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Human VEGF-165 Recombinant Protein, PeproTech®

Human VEGF-165 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Human VEGF-165 Protein (100-20-10UG) in Functional

Bioassay analysis of Human VEGF-165 Recombinant Protein, PeproTech® (Product # 100-20-1MG).

Product Image Gallery

Product Details

100-20-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 2 publications 2 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 6 publications 6 publications

Functional Assay (Functional)

Assay-dependent

View 1 publication 1 publication

Radioimmune Assays (RIA)

View 1 publication 1 publication

In vitro Assay (IV)

View 285 publications 285 publications

Miscellaneous PubMed (Misc)

View 51 publications 51 publications

Product Specifications

Species

Human

Published species

Bovine, Chicken, Chordate, Dog, Fish, Hamster, Horse, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Sheep

Expression System

E. coli

Amino acid sequence

APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Molecular weight

38.2 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to stimulate the proliferation of human umbilical vein endothelial cells (HUVEC). The expected ED50 for this effect is 1.0-10.0ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human VEGF 165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The vascular endothelial growth factor (VEGF) family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.

British journal of haematology

Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y

100-20 was used in Cell Culture to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.

Sat Jul 01 00:00:00 EDT 2023

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Cell metabolism

Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A

100-20 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.

Tue May 02 00:00:00 EDT 2023

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.

The Journal of cell biology

Pellegrino E,Aylan B,Bussi C,Fearns A,Bernard EM,Athanasiadi N,Santucci P,Botella L,Gutierrez MG

100-20 was used in In vitro experiments to find peroxisomes increased ROS levels during Mtb WT infection.

Mon Dec 04 00:00:00 EST 2023

Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.

Communications biology

Breitmeyer R,Vogel S,Heider J,Hartmann SM,Wüst R,Keller AL,Binner A,Fitzgerald JC,Fallgatter AJ,Volkmer H

100-20 was used in Cell Culture to present a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from SCZ patients.

Sat Apr 29 00:00:00 EDT 2023

Sphingosine-1-phosphate controls endothelial sphingolipid homeostasis via ORMDL.

EMBO reports

Sasset L,Chowdhury KH,Manzo OL,Rubinelli L,Konrad C,Maschek JA,Manfredi G,Holland WL,Di Lorenzo A

100-20 was used in Cell Culture to show that disrupting S1PR/ORMDL axis results in ceramide accrual, mitochondrial dysfunction, impaired signal transduction, all underlying endothelial dysfunction, early event in the onset of cardio- and cerebrovascular diseases.

Mon Jan 09 00:00:00 EST 2023

Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling.

Stem cell research & therapy

Kim HJ,Kim G,Chi KY,Kim H,Jang YJ,Jo S,Lee J,Lee Y,Woo DH,Han C,Kim SK,Park HJ,Kim JH

100-20 was used in Cell Culture to demonstrate that mLOs can reproduce parenchymal and non-parenchymal cell interactions and suggest that their application can advance the precise modeling of liver diseases in vitro.

Fri Feb 03 00:00:00 EST 2023

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages.

Nature microbiology

Aylan B,Bernard EM,Pellegrino E,Botella L,Fearns A,Athanasiadi N,Bussi C,Santucci P,Gutierrez MG

100-20 was used in Cell Culture to conclude that ATG7 and ATG14 are both required for restricting Mtb replication in human macrophages.

Mon May 01 00:00:00 EDT 2023

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells.

Cell reports methods

Tamaoki N,Siebert S,Maeda T,Ha NH,Good ML,Huang Y,Vodnala SK,Haro-Mora JJ,Uchida N,Tisdale JF,Sweeney CL,Choi U,Brault J,Koontz S,Malech HL,Yamazaki Y,Isonaka R,Goldstein DS,Kimura M,Takebe T,Zou J,Stroncek DF,Robey PG,Kruhlak MJ,Restifo NP,Vizcardo R

100-20 was used in Cell Culture to demonstrate that organoid-induced HPCs can be differentiated into erythroid cells, macrophages, and T lymphocytes with current maturation protocols.

Mon Apr 24 00:00:00 EDT 2023

C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.

iScience

Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y

100-20 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.

Fri Oct 20 00:00:00 EDT 2023

Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.

Methods in molecular biology (Clifton, N.J.)

