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Product Details
PEP-0941
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human CKIP1.
PEP-0941 can be used as a blocking peptide with polyclonal antibody PA5-20827.
Target Information
CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; HQ0024c protein; JBP; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1; pleckstrin homology domain containing, family O member 1; Pleckstrin homology domain-containing family O member 1; RP11-458I7.3
Gene Aliases: CKIP-1; CKIP1; HQ0024c; JBP; OC120; PLEKHO1
UniProt ID: (Human) Q53GL0
Entrez Gene ID: (Human) 51177
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