Product References
TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling.
The EMBO journal
Lin CP,Traets JJH,Vredevoogd DW,Visser NL,Peeper DS
310-04 was used in Flow cytometry/Cell sorting to find a negative correlation between TSC2 expression and TRAIL signaling in TCGA patient cohorts.
Wed Mar 01 00:00:00 EST 2023
SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response.
Oncoimmunology
Ibáñez-Molero S,van Vliet A,Pozniak J,Hummelink K,Terry AM,Monkhorst K,Sanders J,Hofland I,Landeloos E,Van Herck Y,Bechter O,Kuilman T,Zhong W,Marine JC,Wessels L,Peeper DS
310-04 was used in Sample Preparation to investigate resistance mechanisms in cancer cells to immune checkpoint blockade (ICB) therapy, identifying SERPINB9 as a top differentially expressed gene that hinders T cell-mediated apoptosis in NSCLC.
Wed Dec 14 00:00:00 EST 2022
Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.
Scientific reports
Locquet MA,Ichim G,Bisaccia J,Dutour A,Lebecque S,Castets M,Weber K
Wed May 19 00:00:00 EDT 2021
Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro.
International journal of molecular sciences
Crosley P,Farkkila A,Jenner AL,Burlot C,Cardinal O,Potts KG,Agopsowicz K,Pihlajoki M,Heikinheimo M,Craig M,Fu Y,Hitt MM
310-04 was used in In vitro experiments to study the effectiveness of the activator of procaspase-3 called procaspase-activating compound 1 (PAC-1) in treating adult GCT (AGCT) in combination with selected apoptosis-inducing agents.
Thu Apr 29 00:00:00 EDT 2021
BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma.
The Journal of biological chemistry
Ishii Y,Kolluri KK,Pennycuick A,Zhang X,Nigro E,Alrifai D,Borg E,Falzon M,Shah K,Kumar N,Janes SM
Mon Nov 01 00:00:00 EDT 2021
Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors.
Cancer gene therapy
Golinelli G,Grisendi G,Prapa M,Bestagno M,Spano C,Rossignoli F,Bambi F,Sardi I,Cellini M,Horwitz EM,Feletti A,Pavesi G,Dominici M
Sat Aug 01 00:00:00 EDT 2020
O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jiang Y,Wen T,Yan R,Kim SR,Stowell SR,Wang W,Wang Y,An G,Cummings RD,Ju T
Tue Sep 01 00:00:00 EDT 2020
Targeting PP2A inhibits the growth of triple-negative breast cancer cells.
Cell cycle (Georgetown, Tex.)
Uddin MH,Pimentel JM,Chatterjee M,Allen JE,Zhuang Z,Wu GS
310-04 was used in In vitro experiments to suggest that pharmacological inhibition of PP2A activity could be a novel therapeutic strategy for treating patients with TNBC in a clinical setting.
Sun Mar 01 00:00:00 EST 2020
Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation.
The Journal of biological chemistry
Braunstein I,Engelman R,Yitzhaki O,Ziv T,Galardon E,Benhar M
Fri Mar 13 00:00:00 EDT 2020
In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations.
Cell death & disease
Miles MA,Hawkins CJ
Thu Aug 13 00:00:00 EDT 2020
MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.
Endocrine-related cancer
Saini S,Sripada L,Tulla K,Qiao G,Kunda N,Maker AV,Prabhakar BS
Sat Jun 01 00:00:00 EDT 2019
MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.
Endocrine-related cancer
Saini S,Sripada L,Tulla K,Qiao G,Kunda N,Maker AV,Prabhakar BS
Sat Jun 01 00:00:00 EDT 2019
Engineered human mesenchymal stem cells for neuroblastoma therapeutics.
Oncology reports
Nieddu V,Piredda R,Bexell D,Barton J,Anderson J,Sebire N,Kolluri K,Janes SM,Karteris E,Sala A
310-04 was used in Cell Culture to investigate the use of mesenchymal stem cells to express TRAIL.
Mon Jul 01 00:00:00 EDT 2019
Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis.
Scientific reports
Lee SR,Quan KT,Byun HS,Park I,Kang K,Piao X,Ju E,Ro H,Na M,Hur GM
Wed Sep 18 00:00:00 EDT 2019
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.