Chen SW,Wong YH

100-20 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.

Mon Jun 12 00:00:00 EDT 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

JCI insight

Sleigh JN,Villarroel-Campos D,Surana S,Wickenden T,Tong Y,Simkin RL,Vargas JNS,Rhymes ER,Tosolini AP,West SJ,Zhang Q,Yang XL,Schiavo G

100-20 was used in In vivo experiments to suggest that selectively targeting muscles with BDNF-boosting therapies could represent a viable therapeutic strategy for CMT2D.

Mon May 08 00:00:00 EDT 2023

Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.

The Journal of clinical investigation

Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG

100-20 was used in Cell Culture to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.

Thu Jun 01 00:00:00 EDT 2023

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.

Nature neuroscience

Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M

100-20 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.

Thu Sep 01 00:00:00 EDT 2022

Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors.

The Journal of physiology

Hyun J,Lee M,Rehman J,Pajcini KV,Malik AB

100-20 was used in Sample Preparation (Western Blotting) to show that the Notch to Sema3g signalling axis functions as a feedback mechanism to sculpt the growing vasculature in multiple beds.

Tue Feb 01 00:00:00 EST 2022

Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells.

Biomedicines

Murugesan G,Davidson L,Jannetti L,Crocker PR,Weigle B

100-20 was used in Cell Culture to generate and culture embroyoid bodies (iPSCs). Polarised to either M1 or M2, the macrophages were subjected to quantitative proteomic analysis gaining further insight into their functionalities.

Sun Jan 23 00:00:00 EST 2022

Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.

Oxidative medicine and cellular longevity

Wei B,Hao Z,Zheng H,Qin Y,Zhao F,Shi L

100-20 was used in In vitro experiments to identify a new mechanism for antiangiogenic effect of BA in vascular EC, one that is based on the regulation of mitochondrial-dependent ROS overproduction.

Tue Jan 10 00:00:00 EST 2023

Engineered human blood-brain barrier microfluidic model for vascular permeability analyses.

Nature protocols

Hajal C,Offeddu GS,Shin Y,Zhang S,Morozova O,Hickman D,Knutson CG,Kamm RD

100-20 was used in Cell Culture to show that these properties, coupled with a functional brain endothelial expression profile and the capability to easily test several repeats with low reagent consumption, make this BBB model highly suitable for widespread use in academic and industrial laboratories.

Sat Jan 01 00:00:00 EST 2022

Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors.

Advanced healthcare materials

Ho DLL,Lee S,Du J,Weiss JD,Tam T,Sinha S,Klinger D,Devine S,Hamfeldt A,Leng HT,Herrmann JE,He M,Fradkin LG,Tan TK,Standish D,Tomasello P,Traul D,Dianat N,Ladi R,Vicard Q,Katikireddy K,Skylar-Scott MA

100-20 was used in In vitro experiments to demonstrate an optimized suspension culture-to-3D bioprinting pipeline that enables a sustainable approach to billion cell-scale organ engineering.

Thu Dec 01 00:00:00 EST 2022

Generation of Cardiomyocytes and Endothelial Cells from Human iPSCs by Chemical Modulation of Wnt Signaling.

Methods in molecular biology (Clifton, N.J.)

Joachim A,Ye S,Zhao MT

100-20 was used in Cell Culture to provide protocols to generate iPSC-CMs and iPSC-ECs using small molecule-mediated monolayer differentiation.

Wed Jul 06 00:00:00 EDT 2022

Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.

mBio

Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG

100-20 was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.

Tue Apr 26 00:00:00 EDT 2022

High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis.

Scientific reports

Kramer B,Corallo C,van den Heuvel A,Crawford J,Olivier T,Elstak E,Giordano N,Vulto P,Lanz HL,Janssen RAJ,Tessari MA

100-20 was used in Cell Culture to demonstrate that sera obtained from SSc patients can exert an anti-angiogenic effect on the 3D vessel model, opening the doors to screening for potential SSc drugs, enabling direct patient translatability and personalization of drug treatment.

Sat Oct 08 00:00:00 EDT 2022

Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.

Cell stem cell

Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P

100-20 was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.

Thu Jul 07 00:00:00 EDT 2022

Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies.

