Gibco

Human IL-7 Recombinant Protein, PeproTech®

Human IL-7 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human IL-7 Protein (200-07-10UG) in Functional

Bioassay analysis of Human IL-7 Recombinant Protein, PeproTech® (Product # 200-07-1MG).

Product Image Gallery

Product Details

200-07-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 285 publications 285 publications

Miscellaneous PubMed (Misc)

View 23 publications 23 publications

Product Specifications

Species

Human

Published species

Dog, Hamster, Human, Mouse, Non-human primate, Rabbit, Rat, Virus

Expression System

E. coli

Amino acid sequence

MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH

Molecular weight

17.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

200-07-1MG will be provided as 2 x 500 µg (200-07-500UG).

Recombinant Human IL-7 is a 17.5 kDa protein containing 153 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

200-07 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 EDT 2023

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.

Cell

Banskota S,Raguram A,Suh S,Du SW,Davis JR,Choi EH,Wang X,Nielsen SC,Newby GA,Randolph PB,Osborn MJ,Musunuru K,Palczewski K,Liu DR

Thu Jan 20 00:00:00 EST 2022

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4⁺ T cells allows complex functional analyses.

Nature methods

Albanese M,Ruhle A,Mittermaier J,Mejías-Pérez E,Gapp M,Linder A,Schmacke NA,Hofmann K,Hennrich AA,Levy DN,Humpe A,Conzelmann KK,Hornung V,Fackler OT,Keppler OT

Sat Jan 01 00:00:00 EST 2022

Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.

The Journal of experimental medicine

Liu G,Chen Y,Wang Y,Deng X,Xiao Q,Zhang L,Xu H,Han X,Lei A,He J,Li X,Cao Y,Zhou P,He C,Wu P,Jiang W,Tan M,Chen C,Yang Q,Lu L,Deng K,Yao Z,Zhou J

Mon Mar 07 00:00:00 EST 2022

Disease-associated mutations in topoisomerase IIβ result in defective NK cells.

The Journal of allergy and clinical immunology

Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS

200-07 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.

Wed Jun 01 00:00:00 EDT 2022

Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.

EMBO reports

Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB

200-07 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.

Thu Feb 03 00:00:00 EST 2022

Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.

Frontiers in cell and developmental biology

Lee M,Geitgey DK,Hamilton JAG,Boss JM,Scharer CD,Spangle JM,Haynes KA,Henry CJ

200-07 was used in Sample Preparation (FC/FACS) to investigate T-cell acute lymphoblastic leukemia relationship with obesity in murine models.

Wed Sep 07 00:00:00 EDT 2022

JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.

JCI insight

Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA

200-07 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.

Wed Jun 08 00:00:00 EDT 2022

Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.

STAR protocols

Moosmann C,Müller TR,Busch DH,Schober K

Fri Mar 18 00:00:00 EDT 2022

CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.

Nature communications

Hebbar N,Epperly R,Vaidya A,Thanekar U,Moore SE,Umeda M,Ma J,Patil SL,Langfitt D,Huang S,Cheng C,Klco JM,Gottschalk S,Velasquez MP

Mon Jan 31 00:00:00 EST 2022

Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer.

Nature

Eberhardt CS,Kissick HT,Patel MR,Cardenas MA,Prokhnevska N,Obeng RC,Nasti TH,Griffith CC,Im SJ,Wang X,Shin DM,Carrington M,Chen ZG,Sidney J,Sette A,Saba NF,Wieland A,Ahmed R

Wed Sep 01 00:00:00 EDT 2021

A vaccine targeting mutant IDH1 in newly diagnosed glioma.

Nature

Platten M,Bunse L,Wick A,Bunse T,Le Cornet L,Harting I,Sahm F,Sanghvi K,Tan CL,Poschke I,Green E,Justesen S,Behrens GA,Breckwoldt MO,Freitag A,Rother LM,Schmitt A,Schnell O,Hense J,Misch M,Krex D,Stevanovic S,Tabatabai G,Steinbach JP,Bendszus M,von Deimling A,Schmitt M,Wick W

Thu Apr 01 00:00:00 EDT 2021

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell

Chen PJ,Hussmann JA,Yan J,Knipping F,Ravisankar P,Chen PF,Chen C,Nelson JW,Newby GA,Sahin M,Osborn MJ,Weissman JS,Adamson B,Liu DR

Thu Oct 28 00:00:00 EDT 2021

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.

Immunity

Pan YG,Aiamkitsumrit B,Bartolo L,Wang Y,Lavery C,Marc A,Holec PV,Rappazzo CG,Eilola T,Gimotty PA,Hensley SE,Antia R,Zarnitsyna VI,Birnbaum ME,Su LF

200-07 was used in In vitro experiments to examine how baseline CD4+ T cell repertoire and precursor states impact responses to pathogen infection in humans using primary immunization with yellow fever virus vaccine.

Tue Jun 08 00:00:00 EDT 2021

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.

Immunity

Golebski K,Layhadi JA,Sahiner U,Steveling-Klein EH,Lenormand MM,Li RCY,Bal SM,Heesters BA,Vilà-Nadal G,Hunewald O,Montamat G,He FQ,Ollert M,Fedina O,Lao-Araya M,Vijverberg SJH,Maitland-van der Zee AH,van Drunen CM,Fokkens WJ,Durham SR,Spits H,Shamji MH

Tue Feb 09 00:00:00 EST 2021

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.

Immunity

Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C

Tue Apr 13 00:00:00 EDT 2021

Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL.

Blood

Zheng W,Wei J,Zebley CC,Jones LL,Dhungana Y,Wang YD,Mavuluri J,Long L,Fan Y,Youngblood B,Chi H,Geiger TL

Thu Jul 15 00:00:00 EDT 2021

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.

Cellular & molecular immunology

Moirangthem RD,Ma K,Lizot S,Cordesse A,Olivré J,de Chappedelaine C,Joshi A,Cieslak A,Tchen J,Cagnard N,Asnafi V,Rausell A,Simons L,Zuber J,Taghon T,Staal FJT,Pflumio F,Six E,Cavazzana M,Lagresle-Peyrou C,Soheili T,André I

Thu Jul 01 00:00:00 EDT 2021

Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice.

The Journal of clinical investigation

Harro CM,Perez-Sanz J,Costich TL,Payne KK,Anadon CM,Chaurio RA,Biswas S,Mandal G,Rigolizzo KE,Sprenger KB,Mine JA,Showe LC,Yu X,Liu K,Rodriguez PC,Pinilla-Ibarz J,Sokol L,Conejo-Garcia JR

Mon Feb 01 00:00:00 EST 2021

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

Mon Feb 01 00:00:00 EST 2021

STING agonist promotes CAR T cell trafficking and persistence in breast cancer.

The Journal of experimental medicine

Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS

Mon Feb 01 00:00:00 EST 2021

Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.

EMBO molecular medicine

Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P

Fri Mar 05 00:00:00 EST 2021

Fever supports CD8⁺ effector T cell responses by promoting mitochondrial translation.

Proceedings of the National Academy of Sciences of the United States of America

O'Sullivan D,Stanczak MA,Villa M,Uhl FM,Corrado M,Klein Geltink RI,Sanin DE,Apostolova P,Rana N,Edwards-Hicks J,Grzes KM,Kabat AM,Kyle RL,Fabri M,Curtis JD,Buck MD,Patterson AE,Regina A,Field CS,Baixauli F,Puleston DJ,Pearce EJ,Zeiser R,Pearce EL

Tue Jun 22 00:00:00 EDT 2021

Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.

Molecular therapy. Nucleic acids

Kazuki Y,Uno N,Abe S,Kajitani N,Kazuki K,Yakura Y,Sawada C,Takata S,Sugawara M,Nagashima Y,Okada A,Hiratsuka M,Osaki M,Ferrari G,Tedesco FS,Nishikawa S,Fukumoto K,Takayanagi SI,Kunisato A,Kaneko S,Oshimura M,Tomizuka K

Fri Mar 05 00:00:00 EST 2021

Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.

Mucosal immunology

Qiu J,Zhang J,Ji Y,Sun H,Gu Z,Sun Q,Bai M,Gong J,Tang J,Zhang Y,Li S,Shao Z,Li J,Sheng H,Shen L,Qiu J

Mon Nov 01 00:00:00 EDT 2021

Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.

International journal of cancer

Herda S,Heimann A,Obermayer B,Ciraolo E,Althoff S,Ruß J,Grunert C,Busse A,Bullinger L,Pezzutto A,Blankenstein T,Beule D,Na IK

Tue Jun 15 00:00:00 EDT 2021

Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection.

Cytotherapy

Soni M,Migliori E,Assal A,Chan HT,Ciubotariu R,Pan JB,Cicero K,Pereira M,Mapara MY,Muranski P

Mon Nov 01 00:00:00 EDT 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 EDT 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 EDT 2021

Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs.

Journal of immunology (Baltimore, Md. : 1950)

Perry N,Wasko K,Cheng J,Tabbaa D,Marco E,Giannoukos G,Albright CF,Borges CM

Fri Jan 15 00:00:00 EST 2021

GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma - assessing tumor and T cell interaction.

Translational oncology

Sujjitjoon J,Sayour E,Tsao ST,Uiprasertkul M,Sanpakit K,Buaboonnam J,Yenchitsomanus PT,Atchaneeyasakul LO,Chang LJ

Mon Feb 01 00:00:00 EST 2021

Peripheral leukemia burden at time of apheresis negatively affects the clinical efficacy of CART19 in refractory or relapsed B-ALL.

