Product References
Light and electron microscopy continuum-resolution imaging of 3D cell cultures.
Developmental cell
D'Imprima E,Garcia Montero M,Gawrzak S,Ronchi P,Zagoriy I,Schwab Y,Jechlinger M,Mahamid J
120-10C was used in Cell Culture to demonstrate this workflow on mouse and human 3D cultures and use automated image segmentation to annotate and quantitatively analyze subcellular structures in patient-derived colorectal cancer organoids.
Mon Apr 10 00:00:00 EDT 2023
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Science advances
Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R
120-10C was used in In vitro experiments to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).
Fri Aug 25 00:00:00 EDT 2023
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche.
Nature communications
Manieri E,Tie G,Malagola E,Seruggia D,Madha S,Maglieri A,Huang K,Fujiwara Y,Zhang K,Orkin SH,Wang TC,He R,McCarthy N,Shivdasani RA
120-10C was used in Cell Culture to shed light on spatial, molecular, and functional organization of gastric mesenchyme and the spectrum of signaling sources for epithelial support.
Sat Dec 02 00:00:00 EST 2023
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage.
Cell research
Cao S,Feng H,Yi H,Pan M,Lin L,Zhang YS,Feng Z,Liang W,Cai B,Li Q,Xiong Z,Shen Q,Ke M,Zhao X,Chen H,He Q,Min M,Cai Q,Liu H,Wang J,Pei D,Chen J,Ma Y
120-10C was used in In vitro experiments to elucidate the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development.
Thu Jun 01 00:00:00 EDT 2023
Generating human blastoids modeling blastocyst-stage embryos and implantation.
Nature protocols
Heidari Khoei H,Javali A,Kagawa H,Sommer TM,Sestini G,David L,Slovakova J,Novatchkova M,Scholte Op Reimer Y,Rivron N
120-10C was used in Cell Culture to describe how we formed human blastoids that (1) efficiently achieve the morphology of the blastocyst and (2) form lineages according to the pace and sequence of blastocyst development, (3) ultimately forming cells that transcriptionally reflect the blastocyst (preimplantation stage).
Mon May 01 00:00:00 EDT 2023
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
120-10C was used in Tissue/organ Culture to demonstrate that using an agonist of the nuclear receptor (NR2F1) activates dormancy programs in malignant cells which could be used to prevent metastasis.
Mon Jan 03 00:00:00 EST 2022
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
120-10C was used in Tissue/organ Culture to demonstrate that using an agonist of the nuclear receptor (NR2F1) activates dormancy programs in malignant cells which could be used to prevent metastasis.
Mon Jan 03 00:00:00 EST 2022
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Hepatology (Baltimore, Md.)
Amarachintha SP,Mourya R,Ayabe H,Yang L,Luo Z,Li X,Thanekar U,Shivakumar P,Bezerra JA
Sat Jan 01 00:00:00 EST 2022
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
The EMBO journal
Sun D,Llora Batlle O,van den Ameele J,Thomas JC,He P,Lim K,Tang W,Xu C,Meyer KB,Teichmann SA,Marioni JC,Jackson SP,Brand AH,Rawlins EL
120-10C was used in Cell Culture to establish a new workflow for using primary human organoids to elucidate detailed functional mechanisms underlying normal development and disease.
Wed Nov 02 00:00:00 EDT 2022
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips.
Lab on a chip
Grant J,Lee E,Almeida M,Kim S,LoGrande N,Goyal G,Sesay AM,Breault DT,Prantil-Baun R,Ingber DE
120-10C was used in Sample Preparation to describe a simple strategy which recapitulates in vivo functionality to achieve physiologically relevant oxygen tension in a two-channel human small intestine-on-a-chip (Intestine Chip) lined with primary human duodenal epithelium and intestinal microvascular endothelium in parallel channels separated by a porous membrane while both channels are perfused with oxygenated medium.
Tue Apr 12 00:00:00 EDT 2022
Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors.
Genome medicine
Wang R,Li J,Zhou X,Mao Y,Wang W,Gao S,Wang W,Gao Y,Chen K,Yu S,Wu X,Wen L,Ge H,Fu W,Tang F
120-10C was used in Cell Culture to investigate the genomic and transcriptomic changes in adjacent normie tissues, primary tumors, and metastatic tumors of colorectal cancer patients.
Tue Aug 16 00:00:00 EDT 2022
Generation, Maintenance and HBV Infection of Human Liver Organoids.
Bio-protocol
Romal S,Hossain T,Mahmoudi T
120-10C was used in Cell Culture to propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis.
Sun Mar 20 00:00:00 EDT 2022
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
Nature communications
Song H,Weinstein HNW,Allegakoen P,Wadsworth MH,Xie J,Yang H,Castro EA,Lu KL,Stohr BA,Feng FY,Carroll PR,Wang B,Cooperberg MR,Shalek AK,Huang FW
Mon Jan 10 00:00:00 EST 2022
Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation.
JCI insight
Rochman M,Wen T,Kotliar M,Dexheimer PJ,Ben-Baruch Morgenstern N,Caldwell JM,Lim HW,Rothenberg ME
120-10C was used in Cell Culture to investigate downstream signalling in inflammation during eosinophilic esophagitis.
Wed Jun 08 00:00:00 EDT 2022
In-Depth Comparison of Matrigel Dissolving Methods on Proteomic Profiling of Organoids.
Molecular & cellular proteomics : MCP
Wang M,Yu H,Zhang T,Cao L,Du Y,Xie Y,Ji J,Wu J
Sat Jan 01 00:00:00 EST 2022
Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus.
Frontiers in cellular and infection microbiology
Ekanger CT,Zhou F,Bohan D,Lotsberg ML,Ramnefjell M,Hoareau L,Røsland GV,Lu N,Aanerud M,Gärtner F,Salminen PR,Bentsen M,Halvorsen T,Ræder H,Akslen LA,Langeland N,Cox R,Maury W,Stuhr LEB,Lorens JB,Engelsen AST
120-10C was used in Immunohistochemistry to investigate virulent affects of SARS-CoV-2 mutations on organoid models.
Tue Apr 05 00:00:00 EDT 2022
Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection.
Nature protocols
Gurumurthy RK,Koster S,Kumar N,Meyer TF,Chumduri C
120-10C was used in Cell Culture to describe procedures to introduce human papillomavirus oncogenes into the cervical stem cells by genetic manipulation to model cervical cancer and infection of the organoids with the highly prevalent sexually transmitted bacterial pathogen Chlamydia trachomatis.
Fri Jul 01 00:00:00 EDT 2022
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.
Frontiers in immunology
Gopalakrishnan S,Hansen MD,Skovdahl HK,Roseth IA,van Beelen Granlund A,Østvik AE,Bakke I,Sandvik AK,Bruland T
120-10C was used in Cell Culture to identify a regulatory role for IBD-relevant pro-inflammatory signals on MHC-II expression that is influenced by Tofacitinib.