Biomolecules

Sanchez MM,Tonmoy TI,Park BH,Morgan JT

100-20 was used in In vitro experiments to develop a novel method for generating HSE that include vascular and adipose components and demonstrated potential as an aging model using photoaging as an example.

Wed Dec 07 00:00:00 EST 2022

Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons.

Cell reports

Huang CY,Nicholson MW,Wang JY,Ting CY,Tsai MH,Cheng YC,Liu CL,Chan DZH,Lee YC,Hsu CC,Hsu YH,Yang CF,Chang CMC,Ruan SC,Lin PJ,Lin JH,Chen LL,Hsieh ML,Cheng YY,Hsu WT,Lin YL,Chen CH,Hsu YH,Wu YT,Hacker TA,Wu JC,Kamp TJ,Hsieh PCH

100-20 was used in Cell Culture to study a a population-based human induced pluripotent stem cell (hiPSC) drug screening platform for toxicity assessment.

Tue Apr 05 00:00:00 EDT 2022

3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.

Cell stem cell

Manian KV,Galloway CA,Dalvi S,Emanuel AA,Mereness JA,Black W,Winschel L,Soto C,Li Y,Song Y,DeMaria W,Kumar A,Slukvin I,Schwartz MP,Murphy WL,Anand-Apte B,Chung M,Benoit DSW,Singh R

100-20 was used in Cell Culture to represent that the human 3D model described here provides a platform for investigating RPE-CC biology, AMD/MD pathophysiology, and testing new therapeutic interventions.

Thu May 06 00:00:00 EDT 2021

Fli1⁺ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Matrone G,Xia B,Chen K,Denvir MA,Baker AH,Cooke JP

Tue Aug 03 00:00:00 EDT 2021

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.

Proceedings of the National Academy of Sciences of the United States of America

Lu TM,Houghton S,Magdeldin T,Durán JGB,Minotti AP,Snead A,Sproul A,Nguyen DT,Xiang J,Fine HA,Rosenwaks Z,Studer L,Rafii S,Agalliu D,Redmond D,Lis R

Tue Feb 23 00:00:00 EST 2021

Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.

Aging cell

Gete YG,Koblan LW,Mao X,Trappio M,Mahadik B,Fisher JP,Liu DR,Cao K

Thu Jul 01 00:00:00 EDT 2021

Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.

Aging cell

Gete YG,Koblan LW,Mao X,Trappio M,Mahadik B,Fisher JP,Liu DR,Cao K

Thu Jul 01 00:00:00 EDT 2021

Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.

EMBO reports

Nitzsche A,Pietilä R,Love DT,Testini C,Ninchoji T,Smith RO,Ekvärn E,Larsson J,Roche FP,Egaña I,Jauhiainen S,Berger P,Claesson-Welsh L,Hellström M

Wed Feb 03 00:00:00 EST 2021

A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells.

EMBO reports

Li Y,Wang D,Wang H,Huang X,Wen Y,Wang B,Xu C,Gao J,Liu J,Tong J,Wang M,Su P,Ren S,Ma F,Li HD,Bresnick EH,Zhou J,Shi L

Thu Jan 07 00:00:00 EST 2021

FOXK2 transcriptionally activating VEGFA induces apatinib resistance in anaplastic thyroid cancer through VEGFA/VEGFR1 pathway.

Oncogene

Feng H,Jin Z,Liang J,Zhao Q,Zhan L,Yang Z,Yan J,Kuang J,Cheng X,Qiu W

Fri Oct 01 00:00:00 EDT 2021

Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti-Thy-1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway.

Cell proliferation

Zhao Y,Fu B,Chen P,Li Q,Ouyang Q,Zhang C,Cai G,Wu L,Chen X

Tue Jun 01 00:00:00 EDT 2021

Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.

Stem cells translational medicine

Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H

Tue Jun 01 00:00:00 EDT 2021

Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.

Cancer science

Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K

100-20 was used in Cell Culture to propose a mechanism of neuroblastoma transdifferentiation induced by extracellular growth factors, which can be controlled in clinical situations, providing a new therapeutic possibility.

Mon Feb 01 00:00:00 EST 2021

Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.

Stem cells (Dayton, Ohio)

Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS

Wed Dec 01 00:00:00 EST 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 EDT 2021

CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.