Cell death & disease
Zhu ZC,Liu JW,Yang C,Li MJ,Wu RJ,Xiong ZQ
Mon Feb 11 00:00:00 EST 2019
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway.
Cell death discovery
Wang M,Law ME,Davis BJ,Yaaghubi E,Ghilardi AF,Ferreira RB,Chiang CW,Guryanova OA,Kopinke D,Heldermon CD,Castellano RK,Law BK
Sun Jan 10 00:00:00 EST 2021
Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells.
International journal of cancer
Daßler-Plenker J,Paschen A,Putschli B,Rattay S,Schmitz S,Goldeck M,Bartok E,Hartmann G,Coch C
310-04 was used in In vitro experiments to identify the direct activation of RIG-I in NK cells as a novel mechanism for how RIG-I can trigger enhanced NK cell killing of tumor cells, underscoring the potential of RIG-I activation for tumor immunotherapy.
Mon Apr 01 00:00:00 EDT 2019
Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer.
Scientific reports
Spano C,Grisendi G,Golinelli G,Rossignoli F,Prapa M,Bestagno M,Candini O,Petrachi T,Recchia A,Miselli F,Rovesti G,Orsi G,Maiorana A,Manni P,Veronesi E,Piccinno MS,Murgia A,Pinelli M,Horwitz EM,Cascinu S,Conte P,Dominici M
Mon Feb 11 00:00:00 EST 2019
Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer.
Scientific reports
Spano C,Grisendi G,Golinelli G,Rossignoli F,Prapa M,Bestagno M,Candini O,Petrachi T,Recchia A,Miselli F,Rovesti G,Orsi G,Maiorana A,Manni P,Veronesi E,Piccinno MS,Murgia A,Pinelli M,Horwitz EM,Cascinu S,Conte P,Dominici M
Mon Feb 11 00:00:00 EST 2019
Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer.
Scientific reports
Spano C,Grisendi G,Golinelli G,Rossignoli F,Prapa M,Bestagno M,Candini O,Petrachi T,Recchia A,Miselli F,Rovesti G,Orsi G,Maiorana A,Manni P,Veronesi E,Piccinno MS,Murgia A,Pinelli M,Horwitz EM,Cascinu S,Conte P,Dominici M
Mon Feb 11 00:00:00 EST 2019
Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability.
Cell death & disease
Hope JM,Lopez-Cavestany M,Wang W,Reinhart-King CA,King MR
Mon Nov 04 00:00:00 EST 2019
Defining rules for cancer cell proliferation in TRAIL stimulation.
NPJ systems biology and applications
Deveaux W,Hayashi K,Selvarajoo K
Mon Apr 27 00:00:00 EDT 2020
BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.
Cell death & disease
Delannoy A,Wilhelm E,Eilebrecht S,Alvarado-Cuevas EM,Benecke AG,Bell B
Mon Jan 22 00:00:00 EST 2018
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.
Nature communications
Shiloh R,Gilad Y,Ber Y,Eisenstein M,Aweida D,Bialik S,Cohen S,Kimchi A
Tue May 01 00:00:00 EDT 2018
Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines.
Cell death & disease
Yulis M,Quiros M,Hilgarth R,Parkos CA,Nusrat A
Fri Mar 09 00:00:00 EST 2018
Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma.
Cell death & disease
Zhang N,Liu X,Liu L,Deng Z,Zeng Q,Pang W,Liu Y,Song D,Deng H
Wed Feb 14 00:00:00 EST 2018
Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs.
Scientific reports
Nalli AD,Brown LE,Thomas CL,Sayers TJ,Porco JA,Henrich CJ
Fri Nov 30 00:00:00 EST 2018
Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism.
Cell death & disease
Lincoln FA,Imig D,Boccellato C,Juric V,Noonan J,Kontermann RE,Allgöwer F,Murphy BM,Rehm M
Thu Nov 01 00:00:00 EDT 2018
The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells.
Cell death & disease
Legler K,Hauser C,Egberts JH,Willms A,Heneweer C,Boretius S,Röcken C,Glüer CC,Becker T,Kluge M,Hill O,Gieffers C,Fricke H,Kalthoff H,Lemke J,Trauzold A
Tue May 01 00:00:00 EDT 2018
Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.