Mon Jun 06 00:00:00 EDT 2022
Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments.
eLife
Dady A,Davidson L,Halley PA,Storey KG
120-10C was used in Cell Culture to describe a novel in vitro human neural-rosette assay that recapitulates dorsal spinal cord differentiation but proceeds more rapidly than in the human embryo, suggesting that it lacks endogenous signalling dynamics and demonstrate that intrinsic properties limit human differentiation pace, and that timely extrinsic signals are required for progression through an intrinsic human neural differentiation programme.
Mon Feb 21 00:00:00 EST 2022
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select.
Nature genetics
Niu Y,Ferreira Azevedo CA,Li X,Kamali E,Haagen Nielsen O,Storgaard Sørensen C,Frödin M
120-10C was used in Tissue/organ culture to present clustered regularly interspaced short palindromic repeat (CRISPR)-SelectTIME, CRISPR-SelectSPACE and CRISPR-SelectSTATE, a set of flexible knock-in assays that introduce a genetic variant in a cell population and track its absolute frequencies relative to an internal, neutral control mutation as a function of time, space or a cell state measurable by flow cytometry.
Thu Dec 01 00:00:00 EST 2022
Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia.
EBioMedicine
Xu T,Li X,Guo Y,Uhlin E,Holmberg L,Mitra S,Winn D,Falk A,Sundström E
120-10C was used in Cell Culture to study neuroepithelial-like stem cells derived from Good Manufacturing Practice (GMP)-compliant iPSCs.
Tue Mar 01 00:00:00 EST 2022
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.
Nature cell biology
Chumduri C,Gurumurthy RK,Berger H,Dietrich O,Kumar N,Koster S,Brinkmann V,Hoffmann K,Drabkina M,Arampatzi P,Son D,Klemm U,Mollenkopf HJ,Herbst H,Mangler M,Vogel J,Saliba AE,Meyer TF
Mon Feb 01 00:00:00 EST 2021
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Nature cell biology
Choi J,Jang YJ,Dabrowska C,Iich E,Evans KV,Hall H,Janes SM,Simons BD,Koo BK,Kim J,Lee JH
Wed Sep 01 00:00:00 EDT 2021
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Nature cell biology
Choi J,Jang YJ,Dabrowska C,Iich E,Evans KV,Hall H,Janes SM,Simons BD,Koo BK,Kim J,Lee JH
Wed Sep 01 00:00:00 EDT 2021
Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Cell stem cell
Cordero-Espinoza L,Dowbaj AM,Kohler TN,Strauss B,Sarlidou O,Belenguer G,Pacini C,Martins NP,Dobie R,Wilson-Kanamori JR,Butler R,Prior N,Serup P,Jug F,Henderson NC,Hollfelder F,Huch M
Thu Nov 04 00:00:00 EDT 2021
Epithelial response to IFN-γ promotes SARS-CoV-2 infection.
EMBO molecular medicine
Heuberger J,Trimpert J,Vladimirova D,Goosmann C,Lin M,Schmuck R,Mollenkopf HJ,Brinkmann V,Tacke F,Osterrieder N,Sigal M
Fri Apr 09 00:00:00 EDT 2021
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats.
Experimental & molecular medicine
Yang JM,Chung S,Yun K,Kim B,So S,Kang S,Kang E,Lee JY
Thu Apr 01 00:00:00 EDT 2021
Human cell transformation by combined lineage conversion and oncogene expression.
Oncogene
Sahu B,Pihlajamaa P,Zhang K,Palin K,Ahonen S,Cervera A,Ristimäki A,Aaltonen LA,Hautaniemi S,Taipale J
Wed Sep 01 00:00:00 EDT 2021
Advanced Xenograft Model with Cotransplantation of Patient-Derived Organoids and Endothelial Colony-Forming Cells for Precision Medicine.
Journal of oncology
Kwon J,Oh S,Park M,Kong JS,Lee S,Lee H,Kim Y,Kang KT,Shin US,Jung J
Tue Aug 03 00:00:00 EDT 2021
Repositioning of duloxetine to target pancreatic stellate cells.
Oncology letters
Sagara A,Nakata K,Matsumoto S,Guan W,Shinkawa T,Iwamoto C,Ikenaga N,Ohuchida K,Nakamura M
120-10C was used in Tissue/organ culture to suggest that duloxetine may be a potential drug for suppressing PSC activation and pancreatic cancer growth.
Fri Oct 01 00:00:00 EDT 2021
Modeling human-specific interlaminar astrocytes in the mouse cerebral cortex.
The Journal of comparative neurology
Padmashri R,Ren B,Oldham B,Jung Y,Gough R,Dunaevsky A
Mon Mar 01 00:00:00 EST 2021
Effect of dipeptide on intestinal peptide transporter 1 gene expression: An evaluation using primary cultured chicken intestinal epithelial cells.
Animal science journal = Nihon chikusan Gakkaiho
Tokutake Y,Taciak M,Sato K,Toyomizu M,Kikusato M
Thu Feb 10 00:00:00 EST 2022
Spatio-temporal characterization of fracture healing patterns and assessment of biomaterials by time-lapsed in vivo micro-computed tomography.
Scientific reports
Wehrle E,Tourolle Né Betts DC,Kuhn GA,Floreani E,Nambiar MH,Schroeder BJ,Hofmann S,Müller R
Wed Apr 21 00:00:00 EDT 2021
Re-expression of REG family and DUOXs genes in CRC organoids by co-culturing with CAFs.
Scientific reports
Naruse M,Ochiai M,Sekine S,Taniguchi H,Yoshida T,Ichikawa H,Sakamoto H,Kubo T,Matsumoto K,Ochiai A,Imai T
Fri Jan 22 00:00:00 EST 2021
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
Nature communications
Krieger TG,Le Blanc S,Jabs J,Ten FW,Ishaque N,Jechow K,Debnath O,Leonhardt CS,Giri A,Eils R,Strobel O,Conrad C
Tue Oct 05 00:00:00 EDT 2021
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ.
Nature communications
Della Chiara G,Gervasoni F,Fakiola M,Godano C,D'Oria C,Azzolin L,Bonnal RJP,Moreni G,Drufuca L,Rossetti G,Ranzani V,Bason R,De Simone M,Panariello F,Ferrari I,Fabbris T,Zanconato F,Forcato M,Romano O,Caroli J,Gruarin P,Sarnicola ML,Cordenonsi M,Bardelli A,Zucchini N,Ceretti AP,Mariani NM,Cassingena A,Sartore-Bianchi A,Testa G,Gianotti L,Opocher E,Pisati F,Tripodo C,Macino G,Siena S,Bicciato S,Piccolo S,Pagani M
Tue Apr 20 00:00:00 EDT 2021
Protocol for establishing organoids from human ovarian cancer biopsies.
STAR protocols
Maenhoudt N,Vankelecom H
120-10C was used in Cell Culture to provide a detailed protocol for establishing organoid cultures from patient OC biopsies.
Fri Jun 18 00:00:00 EDT 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
120-10C was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 EST 2021
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells.
Frontiers in cellular and infection microbiology
Shaharuddin SH,Wang V,Santos RS,Gross A,Wang Y,Jawanda H,Zhang Y,Hasan W,Garcia G,Arumugaswami V,Sareen D
Thu Jul 22 00:00:00 EDT 2021
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple-Negative Breast Cancer Tumor Growth.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Y,Zhou Y,Ma X,Chen L
Mon Feb 01 00:00:00 EST 2021
Protocol for generation of lung adenocarcinoma organoids from clinical samples.