Molecular therapy. Methods & clinical development

Deng B,Pan J,Liu Z,Liu S,Chen Y,Qu X,Zhang Y,Lin Y,Zhang Y,Yu X,Zhang Z,Niu X,Luan R,Ma M,Li X,Liu T,Wu X,Niu H,Chang AH,Tong C

Fri Dec 10 00:00:00 EST 2021

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors.

iScience

Portillo AL,Hogg R,Poznanski SM,Rojas EA,Cashell NJ,Hammill JA,Chew MV,Shenouda MM,Ritchie TM,Cao QT,Hirota JA,Dhesy-Thind S,Bramson JL,Ashkar AA

Fri Jun 25 00:00:00 EDT 2021

IL-15 enhances CCR5-mediated migration of memory CD8⁺ T cells by upregulating CCR5 expression in the absence of TCR stimulation.

Cell reports

Seo IH,Eun HS,Kim JK,Lee H,Jeong S,Choi SJ,Lee J,Lee BS,Kim SH,Rou WS,Lee DH,Kim W,Park SH,Shin EC

Tue Jul 27 00:00:00 EDT 2021

Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.

Cell reports

Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C

Tue Jan 12 00:00:00 EST 2021

Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics.

Nature communications

Wilhelm M,Zolg DP,Graber M,Gessulat S,Schmidt T,Schnatbaum K,Schwencke-Westphal C,Seifert P,de Andrade Krätzig N,Zerweck J,Knaute T,Bräunlein E,Samaras P,Lautenbacher L,Klaeger S,Wenschuh H,Rad R,Delanghe B,Huhmer A,Carr SA,Clauser KR,Krackhardt AM,Reimer U,Kuster B

Mon Jun 07 00:00:00 EDT 2021

Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients.

Cancer immunology research

Lulu AM,Cummings KL,Jeffery ED,Myers PT,Underwood D,Lacy RM,Chianese-Bullock KA,Slingluff CL,Modesitt SC,Engelhard VH

200-07 was used in In vitro experiments to suggest that the immunogens generating most phosphopeptide-specific immune memory are rare infectious agents or incipient cancer cells with distinct phosphoproteome dysregulations, and that repetitive immunogenic exposures occur in individual donors.

Mon Nov 01 00:00:00 EDT 2021

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.

Nature communications

Fischer DS,Ansari M,Wagner KI,Jarosch S,Huang Y,Mayr CH,Strunz M,Lang NJ,D'Ippolito E,Hammel M,Mateyka L,Weber S,Wolff LS,Witter K,Fernandez IE,Leuschner G,Milger K,Frankenberger M,Nowak L,Heinig-Menhard K,Koch I,Stoleriu MG,Hilgendorff A,Behr J,Pichlmair A,Schubert B,Theis FJ,Busch DH,Schiller HB,Schober K

Mon Jul 26 00:00:00 EDT 2021

Identification of HLA-A2-Restricted Mutant Epitopes from Neoantigens of Esophageal Squamous Cell Carcinoma.

Vaccines

Wang Z,Ran L,Chen C,Shi R,Dong Y,Li Y,Zhou X,Qi Y,Zhu P,Gao Y,Wu Y

200-07 was used in In vitro experiments to investigate treatment for esophageal squamous cell carcinoma.

Fri Oct 01 00:00:00 EDT 2021

Directly reprogrammed natural killer cells for cancer immunotherapy.

Nature biomedical engineering

Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS

Mon Nov 01 00:00:00 EDT 2021

The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.

Communications biology

Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S

Mon Jun 07 00:00:00 EDT 2021

Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.

Scientific reports

Sivapalan R,Liu J,Chakraborty K,Arthofer E,Choudhry M,Barie PS,Barouch DH,Henley T

Tue Jul 27 00:00:00 EDT 2021

Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.

Molecular therapy. Methods & clinical development

Haeseleer F,Fukazawa Y,Park H,Varco-Merth B,Rust BJ,Smedley JV,Eichholz K,Peterson CW,Mason R,Kiem HP,Roederer M,Picker LJ,Okoye AA,Corey L

Fri Sep 10 00:00:00 EDT 2021

Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.

Molecular & cellular proteomics : MCP

Klaeger S,Apffel A,Clauser KR,Sarkizova S,Oliveira G,Rachimi S,Le PM,Tarren A,Chea V,Abelin JG,Braun DA,Ott PA,Keshishian H,Hacohen N,Keskin DB,Wu CJ,Carr SA

Thu Mar 24 00:00:00 EDT 2022

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.

Cell reports

Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B

Tue Oct 12 00:00:00 EDT 2021

SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.

Cell reports

Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II

200-07 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.

Tue Feb 16 00:00:00 EST 2021

Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.

STAR protocols

Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ

200-07 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.

Fri Dec 17 00:00:00 EST 2021

Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.

Cell reports. Medicine

Müller TR,Jarosch S,Hammel M,Leube J,Grassmann S,Bernard B,Effenberger M,Andrä I,Chaudhry MZ,Käuferle T,Malo A,Cicin-Sain L,Steinberger P,Feuchtinger T,Protzer U,Schumann K,Neuenhahn M,Schober K,Busch DH

Tue Aug 17 00:00:00 EDT 2021

Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients.

Cell reports

Reid JC,Golubeva D,Boyd AL,Hollands CG,Henly C,Orlando L,Leber A,Hébert J,Morabito F,Cutrona G,Agnelli L,Gentile M,Ferrarini M,Neri A,Leber B,Bhatia M

Tue Mar 16 00:00:00 EDT 2021

Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.

Nature communications

Schmidt NM,Wing PAC,Diniz MO,Pallett LJ,Swadling L,Harris JM,Burton AR,Jeffery-Smith A,Zakeri N,Amin OE,Kucykowicz S,Heemskerk MH,Davidson B,Meyer T,Grove J,Stauss HJ,Pineda-Torra I,Jolly C,Jury EC,McKeating JA,Maini MK

Fri May 14 00:00:00 EDT 2021

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.

Communications biology

Lee HK,Jung O,Hennighausen L

Wed Jun 02 00:00:00 EDT 2021

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.

Cell reports. Medicine

Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L

200-07 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.

Tue Nov 16 00:00:00 EST 2021

EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8⁺ T Cells.

Frontiers in immunology

Stairiker CJ,Pfister SX,Hendrickson E,Yang W,Xie T,Lee C,Zhang H,Dillon C,Thomas GD,Salek-Ardakani S

200-07 was used in In vitro experiments to support the requirement of EZH2 function in 4-1BB-mediated CD8+ T cell expansion and effector programming and emphasize the consideration that must be given when combining such antitumoral therapies.

Mon Feb 14 00:00:00 EST 2022

Next Generation Sequencing-Based Identification of T-Cell Receptors for Immunotherapy Against Hepatocellular Carcinoma.

Hepatology communications

Ma Y,Ou J,Lin T,Chen L,Chen J,Wang M

Tue Jun 01 00:00:00 EDT 2021

PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.

Frontiers in immunology

Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y

200-07 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.

Mon Oct 25 00:00:00 EDT 2021

Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors.

Nature cancer

Hirabayashi K,Du H,Xu Y,Shou P,Zhou X,Fucá G,Landoni E,Sun C,Chen Y,Savoldo B,Dotti G

Wed Sep 01 00:00:00 EDT 2021

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.

Nature communications

Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A

Thu Nov 25 00:00:00 EST 2021

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.

Cell

Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW

200-07 was used in Cell Culture to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.

Thu Apr 16 00:00:00 EDT 2020

Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.

Immunity

Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C

Tue Jun 16 00:00:00 EDT 2020

THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.

Cancer cell

Sun C,Shou P,Du H,Hirabayashi K,Chen Y,Herring LE,Ahn S,Xu Y,Suzuki K,Li G,Tsahouridis O,Su L,Savoldo B,Dotti G

Mon Feb 10 00:00:00 EST 2020

Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma.

Blood

Gaydosik AM,Queen DS,Trager MH,Akilov OE,Geskin LJ,Fuschiotti P

Thu Oct 08 00:00:00 EDT 2020

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.

Blood

Rust BJ,Kean LS,Colonna L,Brandenstein KE,Poole NH,Obenza W,Enstrom MR,Maldini CR,Ellis GI,Fennessey CM,Huang ML,Keele BF,Jerome KR,Riley JL,Kiem HP,Peterson CW

Thu Oct 08 00:00:00 EDT 2020

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma.

Blood

De Smedt R,Morscio J,Reunes L,Roels J,Bardelli V,Lintermans B,Van Loocke W,Almeida A,Cheung LC,Kotecha RS,Mansour MR,Uyttebroeck A,Vandenberghe P,La Starza R,Mecucci C,Lammens T,Van Roy N,De Moerloose B,Barata JT,Taghon T,Goossens S,Van Vlierberghe P

Thu May 07 00:00:00 EDT 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes.

The Journal of clinical investigation

Meyer LK,Huang BJ,Delgado-Martin C,Roy RP,Hechmer A,Wandler AM,Vincent TL,Fortina P,Olshen AB,Wood BL,Horton TM,Shannon KM,Teachey DT,Hermiston ML

Mon Feb 03 00:00:00 EST 2020

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.

The Journal of clinical investigation

Cao W,Fang F,Gould T,Li X,Kim C,Gustafson C,Lambert S,Weyand CM,Goronzy JJ

Wed Jul 01 00:00:00 EDT 2020

Mechanosensing through YAP controls T cell activation and metabolism.

The Journal of experimental medicine

Meng KP,Majedi FS,Thauland TJ,Butte MJ

200-07 was used in Sample Preparation (FC/FACS) to study how the YAP mechanosensor is required for sensing the microenvironment mechanical changes which cause lymph nodes to become mechanically stiff as immune cells activate and proliferate within their encapsulated environments.

