Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 17 amino acids near the center of human SCUBE2.
PEP-1105 can be used as a blocking peptide with polyclonal antibody PA5-20991.
SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Protein CEGP1; Scube/You; signal peptide; Signal peptide, CUB and EGF-like domain-containing protein 2; signal peptide, CUB domain, EGF-like 2
Gene Aliases: CEGB1; CEGF1; CEGP1; SCUBE2
UniProt ID: (Human) Q9NQ36
Entrez Gene ID: (Human) 57758
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support