Stem cells (Dayton, Ohio)

Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM

Sat May 01 00:00:00 EDT 2021

Mechanical loading stimulates bone angiogenesis through enhancing type H vessel formation and downregulating exosomal miR-214-3p from bone marrow-derived mesenchymal stem cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wang X,Li X,Li J,Zhai L,Liu D,Abdurahman A,Zhang Y,Yokota H,Zhang P

Fri Jan 01 00:00:00 EST 2021

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.

Stem cells international

Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS

Tue Jun 08 00:00:00 EDT 2021

Fine particulate matter (PM_2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance.

American journal of physiology. Heart and circulatory physiology

Hill BG,Rood B,Ribble A,Haberzettl P

Sat May 01 00:00:00 EDT 2021

Enhanced endothelial barrier function by monoclonal antibody activation of vascular endothelial cadherin.

American journal of physiology. Heart and circulatory physiology

Park KS,Schecterson L,Gumbiner BM

Thu Apr 01 00:00:00 EDT 2021

An in vivo model allowing continuous observation of human vascular formation in the same animal over time.

Scientific reports

Tsukada Y,Muramatsu F,Hayashi Y,Inagaki C,Su H,Iba T,Kidoya H,Takakura N

Tue Jan 12 00:00:00 EST 2021

Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro.

Nature communications

Tan JJ,Guyette JP,Miki K,Xiao L,Kaur G,Wu T,Zhu L,Hansen KJ,Ling KH,Milan DJ,Ott HC

Tue Aug 17 00:00:00 EDT 2021

Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.

iScience

Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y

Fri Nov 19 00:00:00 EST 2021

BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways.

Communications biology

Geng Y,Duan H,Xu L,Witman N,Yan B,Yu Z,Wang H,Tan Y,Lin L,Li D,Bai S,Fritsche-Danielson R,Yuan J,Chien K,Wei M,Fu W

Tue Jan 19 00:00:00 EST 2021

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Nature protocols

Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R

100-20 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.

Mon Feb 01 00:00:00 EST 2021

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.

Science advances

Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG

100-20 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).

Fri Jan 01 00:00:00 EST 2021

Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5.

Cell reports

Richards M,Pal S,Sjöberg E,Martinsson P,Venkatraman L,Claesson-Welsh L

Tue Jun 22 00:00:00 EDT 2021

Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation.

The Journal of biological chemistry

Krantz S,Kim YM,Srivastava S,Leasure JW,Toth PT,Marsboom G,Rehman J

Wed Dec 01 00:00:00 EST 2021

Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.

Cell death & disease

Meng Y,Song C,Ren Z,Li X,Yang X,Ai N,Yang Y,Wang D,Zhan M,Wang J,Lei CL,Liu W,Ge W,Lu L,Chen G

Mon Nov 29 00:00:00 EST 2021

Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.

Nature communications

Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT

Thu Oct 28 00:00:00 EDT 2021

Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome.

Stem cell reports

Zhou D,Tan Y,Liu X,Tang L,Wang H,Shen J,Wang W,Zhuang L,Tao J,Su J,Gong T,Liu X,Liang P,Yu F,Zhao M

Tue Sep 14 00:00:00 EDT 2021

Personalized medicine for reconstruction of critical-size bone defects - a translational approach with customizable vascularized bone tissue.

NPJ Regenerative medicine

Kengelbach-Weigand A,Thielen C,Bäuerle T,Götzl R,Gerber T,Körner C,Beier JP,Horch RE,Boos AM

Thu Aug 19 00:00:00 EDT 2021

Gamma irradiation exposure for collapsed cell junctions and reduced angiogenesis of 3-D in vitro blood vessels.

Scientific reports

Na K,Cho Y,Choi DH,Park MJ,Yang JH,Chung S

Tue Sep 14 00:00:00 EDT 2021

SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.

Cell reports

Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II

100-20 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.

Tue Feb 16 00:00:00 EST 2021

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.

Cell death & disease

De Smedt J,van Os EA,Talon I,Ghosh S,Toprakhisar B,Furtado Madeiro Da Costa R,Zaunz S,Vazquez MA,Boon R,Baatsen P,Smout A,Verhulst S,van Grunsven LA,Verfaillie CM

Thu Jan 14 00:00:00 EST 2021

Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.

