United States of America

Hammitzsch A,Tallant C,Fedorov O,O'Mahony A,Brennan PE,Hay DA,Martinez FO,Al-Mossawi MH,de Wit J,Vecellio M,Wells C,Wordsworth P,Müller S,Knapp S,Bowness P

Tue Aug 25 00:00:00 EDT 2015

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

Proceedings of the National Academy of Sciences of the United States of America

Dasgupta M,Dermawan JK,Willard B,Stark GR

Tue Mar 31 00:00:00 EDT 2015

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.

Oncogene

De Simone V,Franzè E,Ronchetti G,Colantoni A,Fantini MC,Di Fusco D,Sica GS,Sileri P,MacDonald TT,Pallone F,Monteleone G,Stolfi C

Wed Jul 01 00:00:00 EDT 2015

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

Acta physiologica (Oxford, England)

Jean-Gilles L,Braitch M,Latif ML,Aram J,Fahey AJ,Edwards LJ,Robins RA,Tanasescu R,Tighe PJ,Gran B,Showe LC,Alexander SP,Chapman V,Kendall DA,Constantinescu CS

Fri May 01 00:00:00 EDT 2015

Molecular signature of erythroblast enucleation in human embryonic stem cells.

Stem cells (Dayton, Ohio)

Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H

Sat Aug 01 00:00:00 EDT 2015

Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.

Stem cells (Dayton, Ohio)

Fleenor CJ,Rozhok AI,Zaberezhnyy V,Mathew D,Kim J,Tan AC,Bernstein ID,DeGregori J

Wed Apr 01 00:00:00 EDT 2015

IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.

Journal of immunology (Baltimore, Md. : 1950)

Hsu P,Santner-Nanan B,Hu M,Skarratt K,Lee CH,Stormon M,Wong M,Fuller SJ,Nanan R

Thu Oct 15 00:00:00 EDT 2015

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130.

Journal of immunology (Baltimore, Md. : 1950)

Hong SS,Choi JH,Lee SY,Park YH,Park KY,Lee JY,Kim J,Gajulapati V,Goo JI,Singh S,Lee K,Kim YK,Im SH,Ahn SH,Rose-John S,Heo TH,Choi Y

Wed Jul 01 00:00:00 EDT 2015

Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ramos-Amaya A,Rodríguez-Bayona B,López-Blanco R,Andújar E,Pérez-Alegre M,Campos-Caro A,Brieva JA

Sun Feb 01 00:00:00 EST 2015

Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Chadet S,Ivanes F,Benoist L,Salmon-Gandonnière C,Guibon R,Velge-Roussel F,Babuty D,Baron C,Roger S,Angoulvant D

Wed Jul 15 00:00:00 EDT 2015

FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function.

Journal of immunology (Baltimore, Md. : 1950)

Thompson MG,Larson M,Vidrine A,Barrios K,Navarro F,Meyers K,Simms P,Prajapati K,Chitsike L,Hellman LM,Baker BM,Watkins SK

Tue Dec 15 00:00:00 EST 2015

Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.

Journal of immunology (Baltimore, Md. : 1950)

Lourenco S,Teixeira VH,Kalber T,Jose RJ,Floto RA,Janes SM

Wed Apr 01 00:00:00 EDT 2015

Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry.

Journal of immunology (Baltimore, Md. : 1950)

Bushkin Y,Radford F,Pine R,Lardizabal A,Mangura BT,Gennaro ML,Tyagi S

Thu Jan 15 00:00:00 EST 2015

Heme exporter FLVCR is required for T cell development and peripheral survival.

Journal of immunology (Baltimore, Md. : 1950)

Philip M,Funkhouser SA,Chiu EY,Phelps SR,Delrow JJ,Cox J,Fink PJ,Abkowitz JL

Sun Feb 15 00:00:00 EST 2015

The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells.

Journal of immunology (Baltimore, Md. : 1950)

Martin del Campo SE,Levine KM,Mundy-Bosse BL,Grignol VP,Fairchild ET,Campbell AR,Trikha P,Mace TA,Paul BK,Jaime-Ramirez AC,Markowitz J,Kondadasula SV,Guenterberg KD,McClory S,Karpa VI,Pan X,Olencki TE,Monk JP,Mortazavi A,Tridandapani S,Lesinski GB,Byrd JC,Caligiuri MA,Shah MH,Carson WE

Tue Sep 01 00:00:00 EDT 2015

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production.

Journal of immunology (Baltimore, Md. : 1950)

Pundir P,MacDonald CA,Kulka M

Tue Sep 15 00:00:00 EDT 2015

Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models.

Journal of immunology (Baltimore, Md. : 1950)

Guan Y,Zhang L,Li X,Zhang X,Liu S,Gao N,Li L,Gao G,Wei G,Chen Z,Zheng Y,Ma X,Siwko S,Chen JL,Liu M,Li D

Wed Jul 01 00:00:00 EDT 2015

Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production.

Journal of immunology (Baltimore, Md. : 1950)

Chavele KM,Merry E,Ehrenstein MR

Sun Mar 15 00:00:00 EDT 2015

Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Bürgler S,Gimeno A,Parente-Ribes A,Wang D,Os A,Devereux S,Jebsen P,Bogen B,Tjønnfjord GE,Munthe LA

Thu Jan 15 00:00:00 EST 2015

Allergenic Can f 1 and its human homologue Lcn-1 direct dendritic cells to induce divergent immune responses.

Journal of cellular and molecular medicine

Posch B,Irsara C,Gamper FS,Herrmann M,Bindreither D,Fuchs D,Reider N,Redl B,Heufler C

Thu Oct 01 00:00:00 EDT 2015

RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.

RNA biology

Mittelberger F,Meyer C,Waetzig GH,Zacharias M,Valentini E,Svergun DI,Berg K,Lorenzen I,Grötzinger J,Rose-John S,Hahn U

200-06 was used in Cell Culture to investigate aptamer usage and signaling interactions.

Tue Jul 12 00:00:00 EDT 2016

Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action.

CPT: pharmacometrics & systems pharmacology

Michailidou M,Melas IN,Messinis DE,Klamt S,Alexopoulos LG,Kolisis FN,Loutrari H

Mon Jun 01 00:00:00 EDT 2015

Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.

Scientific reports

Yang P,Zhao Y,Zhao L,Yuan J,Chen Y,Varghese Z,Moorhead JF,Chen Y,Ruan XZ

Fri Oct 09 00:00:00 EDT 2015

Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1.

Scientific reports

Wang Y,Xing F,Ye S,Xiao J,Di J,Zeng S,Liu J

Wed Feb 04 00:00:00 EST 2015

Batf is important for IL-4 expression in T follicular helper cells.

Nature communications

Sahoo A,Alekseev A,Tanaka K,Obertas L,Lerman B,Haymaker C,Clise-Dwyer K,McMurray JS,Nurieva R

Mon Aug 17 00:00:00 EDT 2015

Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells.

Scientific reports

Lopes JP,Stylianou M,Nilsson G,Urban CF

Mon Jul 20 00:00:00 EDT 2015

Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.

Scientific reports

Liu J,Zhou F,Chen Q,Kang A,Lu M,Liu W,Zang X,Wang G,Zhang J

Tue Sep 01 00:00:00 EDT 2015

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.

Nature communications

Cohen ES,Scott IC,Majithiya JB,Rapley L,Kemp BP,England E,Rees DG,Overed-Sayer CL,Woods J,Bond NJ,Veyssier CS,Embrey KJ,Sims DA,Snaith MR,Vousden KA,Strain MD,Chan DT,Carmen S,Huntington CE,Flavell L,Xu J,Popovic B,Brightling CE,Vaughan TJ,Butler R,Lowe DC,Higazi DR,Corkill DJ,May RD,Sleeman MA,Mustelin T

Mon Sep 14 00:00:00 EDT 2015

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.

Nature communications

Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M

Wed Nov 04 00:00:00 EST 2015

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Scientific reports

Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y

Fri Dec 18 00:00:00 EST 2015

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.

Nature communications

Wee ZN,Yatim SM,Kohlbauer VK,Feng M,Goh JY,Bao Y,Lee PL,Zhang S,Wang PP,Lim E,Tam WL,Cai Y,Ditzel HJ,Hoon DS,Tan EY,Yu Q

Tue Oct 27 00:00:00 EDT 2015

MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins.