STAR protocols
Li Z,Yu L,Chen D,Meng Z,Chen W,Huang W
Fri Mar 19 00:00:00 EDT 2021
Identification of SUMO Targets Associated With the Pluripotent State in Human Stem Cells.
Molecular & cellular proteomics : MCP
Mojsa B,Tatham MH,Davidson L,Liczmanska M,Branigan E,Hay RT
Thu Mar 24 00:00:00 EDT 2022
Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Nature communications
Iftekhar A,Berger H,Bouznad N,Heuberger J,Boccellato F,Dobrindt U,Hermeking H,Sigal M,Meyer TF
Fri Feb 12 00:00:00 EST 2021
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
Nature communications
Sundberg M,Pinson H,Smith RS,Winden KD,Venugopal P,Tai DJC,Gusella JF,Talkowski ME,Walsh CA,Tegmark M,Sahin M
Tue May 18 00:00:00 EDT 2021
Angiopoietins stimulate pancreatic islet development from stem cells.
Scientific reports
Karanth SS,Sun S,Bi H,Ye K,Jin S
Wed Jun 30 00:00:00 EDT 2021
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells.
Nature communications
Liu H,Li R,Liao HK,Min Z,Wang C,Yu Y,Shi L,Dan J,Hayek A,Martinez Martinez L,Nuñez Delicado E,Izpisua Belmonte JC
Mon Jun 07 00:00:00 EDT 2021
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models.
Cell death & disease
Clark MP,Huynh T,Rao S,Mackiewicz L,Mason H,Romal S,Stutz MD,Ahn SH,Earnest L,Sozzi V,Littlejohn M,Tran BM,Wiedemann N,Vincan E,Torresi J,Netter HJ,Mahmoudi T,Revill P,Pellegrini M,Ebert G
Wed Jun 23 00:00:00 EDT 2021
Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
Cell reports. Medicine
Pandya NJ,Wang C,Costa V,Lopatta P,Meier S,Zampeta FI,Punt AM,Mientjes E,Grossen P,Distler T,Tzouros M,Martí Y,Banfai B,Patsch C,Rasmussen S,Hoener M,Berrera M,Kremer T,Dunkley T,Ebeling M,Distel B,Elgersma Y,Jagasia R
Tue Aug 17 00:00:00 EDT 2021
Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer.
Life (Basel, Switzerland)
Liu LM,Tang Q,Hu X,Zhao JJ,Zhang Y,Ying GG,Zhang F
120-10C was used in Cell Culture to show that p53 function is regulated by PRMT1 in breast cancer cells.
Thu Aug 05 00:00:00 EDT 2021
Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration.
Frontiers in pharmacology
Skovdahl HK,Gopalakrishnan S,Svendsen TD,Granlund AVB,Bakke I,Ginbot ZG,Thorsvik S,Flatberg A,Sporsheim B,Ostrop J,Mollnes TE,Sandvik AK,Bruland T
120-10C was used in Cell Culture to indicate that an oxygen concentration similar to the in vivo epithelial cell environment is of essence in experimental pharmacology.
Tue Jun 01 00:00:00 EDT 2021
Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Nature communications
Schumacher MA,Hsieh JJ,Liu CY,Appel KL,Waddell A,Almohazey D,Katada K,Bernard JK,Bucar EB,Gadeock S,Maselli KM,Washington MK,Grikscheit TC,Warburton D,Rosen MJ,Frey MR
Fri Feb 05 00:00:00 EST 2021
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome.
Nature communications
Banfi F,Rubio A,Zaghi M,Massimino L,Fagnocchi G,Bellini E,Luoni M,Cancellieri C,Bagliani A,Di Resta C,Maffezzini C,Ianielli A,Ferrari M,Piazza R,Mologni L,Broccoli V,Sessa A
Wed Jun 30 00:00:00 EDT 2021
G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease.
Nature communications
Hanna R,Flamier A,Barabino A,Bernier G
Tue Mar 23 00:00:00 EDT 2021
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.
Communications biology
Nguyen L,Jager M,Lieshout R,de Ruiter PE,Locati MD,Besselink N,van der Roest B,Janssen R,Boymans S,de Jonge J,IJzermans JNM,Doukas M,Verstegen MMA,van Boxtel R,van der Laan LJW,Cuppen E,Kuijk E
Thu Nov 18 00:00:00 EST 2021
Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium.
Journal of personalized medicine
Francés-Herrero E,Juárez-Barber E,Campo H,López-Martínez S,de Miguel-Gómez L,Faus A,Pellicer A,Ferrero H,Cervelló I
Thu Jun 03 00:00:00 EDT 2021
Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua.
Cell reports
Cheung VC,Peng CY,Marinić M,Sakabe NJ,Aneas I,Lynch VJ,Ober C,Nobrega MA,Kessler JA
Tue May 18 00:00:00 EDT 2021
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells.
Cancer cell
Hu Z,Artibani M,Alsaadi A,Wietek N,Morotti M,Shi T,Zhong Z,Santana Gonzalez L,El-Sahhar S,Carrami EM,Mallett G,Feng Y,Masuda K,Zheng Y,Chong K,Damato S,Dhar S,Campo L,Garruto Campanile R,Soleymani Majd H,Rai V,Maldonado-Perez D,Jones S,Cerundolo V,Sauka-Spengler T,Yau C,Ahmed AA
Mon Feb 10 00:00:00 EST 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
Mon Aug 10 00:00:00 EDT 2020
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.
Cell stem cell
McCarthy N,Manieri E,Storm EE,Saadatpour A,Luoma AM,Kapoor VN,Madha S,Gaynor LT,Cox C,Keerthivasan S,Wucherpfennig K,Yuan GC,de Sauvage FJ,Turley SJ,Shivdasani RA
120-10C was used in Cell Culture to identify three distinct PDGFRA+ mesenchymal cell types.
Thu Mar 05 00:00:00 EST 2020
A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation.
Cell stem cell
Miao ZF,Adkins-Threats M,Burclaff JR,Osaki LH,Sun JX,Kefalov Y,He Z,Wang ZN,Mills JC
120-10C was used in Tissue/organ culture to show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation.
Thu Jun 04 00:00:00 EDT 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
120-10C was used in Cell Culture to provide deep insights into the pathogenesis of SARS-CoV-2 and the application of defined 3D hAT2 cultures as models for respiratory diseases.
Thu Dec 03 00:00:00 EST 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
120-10C was used in Cell Culture to provide deep insights into the pathogenesis of SARS-CoV-2 and the application of defined 3D hAT2 cultures as models for respiratory diseases.
