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Product Details
PEP-0670
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human TNPO3.
PEP-0670 can be used as a blocking peptide with polyclonal antibody PA5-20550.
Target Information
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Imp12; importin 12; Importin-12; limb girdle muscular dystrophy 1F (autosomal dominant); Transportin-3; Transportin-SR; TRN-SR
Gene Aliases: IPO12; LGMD1F; MTR10A; TNPO3; TRN-SR; TRN-SR2; TRNSR
UniProt ID: (Human) Q9Y5L0
Entrez Gene ID: (Human) 23534
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