The Journal of biological chemistry

Park H,Huang X,Lu C,Cairo MS,Zhou X

Fri Jan 30 00:00:00 EST 2015

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.

Scientific reports

Mailer RK,Joly AL,Liu S,Elias S,Tegner J,Andersson J

Tue Oct 06 00:00:00 EDT 2015

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.

Scientific reports

Lu J,Zeng H,Liang Z,Chen L,Zhang L,Zhang H,Liu H,Jiang H,Shen B,Huang M,Geng M,Spiegel S,Luo C

Thu Oct 08 00:00:00 EDT 2015

The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation.

The Journal of biological chemistry

Silva JP,Vetterlein O,Jose J,Peters S,Kirby H

Fri Feb 27 00:00:00 EST 2015

Critical functions of RhoB in support of glioblastoma tumorigenesis.

Neuro-oncology

Ma Y,Gong Y,Cheng Z,Loganathan S,Kao C,Sarkaria JN,Abel TW,Wang J

200-06 was used in In vitro experiments to suggest that RhoB belongs to an emerging class of nononcogene addiction" factors that are essential for maintenance of malignant phenotypes in human cancers."

Wed Apr 01 00:00:00 EDT 2015

Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis.

Scientific reports

Liu R,Li X,Zhang Z,Zhou M,Sun Y,Su D,Feng X,Gao X,Shi S,Chen W,Sun L

Tue Aug 11 00:00:00 EDT 2015

Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.

Scientific reports

Thakur R,Trivedi R,Rastogi N,Singh M,Mishra DP

Thu May 14 00:00:00 EDT 2015

Computer-assisted quantification of motile and invasive capabilities of cancer cells.

Scientific reports

Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M

Wed Oct 21 00:00:00 EDT 2015

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 EDT 2014

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity

Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR

Thu Sep 18 00:00:00 EDT 2014

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.

Immunity

Nabekura T,Kanaya M,Shibuya A,Fu G,Gascoigne NR,Lanier LL

Thu Feb 20 00:00:00 EST 2014

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

Nature immunology

Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T

200-06 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.

Thu May 01 00:00:00 EDT 2014

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood

Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW

Thu Feb 27 00:00:00 EST 2014

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.

Blood

Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW

Thu Feb 27 00:00:00 EST 2014

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

Blood

Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE

Thu Oct 02 00:00:00 EDT 2014

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.

Blood

Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK

Thu Feb 20 00:00:00 EST 2014

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.

Blood

Wang CX,Sather BD,Wang X,Adair J,Khan I,Singh S,Lang S,Adams A,Curinga G,Kiem HP,Miao CH,Rawlings DJ,Torbett BE

Thu Aug 07 00:00:00 EDT 2014

The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.

Blood

Yang Z,Augustin J,Chang C,Hu J,Shah K,Chang CW,Townes T,Jiang H

Thu Sep 25 00:00:00 EDT 2014

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.

The Journal of clinical investigation

Velu CS,Chaubey A,Phelan JD,Horman SR,Wunderlich M,Guzman ML,Jegga AG,Zeleznik-Le NJ,Chen J,Mulloy JC,Cancelas JA,Jordan CT,Aronow BJ,Marcucci G,Bhat B,Gebelein B,Grimes HL

Wed Jan 01 00:00:00 EST 2014

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

The Journal of clinical investigation

Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP

200-06 was used in Cell Culture to study how invariant NKT (iNKT) terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17 to indicate that tumor suppressor tuberous sclerosis 1 (TSC1)-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions.

Tue Apr 01 00:00:00 EDT 2014

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.

The Journal of clinical investigation

Bluteau D,Balduini A,Balayn N,Currao M,Nurden P,Deswarte C,Leverger G,Noris P,Perrotta S,Solary E,Vainchenker W,Debili N,Favier R,Raslova H

Sat Feb 01 00:00:00 EST 2014

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

The Journal of experimental medicine

Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE

Mon Apr 07 00:00:00 EDT 2014

A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.

Arthritis & rheumatology (Hoboken, N.J.)

Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L

Fri Aug 01 00:00:00 EDT 2014

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma.

Proceedings of the National Academy of Sciences of the United States of America

Yang D,Chen W,Xiong J,Sherrod CJ,Henry DH,Dittmer DP

Tue Nov 04 00:00:00 EST 2014

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma.

Proceedings of the National Academy of Sciences of the United States of America

Yang D,Chen W,Xiong J,Sherrod CJ,Henry DH,Dittmer DP

Tue Nov 04 00:00:00 EST 2014

The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.

Cell death and differentiation

Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW

Wed Jan 01 00:00:00 EST 2014

Chlorin e6 Conjugated Interleukin-6 Receptor Aptamers Selectively Kill Target Cells Upon Irradiation.

Molecular therapy. Nucleic acids

Kruspe S,Meyer C,Hahn U

Tue Jan 21 00:00:00 EST 2014

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.

Molecular therapy. Nucleic acids

Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U

Tue Oct 07 00:00:00 EDT 2014

Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.

Immunology and cell biology

Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B

Wed Jan 01 00:00:00 EST 2014

Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.

Immunology and cell biology

Ghamlouch H,Ouled-Haddou H,Guyart A,Regnier A,Trudel S,Claisse JF,Fuentes V,Royer B,Marolleau JP,Gubler B

Fri Aug 01 00:00:00 EDT 2014

Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.

Stem cells (Dayton, Ohio)

Fernandez I,Ooi TP,Roy K

Wed Jan 01 00:00:00 EST 2014

Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.

Stem cells (Dayton, Ohio)

Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM

Mon Dec 01 00:00:00 EST 2014

Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Mota C,Nunes-Silva V,Pires AR,Matoso P,Victorino RM,Sousa AE,Caramalho I

Mon Dec 15 00:00:00 EST 2014

Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Epaulard O,Adam L,Poux C,Zurawski G,Salabert N,Rosenbaum P,Dereuddre-Bosquet N,Zurawski S,Flamar AL,Oh S,Romain G,Chapon C,Banchereau J,Lévy Y,Le Grand R,Martinon F

Mon Sep 01 00:00:00 EDT 2014

IL-32 promotes angiogenesis.

Journal of immunology (Baltimore, Md. : 1950)

Nold-Petry CA,Rudloff I,Baumer Y,Ruvo M,Marasco D,Botti P,Farkas L,Cho SX,Zepp JA,Azam T,Dinkel H,Palmer BE,Boisvert WA,Cool CD,Taraseviciene-Stewart L,Heinhuis B,Joosten LA,Dinarello CA,Voelkel NF,Nold MF

Wed Jan 15 00:00:00 EST 2014

Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.

Journal of immunology (Baltimore, Md. : 1950)

Yu J,Wang Y,Yan F,Zhang P,Li H,Zhao H,Yan C,Yan F,Ren X

Mon Sep 01 00:00:00 EDT 2014

Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.

Journal of immunology (Baltimore, Md. : 1950)

Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ

Sat Nov 15 00:00:00 EST 2014

IL-2 phosphorylates STAT5 to drive IFN-γ production and activation of human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Herr F,Lemoine R,Gouilleux F,Meley D,Kazma I,Heraud A,Velge-Roussel F,Baron C,Lebranchu Y

Sun Jun 15 00:00:00 EDT 2014

Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.

Stem cells international

Dai R,Rossello R,Chen CC,Kessler J,Davison I,Hochgeschwender U,Jarvis ED

200-06 was used in Cell Culture to demonstrate an efficient method of maintaining chicken induced pluripotent stem (iPSC)-like cells and for differentiating them into action potential generating neurons.

Thu Jan 22 00:00:00 EST 2015

TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.

PloS one

Reichwald K,Jørgensen TZ,Tougaard P,Skov S

200-06 was used in Western Blotting to investigate the role of the cytokine TL1A in autoimmune disease, showing that it induces the production of IL-6 and TNF-alpha, suggesting that it could be a possible target for the treatment of autoimmune disease

Mon Sep 08 00:00:00 EDT 2014

Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.

