Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 18 amino acids near the center of human Anosmin.
PEP-1263 can be used as a blocking peptide with polyclonal antibody PA5-21149.
KAL1 (Anosmin-1) an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
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Protein Aliases: Adhesion molecule-like X-linked; anosmin; Anosmin-1; Anosmin1; Kallmann syndrome interval gene 1; Kallmann syndrome protein; Kallmann syndrome-1 sequence (anosmin-1); WAP four-disulfide core domain 19
Gene Aliases: ADMLX; ANOS1; HH1; HHA; KAL; KAL1; KALIG-1; KALIG1; KMS; WFDC19
UniProt ID: (Human) P23352
Entrez Gene ID: (Human) 3730
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