Cell death and differentiation
Brasacchio D,Alsop AE,Noori T,Lufti M,Iyer S,Simpson KJ,Bird PI,Kluck RM,Johnstone RW,Trapani JA
310-04 was used in Cell Culture to describe a novel role for PACS1 as a regulator of the intrinsic pathway of apoptosis and mitochondrial outer membrane permeabilization by regulating BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis.
Thu Jun 01 00:00:00 EDT 2017
DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells.
Molecular oncology
Xu L,Zhang Y,Qu X,Che X,Guo T,Li C,Ma R,Fan Y,Ma Y,Hou K,Li D,Hu X,Liu B,Yu R,Yan H,Gong J,Liu Y
Fri Dec 01 00:00:00 EST 2017
The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5.
Scientific reports
Oh YT,Deng L,Deng J,Sun SY
Mon Aug 14 00:00:00 EDT 2017
Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL.
Cell death & disease
Elia A,Henry-Grant R,Adiseshiah C,Marboeuf C,Buckley RJ,Clemens MJ,Mudan S,Pyronnet S
Tue Dec 12 00:00:00 EST 2017
Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.
Cell death & disease
Miles MA,Hawkins CJ
Thu Oct 05 00:00:00 EDT 2017
Characterization of MUDENG, a novel anti-apoptotic protein.
Oncogenesis
Choi JH,Lim JB,Wickramanayake DD,Wagley Y,Kim J,Lee HC,Seo HG,Kim TH,Oh JW
Mon May 02 00:00:00 EDT 2016
Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-α activated adipose derived mesenchymal stem cells in breast cancer model.
Scientific reports
Mohammadpour H,Pourfathollah AA,Nikougoftar Zarif M,Shahbazfar AA
Wed Jun 22 00:00:00 EDT 2016
Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.
Cell death discovery
Carr RM,Qiao G,Qin J,Jayaraman S,Prabhakar BS,Maker AV
Tue Sep 20 00:00:00 EDT 2016
Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth.
Scientific reports
Chen L,Xia G,Qiu F,Wu C,Denmon AP,Zi X
Thu Sep 01 00:00:00 EDT 2016
Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells.
Scientific reports
Zhou W,Feng X,Guo S,Wang G
Mon Jun 13 00:00:00 EDT 2016
Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells.
Scientific reports
Oh YT,Deng J,Yue P,Sun SY
Wed May 25 00:00:00 EDT 2016
Mesenchymal progenitors expressing TRAIL induce apoptosis in sarcomas.
Stem cells (Dayton, Ohio)
Grisendi G,Spano C,D'souza N,Rasini V,Veronesi E,Prapa M,Petrachi T,Piccinno S,Rossignoli F,Burns JS,Fiorcari S,Granchi D,Baldini N,Horwitz EM,Guarneri V,Conte P,Paolucci P,Dominici M
Sun Mar 01 00:00:00 EST 2015
Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.
Cell death & disease
Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ
Thu Feb 26 00:00:00 EST 2015
Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.
Cell death & disease
Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ
Thu Feb 26 00:00:00 EST 2015
Piperlongumine and immune cytokine TRAIL synergize to promote tumor death.
Scientific reports
Li J,Sharkey CC,King MR
Mon May 18 00:00:00 EDT 2015
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.
Cell death & disease
Fauster A,Rebsamen M,Huber KV,Bigenzahn JW,Stukalov A,Lardeau CH,Scorzoni S,Bruckner M,Gridling M,Parapatics K,Colinge J,Bennett KL,Kubicek S,Krautwald S,Linkermann A,Superti-Furga G
Thu May 21 00:00:00 EDT 2015
A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.
Cell death & disease
Fauster A,Rebsamen M,Huber KV,Bigenzahn JW,Stukalov A,Lardeau CH,Scorzoni S,Bruckner M,Gridling M,Parapatics K,Colinge J,Bennett KL,Kubicek S,Krautwald S,Linkermann A,Superti-Furga G
Thu May 21 00:00:00 EDT 2015
KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.
Proceedings of the National Academy of Sciences of the United States of America
Koh DI,Han D,Ryu H,Choi WI,Jeon BN,Kim MK,Kim Y,Kim JY,Parry L,Clarke AR,Reynolds AB,Hur MW
Tue Oct 21 00:00:00 EDT 2014
Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.