The Journal of biological chemistry

Gupta S,Hirota M,Waugh SM,Murakami I,Suzuki T,Muraguchi M,Shibamori M,Ishikawa Y,Jarvis TC,Carter JD,Zhang C,Gawande B,Vrkljan M,Janjic N,Schneider DJ

Fri Mar 21 00:00:00 EDT 2014

Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system.

The Journal of biological chemistry

An B,Abbonante V,Yigit S,Balduini A,Kaplan DL,Brodsky B

Fri Feb 21 00:00:00 EST 2014

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.

Nature communications

Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC

Wed Sep 03 00:00:00 EDT 2014

URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription.

Cell death & disease

Fan JL,Zhang J,Dong LW,Fu WJ,Du J,Shi HG,Jiang H,Ye F,Xi H,Zhang CY,Hou J,Wang HY

Thu Mar 13 00:00:00 EDT 2014

Meprin metalloproteases inactivate interleukin 6.

The Journal of biological chemistry

Keiffer TR,Bond JS

Fri Mar 14 00:00:00 EDT 2014

Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.

The Journal of biological chemistry

Dasgupta M,Unal H,Willard B,Yang J,Karnik SS,Stark GR

Fri Oct 31 00:00:00 EDT 2014

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific reports

Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

Wed Apr 23 00:00:00 EDT 2014

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.

Blood

Harada Y,Inoue D,Ding Y,Imagawa J,Doki N,Matsui H,Yahata T,Matsushita H,Ando K,Sashida G,Iwama A,Kitamura T,Harada H

Thu Apr 25 00:00:00 EDT 2013

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Blood

Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A

Thu Nov 14 00:00:00 EST 2013

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.

Blood

Sportoletti P,Varasano E,Rossi R,Bereshchenko O,Cecchini D,Gionfriddo I,Bolli N,Tiacci E,Intermesoli T,Zanghì P,Masciulli A,Martelli MP,Falzetti F,Martelli MF,Falini B

Thu Apr 25 00:00:00 EDT 2013

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.

Blood

Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T

Thu May 16 00:00:00 EDT 2013

Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.

Blood

Laperrousaz B,Jeanpierre S,Sagorny K,Voeltzel T,Ramas S,Kaniewski B,Ffrench M,Salesse S,Nicolini FE,Maguer-Satta V

Thu Nov 28 00:00:00 EST 2013

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Blood

Kauskot A,Vandenbriele C,Louwette S,Gijsbers R,Tousseyn T,Freson K,Verhamme P,Hoylaerts MF

Thu Jun 27 00:00:00 EDT 2013

An analysis of the function and expression of D6 on lymphatic endothelial cells.

Blood

McKimmie CS,Singh MD,Hewit K,Lopez-Franco O,Le Brocq M,Rose-John S,Lee KM,Baker AH,Wheat R,Blackbourn DJ,Nibbs RJ,Graham GJ

Thu May 02 00:00:00 EDT 2013

Genomic impact of transient low-dose decitabine treatment on primary AML cells.

Blood

Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ

Thu Feb 28 00:00:00 EST 2013

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

The Journal of clinical investigation

Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN

Thu Aug 01 00:00:00 EDT 2013

Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

The Journal of experimental medicine

Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I

Mon Feb 11 00:00:00 EST 2013

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.

The Journal of experimental medicine

Long HM,Chagoury OL,Leese AM,Ryan GB,James E,Morton LT,Abbott RJ,Sabbah S,Kwok W,Rickinson AB

Mon May 06 00:00:00 EDT 2013

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome.

The Journal of experimental medicine

Kotlarz D,Ziętara N,Uzel G,Weidemann T,Braun CJ,Diestelhorst J,Krawitz PM,Robinson PN,Hecht J,Puchałka J,Gertz EM,Schäffer AA,Lawrence MG,Kardava L,Pfeifer D,Baumann U,Pfister ED,Hanson EP,Schambach A,Jacobs R,Kreipe H,Moir S,Milner JD,Schwille P,Mundlos S,Klein C

Mon Mar 11 00:00:00 EDT 2013

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Leukemia

Hansen N,Ågerstam H,Wahlestedt M,Landberg N,Askmyr M,Ehinger M,Rissler M,Lilljebjörn H,Johnels P,Ishiko J,Melo JV,Alexander WS,Bryder D,Järås M,Fioretos T

Tue Jan 01 00:00:00 EST 2013

Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Li J,Wei B,Guo A,Liu C,Huang S,Du F,Fan W,Bao C,Pei G

Tue Apr 30 00:00:00 EDT 2013

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ

Fri Nov 01 00:00:00 EDT 2013

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ

Fri Nov 01 00:00:00 EDT 2013

STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.

Journal of immunology (Baltimore, Md. : 1950)

Rodríguez-Bayona B,Ramos-Amaya A,López-Blanco R,Campos-Caro A,Brieva JA

Fri Nov 15 00:00:00 EST 2013

β-Defensins activate human mast cells via Mas-related gene X2.

Journal of immunology (Baltimore, Md. : 1950)

Subramanian H,Gupta K,Lee D,Bayir AK,Ahn H,Ali H

Mon Jul 01 00:00:00 EDT 2013

MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B.

Journal of immunology (Baltimore, Md. : 1950)

Wang S,Zhang X,Ju Y,Zhao B,Yan X,Hu J,Shi L,Yang L,Ma Z,Chen L,Liu Y,Duan Z,Chen X,Meng S

Mon Jul 01 00:00:00 EDT 2013

The road to memory: an early rest for the long journey.

Journal of immunology (Baltimore, Md. : 1950)

Ho LP,Yit PS,Ng LH,Linn YC,Zhao Y,Sun L,Ling KL,Chai Koh MB,Monica Shih MC,Li S,Wang XY,Tien SL,Goh YT

Sun Dec 01 00:00:00 EST 2013

Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.

PloS one

Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X

Fri Jul 19 00:00:00 EDT 2013

Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study.

PloS one

Xi J,Zhu H,Liu D,Nan X,Zheng W,Liu K,Shi W,Chen L,Lv Y,Yan F,Li Y,Xie X,Wang Y,Yue W,Xu X,Wei X,Zhu J,Huang X,Pei X

Fri Jul 19 00:00:00 EDT 2013

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.

Journal of translational medicine

Touboul C,Lis R,Al Farsi H,Raynaud CM,Warfa M,Althawadi H,Mery E,Mirshahi M,Rafii A

Thu Jan 31 00:00:00 EST 2013

High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes.

PloS one

Currao M,Balduini CL,Balduini A

Fri Sep 06 00:00:00 EDT 2013

TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.

PloS one

Liu Y,Yu S,Li Z,Ma J,Zhang Y,Wang H,Yang B,Wu C

Tue Feb 18 00:00:00 EST 2014

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.

PloS one

Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG

Thu Aug 08 00:00:00 EDT 2013

Immunologic targeting of FOXP3 in inflammatory breast cancer cells.

PloS one

Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR

Tue Jul 09 00:00:00 EDT 2013

Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.

PloS one

Luger R,Valookaran S,Knapp N,Vizzardelli C,Dohnal AM,Felzmann T

Fri Sep 06 00:00:00 EDT 2013

Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.

The Journal of biological chemistry

Braun DA,Fribourg M,Sealfon SC

Fri Feb 01 00:00:00 EST 2013

Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.

The Journal of biological chemistry

Ferreira E,Porter RM,Wehling N,O'Sullivan RP,Liu F,Boskey A,Estok DM,Harris MB,Vrahas MS,Evans CH,Wells JW

Fri Oct 11 00:00:00 EDT 2013

A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.

PloS one

Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L

Fri Jul 19 00:00:00 EDT 2013

A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells.

PloS one

Gao XN,Lin J,Ning QY,Gao L,Yao YS,Zhou JH,Li YH,Wang LL,Yu L

Fri Jul 19 00:00:00 EDT 2013

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.

Nature

Landsberg J,Kohlmeyer J,Renn M,Bald T,Rogava M,Cron M,Fatho M,Lennerz V,Wölfel T,Hölzel M,Tüting T

Thu Oct 18 00:00:00 EDT 2012

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

Cell

Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA

Fri Jun 08 00:00:00 EDT 2012

FANCL ubiquitinates β-catenin and enhances its nuclear function.

