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Product Details
A42548
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human PCSK9, amino acids Met-1Gln692 (Accession # NP_777596.1) with a C-eterminal His-tag
Tag
His-tag
Molecular weight
72.5 kDa
Class
Recombinant
Type
Protein
Purity
>95% by SDS-PAGE
Endotoxin concentration
<1.0 EU/µg
Activity
Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag on ProA Biosensor, can bind Human PCSK9 (NARC1) His-tag Recombinant Protein with an affinity constant of 16 nM as determined in BLI assay (Sartorius Octet RED384) (QC tested).
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient
Product Specific Information
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: convertase subtilisin/kexin type 9 preproprotein; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; OTTHUMP00000009833; PC9; Proprotein convertase 9; Proprotein convertase subtilisin/kexin type 9; Subtilisin/kexin-like protease PC9
Gene Aliases: FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; PCSK9; PSEC0052
UniProt ID: (Human) Q8NBP7
Entrez Gene ID: (Human) 255738
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