Mon Aug 03 00:00:00 EDT 2020

CARD8 inflammasome activation triggers pyroptosis in human T cells.

The EMBO journal

Linder A,Bauernfried S,Cheng Y,Albanese M,Jung C,Keppler OT,Hornung V

Thu Oct 01 00:00:00 EDT 2020

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.

Proceedings of the National Academy of Sciences of the United States of America

Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A

Tue Jul 28 00:00:00 EDT 2020

IL-7 induces sCD127 release and mCD127 downregulation in human CD8⁺ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection.

European journal of immunology

Côté SC,Burke Schinkel SC,Berthoud TK,Barros PO,Sanchez-Vidales M,Davidson AM,Crawley AM,Angel JB

Thu Oct 01 00:00:00 EDT 2020

Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response.

Oncogenesis

Giuli MV,Diluvio G,Giuliani E,Franciosa G,Di Magno L,Pignataro MG,Tottone L,Nicoletti C,Besharat ZM,Peruzzi G,Pelullo M,Palermo R,Canettieri G,Talora C,d'Amati G,Bellavia D,Screpanti I,Checquolo S

Sun Oct 18 00:00:00 EDT 2020

Physioxia enhances T-cell development ex vivo from human hematopoietic stem and progenitor cells.

Stem cells (Dayton, Ohio)

Shin DY,Huang X,Gil CH,Aljoufi A,Ropa J,Broxmeyer HE

Sun Nov 01 00:00:00 EDT 2020

p53 Hinders CRISPR/Cas9-Mediated Targeted Gene Disruption in Memory CD8 T Cells In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Kurup SP,Moioffer SJ,Pewe LL,Harty JT

Thu Oct 15 00:00:00 EDT 2020

Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance.

Journal of immunology (Baltimore, Md. : 1950)

Liu GY,Deng XH,Li X,Cao YJ,Xing YF,Zhou P,Lei AH,Yang Q,Deng K,Zhang H,Zhou J

Wed Jul 01 00:00:00 EDT 2020

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.

Nature communications

Kared H,Tan SW,Lau MC,Chevrier M,Tan C,How W,Wong G,Strickland M,Malleret B,Amoah A,Pilipow K,Zanon V,Govern NM,Lum J,Chen JM,Lee B,Florian MC,Geiger H,Ginhoux F,Ruiz-Mateos E,Fulop T,Rajasuriar R,Kamarulzaman A,Ng TP,Lugli E,Larbi A

Mon Feb 10 00:00:00 EST 2020

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.

Nature communications

Mon Feb 10 00:00:00 EST 2020

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.

Nature communications

Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ

200-07 was used in In vitro experiments to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.

Fri Dec 04 00:00:00 EST 2020

B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models.

Oncoimmunology

Huang B,Luo L,Wang J,He B,Feng R,Xian N,Zhang Q,Chen L,Huang G

200-07 was used in In vitro experiments to indicate that B7-H3 specific CAR-T cells have the potential to treat multiple types of advanced solid tumors.

Wed Jul 28 00:00:00 EDT 2021

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.

Stem cell reports

Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM

Tue Feb 11 00:00:00 EST 2020

GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision.

Nature cancer

Wang K,Chen Y,Ahn S,Zheng M,Landoni E,Dotti G,Savoldo B,Han Z

Thu Oct 01 00:00:00 EDT 2020

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.

Nature communications

Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R

200-07 was used in In vitro experiments to provide a potential strategy for targeting triple-negative breast cancer with the combination of Tenascin-C blockade and immune checkpoint inhibitors.

Thu Jul 30 00:00:00 EDT 2020

CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation.

Scientific reports

Elmetwali T,Salman A,Wei W,Hussain SA,Young LS,Palmer DH

Wed Jan 15 00:00:00 EST 2020

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion.

Nature communications

Nahmad AD,Raviv Y,Horovitz-Fried M,Sofer I,Akriv T,Nataf D,Dotan I,Carmi Y,Burstein D,Wine Y,Benhar I,Barzel A

Tue Nov 17 00:00:00 EST 2020

Streamlined selection of cancer antigens for vaccine development through integrative multi-omics and high-content cell imaging.

Scientific reports

Han KC,Park D,Ju S,Lee YE,Heo SH,Kim YA,Lee JE,Lee Y,Park KH,Park SH,Lee HJ,Lee C,Jang M

Fri Apr 03 00:00:00 EDT 2020

Toll-like receptor 7/8-matured RNA-transduced dendritic cells as post-remission therapy in acute myeloid leukaemia: results of a phase I trial.

Clinical & translational immunology

Lichtenegger FS,Schnorfeil FM,Rothe M,Deiser K,Altmann T,Bücklein VL,Köhnke T,Augsberger C,Konstandin NP,Spiekermann K,Moosmann A,Boehm S,Boxberg M,Heemskerk MH,Goerlich D,Wittmann G,Wagner B,Hiddemann W,Schendel DJ,Kvalheim G,Bigalke I,Subklewe M

Wed Apr 13 00:00:00 EDT 2022

Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.

Immunity

Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H

Tue Nov 19 00:00:00 EST 2019

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.

Cancer cell

Du H,Hirabayashi K,Ahn S,Kren NP,Montgomery SA,Wang X,Tiruthani K,Mirlekar B,Michaud D,Greene K,Herrera SG,Xu Y,Sun C,Chen Y,Ma X,Ferrone CR,Pylayeva-Gupta Y,Yeh JJ,Liu R,Savoldo B,Ferrone S,Dotti G

Mon Feb 11 00:00:00 EST 2019

γ-Catenin-Dependent Signals Maintain BCR-ABL1⁺ B Cell Acute Lymphoblastic Leukemia.

Cancer cell

Luong-Gardiol N,Siddiqui I,Pizzitola I,Jeevan-Raj B,Charmoy M,Huang Y,Irmisch A,Curtet S,Angelov GS,Danilo M,Juilland M,Bornhauser B,Thome M,Hantschel O,Chalandon Y,Cazzaniga G,Bourquin JP,Huelsken J,Held W

Mon Apr 15 00:00:00 EDT 2019

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Nature immunology

Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M

200-07 was used in In vitro experiments to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.

Thu Aug 01 00:00:00 EDT 2019

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.

Blood

Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA

Thu Mar 14 00:00:00 EDT 2019

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.

Blood

Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA

Thu Mar 14 00:00:00 EDT 2019

Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Cell stem cell

Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L

200-07 was used in Sample Preparation (FC/FACS) to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.

Thu Oct 03 00:00:00 EDT 2019

A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.

The Journal of experimental medicine

Fernandez IZ,Baxter RM,Garcia-Perez JE,Vendrame E,Ranganath T,Kong DS,Lundquist K,Nguyen T,Ogolla S,Black J,Galambos C,Gumbart JC,Dawany N,Kelsen JR,de Zoeten EF,Quinones R,Eissa H,Verneris MR,Sullivan KE,Rochford R,Blish CA,Kedl RM,Dutmer CM,Hsieh EWY

200-07 was used in In vitro experiments to investigate the clinical and immunological phenotypes of two siblings with the first described human IL-2Rβ defect.

Mon Jun 03 00:00:00 EDT 2019

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

The Journal of experimental medicine

Zhang Z,Gothe F,Pennamen P,James JR,McDonald D,Mata CP,Modis Y,Alazami AM,Acres M,Haller W,Bowen C,Döffinger R,Sinclair J,Brothers S,Zhang Y,Matthews HF,Naudion S,Pelluard F,Alajlan H,Yamazaki Y,Notarangelo LD,Thaventhiran JE,Engelhardt KR,Al-Mousa H,Hambleton S,Rooryck C,Smith KGC,Lenardo MJ

Mon Jun 03 00:00:00 EDT 2019

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.

Leukemia

Akkapeddi P,Fragoso R,Hixon JA,Ramalho AS,Oliveira ML,Carvalho T,Gloger A,Matasci M,Corzana F,Durum SK,Neri D,Bernardes GJL,Barata JT

Sun Sep 01 00:00:00 EDT 2019

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.

Leukemia

Akkapeddi P,Fragoso R,Hixon JA,Ramalho AS,Oliveira ML,Carvalho T,Gloger A,Matasci M,Corzana F,Durum SK,Neri D,Bernardes GJL,Barata JT

Sun Sep 01 00:00:00 EDT 2019

NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.

Leukemia

Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P

Mon Jul 01 00:00:00 EDT 2019

Breaking tolerance with engineered class I antigen-presenting molecules.

Proceedings of the National Academy of Sciences of the United States of America

Parks CA,Henning KR,Pavelko KD,Hansen MJ,Van Keulen VP,Reed BK,Stone JD,Schrum AG,Gil D,Kranz DM,Bordner AJ,Barry MA,Pease LR

Tue Feb 19 00:00:00 EST 2019

MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.

Cancer immunology research

Martinez-Usatorre A,Sempere LF,Carmona SJ,Carretero-Iglesia L,Monnot G,Speiser DE,Rufer N,Donda A,Zehn D,Jandus C,Romero P

200-07 was used in Cell Culture to explore the regulation of miR-155 expression in CD8+ cells.

Sat Jun 01 00:00:00 EDT 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell systems

Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV

200-07 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.

Wed Oct 23 00:00:00 EDT 2019

Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Anderson W,Thorpe J,Long SA,Rawlings DJ

Sun Dec 15 00:00:00 EST 2019

Gene correction for SCID-X1 in long-term hematopoietic stem cells.

Nature communications

Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH

200-07 was used in In vitro experiments to evaluate the use of SCID-X1 in targeting the cDNA in human long-term hematopoietic stem cells.

Tue Apr 09 00:00:00 EDT 2019

Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma.