Blood

Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC

Thu Jul 12 00:00:00 EDT 2012

IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.

Blood

Hodge LS,Ziesmer SC,Yang ZZ,Secreto FJ,Gertz MA,Novak AJ,Ansell SM

Thu Nov 01 00:00:00 EDT 2012

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Blood

Ma CS,Avery DT,Chan A,Batten M,Bustamante J,Boisson-Dupuis S,Arkwright PD,Kreins AY,Averbuch D,Engelhard D,Magdorf K,Kilic SS,Minegishi Y,Nonoyama S,French MA,Choo S,Smart JM,Peake J,Wong M,Gray P,Cook MC,Fulcher DA,Casanova JL,Deenick EK,Tangye SG

Thu Apr 26 00:00:00 EDT 2012

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

Blood

Will B,Zhou L,Vogler TO,Ben-Neriah S,Schinke C,Tamari R,Yu Y,Bhagat TD,Bhattacharyya S,Barreyro L,Heuck C,Mo Y,Parekh S,McMahon C,Pellagatti A,Boultwood J,Montagna C,Silverman L,Maciejewski J,Greally JM,Ye BH,List AF,Steidl C,Steidl U,Verma A

Thu Sep 06 00:00:00 EDT 2012

Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells.

Blood

Gori JL,Chandrasekaran D,Kowalski JP,Adair JE,Beard BC,D'Souza SL,Kiem HP

Thu Sep 27 00:00:00 EDT 2012

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

The Journal of experimental medicine

Kaufmann KB,Gründer A,Hadlich T,Wehrle J,Gothwal M,Bogeska R,Seeger TS,Kayser S,Pham KB,Jutzi JS,Ganzenmüller L,Steinemann D,Schlegelberger B,Wagner JM,Jung M,Will B,Steidl U,Aumann K,Werner M,Günther T,Schüle R,Rambaldi A,Pahl HL

Mon Jan 16 00:00:00 EST 2012

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.

The Journal of experimental medicine

Thiollier C,Lopez CK,Gerby B,Ignacimouttou C,Poglio S,Duffourd Y,Guégan J,Rivera-Munoz P,Bluteau O,Mabialah V,Diop M,Wen Q,Petit A,Bauchet AL,Reinhardt D,Bornhauser B,Gautheret D,Lecluse Y,Landman-Parker J,Radford I,Vainchenker W,Dastugue N,de Botton S,Dessen P,Bourquin JP,Crispino JD,Ballerini P,Bernard OA,Pflumio F,Mercher T

Mon Oct 22 00:00:00 EDT 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 EDT 2012

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Proceedings of the National Academy of Sciences of the United States of America

Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I

Tue Oct 23 00:00:00 EDT 2012

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.

Proceedings of the National Academy of Sciences of the United States of America

Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F

Tue Oct 02 00:00:00 EDT 2012

The Sin3a repressor complex is a master regulator of STAT transcriptional activity.

Proceedings of the National Academy of Sciences of the United States of America

Icardi L,Mori R,Gesellchen V,Eyckerman S,De Cauwer L,Verhelst J,Vercauteren K,Saelens X,Meuleman P,Leroux-Roels G,De Bosscher K,Boutros M,Tavernier J

Tue Jul 24 00:00:00 EDT 2012

T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Molinero LL,Cubre A,Mora-Solano C,Wang Y,Alegre ML

Tue Nov 06 00:00:00 EST 2012

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

Proceedings of the National Academy of Sciences of the United States of America

Lee H,Zhang P,Herrmann A,Yang C,Xin H,Wang Z,Hoon DS,Forman SJ,Jove R,Riggs AD,Yu H

Tue May 15 00:00:00 EDT 2012

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.

Oncogene

Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T

Thu Mar 15 00:00:00 EDT 2012

Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.

Journal of molecular medicine (Berlin, Germany)

Eaton A,Nagy E,Pacault M,Fauconnier J,Bäck M

Mon Oct 01 00:00:00 EDT 2012

Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.

Allergy, asthma & immunology research

Kashiwakura J,Okayama Y,Furue M,Kabashima K,Shimada S,Ra C,Siraganian RP,Kawakami Y,Kawakami T

Thu Nov 01 00:00:00 EDT 2012

Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.

PloS one

Arcipowski KM,Bishop GA

Mon Jan 14 00:00:00 EST 2013

Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.

PloS one

Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S

Thu Dec 13 00:00:00 EST 2012

Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

The Journal of biological chemistry

Khanna-Gupta A,Abayasekara N,Levine M,Sun H,Virgilio M,Nia N,Halene S,Sportoletti P,Jeong JY,Pandolfi PP,Berliner N

Fri Sep 21 00:00:00 EDT 2012

Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts.

PloS one

Steinman RA,Robinson AR,Feghali-Bostwick CA

Tue May 14 00:00:00 EDT 2013

Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo.

PloS one

Waldmeier L,Meyer-Schaller N,Diepenbruck M,Christofori G

Wed Apr 24 00:00:00 EDT 2013

Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.

PloS one

Lee MJ,Lee JK,Choi JW,Lee CS,Sim JH,Cho CH,Lee KH,Cho IH,Chung MH,Kim HR,Ye SK

Tue Jan 22 00:00:00 EST 2013

DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.

PloS one

Guo Z,Zhang H,Rao H,Jiang D,Cong X,Feng B,Wang J,Wei L,Chen H

Thu Nov 08 00:00:00 EST 2012

Artificial extracellular matrices composed of collagen I and high sulfated hyaluronan modulate monocyte to macrophage differentiation under conditions of sterile inflammation.

Biomatter

Kajahn J,Franz S,Rueckert E,Forstreuter I,Hintze V,Moeller S,Simon JC

200-06 was used in Cell Culture to characterise the immunomodulating capacities of artifcial extracellular matrices and identify matrices that may benefit healing of biomaterials.

Thu Mar 20 00:00:00 EDT 2014

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.

PloS one

Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC

Fri Jun 29 00:00:00 EDT 2012

Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.

PloS one

Hulsmans M,Geeraert B,De Keyzer D,Mertens A,Lannoo M,Vanaudenaerde B,Hoylaerts M,Benhabilès N,Tsatsanis C,Mathieu C,Holvoet P

Mon Jun 11 00:00:00 EDT 2012

Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.

The Journal of biological chemistry

Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y

Fri Nov 23 00:00:00 EST 2012

The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers.

BMC cancer

Wang J,Xu K,Wu J,Luo C,Li Y,Wu X,Gao H,Feng G,Yuan BZ

Fri Sep 21 00:00:00 EDT 2012

Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

PloS one

Tsuda K,Yamanaka K,Kitagawa H,Akeda T,Naka M,Niwa K,Nakanishi T,Kakeda M,Gabazza EC,Mizutani H

Fri Aug 03 00:00:00 EDT 2012

Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.

PloS one

Vatolin S,Khan SN,Reu FJ

Tue Mar 12 00:00:00 EDT 2013

Neurotensin and CRH interactions augment human mast cell activation.

PloS one

Alysandratos KD,Asadi S,Angelidou A,Zhang B,Sismanopoulos N,Yang H,Critchfield A,Theoharides TC

Thu May 09 00:00:00 EDT 2013

Influenza A virus infection of human respiratory cells induces primary microRNA expression.

The Journal of biological chemistry

Buggele WA,Johnson KE,Horvath CM

Fri Sep 07 00:00:00 EDT 2012

Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.

PloS one

Sangeetha VM,Kadekar D,Kale VP,Limaye LS

Mon May 14 00:00:00 EDT 2012

Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.

The Journal of biological chemistry

Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z

Fri Aug 24 00:00:00 EDT 2012

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.

Blood cancer journal

Dassé E,Volpe G,Walton DS,Wilson N,Del Pozzo W,O'Neill LP,Slany RK,Frampton J,Dumon S

Fri Jun 01 00:00:00 EDT 2012

Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation.

Cell death & disease

Westerberg CM,Hägglund H,Nilsson G

Thu Nov 15 00:00:00 EST 2012

Baicalin, a natural compound, promotes regulatory T cell differentiation.

