Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 17 amino acids near the amino terminus of human RASSF10.
PEP-1265 can be used as a blocking peptide with polyclonal antibody PA5-21151.
RASSF10 is a member of the N-terminal Ras association domain-containing family of proteins, a family of tumor suppressor genes that are frequently epigenetically inactivated in cancer. These proteins consist of RASSF7-10 and are structurally distinct from RASSF1-6, containing the N-terminal Ras association domain but lacking the Sav/RASSF/Hippo protein interaction domains. While little is known of the function of RASSF10, it is inactivated in both childhood leukemia and gliomas. In secondary glioblastomas, RASSF10 methylation can be used as an independent prognostic associated with worst progression-free survival and overall survival.
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Protein Aliases: Ras association (RalGDS/AF-6) domain family (N-terminal) member 10; Ras association domain-containing protein 10
Gene Aliases: RASSF10
UniProt ID: (Human) A6NK89
Entrez Gene ID: (Human) 644943
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