Cells

Yazdanifar M,Zhou R,Grover P,Williams C,Bose M,Moore LJ,Wu ST,Maher J,Dreau D,Mukherjee AP

200-07 was used in In vitro experiments to show that combination of CAR T cells and biological inhibitors of IDO1, COX1/2, and Gal-9 resulted in significant enhancement of CAR T cell cytotoxicity against PDA cells.

Wed Sep 11 00:00:00 EDT 2019

CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.

Nature communications

Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y

Tue May 21 00:00:00 EDT 2019

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele.

Nature communications

Al-Mossawi H,Yager N,Taylor CA,Lau E,Danielli S,de Wit J,Gilchrist J,Nassiri I,Mahe EA,Lee W,Rizvi L,Makino S,Cheeseman J,Neville M,Knight JC,Bowness P,Fairfax BP

Tue Oct 08 00:00:00 EDT 2019

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

Nature communications

Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA

Fri Jan 04 00:00:00 EST 2019

Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial-Mesenchymal Transition.

Scientific reports

Seol MA,Kim JH,Oh K,Kim G,Seo MW,Shin YK,Sim JH,Shin HM,Seo BY,Lee DS,Ku JL,Han I,Kang I,Park SI,Kim HR

Mon May 06 00:00:00 EDT 2019

Selective cell death of latently HIV-infected CD4⁺ T cells mediated by autosis inducing nanopeptides.

Cell death & disease

Zhang G,Luk BT,Wei X,Campbell GR,Fang RH,Zhang L,Spector SA

Wed May 29 00:00:00 EDT 2019

Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.

Scientific reports

Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B

Mon Aug 05 00:00:00 EDT 2019

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Nature communications

Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP

Tue Jul 02 00:00:00 EDT 2019

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Current protocols in immunology

Souter MNT,Loh L,Li S,Meehan BS,Gherardin NA,Godfrey DI,Rossjohn J,Fairlie DP,Kedzierska K,Pellicci DG,Chen Z,Kjer-Nielsen L,Corbett AJ,McCluskey J,Eckle SBG

200-07 was used in Cell Culture to describe protocols to characterize the phenotype of human MAIT cells in blood and tissues by flow cytometry using fluorescently labeled human MR1 tetramers alongside antibodies specific for MAIT cell markers.

Sun Dec 01 00:00:00 EST 2019

UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.

Scientific reports

Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II

Mon Apr 29 00:00:00 EDT 2019

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

Nature

Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C

Sat Dec 01 00:00:00 EST 2018

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

Nature

Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C

Sat Dec 01 00:00:00 EST 2018

Innate-like Cytotoxic Function of Bystander-Activated CD8⁺ T Cells Is Associated with Liver Injury in Acute Hepatitis A.

Immunity

Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC

Tue Jan 16 00:00:00 EST 2018

The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.

Immunity

Bando JK,Gilfillan S,Song C,McDonald KG,Huang SC,Newberry RD,Kobayashi Y,Allan DSJ,Carlyle JR,Cella M,Colonna M

Tue Jun 19 00:00:00 EDT 2018

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Immunity

Hosokawa H,Ungerbäck J,Wang X,Matsumoto M,Nakayama KI,Cohen SM,Tanaka T,Rothenberg EV

Tue Jun 19 00:00:00 EDT 2018

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Cancer cell

Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ

Mon Feb 12 00:00:00 EST 2018

SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells.

Cell host & microbe

Campbell GR,Bruckman RS,Chu YL,Trout RN,Spector SA

200-07 was used in Cell Culture to study how DIABLO/SMAC mimetics (birinapant, GDC-0152, and embelin) selectively kill HIV-Long-lived resting memory CD4+ T cells (TCM) without increasing virus production or targeting uninfected TCM.

Wed Nov 14 00:00:00 EST 2018

Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.

The Journal of experimental medicine

Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F

Mon May 07 00:00:00 EDT 2018

Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.

The Journal of experimental medicine

Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F

Mon May 07 00:00:00 EDT 2018

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Developmental cell

Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T

200-07 was used in In vitro experiments to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.

Mon Feb 05 00:00:00 EST 2018

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

Frontiers in immunology

Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

200-07 was used in Sample Preparation (FC/FACS) to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.

Mon Apr 08 00:00:00 EDT 2019

Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Aue G,Sun C,Liu D,Park JH,Pittaluga S,Tian X,Lee E,Soto S,Valdez J,Maric I,Stetler-Stevenson M,Yuan C,Nakamura Y,Muranski P,Wiestner A

Mon Oct 01 00:00:00 EDT 2018

IL-21 Selectively Protects CD62L⁺ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy.

Journal of immunology (Baltimore, Md. : 1950)

Ngai H,Tian G,Courtney AN,Ravari SB,Guo L,Liu B,Jin J,Shen ET,Di Pierro EJ,Metelitsa LS

Mon Oct 01 00:00:00 EDT 2018

Directed evolution of CRISPR-Cas9 to increase its specificity.

Nature communications

Lee JK,Jeong E,Lee J,Jung M,Shin E,Kim YH,Lee K,Jung I,Kim D,Kim S,Kim JS

Mon Aug 06 00:00:00 EDT 2018

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.

Nature communications

Helsen CW,Hammill JA,Lau VWC,Mwawasi KA,Afsahi A,Bezverbnaya K,Newhook L,Hayes DL,Aarts C,Bojovic B,Denisova GF,Kwiecien JM,Brain I,Derocher H,Milne K,Nelson BH,Bramson JL

Fri Aug 03 00:00:00 EDT 2018

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature communications

Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II

Tue May 08 00:00:00 EDT 2018

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Nature communications

Mudd JC,Busman-Sahay K,DiNapoli SR,Lai S,Sheik V,Lisco A,Deleage C,Richardson B,Palesch DJ,Paiardini M,Cameron M,Sereti I,Reeves RK,Estes JD,Brenchley JM

Thu Sep 27 00:00:00 EDT 2018

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Nature communications

Mudd JC,Busman-Sahay K,DiNapoli SR,Lai S,Sheik V,Lisco A,Deleage C,Richardson B,Palesch DJ,Paiardini M,Cameron M,Sereti I,Reeves RK,Estes JD,Brenchley JM

Thu Sep 27 00:00:00 EDT 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

200-07 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.

Cell reports

Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M

200-07 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.

Tue Aug 14 00:00:00 EDT 2018

Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls.

Scientific reports

Vasko T,Hoffmann J,Gostek S,Schettgen T,Quinete N,Preisinger C,Kraus T,Ziegler P

Thu Nov 15 00:00:00 EST 2018

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.

Nature communications

Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR

Thu Aug 30 00:00:00 EDT 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 EDT 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 EDT 2018

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir.

Nature communications

Badia R,Ballana E,Castellví M,García-Vidal E,Pujantell M,Clotet B,Prado JG,Puig J,Martínez MA,Riveira-Muñoz E,Esté JA

200-07 was used in Cell Culture to demonstrate that CD32 expression is a marker of CD4+ T cell activation in HIV+ individuals and raises questions regarding the immune resting status of CD32+ cells harboring HIV-1 proviruses.

Mon Jul 16 00:00:00 EDT 2018

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir.

Nature communications

Badia R,Ballana E,Castellví M,García-Vidal E,Pujantell M,Clotet B,Prado JG,Puig J,Martínez MA,Riveira-Muñoz E,Esté JA

Mon Jul 16 00:00:00 EDT 2018

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.

Stem cell reports

Ueda N,Uemura Y,Zhang R,Kitayama S,Iriguchi S,Kawai Y,Yasui Y,Tatsumi M,Ueda T,Liu TY,Mizoro Y,Okada C,Watanabe A,Nakanishi M,Senju S,Nishimura Y,Kuzushima K,Kiyoi H,Naoe T,Kaneko S

Tue Jun 05 00:00:00 EDT 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Origin and differentiation of human memory CD8 T cells after vaccination.

Nature

Akondy RS,Fitch M,Edupuganti S,Yang S,Kissick HT,Li KW,Youngblood BA,Abdelsamed HA,McGuire DJ,Cohen KW,Alexe G,Nagar S,McCausland MM,Gupta S,Tata P,Haining WN,McElrath MJ,Zhang D,Hu B,Greenleaf WJ,Goronzy JJ,Mulligan MJ,Hellerstein M,Ahmed R

Thu Dec 21 00:00:00 EST 2017

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Cancer cell

Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR

Mon Nov 13 00:00:00 EST 2017

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Cancer cell

Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR

Mon Nov 13 00:00:00 EST 2017

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.

Blood

Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B

Thu Dec 21 00:00:00 EST 2017

Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding.

Blood

Belderbos ME,Koster T,Ausema B,Jacobs S,Sowdagar S,Zwart E,de Bont E,de Haan G,Bystrykh LV

Thu Jun 15 00:00:00 EDT 2017

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

The Journal of experimental medicine

Abolhassani H,Edwards ES,Ikinciogullari A,Jing H,Borte S,Buggert M,Du L,Matsuda-Lennikov M,Romano R,Caridha R,Bade S,Zhang Y,Frederiksen J,Fang M,Bal SK,Haskologlu S,Dogu F,Tacyildiz N,Matthews HF,McElwee JJ,Gostick E,Price DA,Palendira U,Aghamohammadi A,Boisson B,Rezaei N,Karlsson AC,Lenardo MJ,Casanova JL,Hammarström L,Tangye SG,Su HC,Pan-Hammarström Q

Sun Jan 01 00:00:00 EST 2017

The chromatin accessibility signature of human immune aging stems from CD8⁺ T cells.

