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Search Thermo Fisher Scientific
This peptide corresponds to 16 amino acids near the carboxy terminus of human LMX1A.
PEP-1512 can be used as a blocking peptide with polyclonal antibody PA5-34470.
The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LIM homeobox transcription factor 1, alpha; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX-1; LMX-1.1; MGC87616
Gene Aliases: LMX1; LMX1.1; LMX1A
UniProt ID: (Human) B3KXP6
Entrez Gene ID: (Human) 4009
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