Cell death and differentiation
King HA,Cobbold LC,Pichon X,Pöyry T,Wilson LA,Booden H,Jukes-Jones R,Cain K,Lilley KS,Bushell M,Willis AE
Wed Jan 01 00:00:00 EST 2014
Histone deacetylase inhibitor sensitizes apoptosis-resistant melanomas to cytotoxic human T lymphocytes through regulation of TRAIL/DR5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Jazirehi AR,Kurdistani SK,Economou JS
Tue Apr 15 00:00:00 EDT 2014
Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib.
The Journal of biological chemistry
Edagawa M,Kawauchi J,Hirata M,Goshima H,Inoue M,Okamoto T,Murakami A,Maehara Y,Kitajima S
Fri Aug 01 00:00:00 EDT 2014
Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells.
Cell death & disease
Teng Y,Gao M,Wang J,Kong Q,Hua H,Luo T,Jiang Y
Thu Feb 13 00:00:00 EST 2014
A reversible gene trap collection empowers haploid genetics in human cells.
Nature methods
Bürckstümmer T,Banning C,Hainzl P,Schobesberger R,Kerzendorfer C,Pauler FM,Chen D,Them N,Schischlik F,Rebsamen M,Smida M,Fece de la Cruz F,Lapao A,Liszt M,Eizinger B,Guenzl PM,Blomen VA,Konopka T,Gapp B,Parapatics K,Maier B,Stöckl J,Fischl W,Salic S,Taba Casari MR,Knapp S,Bennett KL,Bock C,Colinge J,Kralovics R,Ammerer G,Casari G,Brummelkamp TR,Superti-Furga G,Nijman SM
Tue Oct 01 00:00:00 EDT 2013
Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma.
Cell death & disease
Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW
Thu Sep 12 00:00:00 EDT 2013
MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.
PloS one
Turner A,Li LC,Pilli T,Qian L,Wiley EL,Setty S,Christov K,Ganesh L,Maker AV,Li P,Kanteti P,Das Gupta TK,Prabhakar BS
Wed Aug 28 00:00:00 EDT 2013
Transcriptome analysis of glioma cells for the dynamic response to γ-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas.
Cell death & disease
Ma H,Rao L,Wang HL,Mao ZW,Lei RH,Yang ZY,Qing H,Deng YL
Thu Oct 31 00:00:00 EDT 2013
Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
The Journal of biological chemistry
Xu J,Xu Z,Zhou JY,Zhuang Z,Wang E,Boerner J,Wu GS
Fri Nov 15 00:00:00 EST 2013
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
The Journal of biological chemistry
Gupta SC,Francis SK,Nair MS,Mo YY,Aggarwal BB
Fri Nov 08 00:00:00 EST 2013
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
The Journal of biological chemistry
Hong S,Kim HY,Kim J,Ha HT,Kim YM,Bae E,Kim TH,Lee KC,Kim SJ
Fri Feb 01 00:00:00 EST 2013
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.
PloS one
Reuss DE,Mucha J,Hagenlocher C,Ehemann V,Kluwe L,Mautner V,von Deimling A
Tue Aug 06 00:00:00 EDT 2013
Global kinetic analysis of proteolysis via quantitative targeted proteomics.
Proceedings of the National Academy of Sciences of the United States of America
Agard NJ,Mahrus S,Trinidad JC,Lynn A,Burlingame AL,Wells JA
Tue Feb 07 00:00:00 EST 2012
STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death.
Journal of biomedical science
Huang DY,Chao Y,Tai MH,Yu YH,Lin WW
Fri Mar 30 00:00:00 EDT 2012
Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.
PloS one
Kong R,Jia G,Cheng ZX,Wang YW,Mu M,Wang SJ,Pan SH,Gao Y,Jiang HC,Dong DL,Sun B
Mon Oct 29 00:00:00 EDT 2012
The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.
Cell death & disease
Grunert M,Gottschalk K,Kapahnke J,Gündisch S,Kieser A,Jeremias I
Thu Oct 25 00:00:00 EDT 2012
Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis.
Journal of ovarian research
Lane D,Matte I,Rancourt C,Piché A
Thu Nov 15 00:00:00 EST 2012
Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3.
Cell death & disease
Hsieh YJ,Chien KY,Lin SY,Sabu S,Hsu RM,Chi LM,Lyu PC,Yu JS
Thu Jul 12 00:00:00 EDT 2012
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.