BMC complementary and alternative medicine

Yang J,Yang X,Li M

Wed May 16 00:00:00 EDT 2012

Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survival.

PloS one

Ekoff M,Lyberg K,Krajewska M,Arvidsson M,Rak S,Reed JC,Harvima I,Nilsson G

Thu Dec 13 00:00:00 EST 2012

Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin.

Journal of neuroinflammation

Asadi S,Theoharides TC

Fri May 04 00:00:00 EDT 2012

Enhancement of myeloma development mediated though myeloma cell-Th2 cell interactions after microbial antigen presentation by myeloma cells and DCs.

Blood cancer journal

Tian F,Li J,Li Y,Luo S

Fri Jun 01 00:00:00 EDT 2012

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Cell

Bock C,Kiskinis E,Verstappen G,Gu H,Boulting G,Smith ZD,Ziller M,Croft GF,Amoroso MW,Oakley DH,Gnirke A,Eggan K,Meissner A

Fri Feb 04 00:00:00 EST 2011

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.

Cell research

Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R

Tue Mar 01 00:00:00 EST 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Cancer cell

Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R

Tue Sep 13 00:00:00 EDT 2011

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.

Cancer cell

Liu F,Zhao X,Perna F,Wang L,Koppikar P,Abdel-Wahab O,Harr MW,Levine RL,Xu H,Tefferi A,Deblasio A,Hatlen M,Menendez S,Nimer SD

Tue Feb 15 00:00:00 EST 2011

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Blood

Bosco MC,Pierobon D,Blengio F,Raggi F,Vanni C,Gattorno M,Eva A,Novelli F,Cappello P,Giovarelli M,Varesio L

Thu Mar 03 00:00:00 EST 2011

Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1.

Blood

Hodge LS,Novak AJ,Grote DM,Braggio E,Ketterling RP,Manske MK,Price Troska TL,Ziesmer SC,Fonseca R,Witzig TE,Morice WG,Gertz MA,Ansell SM

Thu May 12 00:00:00 EDT 2011

miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.

Blood

Lu C,Huang X,Zhang X,Roensch K,Cao Q,Nakayama KI,Blazar BR,Zeng Y,Zhou X

Thu Apr 21 00:00:00 EDT 2011

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.

Blood

Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R

Thu Apr 21 00:00:00 EDT 2011

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.

Blood

Sheng Z,Ma L,Sun JE,Zhu LJ,Green MR

Thu Sep 08 00:00:00 EDT 2011

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Blood

Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ

Thu Mar 17 00:00:00 EDT 2011

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

Blood

Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ

Thu Feb 03 00:00:00 EST 2011

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

Blood

Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S

Thu Dec 01 00:00:00 EST 2011

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood

Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E

Thu Jan 06 00:00:00 EST 2011

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

Blood

Roy D,Sin SH,Damania B,Dittmer DP

Thu Aug 18 00:00:00 EDT 2011

Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.

Blood

Hu K,Yu J,Suknuntha K,Tian S,Montgomery K,Choi KD,Stewart R,Thomson JA,Slukvin II

Thu Apr 07 00:00:00 EDT 2011

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting.

Blood

Zou J,Sweeney CL,Chou BK,Choi U,Pan J,Wang H,Dowey SN,Cheng L,Malech HL

Thu May 26 00:00:00 EDT 2011

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.

The Journal of clinical investigation

Wu X,Simpson J,Hong JH,Kim KH,Thavarajah NK,Backx PH,Neel BG,Araki T

Tue Mar 01 00:00:00 EST 2011

Molecular target characterization and antimyeloma activity of the novel, insulin-like growth factor 1 receptor inhibitor, GTx-134.

Clinical cancer research : an official journal of the American Association for Cancer Research

Liang SB,Yang XZ,Trieu Y,Li Z,Zive J,Leung-Hagesteijn C,Wei E,Zozulya S,Coss CC,Dalton JT,Fantus IG,Trudel S

Fri Jul 15 00:00:00 EDT 2011

Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.

Proceedings of the National Academy of Sciences of the United States of America

Chihara N,Aranami T,Sato W,Miyazaki Y,Miyake S,Okamoto T,Ogawa M,Toda T,Yamamura T

Tue Mar 01 00:00:00 EST 2011

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.

Arthritis research & therapy

Migita K,Komori A,Torigoshi T,Maeda Y,Izumi Y,Jiuchi Y,Miyashita T,Nakamura M,Motokawa S,Ishibashi H

Fri May 06 00:00:00 EDT 2011

Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.

Journal of immunology (Baltimore, Md. : 1950)

Okano S,Yonemitsu Y,Shirabe K,Kakeji Y,Maehara Y,Harada M,Yoshikai Y,Inoue M,Hasegawa M,Sueishi K

Tue Feb 01 00:00:00 EST 2011

The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Fujimoto M,Nakano M,Terabe F,Kawahata H,Ohkawara T,Han Y,Ripley B,Serada S,Nishikawa T,Kimura A,Nomura S,Kishimoto T,Naka T

Sat Jan 01 00:00:00 EST 2011

The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Ortner D,Grabher D,Hermann M,Kremmer E,Hofer S,Heufler C

Sat Oct 15 00:00:00 EDT 2011

Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Rådinger M,Smrž D,Metcalfe DD,Gilfillan AM

Thu Dec 01 00:00:00 EST 2011

Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa.

PloS one

Harel E,Rubinstein A,Nissan A,Khazanov E,Nadler Milbauer M,Barenholz Y,Tirosh B

Tue Feb 14 00:00:00 EST 2012

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

The Journal of biological chemistry

Ehlting C,Ronkina N,Böhmer O,Albrecht U,Bode KA,Lang KS,Kotlyarov A,Radzioch D,Gaestel M,Häussinger D,Bode JG

Fri Jul 08 00:00:00 EDT 2011

Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α.

BMC genomics

Wang Z,Bishop EP,Burke PA

Fri Feb 25 00:00:00 EST 2011

Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.

PloS one

Mack AA,Kroboth S,Rajesh D,Wang WB

Mon Apr 02 00:00:00 EDT 2012

Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.

PloS one

Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P

Fri Feb 11 00:00:00 EST 2011

Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.

PloS one

Badr G,Lefevre EA,Mohany M

Thu Dec 29 00:00:00 EST 2011

Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression.

The Journal of biological chemistry

von Rossum A,Krall R,Escalante NK,Choy JC

Fri Jun 17 00:00:00 EDT 2011

GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.

The Journal of biological chemistry

Elsawa SF,Almada LL,Ziesmer SC,Novak AJ,Witzig TE,Ansell SM,Fernandez-Zapico ME

Fri Jun 17 00:00:00 EDT 2011

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.

Molecular cancer

Zhao M,Ma J,Zhu HY,Zhang XH,Du ZY,Xu YJ,Yu XD

Mon Aug 29 00:00:00 EDT 2011

Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1.

Virology journal

Datta S,Hazari S,Chandra PK,Samara M,Poat B,Gunduz F,Wimley WC,Hauser H,Koster M,Lamaze C,Balart LA,Garry RF,Dash S

Thu Jul 14 00:00:00 EDT 2011

Immunoglobulin E oligomers identified in blood components activate mast cells: relevance to anaphylactic transfusion reaction.

Transfusion

Abe T,Matsumoto C,Shimada E,Mazda T,Takanashi M,Kawaguchi K,Hamasaki T,Mita H,Akiyama K,Okazaki H,Satake M,Tadokoro K

200-06 was used in Cell Culture to suggest that these IgEs were dimeric and trimeric and that they directly activated the transfusion recipient's mast cells by triggering the crosslinking of Fcε receptor I, thereby inducing an anaphylactic transfusion reaction.

Tue Nov 01 00:00:00 EDT 2011

Comparative study of hematopoietic differentiation between human embryonic stem cell lines.

PloS one

Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A

Fri Oct 21 00:00:00 EDT 2011

Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.

The Journal of biological chemistry

Sarma NJ,Yaseen NR

Fri Nov 11 00:00:00 EST 2011

Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

PloS one

Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S

Fri Apr 29 00:00:00 EDT 2011

Efficient feeder-free episomal reprogramming with small molecules.

PloS one

Yu J,Chau KF,Vodyanik MA,Jiang J,Jiang Y

Tue Mar 01 00:00:00 EST 2011

LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release.

