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This peptide corresponds to 16 amino acids near the carboxy terminus of human PEAR1.
PEP-1171 can be used as a blocking peptide with polyclonal antibody PA5-21057.
Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.
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Protein Aliases: hPEAR1; Multiple EGF-like domains protein 12; multiple EGF-like-domains 12; Multiple epidermal growth factor-like domains protein 12; Platelet endothelial aggregation receptor 1; RP11-107D16.3
Gene Aliases: JEDI; MEGF12; PEAR1
UniProt ID: (Human) Q5VY43
Entrez Gene ID: (Human) 375033
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