Thu Dec 03 00:00:00 EST 2020
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
Cell stem cell
Fumagalli A,Oost KC,Kester L,Morgner J,Bornes L,Bruens L,Spaargaren L,Azkanaz M,Schelfhorst T,Beerling E,Heinz MC,Postrach D,Seinstra D,Sieuwerts AM,Martens JWM,van der Elst S,van Baalen M,Bhowmick D,Vrisekoop N,Ellenbroek SIJ,Suijkerbuijk SJE,Snippert HJ,van Rheenen J
120-10C was used in Flow cytometry/Cell sorting to show that most colorectal cancer metastases are seeded by Lgr5- cells, which display intrinsic capacity to become CSCs in a niche-independent manner and can restore epithelial hierarchies in metastatic tumors.
Thu Apr 02 00:00:00 EDT 2020
Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.
The Journal of clinical investigation
Pinzon-Guzman C,Sangadala S,Riera KM,Popova EY,Manning E,Huh WJ,Alexander MS,Shelton JS,Boden SD,Goldenring JR
Mon Aug 03 00:00:00 EDT 2020
Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.
The EMBO journal
Hoffmann K,Berger H,Kulbe H,Thillainadarasan S,Mollenkopf HJ,Zemojtel T,Taube E,Darb-Esfahani S,Mangler M,Sehouli J,Chekerov R,Braicu EI,Meyer TF,Kessler M
Mon Mar 16 00:00:00 EDT 2020
Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics.
Proceedings of the National Academy of Sciences of the United States of America
Buchholz DE,Carroll TS,Kocabas A,Zhu X,Behesti H,Faust PL,Stalbow L,Fang Y,Hatten ME
Tue Jun 30 00:00:00 EDT 2020
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.
Cell death and differentiation
Nguyen PM,Dagley LF,Preaudet A,Lam N,Giam M,Fung KY,Aizel K,van Duijneveldt G,Tan CW,Hirokawa Y,Yip HYK,Love CG,Poh AR,Cruz A,Burstroem C,Feltham R,Abdirahman SM,Meiselbach K,Low RRJ,Palmieri M,Ernst M,Webb AI,Burgess T,Sieber OM,Bouillet P,Putoczki TL
Sat Feb 01 00:00:00 EST 2020
Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids.
Advanced healthcare materials
Krüger M,Oosterhoff LA,van Wolferen ME,Schiele SA,Walther A,Geijsen N,De Laporte L,van der Laan LJW,Kock LM,Spee B
Sun Mar 01 00:00:00 EST 2020
Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids.
Cell systems
Trapecar M,Communal C,Velazquez J,Maass CA,Huang YJ,Schneider K,Wright CW,Butty V,Eng G,Yilmaz O,Trumper D,Griffith LG
120-10C was used in Cell Culture to underscore the emerging utility of human physiomimetic technology in combination with systems immunology to study causality and the fundamental entanglement of immunity, metabolism, and tissue homeostasis.
Wed Mar 25 00:00:00 EDT 2020
Disruption of BMP Signaling Prevents Hyperthyroidism-Induced Bone Loss in Male Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Lademann F,Weidner H,Tsourdi E,Kumar R,Rijntjes E,Köhrle J,Hofbauer LC,Rauner M
Thu Oct 01 00:00:00 EDT 2020
The Sca-1+ and Sca-1- mouse prostatic luminal cell lineages are independently sustained.
Stem cells (Dayton, Ohio)
Kwon OJ,Choi JM,Zhang L,Jia D,Li Z,Zhang Y,Jung SY,Creighton CJ,Xin L
Sun Nov 01 00:00:00 EDT 2020
Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche.
Stem cells (Dayton, Ohio)
Oszvald Á,Szvicsek Z,Sándor GO,Kelemen A,Soós AÁ,Pálóczi K,Bursics A,Dede K,Tölgyes T,Buzás EI,Zeöld A,Wiener Z
Sat Feb 01 00:00:00 EST 2020
Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche.
Stem cells (Dayton, Ohio)
Oszvald Á,Szvicsek Z,Sándor GO,Kelemen A,Soós AÁ,Pálóczi K,Bursics A,Dede K,Tölgyes T,Buzás EI,Zeöld A,Wiener Z
Sat Feb 01 00:00:00 EST 2020
Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.
The FEBS journal
Fernández-Barral A,Costales-Carrera A,Buira SP,Jung P,Ferrer-Mayorga G,Larriba MJ,Bustamante-Madrid P,Domínguez O,Real FX,Guerra-Pastrián L,Lafarga M,García-Olmo D,Cantero R,Del Peso L,Batlle E,Rojo F,Muñoz A,Barbáchano A
Wed Jan 01 00:00:00 EST 2020
Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells.
International journal of molecular sciences
Naumovska E,Aalderink G,Wong Valencia C,Kosim K,Nicolas A,Brown S,Vulto P,Erdmann KS,Kurek D
120-10C was used in Cell Culture to study the direct differentiation of induced pluripotent stem cells.
Tue Jul 14 00:00:00 EDT 2020
Towards personalized induction therapy for esophageal adenocarcinoma: organoids derived from endoscopic biopsy recapitulate the pre-treatment tumor.
Scientific reports
Derouet MF,Allen J,Wilson GW,Ng C,Radulovich N,Kalimuthu S,Tsao MS,Darling GE,Yeung JC
Thu Sep 03 00:00:00 EDT 2020
The mutational impact of culturing human pluripotent and adult stem cells.
Nature communications
Kuijk E,Jager M,van der Roest B,Locati MD,Van Hoeck A,Korzelius J,Janssen R,Besselink N,Boymans S,van Boxtel R,Cuppen E
Tue May 19 00:00:00 EDT 2020
Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium.
Biomolecules
Zhu M,Iwano T,Takeda S
120-10C was used in Cell Culture to optimise the culture condition for the stable expansion of basal stem cells, and inducing differentiation of basal cells into polarized secretory and ciliated cells in the air-liquid interface (ALI) condition that suitable for long-term culture.
Thu Sep 03 00:00:00 EDT 2020
Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
Scientific reports
Nanki Y,Chiyoda T,Hirasawa A,Ookubo A,Itoh M,Ueno M,Akahane T,Kameyama K,Yamagami W,Kataoka F,Aoki D
Tue Jul 28 00:00:00 EDT 2020
BrainPhys neuronal medium optimized for imaging and optogenetics in vitro.
Nature communications
Zabolocki M,McCormack K,van den Hurk M,Milky B,Shoubridge AP,Adams R,Tran J,Mahadevan-Jansen A,Reineck P,Thomas J,Hutchinson MR,Mak CKH,Añonuevo A,Chew LH,Hirst AJ,Lee VM,Knock E,Bardy C
Tue Nov 03 00:00:00 EST 2020
Development of a human primary gut-on-a-chip to model inflammatory processes.
Scientific reports
Beaurivage C,Kanapeckaite A,Loomans C,Erdmann KS,Stallen J,Janssen RAJ
Tue Dec 08 00:00:00 EST 2020
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Cell stem cell
Bowers M,Liang T,Gonzalez-Bohorquez D,Zocher S,Jaeger BN,Kovacs WJ,Röhrl C,Cramb KML,Winterer J,Kruse M,Dimitrieva S,Overall RW,Wegleiter T,Najmabadi H,Semenkovich CF,Kempermann G,Földy C,Jessberger S
120-10C was used in Cell Culture to investigate lipid metabolism and cognitive function in neural stem/progenitor cells and human embryonic stem cells.