PloS one

Lundequist A,Boyce JA

Mon Mar 28 00:00:00 EDT 2011

Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.

The Journal of biological chemistry

Nishimura K,Sano M,Ohtaka M,Furuta B,Umemura Y,Nakajima Y,Ikehara Y,Kobayashi T,Segawa H,Takayasu S,Sato H,Motomura K,Uchida E,Kanayasu-Toyoda T,Asashima M,Nakauchi H,Yamaguchi T,Nakanishi M

Fri Feb 11 00:00:00 EST 2011

In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes.

PloS one

Balduini A,Badalucco S,Pugliano MT,Baev D,De Silvestri A,Cattaneo M,Rosti V,Barosi G

Mon Nov 07 00:00:00 EST 2011

The Journal of biological chemistry

Subramanian H,Gupta K,Guo Q,Price R,Ali H

Fri Dec 30 00:00:00 EST 2011

DNA damage-mediated induction of a chemoresistant niche.

Cell

Gilbert LA,Hemann MT

Fri Oct 29 00:00:00 EDT 2010

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Cancer cell

Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW

Tue Dec 14 00:00:00 EST 2010

Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal.

Blood

Skorokhod OA,Caione L,Marrocco T,Migliardi G,Barrera V,Arese P,Piacibello W,Schwarzer E

Thu Nov 18 00:00:00 EST 2010

A revised model for the secretion of tPA and cytokines from cultured endothelial cells.

Blood

Knipe L,Meli A,Hewlett L,Bierings R,Dempster J,Skehel P,Hannah MJ,Carter T

Thu Sep 23 00:00:00 EDT 2010

Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.

Blood

Singbrant S,Karlsson G,Ehinger M,Olsson K,Jaako P,Miharada K,Stadtfeld M,Graf T,Karlsson S

Thu Jun 10 00:00:00 EDT 2010

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.

Blood

Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT

Thu Dec 23 00:00:00 EST 2010

W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.

Blood

Jansson L,Larsson J

Thu Jan 07 00:00:00 EST 2010

Low-strength T-cell activation promotes Th17 responses.

Blood

Purvis HA,Stoop JN,Mann J,Woods S,Kozijn AE,Hambleton S,Robinson JH,Isaacs JD,Anderson AE,Hilkens CM

Thu Dec 02 00:00:00 EST 2010

Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.

Blood

Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H

Thu Dec 02 00:00:00 EST 2010

Serum response factor is an essential transcription factor in megakaryocytic maturation.

Blood

Halene S,Gao Y,Hahn K,Massaro S,Italiano JE,Schulz V,Lin S,Kupfer GM,Krause DS

Thu Sep 16 00:00:00 EDT 2010

Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential.

Blood

Grassinger J,Haylock DN,Williams B,Olsen GH,Nilsson SK

Thu Oct 28 00:00:00 EDT 2010

Evidence for a cross-talk between human neutrophils and Th17 cells.

Blood

Pelletier M,Maggi L,Micheletti A,Lazzeri E,Tamassia N,Costantini C,Cosmi L,Lunardi C,Annunziato F,Romagnani S,Cassatella MA

Thu Jan 14 00:00:00 EST 2010

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.

Blood

Perna F,Gurvich N,Hoya-Arias R,Abdel-Wahab O,Levine RL,Asai T,Voza F,Menendez S,Wang L,Liu F,Zhao X,Nimer SD

Thu Oct 14 00:00:00 EDT 2010

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.

The Journal of experimental medicine

Yu L,Ji W,Zhang H,Renda MJ,He Y,Lin S,Cheng EC,Chen H,Krause DS,Min W

Mon Jun 07 00:00:00 EDT 2010

Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.

The Journal of experimental medicine

Buono M,Visigalli I,Bergamasco R,Biffi A,Cosma MP

Mon Aug 02 00:00:00 EDT 2010

IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.

Proceedings of the National Academy of Sciences of the United States of America

Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E

Tue Jan 12 00:00:00 EST 2010

Marburg virus evades interferon responses by a mechanism distinct from ebola virus.

PLoS pathogens

Valmas C,Grosch MN,Schümann M,Olejnik J,Martinez O,Best SM,Krähling V,Basler CF,Mühlberger E

Fri Jan 15 00:00:00 EST 2010

Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.

Stem cells (Dayton, Ohio)

Zhang QZ,Su WR,Shi SH,Wilder-Smith P,Xiang AP,Wong A,Nguyen AL,Kwon CW,Le AD

Fri Oct 01 00:00:00 EDT 2010

The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: potential for therapeutics.

Journal of immunology (Baltimore, Md. : 1950)

Karlberg M,Ekoff M,Huang DC,Mustonen P,Harvima IT,Nilsson G

Sun Aug 15 00:00:00 EDT 2010

Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin.

Journal of immunology (Baltimore, Md. : 1950)

Bleck B,Tse DB,Gordon T,Ahsan MR,Reibman J

Wed Dec 01 00:00:00 EST 2010

Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.

Journal of immunology (Baltimore, Md. : 1950)

Kuang DM,Peng C,Zhao Q,Wu Y,Zhu LY,Wang J,Yin XY,Li L,Zheng L

Sun Aug 01 00:00:00 EDT 2010

The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.

Journal of immunology (Baltimore, Md. : 1950)

Thacker SG,Berthier CC,Mattinzoli D,Rastaldi MP,Kretzler M,Kaplan MJ

Fri Oct 01 00:00:00 EDT 2010

Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Yeh N,Glosson NL,Wang N,Guindon L,McKinley C,Hamada H,Li Q,Dutton RW,Shrikant P,Zhou B,Brutkiewicz RR,Blum JS,Kaplan MH

Sun Aug 15 00:00:00 EDT 2010

RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.

Journal of immunology (Baltimore, Md. : 1950)

Burgler S,Mantel PY,Bassin C,Ouaked N,Akdis CA,Schmidt-Weber CB

Tue Jun 01 00:00:00 EDT 2010

Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Rådinger M,Kuehn HS,Kim MS,Metcalfe DD,Gilfillan AM

Fri Jan 15 00:00:00 EST 2010

CXCR7 protein is not expressed on human or mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ

Mon Nov 01 00:00:00 EDT 2010

CXCR7 protein is not expressed on human or mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ

Mon Nov 01 00:00:00 EDT 2010

CD72 negatively regulates KIT-mediated responses in human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kataoka TR,Kumanogoh A,Bandara G,Metcalfe DD,Gilfillan AM

Mon Mar 01 00:00:00 EST 2010

Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Niyonsaba F,Ushio H,Hara M,Yokoi H,Tominaga M,Takamori K,Kajiwara N,Saito H,Nagaoka I,Ogawa H,Okumura K

Thu Apr 01 00:00:00 EDT 2010

miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.

Journal of immunology (Baltimore, Md. : 1950)

Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H

Sat May 01 00:00:00 EDT 2010

Zinc and lead leaching from contaminated industrial waste sludges using coupled processes.

Environmental technology

Cheikh M,Magnin JP,Gondrexon N,Willison J,Hassen A

Tue Dec 14 00:00:00 EST 2010

Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.

The Journal of biological chemistry

Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ

Fri Jul 02 00:00:00 EDT 2010

Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse.

PloS one

V M S,Kale VP,Limaye LS

Tue Aug 17 00:00:00 EDT 2010

Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation.

Molecular cancer

Cheng HL,Su SJ,Huang LW,Hsieh BS,Hu YC,Hung TC,Chang KL

Fri May 28 00:00:00 EDT 2010

Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.

The Journal of biological chemistry

Zhang Y,Tang W,Jones MC,Xu W,Halene S,Wu D

Fri Aug 06 00:00:00 EDT 2010

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.

PloS one

Valeri A,Alonso-Ferrero ME,Río P,Pujol MR,Casado JA,Pérez L,Jacome A,Agirre X,Calasanz MJ,Hanenberg H,Surrallés J,Prosper F,Albella B,Bueren JA

Tue Dec 28 00:00:00 EST 2010

Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector.

Virology journal

Fratini P,Strauss BE

Fri Jan 22 00:00:00 EST 2010

Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.