The Journal of biological chemistry
Le Goff A,Ji Z,Leclercq B,Bourette RP,Mougel A,Guerardel C,de Launoit Y,Vicogne J,Goormachtigh G,Fafeur V
Fri Oct 12 00:00:00 EDT 2012
Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells.
PloS one
Zhang S,Li G,Zhao Y,Liu G,Wang Y,Ma X,Li D,Wu Y,Lu J
Thu May 30 00:00:00 EDT 2013
DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines.
PloS one
Furusawa Y,Fujiwara Y,Campbell P,Zhao QL,Ogawa R,Hassan MA,Tabuchi Y,Takasaki I,Takahashi A,Kondo T
Mon May 14 00:00:00 EDT 2012
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Cancer cell
Chen Q,Zhang XH,Massagué J
Tue Oct 18 00:00:00 EDT 2011
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells.
The Journal of clinical investigation
Siegelin MD,Dohi T,Raskett CM,Orlowski GM,Powers CM,Gilbert CA,Ross AH,Plescia J,Altieri DC
Fri Apr 01 00:00:00 EDT 2011
2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression.
Molecular cancer therapeutics
Stolfi C,Caruso R,Franzè E,Rizzo A,Rotondi A,Monteleone I,Fantini MC,Pallone F,Monteleone G
310-04 was used in In vitro experiments to investigate TRAIL-induced apoptosis in colon cancer.
Sat Oct 01 00:00:00 EDT 2011
Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells.
Evidence-based complementary and alternative medicine : eCAM
Szliszka E,Czuba ZP,Bronikowska J,Mertas A,Paradysz A,Krol W
Thu Aug 23 00:00:00 EDT 2012
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
BMC cancer
Maurer GD,Brucker DP,Bähr O,Harter PN,Hattingen E,Walenta S,Mueller-Klieser W,Steinbach JP,Rieger J
Tue Jul 26 00:00:00 EDT 2011
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
The Journal of biological chemistry
Gupta SC,Reuter S,Phromnoi K,Park B,Hema PS,Nair M,Aggarwal BB
Fri Jan 14 00:00:00 EST 2011
Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.
The Journal of biological chemistry
Prasad S,Yadav VR,Kannappan R,Aggarwal BB
Fri Feb 18 00:00:00 EST 2011
Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis.
Cancer cell international
Vindrieux D,Réveiller M,Chantepie J,Yakoub S,Deschildre C,Ruffion A,Devonec M,Benahmed M,Grataroli R
Fri Dec 02 00:00:00 EST 2011
The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells.
BMC biology
Tang H,Qin Y,Li J,Gong X
Sat Mar 19 00:00:00 EDT 2011
5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells.
BMC cancer
Xie ZH,Quan MF,Liu F,Cao JG,Zhang JS
Fri Jul 29 00:00:00 EDT 2011
The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells.
Oncogene
Goncharenko-Khaider N,Lane D,Matte I,Rancourt C,Piché A
Thu Oct 07 00:00:00 EDT 2010
c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.
PloS one
Kauh J,Fan S,Xia M,Yue P,Yang L,Khuri FR,Sun SY
Wed Apr 28 00:00:00 EDT 2010
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression.
Molecular cancer
Jang JY,Jeon YK,Choi Y,Kim CW
Tue Sep 28 00:00:00 EDT 2010
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
The Journal of biological chemistry
Sung B,Park B,Yadav VR,Aggarwal BB
Fri Apr 09 00:00:00 EDT 2010
Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation.
PloS one
Grabarczyk P,Nähse V,Delin M,Przybylski G,Depke M,Hildebrandt P,Völker U,Schmidt CA
Thu Sep 02 00:00:00 EDT 2010
Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
The Journal of biological chemistry
Sung B,Ravindran J,Prasad S,Pandey MK,Aggarwal BB
Fri Nov 12 00:00:00 EST 2010
Potentiation of tumor necrosis factor-alpha-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4.
The Journal of biological chemistry
Qiu J,Xiao J,Han C,Li N,Shen X,Jiang H,Cao X
Fri Apr 16 00:00:00 EDT 2010
Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.
Molecular cancer
Chen S,Fu L,Raja SM,Yue P,Khuri FR,Sun SY
Fri Jan 29 00:00:00 EST 2010
c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.