Thu Jul 02 00:00:00 EDT 2020
LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells.
Stem cell research & therapy
He F,Li N,Huang HB,Wang JB,Yang XF,Wang HD,Huang W,Li FR
120-10C was used in Cell Culture to investigate the role of LSD1 on insulin production from human embryonic stem cell line H9.
Tue Apr 28 00:00:00 EDT 2020
Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery.
Neuroscience letters
Soubannier V,Maussion G,Chaineau M,Sigutova V,Rouleau G,Durcan TM,Stifani S
120-10C was used in Cell Culture to investigate the use of human induced pluripotent stem cells-derived astrocytes in studying neurological diseases.
Mon Jul 13 00:00:00 EDT 2020
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Nature communications
Chang KC,Diermeier SD,Yu AT,Brine LD,Russo S,Bhatia S,Alsudani H,Kostroff K,Bhuiya T,Brogi E,Pappin DJ,Bennett CF,Rigo F,Spector DL
Tue Dec 22 00:00:00 EST 2020
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation.
Nature communications
Cho YH,Ro EJ,Yoon JS,Mizutani T,Kang DW,Park JC,Il Kim T,Clevers H,Choi KY
Wed Oct 21 00:00:00 EDT 2020
Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis.
Scientific reports
Hasaart KAL,Manders F,van der Hoorn ML,Verheul M,Poplonski T,Kuijk E,de Sousa Lopes SMC,van Boxtel R
Fri Jul 31 00:00:00 EDT 2020
WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations.
Scientific reports
Rose IM,Bidarimath M,Webster A,Godwin AK,Flesken-Nikitin A,Nikitin AY
Wed Jun 17 00:00:00 EDT 2020
p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids.
Cell death & disease
Marin Navarro A,Pronk RJ,van der Geest AT,Oliynyk G,Nordgren A,Arsenian-Henriksson M,Falk A,Wilhelm M
Thu Jan 23 00:00:00 EST 2020
Establishment of Pancreatic Organoids from Normal Tissue and Tumors.
STAR protocols
Driehuis E,Gracanin A,Vries RGJ,Clevers H,Boj SF
120-10C was used in Tissue/organ culture to detail the generation of pancreatic tumor organoid models that can be cryopreserved and serve as living biobank for drug screening.
Fri Dec 18 00:00:00 EST 2020
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Cell
Wang H,Xiang D,Liu B,He A,Randle HJ,Zhang KX,Dongre A,Sachs N,Clark AP,Tao L,Chen Q,Botchkarev VV,Xie Y,Dai N,Clevers H,Li Z,Livingston DM
Thu Jun 27 00:00:00 EDT 2019
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
Cell stem cell
Xu R,Brawner AT,Li S,Liu JJ,Kim H,Xue H,Pang ZP,Kim WY,Hart RP,Liu Y,Jiang P
120-10C was used in Tissue/organ culture to conclude that altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Thu Jun 06 00:00:00 EDT 2019
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Oncogene
Wagner S,Vlachogiannis G,De Haven Brandon A,Valenti M,Box G,Jenkins L,Mancusi C,Self A,Manodoro F,Assiotis I,Robinson P,Chauhan R,Rust AG,Matthews N,Eason K,Khan K,Starling N,Cunningham D,Sadanandam A,Isacke CM,Kirkin V,Valeri N,Whittaker SR
Fri Mar 01 00:00:00 EST 2019
Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.
Stem cells and development
Singh RK,Occelli LM,Binette F,Petersen-Jones SM,Nasonkin IO
Sun Sep 01 00:00:00 EDT 2019
Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-α-stimulated gene-6 in inflammatory bowel disease models.
Cell death & disease
Yang H,Feng R,Fu Q,Xu S,Hao X,Qiu Y,Feng T,Zeng Z,Chen M,Zhang S
Thu Sep 26 00:00:00 EDT 2019
Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation.
Nature communications
Subramanian A,Sidhom EH,Emani M,Vernon K,Sahakian N,Zhou Y,Kost-Alimova M,Slyper M,Waldman J,Dionne D,Nguyen LT,Weins A,Marshall JL,Rosenblatt-Rosen O,Regev A,Greka A
Fri Nov 29 00:00:00 EST 2019
Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity.
Nature communications
Santos CP,Lapi E,Martínez de Villarreal J,Álvaro-Espinosa L,Fernández-Barral A,Barbáchano A,Domínguez O,Laughney AM,Megías D,Muñoz A,Real FX
120-10C was used in Cell Culture to investigate the growth of mouse urothelial organoids expressing CD49f/ITGA6.
Fri Sep 27 00:00:00 EDT 2019
TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
The Journal of biological chemistry
Henen MA,Mahlawat P,Zwieb C,Kodali RB,Hinck CS,Hanna RD,Krzysiak TC,Ilangovan U,Cano KE,Hinck G,Vonberg M,McCabe M,Hinck AP
Fri Mar 01 00:00:00 EST 2019
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer.
Nature communications
Christensen S,Van der Roest B,Besselink N,Janssen R,Boymans S,Martens JWM,Yaspo ML,Priestley P,Kuijk E,Cuppen E,Van Hoeck A
Tue Oct 08 00:00:00 EDT 2019
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nature communications
Segal JM,Kent D,Wesche DJ,Ng SS,Serra M,Oulès B,Kar G,Emerton G,Blackford SJI,Darmanis S,Miquel R,Luong TV,Yamamoto R,Bonham A,Jassem W,Heaton N,Vigilante A,King A,Sancho R,Teichmann S,Quake SR,Nakauchi H,Rashid ST
Fri Jul 26 00:00:00 EDT 2019
A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhuang J,Zhang J,Wu M,Zhang Y
Fri Nov 01 00:00:00 EDT 2019
Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant.
Scientific reports
Ito K,Matsuura K,Mihara Y,Sakamoto Y,Hasegawa K,Kokudo N,Shimizu T
Thu Apr 11 00:00:00 EDT 2019
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Nature communications
Zhao Y,Sun X,Hu D,Prosdocimo DA,Hoppel C,Jain MK,Ramachandran R,Qi X
Tue Mar 26 00:00:00 EDT 2019
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
Thu May 02 00:00:00 EDT 2019
Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.
Nature communications
Kessler M,Hoffmann K,Fritsche K,Brinkmann V,Mollenkopf HJ,Thieck O,Teixeira da Costa AR,Braicu EI,Sehouli J,Mangler M,Berger H,Meyer TF
Mon Mar 18 00:00:00 EDT 2019
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.
Nature communications
Zhan T,Ambrosi G,Wandmacher AM,Rauscher B,Betge J,Rindtorff N,Häussler RS,Hinsenkamp I,Bamberg L,Hessling B,Müller-Decker K,Erdmann G,Burgermeister E,Ebert MP,Boutros M
Thu May 16 00:00:00 EDT 2019
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer.
Nature communications
Zhan T,Ambrosi G,Wandmacher AM,Rauscher B,Betge J,Rindtorff N,Häussler RS,Hinsenkamp I,Bamberg L,Hessling B,Müller-Decker K,Erdmann G,Burgermeister E,Ebert MP,Boutros M
Thu May 16 00:00:00 EDT 2019
FOXF2 reprograms breast cancer cells into bone metastasis seeds.