Molecular pain

Chen T,Koga K,Li XY,Zhuo M

Fri Apr 09 00:00:00 EDT 2010

C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity.

The Journal of biological chemistry

Zannetti C,Bonnay F,Takeshita F,Parroche P,Ménétrier-Caux C,Tommasino M,Hasan UA

Fri Nov 05 00:00:00 EDT 2010

Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.

Nature protocols

Giorgetti A,Montserrat N,Rodriguez-Piza I,Azqueta C,Veiga A,Izpisúa Belmonte JC

Thu Apr 01 00:00:00 EDT 2010

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity.

Journal of inflammation (London, England)

Jensen SS,Gad M

Tue Jul 27 00:00:00 EDT 2010

In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.

PloS one

Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR

Fri Aug 27 00:00:00 EDT 2010

Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro.

Journal of experimental & clinical cancer research : CR

Huang C,Yang G,Jiang T,Huang K,Cao J,Qiu Z

Wed May 19 00:00:00 EDT 2010

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

Molecular cancer

Bill MA,Fuchs JR,Li C,Yui J,Bakan C,Benson DM,Schwartz EB,Abdelhamid D,Lin J,Hoyt DG,Fossey SL,Young GS,Carson WE,Li PK,Lesinski GB

Fri Jun 25 00:00:00 EDT 2010

Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.

BMC systems biology

Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A

Wed Jun 16 00:00:00 EDT 2010

ErythRED, a hESC line enabling identification of erythroid cells.

Nature methods

Hatzistavrou T,Micallef SJ,Ng ES,Vadolas J,Stanley EG,Elefanty AG

Tue Sep 01 00:00:00 EDT 2009

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

Immunity

Chung Y,Chang SH,Martinez GJ,Yang XO,Nurieva R,Kang HS,Ma L,Watowich SS,Jetten AM,Tian Q,Dong C

Fri Apr 17 00:00:00 EDT 2009

Intraclonal competition limits the fate determination of regulatory T cells in the thymus.

Nature immunology

Bautista JL,Lio CW,Lathrop SK,Forbush K,Liang Y,Luo J,Rudensky AY,Hsieh CS

Mon Jun 01 00:00:00 EDT 2009

PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.

Blood

Hikata T,Takaishi H,Takito J,Hakozaki A,Furukawa M,Uchikawa S,Kimura T,Okada Y,Matsumoto M,Yoshimura A,Nishimura R,Reddy SV,Asahara H,Toyama Y

Thu Mar 05 00:00:00 EST 2009

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype.

Blood

Soriani A,Zingoni A,Cerboni C,Iannitto ML,Ricciardi MR,Di Gialleonardo V,Cippitelli M,Fionda C,Petrucci MT,Guarini A,Foà R,Santoni A

Thu Apr 09 00:00:00 EDT 2009

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.

Blood

Will B,Kawahara M,Luciano JP,Bruns I,Parekh S,Erickson-Miller CL,Aivado MA,Verma A,Steidl U

Thu Oct 29 00:00:00 EDT 2009

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs.

Blood

Aichberger KJ,Gleixner KV,Mirkina I,Cerny-Reiterer S,Peter B,Ferenc V,Kneidinger M,Baumgartner C,Mayerhofer M,Gruze A,Pickl WF,Sillaber C,Valent P

Thu Dec 17 00:00:00 EST 2009

The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.

Blood

Oehler VG,Guthrie KA,Cummings CL,Sabo K,Wood BL,Gooley T,Yang T,Epping MT,Shou Y,Pogosova-Agadjanyan E,Ladne P,Stirewalt DL,Abkowitz JL,Radich JP

Thu Oct 08 00:00:00 EDT 2009

Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.

Blood

Jin W,Zhou XF,Yu J,Cheng X,Sun SC

Thu Jun 25 00:00:00 EDT 2009

Role for MKL1 in megakaryocytic maturation.

Blood

Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

Thu Mar 19 00:00:00 EDT 2009

Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.

Blood

Kandilci A,Grosveld GC

Thu Aug 20 00:00:00 EDT 2009

Distinct roles of stress-activated protein kinases in Fanconi anemia-type C-deficient hematopoiesis.

Blood

Saadatzadeh MR,Bijangi-Vishehsaraei K,Kapur R,Haneline LS

Thu Mar 19 00:00:00 EDT 2009

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.

Blood

Schwieger M,Schüler A,Forster M,Engelmann A,Arnold MA,Delwel R,Valk PJ,Löhler J,Slany RK,Olson EN,Stocking C

Thu Sep 17 00:00:00 EDT 2009

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Blood

Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD

Thu Oct 01 00:00:00 EDT 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

The Journal of clinical investigation

Ford AM,Palmi C,Bueno C,Hong D,Cardus P,Knight D,Cazzaniga G,Enver T,Greaves M

Wed Apr 01 00:00:00 EDT 2009

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.

The Journal of clinical investigation

Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T

Sun Mar 01 00:00:00 EST 2009

Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y

Tue Sep 15 00:00:00 EDT 2009

Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients: preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells.

Clinical immunology (Orlando, Fla.)

Okumura S,Yuki K,Kobayashi R,Okamura S,Ohmori K,Saito H,Ra C,Okayama Y

Sun Feb 01 00:00:00 EST 2009

Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing.

The Journal of cell biology

Chong HC,Tan MJ,Philippe V,Tan SH,Tan CK,Ku CW,Goh YY,Wahli W,Michalik L,Tan NS

Mon Mar 23 00:00:00 EDT 2009

A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.

PLoS pathogens

Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B

Sun Feb 01 00:00:00 EST 2009

Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells.

Journal of leukocyte biology

Hegde S,Jankowska-Gan E,Roenneburg DA,Torrealba J,Burlingham WJ,Gumperz JE

Thu Oct 01 00:00:00 EDT 2009

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Immunology and cell biology

Ma CS,Suryani S,Avery DT,Chan A,Nanan R,Santner-Nanan B,Deenick EK,Tangye SG

Thu Jan 14 00:00:00 EST 2010

Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.

Stem cells (Dayton, Ohio)

Compte M,Cuesta AM,Sánchez-Martín D,Alonso-Camino V,Vicario JL,Sanz L,Alvarez-Vallina L

Sun Mar 01 00:00:00 EST 2009

Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.

Stem cells (Dayton, Ohio)

Tian X,Hexum MK,Penchev VR,Taylor RJ,Shultz LD,Kaufman DS

Sun Nov 01 00:00:00 EDT 2009

A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.

Stem cells (Dayton, Ohio)

Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A

Thu Jan 01 00:00:00 EST 2009

Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7.

The international journal of biochemistry & cell biology

Kalwitz G,Endres M,Neumann K,Skriner K,Ringe J,Sezer O,Sittinger M,Häupl T,Kaps C

Sun Mar 01 00:00:00 EST 2009

IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Sundstrom JB,Hair GA,Ansari AA,Secor WE,Gilfillan AM,Metcalfe DD,Kirshenbaum AS

Fri May 15 00:00:00 EDT 2009

Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kato A,Chustz RT,Ogasawara T,Kulka M,Saito H,Schleimer RP,Matsumoto K

Mon Jun 01 00:00:00 EDT 2009

MHC class I/peptide transfer between dendritic cells overcomes poor cross-presentation by monocyte-derived APCs that engulf dying cells.

Journal of immunology (Baltimore, Md. : 1950)

Qu C,Nguyen VA,Merad M,Randolph GJ

Sun Mar 15 00:00:00 EDT 2009

The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.

Journal of immunology (Baltimore, Md. : 1950)

Boehmler AM,Drost A,Jaggy L,Seitz G,Wiesner T,Denzlinger C,Kanz L,Möhle R

Mon Jun 01 00:00:00 EDT 2009

Developmental switch of the expression of ion channels in human dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Zsiros E,Kis-Toth K,Hajdu P,Gaspar R,Bielanska J,Felipe A,Rajnavolgyi E,Panyi G

Thu Oct 01 00:00:00 EDT 2009

Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts.

