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Invitrogen
Human PPARG, Ligand Binding Domain, GST Tag Recombinant Protein
Product Details
PV4546
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
201-475
Tag
GST-tag
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
proprietary buffer
Contains
no preservative
Storage conditions
-80° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
PPARG (peroxisome proliferator activated receptor gamma) ligand binding domain a 59.00 kDa recombinant human protein (amino acids 201-475) expressed as a GST-tagged fusion protein in baculovirus-infected insect cells. PPAR γ-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Protein Form: Recombinant, Ligand Binding Domain
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor gamma variant 1; Peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; PPARy
Gene Aliases: CIMT1; GLM1; NR1C3; PPARG; PPARG1; PPARG2; PPARgamma
UniProt ID: (Human) P37231
Entrez Gene ID: (Human) 5468
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