Nature communications
Wang S,Li GX,Tan CC,He R,Kang LJ,Lu JT,Li XQ,Wang QS,Liu PF,Zhai QL,Feng YM
Thu Jun 20 00:00:00 EDT 2019
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Nature communications
Kim M,Mun H,Sung CO,Cho EJ,Jeon HJ,Chun SM,Jung DJ,Shin TH,Jeong GS,Kim DK,Choi EK,Jeong SY,Taylor AM,Jain S,Meyerson M,Jang SJ
Thu Sep 05 00:00:00 EDT 2019
Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube.
Cells
Zhu M,Iwano T,Takeda S
120-10C was used in Cell Culture to investigate the role of estrogen and epidermal growth factor on regulating cell differentiation using porcine fallopian tube epithelial cells.
Mon Aug 19 00:00:00 EDT 2019
SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.
Cell
Wang CY,Jégu T,Chu HP,Oh HJ,Lee JT
Thu Jul 12 00:00:00 EDT 2018
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Cell
Sachs N,de Ligt J,Kopper O,Gogola E,Bounova G,Weeber F,Balgobind AV,Wind K,Gracanin A,Begthel H,Korving J,van Boxtel R,Duarte AA,Lelieveld D,van Hoeck A,Ernst RF,Blokzijl F,Nijman IJ,Hoogstraat M,van de Ven M,Egan DA,Zinzalla V,Moll J,Boj SF,Voest EE,Wessels L,van Diest PJ,Rottenberg S,Vries RGJ,Cuppen E,Clevers H
Thu Jan 11 00:00:00 EST 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.
Cancer discovery
Hill SJ,Decker B,Roberts EA,Horowitz NS,Muto MG,Worley MJ,Feltmate CM,Nucci MR,Swisher EM,Nguyen H,Yang C,Morizane R,Kochupurakkal BS,Do KT,Konstantinopoulos PA,Liu JF,Bonventre JV,Matulonis UA,Shapiro GI,Berkowitz RS,Crum CP,D'Andrea AD
120-10C was used in Tissue/organ culture to demonstrate a platform for functional profiling of DNA repair in short-term patient-derived high-grade serous ovarian cancer (HGSC) organoids as a means of assessing targetable defects in the parent tumors, offering more suitable treatment options.
Thu Nov 01 00:00:00 EDT 2018
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.
The Journal of experimental medicine
Kanaya T,Sakakibara S,Jinnohara T,Hachisuka M,Tachibana N,Hidano S,Kobayashi T,Kimura S,Iwanaga T,Nakagawa T,Katsuno T,Kato N,Akiyama T,Sato T,Williams IR,Ohno H
Mon Feb 05 00:00:00 EST 2018
Antagonizing CD105 enhances radiation sensitivity in prostate cancer.
Oncogene
Madhav A,Andres A,Duong F,Mishra R,Haldar S,Liu Z,Angara B,Gottlieb R,Zumsteg ZS,Bhowmick NA
Wed Aug 01 00:00:00 EDT 2018
Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.
Nature communications
Russo M,Lamba S,Lorenzato A,Sogari A,Corti G,Rospo G,Mussolin B,Montone M,Lazzari L,Arena S,Oddo D,Linnebacher M,Sartore-Bianchi A,Pietrantonio F,Siena S,Di Nicolantonio F,Bardelli A
Tue Jun 12 00:00:00 EDT 2018
Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents.
PloS one
Southard SM,Kotipatruni RP,Rust WL
120-10C was used in Cell Culture to show that SR1423 is a candidate cell line for the production of insulin-producing cells useful for the treatment of diabetes.
Thu Feb 21 00:00:00 EST 2019
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
PloS one
Sambathkumar R,Akkerman R,Dastidar S,Roelandt P,Kumar M,Bajaj M,Mestre Rosa AR,Helsen N,Vanslembrouck V,Kalo E,Khurana S,Laureys J,Gysemans C,Faas MM,de Vos P,Verfaillie CM
120-10C was used in Tissue/organ culture to investigate 14 transcription factors in multipotent adult progenitor cell reprogramming for hepatocyte and endocrine pacreatic-like cell culture.
Tue Jul 31 00:00:00 EDT 2018
Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.
Cell death & disease
Xu Y,Luo X,Fang Z,Zheng X,Zeng Y,Zhu C,Gu J,Tang F,Hu Y,Hu G,Jin Y,Li H
Tue Sep 11 00:00:00 EDT 2018
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
Bayrer JR,Wang H,Nattiv R,Suzawa M,Escusa HS,Fletterick RJ,Klein OD,Moore DD,Ingraham HA
Wed Oct 10 00:00:00 EDT 2018
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications
Bayrer JR,Wang H,Nattiv R,Suzawa M,Escusa HS,Fletterick RJ,Klein OD,Moore DD,Ingraham HA
Wed Oct 10 00:00:00 EDT 2018
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Cell reports
Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E
120-10C was used in Cell Culture to analyse the molecular heterogeneity in basal and luminal prostate compartments.
Tue Dec 18 00:00:00 EST 2018
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.
Scientific reports
Kasendra M,Tovaglieri A,Sontheimer-Phelps A,Jalili-Firoozinezhad S,Bein A,Chalkiadaki A,Scholl W,Zhang C,Rickner H,Richmond CA,Li H,Breault DT,Ingber DE
Tue Feb 13 00:00:00 EST 2018
Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.
Scientific reports
Shibata W,Kinoshita H,Hikiba Y,Sato T,Ishii Y,Sue S,Sugimori M,Suzuki N,Sakitani K,Ijichi H,Mori R,Endo I,Maeda S
Wed Apr 18 00:00:00 EDT 2018
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.
Scientific reports
Sahakyan V,Duelen R,Tam WL,Roberts SJ,Grosemans H,Berckmans P,Ceccarelli G,Pelizzo G,Broccoli V,Deprest J,Luyten FP,Verfaillie CM,Sampaolesi M
Tue Feb 13 00:00:00 EST 2018
Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Nature communications
Kang MH,Choi H,Oshima M,Cheong JH,Kim S,Lee JH,Park YS,Choi HS,Kweon MN,Pack CG,Lee JS,Mills GB,Myung SJ,Park YY
Tue May 15 00:00:00 EDT 2018
Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system.
Scientific reports
Garnier D,Li R,Delbos F,Fourrier A,Collet C,Guguen-Guillouzo C,Chesné C,Nguyen TH
Tue May 29 00:00:00 EDT 2018
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs.
Stem cell reports
Wu M,Zhang D,Bi C,Mi T,Zhu W,Xia L,Teng Z,Hu B,Wu Y
Tue Sep 11 00:00:00 EDT 2018
Culture and characterization of chicken small intestinal crypts.
Poultry science
Li J,Li J,Zhang SY,Li RX,Lin X,Mi YL,Zhang CQ
120-10C was used in Tissue/organ culture to study the crypts of chickens small intestines.
Tue May 01 00:00:00 EDT 2018
BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation.