Journal of immunology (Baltimore, Md. : 1950)

Nurieva R,Yang XO,Chung Y,Dong C

Sun Mar 01 00:00:00 EST 2009

1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Széles L,Keresztes G,Töröcsik D,Balajthy Z,Krenács L,Póliska S,Steinmeyer A,Zuegel U,Pruenster M,Rot A,Nagy L

Sun Feb 15 00:00:00 EST 2009

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B

Sat Aug 01 00:00:00 EDT 2009

Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.

Journal of immunology (Baltimore, Md. : 1950)

Kishuku M,Nishioka Y,Abe S,Kishi J,Ogino H,Aono Y,Azuma M,Kinoshita K,Batmunkh R,Makino H,Ranjan P,Minakuchi K,Sone S

Tue Dec 15 00:00:00 EST 2009

Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells.

Journal of immunology (Baltimore, Md. : 1950)

La Rocca R,Fulciniti M,Lakshmikanth T,Mesuraca M,Ali TH,Mazzei V,Amodio N,Catalano L,Rotoli B,Ouerfelli O,Grieco M,Gulletta E,Bond HM,Morrone G,Ferrone S,Carbone E

Wed Apr 15 00:00:00 EDT 2009

Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.

Journal of neurotrauma

Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ

Wed Apr 01 00:00:00 EDT 2009

Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.

Human gene therapy

Horiuchi Y,Onodera M,Miyagawa Y,Sato B,Onda K,Katagiri YU,Okita H,Okada M,Otsu M,Kume A,Okuyama T,Fujimoto J,Kuratsuji T,Kiyokawa N

Wed Jul 01 00:00:00 EDT 2009

Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling.

The Journal of biological chemistry

Thompson BR,Mazurkiewicz-Muñoz AM,Suttles J,Carter-Su C,Bernlohr DA

Fri May 15 00:00:00 EDT 2009

Mechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells.

The Journal of biological chemistry

Zhu P,Liu X,Treml LS,Cancro MP,Freedman BD

Fri Aug 21 00:00:00 EDT 2009

Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis.

PloS one

Zhang Q,Yamaza T,Kelly AP,Shi S,Wang S,Brown J,Wang L,French SW,Shi S,Le AD

Wed Nov 11 00:00:00 EST 2009

FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.

The Journal of biological chemistry

Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y

Fri Mar 20 00:00:00 EDT 2009

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

The Journal of biological chemistry

McGillicuddy FC,Chiquoine EH,Hinkle CC,Kim RJ,Shah R,Roche HM,Smyth EM,Reilly MP

Fri Nov 13 00:00:00 EST 2009

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.

PloS one

Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P

Wed Nov 18 00:00:00 EST 2009

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

Blood

Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T

Fri Feb 15 00:00:00 EST 2008

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

Blood

Nelson EA,Walker SR,Kepich A,Gashin LB,Hideshima T,Ikeda H,Chauhan D,Anderson KC,Frank DA

Mon Dec 15 00:00:00 EST 2008

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.

Blood

Takayama N,Nishikii H,Usui J,Tsukui H,Sawaguchi A,Hiroyama T,Eto K,Nakauchi H

Sun Jun 01 00:00:00 EDT 2008

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3.

The Journal of experimental medicine

Ma CS,Chew GY,Simpson N,Priyadarshi A,Wong M,Grimbacher B,Fulcher DA,Tangye SG,Cook MC

Mon Jul 07 00:00:00 EDT 2008

Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies.

Clinical immunology (Orlando, Fla.)

Bradshaw EM,Kent SC,Tripuraneni V,Orban T,Ploegh HL,Hafler DA,Love JC

Wed Oct 01 00:00:00 EDT 2008

Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells.

Stem cells (Dayton, Ohio)

Johansson S,Price J,Modo M

Mon Sep 01 00:00:00 EDT 2008

RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Bansal G,DiVietro JA,Kuehn HS,Rao S,Nocka KH,Gilfillan AM,Druey KM

Mon Dec 01 00:00:00 EST 2008

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kuehn HS,Swindle EJ,Kim MS,Beaven MA,Metcalfe DD,Gilfillan AM

Mon Dec 01 00:00:00 EST 2008

Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress.

Journal of immunology (Baltimore, Md. : 1950)

Ando T,Mimura K,Johansson CC,Hanson MG,Mougiakakos D,Larsson C,Martins da Palma T,Sakurai D,Norell H,Li M,Nishimura MI,Kiessling R

Mon Dec 15 00:00:00 EST 2008

IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.

Journal of immunology (Baltimore, Md. : 1950)

Hu Y,Hu X,Boumsell L,Ivashkiv LB

Sun Jun 15 00:00:00 EDT 2008

B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.

Journal of immunology (Baltimore, Md. : 1950)

Takagi R,Higashi T,Hashimoto K,Nakano K,Mizuno Y,Okazaki Y,Matsushita S

Tue Jul 01 00:00:00 EDT 2008

c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130.

Molecular and cellular biology

Tanaka Y,Tanaka N,Saeki Y,Tanaka K,Murakami M,Hirano T,Ishii N,Sugamura K

Fri Aug 01 00:00:00 EDT 2008

Interferon-alpha controls IL-17 expression in vitro and in vivo.

Immunobiology

Moschen AR,Geiger S,Krehan I,Kaser A,Tilg H

Thu Feb 05 00:00:00 EST 2009

Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors.

BMC immunology

Moldenhauer A,Genter G,Lun A,Bal G,Kiesewetter H,Salama A

Wed Oct 01 00:00:00 EDT 2008

The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.

PloS one

Bauler TJ,Hendriks WJ,King PD

Thu Feb 19 00:00:00 EST 2009

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.

BMC immunology

Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD

Thu Aug 07 00:00:00 EDT 2008

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.

Blood

Khanna-Gupta A,Sun H,Zibello T,Lee HM,Dahl R,Boxer LA,Berliner N

Tue May 15 00:00:00 EDT 2007

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.

Oncogene

Rigby RJ,Simmons JG,Greenhalgh CJ,Alexander WS,Lund PK

Thu Jul 19 00:00:00 EDT 2007

The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.

The Journal of biological chemistry

Ziesché E,Bachmann M,Kleinert H,Pfeilschifter J,Mühl H

Fri Jun 01 00:00:00 EDT 2007

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.

Blood

Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F

Wed Mar 01 00:00:00 EST 2006

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.

The Journal of clinical investigation

Wong PK,Egan PJ,Croker BA,O'Donnell K,Sims NA,Drake S,Kiu H,McManus EJ,Alexander WS,Roberts AW,Wicks IP

Thu Jun 01 00:00:00 EDT 2006

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Proceedings of the National Academy of Sciences of the United States of America

Bauer A,Villunger A,Labi V,Fischer SF,Strasser A,Wagner H,Schmid RM,Häcker G

Tue Jul 18 00:00:00 EDT 2006

Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells.

Journal of immunology (Baltimore, Md. : 1950)

González-García I,Ocaña E,Jiménez-Gómez G,Campos-Caro A,Brieva JA

Sat Apr 01 00:00:00 EST 2006

Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains.

Nature biotechnology

Silverman J,Liu Q,Bakker A,To W,Duguay A,Alba BM,Smith R,Rivas A,Li P,Le H,Whitehorn E,Moore KW,Swimmer C,Perlroth V,Vogt M,Kolkman J,Stemmer WP

Thu Dec 01 00:00:00 EST 2005

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes.

American journal of respiratory and critical care medicine

Morris GE,Whyte MK,Martin GF,Jose PJ,Dower SK,Sabroe I

Fri Apr 15 00:00:00 EDT 2005

Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.

The Journal of experimental medicine

Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ

Mon Jun 20 00:00:00 EDT 2005

Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.

Journal of immunology (Baltimore, Md. : 1950)

van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P

Tue Feb 15 00:00:00 EST 2005

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Mon Jul 05 00:00:00 EDT 2004

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The Journal of neuroscience : the official journal of the Society for Neuroscience

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Bioinformatics

Protein Aliases: B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; H-IL-6; Hybridoma growth factor; IFN-beta-2; IL-6; ILN; Interferon beta-2; Interleukin; interleukin BSF-2; Interleukin-6; Interleukin6; M-IL-6; R-IL-6

Human IL-6 Recombinant Protein, PeproTech®

Human IL-6 Protein (200-06-20UG) in Functional

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200-06-20UG

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