Stem cell research & therapy

Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N

100-20 was used in Cell Culture to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.

Tue Sep 28 00:00:00 EDT 2021

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain.

Science advances

Hajal C,Shin Y,Li L,Serrano JC,Jacks T,Kamm RD

100-20 was used in Tissue/organ culture to investigate if astrocytes promote cancer cell transmigration via their secretion of C-C motif chemokine ligand 2 (CCL2) using a a three-dimensional in vitro blood-brain barrier microvascular model.

Tue Jun 01 00:00:00 EDT 2021

Mitogen-Inducible Gene 6 Inhibits Angiogenesis by Binding to SHC1 and Suppressing Its Phosphorylation.

Frontiers in cell and developmental biology

Liu L,Xing L,Chen R,Zhang J,Huang Y,Huang L,Xie B,Ren X,Wang S,Kuang H,Lin X,Kumar A,Kim JK,Lee C,Li X

100-20 was used in In vitro experiments to show that MIG6 is a potent endogenous inhibitor of angiogenesis that may have therapeutic value in anti-angiogenic therapy.

Fri Mar 12 00:00:00 EST 2021

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.

Nature

Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP

Tue Sep 01 00:00:00 EDT 2020

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.

Cell

Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X

Thu Apr 16 00:00:00 EDT 2020

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

Cell

Monteil V,Kwon H,Prado P,Hagelkrüys A,Wimmer RA,Stahl M,Leopoldi A,Garreta E,Hurtado Del Pozo C,Prosper F,Romero JP,Wirnsberger G,Zhang H,Slutsky AS,Conder R,Montserrat N,Mirazimi A,Penninger JM

100-20 was used in Cell Culture to show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2.

Thu May 14 00:00:00 EDT 2020

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

Cell

Monteil V,Kwon H,Prado P,Hagelkrüys A,Wimmer RA,Stahl M,Leopoldi A,Garreta E,Hurtado Del Pozo C,Prosper F,Romero JP,Wirnsberger G,Zhang H,Slutsky AS,Conder R,Montserrat N,Mirazimi A,Penninger JM

100-20 was used in Cell Culture to show that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids, which can be inhibited by hrsACE2.

Thu May 14 00:00:00 EDT 2020

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.

Cell stem cell

Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A

100-20 was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.

Thu Nov 05 00:00:00 EST 2020

Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.

The Journal of clinical investigation

Masoud AG,Lin J,Azad AK,Farhan MA,Fischer C,Zhu LF,Zhang H,Sis B,Kassiri Z,Moore RB,Kim D,Anderson CC,Vederas JC,Adam BA,Oudit GY,Murray AG

Thu Jan 02 00:00:00 EST 2020

Methylation in pericytes after acute injury promotes chronic kidney disease.

The Journal of clinical investigation

Chou YH,Pan SY,Shao YH,Shih HM,Wei SY,Lai CF,Chiang WC,Schrimpf C,Yang KC,Lai LC,Chen YM,Chu TS,Lin SL

Tue Sep 01 00:00:00 EDT 2020

An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization.

Proceedings of the National Academy of Sciences of the United States of America

Usui-Ouchi A,Aguilar E,Murinello S,Prins M,Gantner ML,Wright PE,Berlow RB,Friedlander M

Tue Nov 10 00:00:00 EST 2020

A novel method to improve the osteogenesis capacity of hUCMSCs with dual-directional pre-induction under screened co-culture conditions.

Cell proliferation

Rong Q,Li S,Zhou Y,Geng Y,Liu S,Wu W,Forouzanfar T,Wu G,Zhang Z,Zhou M

Sat Feb 01 00:00:00 EST 2020

Biallelic correction of sickle cell disease-derived induced pluripotent stem cells (iPSCs) confirmed at the protein level through serum-free iPS-sac/erythroid differentiation.

Stem cells translational medicine

Haro-Mora JJ,Uchida N,Demirci S,Wang Q,Zou J,Tisdale JF

Fri May 01 00:00:00 EDT 2020

Biallelic correction of sickle cell disease-derived induced pluripotent stem cells (iPSCs) confirmed at the protein level through serum-free iPS-sac/erythroid differentiation.