Journal of experimental & clinical cancer research : CR
Deng G,Zeng S,Qu Y,Luo Q,Guo C,Yin L,Han Y,Li Y,Cai C,Fu Y,Shen H
120-10C was used in In vitro experiments to investigate the roles of BMP4 and autophagy on hepatocellular carcinoma.
Mon Jul 16 00:00:00 EDT 2018
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Nature communications
Li X,Francies HE,Secrier M,Perner J,Miremadi A,Galeano-Dalmau N,Barendt WJ,Letchford L,Leyden GM,Goffin EK,Barthorpe A,Lightfoot H,Chen E,Gilbert J,Noorani A,Devonshire G,Bower L,Grantham A,MacRae S,Grehan N,Wedge DC,Fitzgerald RC,Garnett MJ
Mon Jul 30 00:00:00 EDT 2018
Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
Nature communications
Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH
Fri Sep 14 00:00:00 EDT 2018
Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines.
Stem cell reports
Perriot S,Mathias A,Perriard G,Canales M,Jonkmans N,Merienne N,Meunier C,El Kassar L,Perrier AL,Laplaud DA,Schluep M,Déglon N,Du Pasquier R
Tue Nov 13 00:00:00 EST 2018
Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion.
Brain pathology (Zurich, Switzerland)
Uemura MT,Ihara M,Maki T,Nakagomi T,Kaji S,Uemura K,Matsuyama T,Kalaria RN,Kinoshita A,Takahashi R
120-10C was used in In vitro experiments to suggest ischemic white matter damage evolves in parallel with BMP4 upregulation in pericytes.
Sun Jul 01 00:00:00 EDT 2018
Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion.
Brain pathology (Zurich, Switzerland)
Uemura MT,Ihara M,Maki T,Nakagomi T,Kaji S,Uemura K,Matsuyama T,Kalaria RN,Kinoshita A,Takahashi R
120-10C was used in In vitro experiments to suggest ischemic white matter damage evolves in parallel with BMP4 upregulation in pericytes.
Sun Jul 01 00:00:00 EDT 2018
Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Nature
Sigal M,Logan CY,Kapalczynska M,Mollenkopf HJ,Berger H,Wiedenmann B,Nusse R,Amieva MR,Meyer TF
Thu Aug 24 00:00:00 EDT 2017
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
Neuron
Petersen MA,Ryu JK,Chang KJ,Etxeberria A,Bardehle S,Mendiola AS,Kamau-Devers W,Fancy SPJ,Thor A,Bushong EA,Baeza-Raja B,Syme CA,Wu MD,Rios Coronado PE,Meyer-Franke A,Yahn S,Pous L,Lee JK,Schachtrup C,Lassmann H,Huang EJ,Han MH,Absinta M,Reich DS,Ellisman MH,Rowitch DH,Chan JR,Akassoglou K
Wed Dec 06 00:00:00 EST 2017
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells.
Nature protocols
Morizane R,Bonventre JV
120-10C was used in Cell Culture to develop a high-efficiency protocol with quick turn-around to generate nephron progenitor cells (NPCs) and kidney organoids from hPSCs.
Sun Jan 01 00:00:00 EST 2017
Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells.
Stem cell reports
Santos R,Vadodaria KC,Jaeger BN,Mei A,Lefcochilos-Fogelquist S,Mendes APD,Erikson G,Shokhirev M,Randolph-Moore L,Fredlender C,Dave S,Oefner R,Fitzpatrick C,Pena M,Barron JJ,Ku M,Denli AM,Kerman BE,Charnay P,Kelsoe JR,Marchetto MC,Gage FH
Tue Jun 06 00:00:00 EDT 2017
A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug.
Scientific reports
Chen C,Choudhury S,Wangsa D,Lescott CJ,Wilkins DJ,Sripadhan P,Liu X,Wangsa D,Ried T,Moskaluk C,Wick MJ,Glasgow E,Schlegel R,Agarwal S
Tue Sep 12 00:00:00 EDT 2017
A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug.
Scientific reports
Chen C,Choudhury S,Wangsa D,Lescott CJ,Wilkins DJ,Sripadhan P,Liu X,Wangsa D,Ried T,Moskaluk C,Wick MJ,Glasgow E,Schlegel R,Agarwal S
Tue Sep 12 00:00:00 EDT 2017
DLL4 overexpression increases gastric cancer stem/progenitor cell self-renewal ability and correlates with poor clinical outcome via Notch-1 signaling pathway activation.
Cancer medicine
Miao ZF,Xu H,Xu HM,Wang ZN,Zhao TT,Song YX,Xu YY
Sun Jan 01 00:00:00 EST 2017
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.
Molecular systems biology
Chen KY,Srinivasan T,Tung KL,Belmonte JM,Wang L,Murthy PKL,Choi J,Rakhilin N,King S,Varanko AK,Witherspoon M,Nishimura N,Glazier JA,Lipkin SM,Bu P,Shen X
Fri Apr 28 00:00:00 EDT 2017
The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation.
Scientific reports
Golkaram M,Jang J,Hellander S,Kosik KS,Petzold LR
Tue Oct 17 00:00:00 EDT 2017
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
PloS one
Geng Z,Walsh PJ,Truong V,Hill C,Ebeling M,Kapphahn RJ,Montezuma SR,Yuan C,Roehrich H,Ferrington DA,Dutton JR
Thu Aug 17 00:00:00 EDT 2017
The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide.
The Journal of biological chemistry
Lanchec E,Désilets A,Béliveau F,Flamier A,Mahmoud S,Bernier G,Gris D,Leduc R,Lavoie C
Fri Dec 15 00:00:00 EST 2017
Organoid culture systems for prostate epithelial and cancer tissue.
Nature protocols
Drost J,Karthaus WR,Gao D,Driehuis E,Sawyers CL,Chen Y,Clevers H
120-10C was used in Cell Culture to describe a strategy for the generation of 3D prostate organoid cultures from a variety of cell types.
Mon Feb 01 00:00:00 EST 2016
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Stem cells (Dayton, Ohio)
Dafinca R,Scaber J,Ababneh N,Lalic T,Weir G,Christian H,Vowles J,Douglas AG,Fletcher-Jones A,Browne C,Nakanishi M,Turner MR,Wade-Martins R,Cowley SA,Talbot K
Mon Aug 01 00:00:00 EDT 2016
Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.
Nature communications
Yamamoto Y,Wang X,Bertrand D,Kern F,Zhang T,Duleba M,Srivastava S,Khor CC,Hu Y,Wilson LH,Blaszyk H,Rolshud D,Teh M,Liu J,Howitt BE,Vincent M,Crum CP,Nagarajan N,Ho KY,McKeon F,Xian W
Tue Jan 19 00:00:00 EST 2016
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Nature communications
Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X
Fri Aug 26 00:00:00 EDT 2016
Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.
Scientific reports
Barnea-Cramer AO,Wang W,Lu SJ,Singh MS,Luo C,Huo H,McClements ME,Barnard AR,MacLaren RE,Lanza R
Wed Jul 13 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
120-10C was used in Cell Culture to provide a protocol for human liver and pancreas organoids from cell isolation and long-term expansion to genetic manipulation in vitro.