The Journal of experimental medicine

Ucar D,Márquez EJ,Chung CH,Marches R,Rossi RJ,Uyar A,Wu TC,George J,Stitzel ML,Palucka AK,Kuchel GA,Banchereau J

Mon Oct 02 00:00:00 EDT 2017

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.

Leukemia

Delgado-Martin C,Meyer LK,Huang BJ,Shimano KA,Zinter MS,Nguyen JV,Smith GA,Taunton J,Winter SS,Roderick JR,Kelliher MA,Horton TM,Wood BL,Teachey DT,Hermiston ML

Fri Dec 01 00:00:00 EST 2017

Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.

Proceedings of the National Academy of Sciences of the United States of America

Ripamonti A,Provasi E,Lorenzo M,De Simone M,Ranzani V,Vangelisti S,Curti S,Bonnal RJP,Pignataro L,Torretta S,Geginat J,Rossetti G,Pagani M,Abrignani S

Tue Nov 28 00:00:00 EST 2017

Curtailed T-cell activation curbs effector differentiation and generates CD8⁺ T cells with a naturally-occurring memory stem cell phenotype.

European journal of immunology

Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E

Fri Sep 01 00:00:00 EDT 2017

Adaptive from Innate: Human IFN-γ⁺CD4⁺ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.

Journal of immunology (Baltimore, Md. : 1950)

Das A,Rouault-Pierre K,Kamdar S,Gomez-Tourino I,Wood K,Donaldson I,Mein CA,Bonnet D,Hayday AC,Gibbons DL

Fri Sep 01 00:00:00 EDT 2017

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Schmueck-Henneresse M,Omer B,Shum T,Tashiro H,Mamonkin M,Lapteva N,Sharma S,Rollins L,Dotti G,Reinke P,Volk HD,Rooney CM

Sat Jul 01 00:00:00 EDT 2017

CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.

Journal of immunology (Baltimore, Md. : 1950)

Minami H,Nagaharu K,Nakamori Y,Ohishi K,Shimojo N,Kageyama Y,Matsumoto T,Sugimoto Y,Tawara I,Masuya M,Miwa H,Katayama N

Sun Oct 01 00:00:00 EDT 2017

TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.

Journal of immunology (Baltimore, Md. : 1950)

Sabins NC,Chornoguz O,Leander K,Kaplan F,Carter R,Kinder M,Bachman K,Verona R,Shen S,Bhargava V,Santulli-Marotto S

Fri Dec 15 00:00:00 EST 2017

Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity.

Scientific reports

Park S,Shevlin E,Vedvyas Y,Zaman M,Park S,Hsu YS,Min IM,Jin MM

Mon Oct 30 00:00:00 EDT 2017

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.

Oncotarget

Jiang Z,Wu D,Ye W,Weng J,Lai P,Shi P,Guo X,Huang G,Deng Q,Tang Y,Zhao H,Cui S,Lin S,Wang S,Li B,Wu Q,Li Y,Liu P,Pei D,Du X,Yao Y,Li P

200-07 was used in Cell Culture to develop a defined condition for the ex vivo expansion of primary B-ALL cells that is suitable for high-throughput screening of novel compounds.

Tue Dec 05 00:00:00 EST 2017

Butyrate and propionate inhibit antigen-specific CD8⁺ T cell activation by suppressing IL-12 production by antigen-presenting cells.

Scientific reports

Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A

Mon Nov 06 00:00:00 EST 2017

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

Nature communications

Al-Mossawi MH,Chen L,Fang H,Ridley A,de Wit J,Yager N,Hammitzsch A,Pulyakhina I,Fairfax BP,Simone D,Yi Y,Bandyopadhyay S,Doig K,Gundle R,Kendrick B,Powrie F,Knight JC,Bowness P

Wed Nov 15 00:00:00 EST 2017

Peripheral human CD4⁺CD8⁺ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15.

Scientific reports

Clénet ML,Gagnon F,Moratalla AC,Viel EC,Arbour N

Thu Sep 14 00:00:00 EDT 2017

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell stem cell

Kotini AG,Chang CJ,Chow A,Yuan H,Ho TC,Wang T,Vora S,Solovyov A,Husser C,Olszewska M,Teruya-Feldstein J,Perumal D,Klimek VM,Spyridonidis A,Rampal RK,Silverman L,Reddy EP,Papaemmanuil E,Parekh S,Greenbaum BD,Leslie CS,Kharas MG,Papapetrou EP

200-07 was used in Cell Culture to provide insight into the cellular events demarcating the initiation and progression of myeloid transformation and a new platform for testing genetic and pharmacological interventions.

Thu Mar 02 00:00:00 EST 2017

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.

Stem cell reports

Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK

Tue Sep 12 00:00:00 EDT 2017

Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.

Stem cell reports

Zeng J,Tang SY,Toh LL,Wang S

Tue Dec 12 00:00:00 EST 2017

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing.

Cell

Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A

Thu Sep 22 00:00:00 EDT 2016

Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Immunity

Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O

Tue Jul 19 00:00:00 EDT 2016

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.

The Journal of clinical investigation

Kagoya Y,Nakatsugawa M,Yamashita Y,Ochi T,Guo T,Anczurowski M,Saso K,Butler MO,Arrowsmith CH,Hirano N

Thu Sep 01 00:00:00 EDT 2016

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America

Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J

Tue Oct 25 00:00:00 EDT 2016

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.

Molecular therapy. Nucleic acids

Grier AE,Burleigh S,Sahni J,Clough CA,Cardot V,Choe DC,Krutein MC,Rawlings DJ,Jensen MC,Scharenberg AM,Jacoby K

Tue Apr 19 00:00:00 EDT 2016

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Molecular therapy. Nucleic acids

Romano Ibarra GS,Paul B,Sather BD,Younan PM,Sommer K,Kowalski JP,Hale M,Stoddard B,Jarjour J,Astrakhan A,Kiem HP,Rawlings DJ

Tue Aug 23 00:00:00 EDT 2016

Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.

Journal of immunology (Baltimore, Md. : 1950)

Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V

Thu Dec 01 00:00:00 EST 2016

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.

Journal of immunology (Baltimore, Md. : 1950)

Dan JM,Lindestam Arlehamn CS,Weiskopf D,da Silva Antunes R,Havenar-Daughton C,Reiss SM,Brigger M,Bothwell M,Sette A,Crotty S

Mon Aug 01 00:00:00 EDT 2016

Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Galaine J,Kellermann G,Guillaume Y,Boidot R,Picard E,Loyon R,Queiroz L,Boullerot L,Beziaud L,Jary M,Mansi L,André C,Lethier L,Ségal-Bendirdjian E,Borg C,Godet Y,Adotévi O

Thu Sep 01 00:00:00 EDT 2016

Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model.

Cell death & disease

Gomez-Cadena A,Urueña C,Prieto K,Martinez-Usatorre A,Donda A,Barreto A,Romero P,Fiorentino S

Thu Jun 02 00:00:00 EDT 2016

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

Stem cell reports

D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II

Tue Feb 09 00:00:00 EST 2016

Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.

Nature communications

Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C

Tue Mar 15 00:00:00 EDT 2016

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.

Cell death & disease

Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R

Thu Apr 07 00:00:00 EDT 2016

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature communications

Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM

Mon Nov 21 00:00:00 EST 2016

The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.

The Journal of biological chemistry

Lykken EA,Li QJ

Fri Nov 04 00:00:00 EDT 2016

High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.

Blood

Wegner J,Hackenberg S,Scholz CJ,Chuvpilo S,Tyrsin D,Matskevich AA,Grigoleit GU,Stevanović S,Hünig T

Thu Jul 09 00:00:00 EDT 2015

T memory stem cells are the hierarchical apex of adult T-cell leukemia.

Blood

Nagai Y,Kawahara M,Hishizawa M,Shimazu Y,Sugino N,Fujii S,Kadowaki N,Takaori-Kondo A

Thu Jun 04 00:00:00 EDT 2015

Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.

Blood

Leone P,Berardi S,Frassanito MA,Ria R,De Re V,Cicco S,Battaglia S,Ditonno P,Dammacco F,Vacca A,Racanelli V

Thu Sep 17 00:00:00 EDT 2015

Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.

Blood

Geskin LJ,Viragova S,Stolz DB,Fuschiotti P

Thu Apr 30 00:00:00 EDT 2015

Survivin-specific T cell receptor targets tumor but not T cells.

The Journal of clinical investigation

Arber C,Feng X,Abhyankar H,Romero E,Wu MF,Heslop HE,Barth P,Dotti G,Savoldo B

Thu Jan 01 00:00:00 EST 2015

Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.

Proceedings of the National Academy of Sciences of the United States of America

McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R

Tue Mar 31 00:00:00 EDT 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America

Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X

Tue Dec 29 00:00:00 EST 2015

Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.

Aging cell

van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM

Thu Oct 01 00:00:00 EDT 2015

Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer.

Cancer science

Mayanagi S,Kitago M,Sakurai T,Matsuda T,Fujita T,Higuchi H,Taguchi J,Takeuchi H,Itano O,Aiura K,Hamamoto Y,Takaishi H,Okamoto M,Sunamura M,Kawakami Y,Kitagawa Y

Wed Apr 01 00:00:00 EDT 2015

Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells.

Stem cells (Dayton, Ohio)

Pan QZ,Pan K,Wang QJ,Weng DS,Zhao JJ,Zheng HX,Zhang XF,Jiang SS,Lv L,Tang Y,Li YQ,He J,Liu Q,Chen CL,Zhang HX,Xia JC

Sun Feb 01 00:00:00 EST 2015

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio)

Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS

Wed Apr 01 00:00:00 EDT 2015

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.

Stem cells (Dayton, Ohio)

Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS

Wed Apr 01 00:00:00 EDT 2015

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.

