Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
RP-88091
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human KLK6 isoform 1, amino acids Met1-Lys244 (Accession # Q92876-1) with a C-terminal His-tag
Tag
His-tag
Molecular weight
10, 25 kDa
Class
Recombinant
Type
Protein
Purity
>95% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Activity
Measured by its ability to cleave the fluorogenic peptide substrate Boc-QARAMC. The specific activity is > 250 pmols/min/ µg. (Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form)
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5-8% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (200 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
Kallikreins, including Kallikrein 6, are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: kallikrein 6; kallikrein 7; Kallikrein-6; Kallikrein6; MGC9355; Neurosin; Protease M; Serine protease 18; Serine protease 9; SP59; Zyme
Gene Aliases: Bssp; hK6; KLK6; Klk7; PRSS18; PRSS9; SP59
UniProt ID: (Human) Q6H301
Entrez Gene ID: (Human) 5653
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support