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Product Details
PEP-0972
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human TMEM38A.
PEP-0972 can be used as a blocking peptide with polyclonal antibody PA5-20858.
Target Information
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane protein 38A; TRIC-A; Trimeric intracellular cation channel type A
Gene Aliases: TMEM38A; TRIC-A; TRICA
UniProt ID: (Human) Q9H6F2
Entrez Gene ID: (Human) 79041
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