Journal of immunology (Baltimore, Md. : 1950)

Bending D,Giannakopoulou E,Lom H,Wedderburn LR

Tue Dec 15 00:00:00 EST 2015

Knowledge, Behavioral, and Sociocultural Factors Related to Human Papillomavirus Infection and Cervical Cancer Screening Among Inner-City Women in Panama.

Journal of community health

Vamos CA,Calvo AE,Daley EM,Giuliano AR,López Castillo H

Tue Dec 01 00:00:00 EST 2015

TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1.

Scientific reports

Allam A,Majji S,Peachman K,Jagodzinski L,Kim J,Ratto-Kim S,Wijayalath W,Merbah M,Kim JH,Michael NL,Alving CR,Casares S,Rao M

Tue Jun 02 00:00:00 EDT 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 EDT 2015

Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.

Scientific reports

Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J

Mon Oct 12 00:00:00 EDT 2015

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 EDT 2014

Targeted genome editing in human repopulating haematopoietic stem cells.

Nature

Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L

Thu Jun 12 00:00:00 EDT 2014

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity

Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR

Thu Sep 18 00:00:00 EDT 2014

Blood

Xu Y,Zhang M,Ramos CA,Durett A,Liu E,Dakhova O,Liu H,Creighton CJ,Gee AP,Heslop HE,Rooney CM,Savoldo B,Dotti G

Thu Jun 12 00:00:00 EDT 2014

Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.

Blood

Zhang SL,Wang X,Manna S,Zlotoff DA,Bryson JL,Blazar BR,Bhandoola A

Thu Jul 10 00:00:00 EDT 2014

Essential role for autophagy during invariant NKT cell development.

Proceedings of the National Academy of Sciences of the United States of America

Salio M,Puleston DJ,Mathan TS,Shepherd D,Stranks AJ,Adamopoulou E,Veerapen N,Besra GS,Hollander GA,Simon AK,Cerundolo V

Tue Dec 30 00:00:00 EST 2014

Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.

Proceedings of the National Academy of Sciences of the United States of America

Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL

Tue May 20 00:00:00 EDT 2014

Diversity and clonal selection in the human T-cell repertoire.

Proceedings of the National Academy of Sciences of the United States of America

Qi Q,Liu Y,Cheng Y,Glanville J,Zhang D,Lee JY,Olshen RA,Weyand CM,Boyd SD,Goronzy JJ

Tue Sep 09 00:00:00 EDT 2014

5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies.

Blood cancer journal

Gang AO,Frøsig TM,Brimnes MK,Lyngaa R,Treppendahl MB,Grønbæk K,Dufva IH,Straten PT,Hadrup SR

Fri Mar 28 00:00:00 EDT 2014

CD8⁺ T-cell recognition of a synthetic epitope formed by t-butyl modification.

Immunology

Reid RA,Redman JE,Rizkallah P,Fegan C,Pepper C,Man S

Sun Oct 05 00:00:00 EDT 2014

Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.

Stem cells (Dayton, Ohio)

Fernandez I,Ooi TP,Roy K

Wed Jan 01 00:00:00 EST 2014

Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.

Journal of immunology (Baltimore, Md. : 1950)

Bonami RH,Sullivan AM,Case JB,Steinberg HE,Hoek KL,Khan WN,Kendall PL

Sat Feb 15 00:00:00 EST 2014

Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response.

Journal of immunology (Baltimore, Md. : 1950)

Zhao L,Mei Y,Sun Q,Guo L,Wu Y,Yu X,Hu B,Liu X,Liu H

Tue Jul 15 00:00:00 EDT 2014

Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response.

Journal of immunology (Baltimore, Md. : 1950)

Zhao L,Mei Y,Sun Q,Guo L,Wu Y,Yu X,Hu B,Liu X,Liu H

Tue Jul 15 00:00:00 EDT 2014

IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.

Journal of immunology (Baltimore, Md. : 1950)

Morandi F,Di Carlo E,Ferrone S,Petretto A,Pistoia V,Airoldi I

Sat Mar 15 00:00:00 EDT 2014

Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Du MR,Guo PF,Piao HL,Wang SC,Sun C,Jin LP,Tao Y,Li YH,Zhang D,Zhu R,Fu Q,Li DJ

Sat Feb 15 00:00:00 EST 2014

X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.

Journal of immunology (Baltimore, Md. : 1950)

Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC

Mon Dec 01 00:00:00 EST 2014

X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.

Journal of immunology (Baltimore, Md. : 1950)

Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC

Mon Dec 01 00:00:00 EST 2014

Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.

Journal of immunology (Baltimore, Md. : 1950)

Kim PS,Jochems C,Grenga I,Donahue RN,Tsang KY,Gulley JL,Schlom J,Farsaci B

Sat Mar 15 00:00:00 EDT 2014

Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.

Journal of immunology (Baltimore, Md. : 1950)

Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C

Wed Jan 01 00:00:00 EST 2014

Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand.

Cell death & disease

Nazzal D,Gradolatto A,Truffault F,Bismuth J,Berrih-Aknin S

Thu Sep 11 00:00:00 EDT 2014

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific reports

Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

Wed Apr 23 00:00:00 EDT 2014

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Blood

Wölfl M,Schwinn S,Yoo YE,Reß ML,Braun M,Chopra M,Schreiber SC,Ayala VI,Ohlen C,Eyrich M,Beilhack A,Schlegel PG

Thu Aug 15 00:00:00 EDT 2013

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Blood

Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS

Thu Apr 04 00:00:00 EDT 2013

Notch controls generation and function of human effector CD8+ T cells.

Blood

Kuijk LM,Verstege MI,Rekers NV,Bruijns SC,Hooijberg E,Roep BO,de Gruijl TD,van Kooyk Y,Unger WW

Thu Apr 04 00:00:00 EDT 2013

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

Blood

Amabile G,Welner RS,Nombela-Arrieta C,D'Alise AM,Di Ruscio A,Ebralidze AK,Kraytsberg Y,Ye M,Kocher O,Neuberg DS,Khrapko K,Silberstein LE,Tenen DG

Thu Feb 21 00:00:00 EST 2013

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

Blood

Amabile G,Welner RS,Nombela-Arrieta C,D'Alise AM,Di Ruscio A,Ebralidze AK,Kraytsberg Y,Ye M,Kocher O,Neuberg DS,Khrapko K,Silberstein LE,Tenen DG

Thu Feb 21 00:00:00 EST 2013

Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.

Blood

Miyazaki Y,Fujiwara H,Asai H,Ochi F,Ochi T,Azuma T,Ishida T,Okamoto S,Mineno J,Kuzushima K,Shiku H,Yasukawa M

Thu Jun 13 00:00:00 EDT 2013

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Blood

Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A

Thu Nov 14 00:00:00 EST 2013

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.

Blood

Koss B,Morrison J,Perciavalle RM,Singh H,Rehg JE,Williams RT,Opferman JT

Thu Aug 29 00:00:00 EDT 2013

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.

Blood

Koss B,Morrison J,Perciavalle RM,Singh H,Rehg JE,Williams RT,Opferman JT

Thu Aug 29 00:00:00 EDT 2013

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

Blood

Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C

Thu Jan 24 00:00:00 EST 2013

Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.

PLoS pathogens

Introini A,Vanpouille C,Lisco A,Grivel JC,Margolis L

Fri Feb 01 00:00:00 EST 2013

Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.

PLoS pathogens

Introini A,Vanpouille C,Lisco A,Grivel JC,Margolis L

Fri Feb 01 00:00:00 EST 2013

Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?

Journal of immunology (Baltimore, Md. : 1950)

Li L,Nishio J,van Maurik A,Mathis D,Benoist C

Tue Oct 01 00:00:00 EDT 2013

Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.

Journal of immunology (Baltimore, Md. : 1950)

Tallerico R,Todaro M,Di Franco S,Maccalli C,Garofalo C,Sottile R,Palmieri C,Tirinato L,Pangigadde PN,La Rocca R,Mandelboim O,Stassi G,Di Fabrizio E,Parmiani G,Moretta A,Dieli F,Kärre K,Carbone E

Fri Mar 01 00:00:00 EST 2013

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y

Sat Jun 15 00:00:00 EDT 2013

Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory.

Journal of immunology (Baltimore, Md. : 1950)

Choi YS,Yang JA,Yusuf I,Johnston RJ,Greenbaum J,Peters B,Crotty S

Mon Apr 15 00:00:00 EDT 2013

B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Henry-Bonami RA,Williams JM,Rachakonda AB,Karamali M,Kendall PL,Thomas JW

Sat Jun 15 00:00:00 EDT 2013

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PloS one

Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK

Wed Jul 03 00:00:00 EDT 2013

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

PloS one

Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK

Wed Jul 03 00:00:00 EDT 2013

IRX-2, a novel immunotherapeutic, enhances functions of human dendritic cells.

PloS one

Schilling B,Harasymczuk M,Schuler P,Egan J,Ferrone S,Whiteside TL

Fri Sep 06 00:00:00 EDT 2013

Functional heterogeneity of human effector CD8+ T cells.

Blood

Takata H,Naruto T,Takiguchi M

Thu Feb 09 00:00:00 EST 2012

The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Blood

Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B

Thu May 31 00:00:00 EDT 2012

The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Blood

Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B

Thu May 31 00:00:00 EDT 2012

Mast cells play a protumorigenic role in primary cutaneous lymphoma.

Blood

Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K

Thu Sep 06 00:00:00 EDT 2012

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.