Thu Sep 01 00:00:00 EDT 2016
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.
Nature protocols
Broutier L,Andersson-Rolf A,Hindley CJ,Boj SF,Clevers H,Koo BK,Huch M
120-10C was used in Cell Culture to provide a protocol for human liver and pancreas organoids from cell isolation and long-term expansion to genetic manipulation in vitro.
Thu Sep 01 00:00:00 EDT 2016
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific reports
Borgs L,Peyre E,Alix P,Hanon K,Grobarczyk B,Godin JD,Purnelle A,Krusy N,Maquet P,Lefebvre P,Seutin V,Malgrange B,Nguyen L
Mon Sep 19 00:00:00 EDT 2016
Sequential cancer mutations in cultured human intestinal stem cells.
Nature
Drost J,van Jaarsveld RH,Ponsioen B,Zimberlin C,van Boxtel R,Buijs A,Sachs N,Overmeer RM,Offerhaus GJ,Begthel H,Korving J,van de Wetering M,Schwank G,Logtenberg M,Cuppen E,Snippert HJ,Medema JP,Kops GJ,Clevers H
Thu May 07 00:00:00 EDT 2015
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Cell
Huch M,Gehart H,van Boxtel R,Hamer K,Blokzijl F,Verstegen MM,Ellis E,van Wenum M,Fuchs SA,de Ligt J,van de Wetering M,Sasaki N,Boers SJ,Kemperman H,de Jonge J,Ijzermans JN,Nieuwenhuis EE,Hoekstra R,Strom S,Vries RR,van der Laan LJ,Cuppen E,Clevers H
Thu Jan 15 00:00:00 EST 2015
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.
Proceedings of the National Academy of Sciences of the United States of America
Bardy C,van den Hurk M,Eames T,Marchand C,Hernandez RV,Kellogg M,Gorris M,Galet B,Palomares V,Brown J,Bang AG,Mertens J,Böhnke L,Boyer L,Simon S,Gage FH
Tue May 19 00:00:00 EDT 2015
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.
Nature communications
Kessler M,Hoffmann K,Brinkmann V,Thieck O,Jackisch S,Toelle B,Berger H,Mollenkopf HJ,Mangler M,Sehouli J,Fotopoulou C,Meyer TF
Tue Dec 08 00:00:00 EST 2015
Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine.
Scientific reports
Ozawa T,Takayama K,Okamoto R,Negoro R,Sakurai F,Tachibana M,Kawabata K,Mizuguchi H
Thu Nov 12 00:00:00 EST 2015
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
Stem cell reports
Nantasanti S,Spee B,Kruitwagen HS,Chen C,Geijsen N,Oosterhoff LA,van Wolferen ME,Pelaez N,Fieten H,Wubbolts RW,Grinwis GC,Chan J,Huch M,Vries RRG,Clevers H,de Bruin A,Rothuizen J,Penning LC,Schotanus BA
Tue Nov 10 00:00:00 EST 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 EST 2015
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
Nature communications
Dettmer U,Newman AJ,Soldner F,Luth ES,Kim NC,von Saucken VE,Sanderson JB,Jaenisch R,Bartels T,Selkoe D
Tue Jun 16 00:00:00 EDT 2015
Organoid cultures derived from patients with advanced prostate cancer.
Cell
Gao D,Vela I,Sboner A,Iaquinta PJ,Karthaus WR,Gopalan A,Dowling C,Wanjala JN,Undvall EA,Arora VK,Wongvipat J,Kossai M,Ramazanoglu S,Barboza LP,Di W,Cao Z,Zhang QF,Sirota I,Ran L,MacDonald TY,Beltran H,Mosquera JM,Touijer KA,Scardino PT,Laudone VP,Curtis KR,Rathkopf DE,Morris MJ,Danila DC,Slovin SF,Solomon SB,Eastham JA,Chi P,Carver B,Rubin MA,Scher HI,Clevers H,Sawyers CL,Chen Y
Thu Sep 25 00:00:00 EDT 2014
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
Cell
Azzolin L,Panciera T,Soligo S,Enzo E,Bicciato S,Dupont S,Bresolin S,Frasson C,Basso G,Guzzardo V,Fassina A,Cordenonsi M,Piccolo S
Thu Jul 03 00:00:00 EDT 2014
BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.
Stem cells (Dayton, Ohio)
Richter A,Valdimarsdottir L,Hrafnkelsdottir HE,Runarsson JF,Omarsdottir AR,Ward-van Oostwaard D,Mummery C,Valdimarsdottir G
Sat Mar 01 00:00:00 EST 2014
Peritoneal milky spots serve as a hypoxic niche and favor gastric cancer stem/progenitor cell peritoneal dissemination through hypoxia-inducible factor 1α.
Stem cells (Dayton, Ohio)
Miao ZF,Wang ZN,Zhao TT,Xu YY,Gao J,Miao F,Xu HM
Mon Dec 01 00:00:00 EST 2014
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
The Journal of experimental medicine
Das I,Png CW,Oancea I,Hasnain SZ,Lourie R,Proctor M,Eri RD,Sheng Y,Crane DI,Florin TH,McGuckin MA
Mon Jun 03 00:00:00 EDT 2013
Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening.
Translational psychiatry
Boissart C,Poulet A,Georges P,Darville H,Julita E,Delorme R,Bourgeron T,Peschanski M,Benchoua A
Tue Aug 20 00:00:00 EDT 2013
Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
The Journal of clinical investigation
Varela C,Denis JA,Polentes J,Feyeux M,Aubert S,Champon B,Piétu G,Peschanski M,Lefort N
Wed Feb 01 00:00:00 EST 2012
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Su CT,Fabb SA,Hartley BJ,Beh SJ,Zeng WR,Haynes JM,Pouton CW
Sun Jul 01 00:00:00 EDT 2012
A unique chromatin signature uncovers early developmental enhancers in humans.
Nature
Rada-Iglesias A,Bajpai R,Swigut T,Brugmann SA,Flynn RA,Wysocka J
Thu Feb 10 00:00:00 EST 2011
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
Blood
Steinbicker AU,Sachidanandan C,Vonner AJ,Yusuf RZ,Deng DY,Lai CS,Rauwerdink KM,Winn JC,Saez B,Cook CM,Szekely BA,Roy CN,Seehra JS,Cuny GD,Scadden DT,Peterson RT,Bloch KD,Yu PB
Thu May 05 00:00:00 EDT 2011
NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells.
Immune network
Kang K,Jung H,Nam S,Lim JS
Thu Dec 01 00:00:00 EST 2011
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications
Devine MJ,Ryten M,Vodicka P,Thomson AJ,Burdon T,Houlden H,Cavaleri F,Nagano M,Drummond NJ,Taanman JW,Schapira AH,Gwinn K,Hardy J,Lewis PA,Kunath T
Tue Aug 23 00:00:00 EDT 2011
Comparison of proliferative and multilineage differentiation potentials of cord matrix, cord blood, and bone marrow mesenchymal stem cells.
Asian journal of transfusion science
Shetty P,Cooper K,Viswanathan C
Fri Jan 01 00:00:00 EST 2010