Molecular cancer
Fu L,Lin YD,Elrod HA,Yue P,Oh Y,Li B,Tao H,Chen GZ,Shin DM,Khuri FR,Sun SY
Mon Dec 20 00:00:00 EST 2010
c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.
Molecular cancer
Fu L,Lin YD,Elrod HA,Yue P,Oh Y,Li B,Tao H,Chen GZ,Shin DM,Khuri FR,Sun SY
Mon Dec 20 00:00:00 EST 2010
The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation.
Neoplasia (New York, N.Y.)
Fan S,Li Y,Yue P,Khuri FR,Sun SY
Thu Apr 01 00:00:00 EDT 2010
Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.
The Journal of biological chemistry
Thoh M,Kumar P,Nagarajaram HA,Manna SK
Fri Feb 19 00:00:00 EST 2010
The prosurvival activity of ascites against TRAIL is associated with a shorter disease-free interval in patients with ovarian cancer.
Journal of ovarian research
Lane D,Matte I,Rancourt C,Piché A
Mon Jan 18 00:00:00 EST 2010
Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells.
PloS one
Xu J,Zhou JY,Wei WZ,Wu GS
Mon Apr 19 00:00:00 EDT 2010
Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells.
PloS one
Xu J,Zhou JY,Wei WZ,Wu GS
Mon Apr 19 00:00:00 EDT 2010
Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.
Blood
Fakler M,Loeder S,Vogler M,Schneider K,Jeremias I,Debatin KM,Fulda S
Thu Feb 19 00:00:00 EST 2009
Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells.
Blood
Lundqvist A,Yokoyama H,Smith A,Berg M,Childs R
Thu Jun 11 00:00:00 EDT 2009
Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Elias A,Siegelin MD,Steinmüller A,von Deimling A,Lass U,Korn B,Mueller W
Tue Sep 01 00:00:00 EDT 2009
SC68896, a novel small molecule proteasome inhibitor, exerts antiglioma activity in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research
Roth P,Kissel M,Herrmann C,Eisele G,Leban J,Weller M,Schmidt F
Sun Nov 01 00:00:00 EDT 2009
TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP.
Oncogene
Morioka S,Omori E,Kajino T,Kajino-Sakamoto R,Matsumoto K,Ninomiya-Tsuji J
Thu Jun 11 00:00:00 EDT 2009
Response of bladder carcinoma cells to TRAIL and antisense oligonucleotide, Bcl-2 or clusterin treatments.
The Journal of urology
Sun B,Moibi JA,Mak A,Xiao Z,Roa W,Moore RB
Sun Mar 01 00:00:00 EST 2009
Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy.
Stem cells (Dayton, Ohio)
Menon LG,Kelly K,Yang HW,Kim SK,Black PM,Carroll RS
Tue Sep 01 00:00:00 EDT 2009
Synergistic Induction of Apoptosis in Primary B-CLL Cells after Treatment with Recombinant Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Histone Deacetylase Inhibitors.
Journal of oncology
Norian LA,Kucaba TA,Earel JK,Knutson T,Vanoosten RL,Griffith TS
Thu Jul 25 00:00:00 EDT 2013
Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts.
FEBS letters
Xu L,Qu X,Zhang Y,Hu X,Yang X,Hou K,Teng Y,Zhang J,Sada K,Liu Y
Wed Mar 04 00:00:00 EST 2009
Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression.
The Journal of biological chemistry
Wang C,Qi R,Li N,Wang Z,An H,Zhang Q,Yu Y,Cao X
Fri Jun 12 00:00:00 EDT 2009
Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.
The Journal of biological chemistry
Autefage H,Albinet V,Garcia V,Berges H,Nicolau ML,Therville N,Altié MF,Caillaud C,Levade T,Andrieu-Abadie N
Fri Apr 24 00:00:00 EDT 2009
Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
International journal of molecular sciences
Szliszka E,Czuba ZP,Jernas K,Król W
Tue Jan 01 00:00:00 EST 2008
MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.
The Journal of biological chemistry
Mulherkar N,Prasad KV,Prabhakar BS
Fri Apr 20 00:00:00 EDT 2007
Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.
Cancer research
Hao C,Beguinot F,Condorelli G,Trencia A,Van Meir EG,Yong VW,Parney IF,Roa WH,Petruk KC
Thu Feb 01 00:00:00 EST 2001