Blood

Cimbro R,Vassena L,Arthos J,Cicala C,Kehrl JH,Park C,Sereti I,Lederman MM,Fauci AS,Lusso P

Thu Sep 27 00:00:00 EDT 2012

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

Blood

van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM

Thu Dec 13 00:00:00 EST 2012

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

Blood

van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM

Thu Dec 13 00:00:00 EST 2012

Zebrafish screen identifies novel compound with selective toxicity against leukemia.

Blood

Ridges S,Heaton WL,Joshi D,Choi H,Eiring A,Batchelor L,Choudhry P,Manos EJ,Sofla H,Sanati A,Welborn S,Agarwal A,Spangrude GJ,Miles RR,Cox JE,Frazer JK,Deininger M,Balan K,Sigman M,Müschen M,Perova T,Johnson R,Montpellier B,Guidos CJ,Jones DA,Trede NS

Thu Jun 14 00:00:00 EDT 2012

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.

Blood

Chang KH,Sanchez-Aguilera A,Shen S,Sengupta A,Madhu MN,Ficker AM,Dunn SK,Kuenzi AM,Arnett JL,Santho RA,Agirre X,Perentesis JP,Deininger MW,Zheng Y,Bustelo XR,Williams DA,Cancelas JA

Thu Jul 26 00:00:00 EDT 2012

IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.

The Journal of clinical investigation

Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS

Fri Jun 01 00:00:00 EDT 2012

Early ontogenic origin of the hematopoietic stem cell lineage.

Proceedings of the National Academy of Sciences of the United States of America

Tanaka Y,Hayashi M,Kubota Y,Nagai H,Sheng G,Nishikawa S,Samokhvalov IM

Tue Mar 20 00:00:00 EDT 2012

Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.

Stem cells (Dayton, Ohio)

Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I

Wed Aug 01 00:00:00 EDT 2012

Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Journal of immunology (Baltimore, Md. : 1950)

Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA

Sun Jul 15 00:00:00 EDT 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 EDT 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 EDT 2012

Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Bilwani FA,Knight KL

Thu Nov 01 00:00:00 EDT 2012

IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.

Journal of immunology (Baltimore, Md. : 1950)

Paine A,Kirchner H,Immenschuh S,Oelke M,Blasczyk R,Eiz-Vesper B

Wed Feb 15 00:00:00 EST 2012

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Kreft KL,Verbraak E,Wierenga-Wolf AF,van Meurs M,Oostra BA,Laman JD,Hintzen RQ

Wed Feb 15 00:00:00 EST 2012

Evidence for involvement of Th17 type responses in post kala azar dermal leishmaniasis (PKDL).

PLoS neglected tropical diseases

Katara GK,Ansari NA,Singh A,Ramesh V,Salotra P

Fri Sep 28 00:00:00 EDT 2012

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.

BMC cancer

Blix ES,Irish JM,Husebekk A,Delabie J,Forfang L,Tierens AM,Myklebust JH,Kolstad A

Tue Oct 16 00:00:00 EDT 2012

Autophagy creates a CTL epitope that mimics tumor-associated antigens.

PloS one

Demachi-Okamura A,Torikai H,Akatsuka Y,Miyoshi H,Yoshimori T,Kuzushima K

Wed May 01 00:00:00 EDT 2013

Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells.

Frontiers in immunology

Hoorweg K,Peters CP,Cornelissen F,Aparicio-Domingo P,Papazian N,Kazemier G,Mjösberg JM,Spits H,Cupedo T

Thu Aug 23 00:00:00 EDT 2012

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC immunology

Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ

Thu Aug 16 00:00:00 EDT 2012

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC immunology

Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ

Thu Aug 16 00:00:00 EDT 2012

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

PloS one

Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R

Wed Apr 24 00:00:00 EDT 2013

Characterization of T-cell responses against IκBα in cancer patients.

Oncoimmunology

Munir S,Frøsig TM,Hansen M,Svane IM,Andersen MH

Thu Nov 01 00:00:00 EDT 2012

Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.

The Journal of biological chemistry

Mitra A,Ross JA,Rodriguez G,Nagy ZS,Wilson HL,Kirken RA

Fri May 11 00:00:00 EDT 2012

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.

Nature

Duy C,Hurtz C,Shojaee S,Cerchietti L,Geng H,Swaminathan S,Klemm L,Kweon SM,Nahar R,Braig M,Park E,Kim YM,Hofmann WK,Herzog S,Jumaa H,Koeffler HP,Yu JJ,Heisterkamp N,Graeber TG,Wu H,Ye BH,Melnick A,Müschen M

Thu May 19 00:00:00 EDT 2011

Activation of STAT6 by STING is critical for antiviral innate immunity.

Cell

Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

Fri Oct 14 00:00:00 EDT 2011

Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.

Blood

Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E

Thu Feb 03 00:00:00 EST 2011

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

Blood

Bluteau D,Gilles L,Hilpert M,Antony-Debré I,James C,Debili N,Camara-Clayette V,Wagner-Ballon O,Cordette-Lagarde V,Robert T,Ripoche H,Gonin P,Swierczek S,Prchal J,Vainchenker W,Favier R,Raslova H

Thu Dec 08 00:00:00 EST 2011

IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.

Blood

Bondanza A,Hambach L,Aghai Z,Nijmeijer B,Kaneko S,Mastaglio S,Radrizzani M,Fleischhauer K,Ciceri F,Bordignon C,Bonini C,Goulmy E

Thu Jun 16 00:00:00 EDT 2011

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Blood

Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ

Thu Mar 17 00:00:00 EDT 2011

Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators.

Blood

Sørensen RB,Hadrup SR,Svane IM,Hjortsø MC,Thor Straten P,Andersen MH

Thu Feb 17 00:00:00 EST 2011

STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.

Blood

Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E

Thu Jan 06 00:00:00 EST 2011

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.

Blood

Park YP,Choi SC,Kiesler P,Gil-Krzewska A,Borrego F,Weck J,Krzewski K,Coligan JE

Thu Sep 15 00:00:00 EDT 2011

Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells.

PLoS pathogens

Bosque A,Famiglietti M,Weyrich AS,Goulston C,Planelles V

Sat Oct 01 00:00:00 EDT 2011

Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors.

Cancer immunology, immunotherapy : CII

Andersen RS,Sørensen RB,Ritter C,Svane IM,Becker JC,thor Straten P,Andersen MH

Tue Feb 01 00:00:00 EST 2011

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Zhan Y,Zhang Y,Gray D,Carrington EM,Bouillet P,Ko HJ,O'Reilly L,Wicks IP,Strasser A,Lew AM

Mon Aug 15 00:00:00 EDT 2011

Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

Journal of immunology (Baltimore, Md. : 1950)

Kurtulus S,Tripathi P,Moreno-Fernandez ME,Sholl A,Katz JD,Grimes HL,Hildeman DA

Sun May 15 00:00:00 EDT 2011

Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Feng N,Vegh P,Rothenberg EV,Yui MA

Sat Jan 15 00:00:00 EST 2011

Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Muralidharan S,Hanley PJ,Liu E,Chakraborty R,Bollard C,Shpall E,Rooney C,Savoldo B,Rodgers J,Dotti G

Tue Nov 15 00:00:00 EST 2011

Host-based Th2 cell therapy for prolongation of cardiac allograft viability.

PloS one

Amarnath S,Chen H,Foley JE,Costanzo CM,Sennesh JD,Solomon MA,Fowler DH

Fri Apr 29 00:00:00 EDT 2011

Generation of multivirus-specific T cells to prevent/treat viral infections after allogeneic hematopoietic stem cell transplant.

Journal of visualized experiments : JoVE

Gerdemann U,Vera JF,Rooney CM,Leen AM

Fri May 27 00:00:00 EDT 2011

Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.

PloS one

Sjeklocha LM,Park CW,Wong PY,Roney MJ,Belcher JD,Kaufman DS,Vercellotti GM,Hebbel RP,Steer CJ

Mon May 21 00:00:00 EDT 2012

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.

BMC immunology

Awong G,Herer E,La Motte-Mohs RN,Zúñiga-Pflücker JC

Wed Mar 23 00:00:00 EDT 2011

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.

PloS one

Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B

Mon Aug 27 00:00:00 EDT 2012

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.

PloS one

Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X

Mon Aug 27 00:00:00 EDT 2012

Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.

PloS one

Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G

Mon Aug 27 00:00:00 EDT 2012

A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.

Blood

Sivori S,Falco M,Carlomagno S,Romeo E,Soldani C,Bensussan A,Viola A,Moretta L,Moretta A

Thu Sep 09 00:00:00 EDT 2010

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation.

Blood

Birkholz K,Schwenkert M,Kellner C,Gross S,Fey G,Schuler-Thurner B,Schuler G,Schaft N,Dörrie J

Thu Sep 30 00:00:00 EDT 2010

IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.

Blood

Henriques CM,Rino J,Nibbs RJ,Graham GJ,Barata JT

Thu Apr 22 00:00:00 EDT 2010

Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma.

Blood

Racanelli V,Leone P,Frassanito MA,Brunetti C,Perosa F,Ferrone S,Dammacco F

Thu Feb 11 00:00:00 EST 2010

Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.

Blood

Guo PF,Du MR,Wu HX,Lin Y,Jin LP,Li DJ

Thu Sep 23 00:00:00 EDT 2010

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.

The Journal of clinical investigation

Peperzak V,Xiao Y,Veraar EA,Borst J

Fri Jan 01 00:00:00 EST 2010

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.

Proceedings of the National Academy of Sciences of the United States of America

Cella M,Otero K,Colonna M

Tue Jun 15 00:00:00 EDT 2010

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

PLoS pathogens

Joosten SA,van Meijgaarden KE,van Weeren PC,Kazi F,Geluk A,Savage ND,Drijfhout JW,Flower DR,Hanekom WA,Klein MR,Ottenhoff TH

Fri Feb 26 00:00:00 EST 2010

Fine-scale staging of T cell lineage commitment in adult mouse thymus.