Stem cells translational medicine

Haro-Mora JJ,Uchida N,Demirci S,Wang Q,Zou J,Tisdale JF

Fri May 01 00:00:00 EDT 2020

Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit⁺ cardiac interstitial cells.

Stem cells translational medicine

Wang BJ,Alvarez R,Muliono A,Sengphanith S,Monsanto MM,Weeks J,Sacripanti R,Sussman MA

Fri May 01 00:00:00 EDT 2020

Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit⁺ cardiac interstitial cells.

Stem cells translational medicine

Wang BJ,Alvarez R,Muliono A,Sengphanith S,Monsanto MM,Weeks J,Sacripanti R,Sussman MA

Fri May 01 00:00:00 EDT 2020

AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Acta physiologica (Oxford, England)

Benz PM,Ding Y,Stingl H,Loot AE,Zink J,Wittig I,Popp R,Fleming I

Wed Jan 01 00:00:00 EST 2020

AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Acta physiologica (Oxford, England)

Benz PM,Ding Y,Stingl H,Loot AE,Zink J,Wittig I,Popp R,Fleming I

Wed Jan 01 00:00:00 EST 2020

miR‑126 regulates the progression of epithelial ovarian cancer in vitro and in vivo by targeting VEGF‑A.

International journal of oncology

Liu L,Yuan L,Huang D,Han Q,Cai J,Wang S,Cao J

100-20 was used in Sample Preparation (Western Blotting) to investigate miRNA-126 in ovarian cancer.

Tue Sep 01 00:00:00 EDT 2020

Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lee SW,Kim HK,Naidansuren P,Ham KA,Choi HS,Ahn HY,Kim M,Kang DH,Kang SW,Joe YA

Sat Aug 01 00:00:00 EDT 2020

Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Nishihara H,Gastfriend BD,Soldati S,Perriot S,Mathias A,Sano Y,Shimizu F,Gosselet F,Kanda T,Palecek SP,Du Pasquier R,Shusta EV,Engelhardt B

Tue Dec 01 00:00:00 EST 2020

cMet agonistic antibody attenuates apoptosis in ischaemia-reperfusion-induced kidney injury.

Journal of cellular and molecular medicine

An JN,Li L,Lee J,Yu SS,Lee J,Kim YC,Kim DK,Oh YK,Lim CS,Kim YS,Kim S,Yang SH,Lee JP

Fri May 01 00:00:00 EDT 2020

Role of Elevated SFLT-1 on the Regulation of Placental Transporters in Women With Pre-Eclampsia.

Clinical and translational science

Kojovic D,V Workewych N,Piquette-Miller M

Fri May 01 00:00:00 EDT 2020

Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.

Journal of biomedical materials research. Part B, Applied biomaterials

Reid JA,Callanan A

Wed Apr 01 00:00:00 EDT 2020

Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming.

Nature communications

Krawczyk K,Scheller L,Kim H,Fussenegger M

Thu Jan 30 00:00:00 EST 2020

Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2.

Science advances

Zhao G,Weiner AI,Neupauer KM,de Mello Costa MF,Palashikar G,Adams-Tzivelekidis S,Mangalmurti NS,Vaughan AE

100-20 was used in In vitro experiments to demonstrate that lung endothelium possesses substantial regenerative capacity and lineage tracing reveals that native endothelium is the source of vascular repair after influenza injury.

Sun Nov 01 00:00:00 EDT 2020

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.

Stem cell reports

Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A

Tue Jan 14 00:00:00 EST 2020

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.

Stem cell reports

Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM

Tue Feb 11 00:00:00 EST 2020

iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome.

Scientific reports

Galat Y,Perepitchka M,Elcheva I,Iannaccone S,Iannaccone PM,Galat V

Thu Aug 06 00:00:00 EDT 2020

Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.

Cell death & disease

Ma LL,Guo LL,Luo Y,Liu GL,Lei Y,Jing FY,Zhang YL,Tong GH,Jing ZL,Shen L,Tang MS,Ding YQ,Deng YJ

Thu Mar 05 00:00:00 EST 2020

Modulating electrospun polycaprolactone scaffold morphology and composition to alter endothelial cell proliferation and angiogenic gene response.

PloS one

Reid JA,McDonald A,Callanan A

Tue Dec 08 00:00:00 EST 2020

Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.