Journal of immunology (Baltimore, Md. : 1950)

Yui MA,Feng N,Rothenberg EV

Thu Jul 01 00:00:00 EDT 2010

A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.

Journal of immunology (Baltimore, Md. : 1950)

Liang X,Weigand LU,Schuster IG,Eppinger E,van der Griendt JC,Schub A,Leisegang M,Sommermeyer D,Anderl F,Han Y,Ellwart J,Moosmann A,Busch DH,Uckert W,Peschel C,Krackhardt AM

Mon Feb 01 00:00:00 EST 2010

Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

Journal of immunology (Baltimore, Md. : 1950)

Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I

Thu Jul 15 00:00:00 EDT 2010

An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Martin JF,Perry JS,Jakhete NR,Wang X,Bielekova B

Thu Jul 15 00:00:00 EDT 2010

STAT5 is critical to maintain effector CD8+ T cell responses.

Journal of immunology (Baltimore, Md. : 1950)

Tripathi P,Kurtulus S,Wojciechowski S,Sholl A,Hoebe K,Morris SC,Finkelman FD,Grimes HL,Hildeman DA

Sun Aug 15 00:00:00 EDT 2010

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.

Gene therapy

Centlivre M,Zhou X,Pouw SM,Weijer K,Kleibeuker W,Das AT,Blom B,Seppen J,Berkhout B,Legrand N

Fri Jan 01 00:00:00 EST 2010

Impact of γ-chain cytokines on EBV-specific T cell cultures.

Journal of translational medicine

Merlo A,Turrini R,Trento C,Zanovello P,Dolcetti R,Rosato A

Mon Nov 22 00:00:00 EST 2010

Hepatic interleukin-7 expression regulates T cell responses.

Immunity

Sawa Y,Arima Y,Ogura H,Kitabayashi C,Jiang JJ,Fukushima T,Kamimura D,Hirano T,Murakami M

Fri Mar 20 00:00:00 EDT 2009

T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.

Blood

Ahlen MT,Husebekk A,Killie MK,Skogen B,Stuge TB

Thu Apr 16 00:00:00 EDT 2009

Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.

Blood

Figueiredo C,Wittmann M,Wang D,Dressel R,Seltsam A,Blasczyk R,Eiz-Vesper B

Thu Mar 26 00:00:00 EDT 2009

Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.

Blood

Xue X,Huang X,Nodland SE,Mátés L,Ma L,Izsvák Z,Ivics Z,LeBien TW,McIvor RS,Wagner JE,Zhou X

Thu Aug 13 00:00:00 EDT 2009

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

Blood

Awong G,Herer E,Surh CD,Dick JE,La Motte-Mohs RN,Zúñiga-Pflücker JC

Thu Jul 30 00:00:00 EDT 2009

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

Blood

Kaneko S,Mastaglio S,Bondanza A,Ponzoni M,Sanvito F,Aldrighetti L,Radrizzani M,La Seta-Catamancio S,Provasi E,Mondino A,Nagasawa T,Fleischhauer K,Russo V,Traversari C,Ciceri F,Bordignon C,Bonini C

Thu Jan 29 00:00:00 EST 2009

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

Blood

Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD

Thu Oct 01 00:00:00 EDT 2009

Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition.

Proceedings of the National Academy of Sciences of the United States of America

Nicholls S,Piper KP,Mohammed F,Dafforn TR,Tenzer S,Salim M,Mahendra P,Craddock C,van Endert P,Schild H,Cobbold M,Engelhard VH,Moss PA,Willcox BE

Tue Mar 10 00:00:00 EDT 2009

IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.

Cell death and differentiation

Czystowska M,Han J,Szczepanski MJ,Szajnik M,Quadrini K,Brandwein H,Hadden JW,Signorelli K,Whiteside TL

Fri May 01 00:00:00 EDT 2009

Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells.

Cancer gene therapy

Symes JC,Siatskas C,Fowler DH,Medin JA

Fri May 01 00:00:00 EDT 2009

CD40 regulates human dendritic cell-derived IL-7 production that, in turn, contributes to CD8(+) T-cell antigen-specific expansion.

Immunology and cell biology

Carreno BM,Becker-Hapak M,Linette GP

Sun Feb 01 00:00:00 EST 2009

Functional silencing is initiated and maintained in immature anti-insulin B cells.

Journal of immunology (Baltimore, Md. : 1950)

Henry RA,Acevedo-Suárez CA,Thomas JW

Sun Mar 15 00:00:00 EDT 2009

Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.

Journal of immunology (Baltimore, Md. : 1950)

Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B

Sat Aug 01 00:00:00 EDT 2009

Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers.

Journal of immunology (Baltimore, Md. : 1950)

Rayment R,Kooij TW,Zhang W,Siebold C,Murphy MF,Allen D,Willcox N,Roberts DJ

Wed Jul 01 00:00:00 EDT 2009

Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model.

Gene therapy

ter Brake O,Legrand N,von Eije KJ,Centlivre M,Spits H,Weijer K,Blom B,Berkhout B

Thu Jan 01 00:00:00 EST 2009

A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocols.

Vaccine

Lundberg K,Roos AK,Pavlenko M,Leder C,Wehrum D,Guevara-Patiño J,Andersen RS,Pisa P

Wed Mar 04 00:00:00 EST 2009

Long-term culture of primary human lymphoblastic leukemia cells in the absence of serum or hematopoietic growth factors.

Experimental hematology

Nijmeijer BA,Szuhai K,Goselink HM,van Schie ML,van der Burg M,de Jong D,Marijt EW,Ottmann OG,Willemze R,Falkenburg JH

Sun Mar 01 00:00:00 EST 2009

Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.

The Journal of biological chemistry

Sakaguchi M,Kataoka K,Abarzua F,Tanimoto R,Watanabe M,Murata H,Than SS,Kurose K,Kashiwakura Y,Ochiai K,Nasu Y,Kumon H,Huh NH

Fri May 22 00:00:00 EDT 2009

Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.

The Journal of biological chemistry

Sakaguchi M,Kataoka K,Abarzua F,Tanimoto R,Watanabe M,Murata H,Than SS,Kurose K,Kashiwakura Y,Ochiai K,Nasu Y,Kumon H,Huh NH

Fri May 22 00:00:00 EDT 2009

Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells.

PloS one

Vercoulen Y,Wehrens EJ,van Teijlingen NH,de Jager W,Beekman JM,Prakken BJ

Fri Sep 25 00:00:00 EDT 2009

The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.

PloS one

Sørensen RB,Berge-Hansen L,Junker N,Hansen CA,Hadrup SR,Schumacher TN,Svane IM,Becker JC,thor Straten P,Andersen MH

Mon Sep 07 00:00:00 EDT 2009

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

The Journal of clinical investigation

Skowera A,Ellis RJ,Varela-Calviño R,Arif S,Huang GC,Van-Krinks C,Zaremba A,Rackham C,Allen JS,Tree TI,Zhao M,Dayan CM,Sewell AK,Unger WW,Drijfhout JW,Ossendorp F,Roep BO,Peakman M

Wed Oct 01 00:00:00 EDT 2008

Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.

Clinical cancer research : an official journal of the American Association for Cancer Research

Su Z,Frye C,Bae KM,Kelley V,Vieweg J

Wed Oct 01 00:00:00 EDT 2008

T cell responses to whole SARS coronavirus in humans.

Journal of immunology (Baltimore, Md. : 1950)

Li CK,Wu H,Yan H,Ma S,Wang L,Zhang M,Tang X,Temperton NJ,Weiss RA,Brenchley JM,Douek DC,Mongkolsapaya J,Tran BH,Lin CL,Screaton GR,Hou JL,McMichael AJ,Xu XN

Wed Oct 15 00:00:00 EDT 2008

In vitro human T cell development directed by notch-ligand interactions.

Methods in molecular biology (Clifton, N.J.)

Awong G,La Motte-Mohs RN,Zúñiga-Pflücker JC

200-07 was used in Cell Culture to outline a simple in vitro protocol for generating large numbers of human T-lineage cells from umbilical cord blood (CB)- derived hematopoietic stem cells (HSCs) using a bone marrow stromal cell line.

Tue Apr 29 00:00:00 EDT 2008

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T

Sat Sep 15 00:00:00 EDT 2007

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Proceedings of the National Academy of Sciences of the United States of America

Bauer A,Villunger A,Labi V,Fischer SF,Strasser A,Wagner H,Schmid RM,Häcker G

Tue Jul 18 00:00:00 EDT 2006

Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.

Journal of immunology (Baltimore, Md. : 1950)

van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P

Tue Feb 15 00:00:00 EST 2005

Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.

The Journal of experimental medicine

Lin L,Gerth AJ,Peng SL

Mon Jul 05 00:00:00 EDT 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

Cancer research

Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT

Sat Feb 15 00:00:00 EST 2003

Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.

Blood

Yu H,Fehniger TA,Fuchshuber P,Thiel KS,Vivier E,Carson WE,Caligiuri MA

Sun Nov 15 00:00:00 EST 1998

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA

Tue Sep 15 00:00:00 EDT 1998

Bioinformatics

Protein Aliases: CD127; CD127 antigen; CDw127; H-IL-7; IL-7; IL-7 receptor subunit alpha; IL-7R subunit alpha; ILN; Interleukin; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin-7; Interleukin-7 receptor subunit alpha; Interleukin7; M-IL-7

Human IL-7 Recombinant Protein, PeproTech®

Human IL-7 Protein (200-07-10UG) in Functional

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200-07-10UG

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