STAR protocols

Ryan SK,Jordan-Sciutto KL,Anderson SA

Fri Dec 18 00:00:00 EST 2020

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.

Cell reports

Tan JME,van der Stoel MM,van den Berg M,van Loon NM,Moeton M,Scholl E,van der Wel NN,Kovačević I,Hordijk PL,Loregger A,Huveneers S,Zelcer N

100-20 was used in Cell Culture to propose a mechanistic link between regulation of cholesterol homeostasis by the MARCH6-SQLE axis and endothelial integrity and angiogenesis.

Tue Aug 04 00:00:00 EDT 2020

Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.

Bio-protocol

Chen IP

100-20 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.

Sun Dec 20 00:00:00 EST 2020

Increased vasculogenesis of endothelial cells in hyaluronic acid augmented fibrin-based natural hydrogels - from in vitro to in vivo models.

European cells & materials

Lin HC,Wang CK,Tung YC,Chiu FY,Su YP

100-20 was used in Cell Culture to study the unsatisfactory mechanical strength and degree of vascularisation of Fibrin-based hydrogels.

Sun Sep 20 00:00:00 EDT 2020

Targeting the ERβ/Angiopoietin-2/Tie-2 signaling-mediated angiogenesis with the FDA-approved anti-estrogen Faslodex to increase the Sunitinib sensitivity in RCC.

Cell death & disease

Gu J,Zhang Y,Han Z,Gao L,Cui J,Sun Y,Niu Y,You B,Huang CP,Chang C,Wang X,Yeh S

Thu May 14 00:00:00 EDT 2020

B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression.

Cell death & disease

Wang R,Ma Y,Zhan S,Zhang G,Cao L,Zhang X,Shi T,Chen W

Thu Jan 23 00:00:00 EST 2020

Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification.

Cell reports

Qiu J,Nordling S,Vasavada HH,Butcher EC,Hirschi KK

100-20 was used in In vitro experiments to demonstarte the use of retinoic acid in promoting endothelial cell cycle early G1 state thus stimulating HSPCs specification towards hemogenic endothelial cells; insight for ex vivo regenrative medicine applications.

Tue Dec 01 00:00:00 EST 2020

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.

eLife

Xiong Y,Scerbo MJ,Seelig A,Volta F,O'Brien N,Dicker A,Padula D,Lickert H,Gerdes JM,Berggren PO

100-20 was used in Cell Culture to investigate effects of cilia on islet vascularisation.

Tue Nov 17 00:00:00 EST 2020

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.

Cell reports

Wesely J,Kotini AG,Izzo F,Luo H,Yuan H,Sun J,Georgomanoli M,Zviran A,Deslauriers AG,Dusaj N,Nimer SD,Leslie C,Landau DA,Kharas MG,Papapetrou EP

100-20 was used in Cell Culture to empower efforts to therapeutically target AML LSCs.

Tue Jun 02 00:00:00 EDT 2020

Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC-Derived Embryonic Stage Mesodermal Precursor Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Ullah I,Busch JF,Rabien A,Ergün B,Stamm C,Knosalla C,Hippenstiel S,Reinke P,Kurtz A

Sun Mar 01 00:00:00 EST 2020

Endothelial Progenitor Cells Produced From Human Pluripotent Stem Cells by a Synergistic Combination of Cytokines, Small Compounds, and Serum-Free Medium.

Frontiers in cell and developmental biology

Farkas S,Simara P,Rehakova D,Veverkova L,Koutna I

100-20 was used in In vitro experiments to devise a robust three-phase protocol exploiting the synergy of multiple differentiation effector to efficently convert hPSCs into EPCs.

Mon Sep 28 00:00:00 EDT 2020

Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

Nature

Ramachandran P,Dobie R,Wilson-Kanamori JR,Dora EF,Henderson BEP,Luu NT,Portman JR,Matchett KP,Brice M,Marwick JA,Taylor RS,Efremova M,Vento-Tormo R,Carragher NO,Kendall TJ,Fallowfield JA,Harrison EM,Mole DJ,Wigmore SJ,Newsome PN,Weston CJ,Iredale JP,Tacke F,Pollard JW,Ponting CP,Marioni JC,Teichmann SA,Henderson NC

100-20 was used in In vitro experiments to investigate molecular definitions for non-parenchymal cell types in the healthy and cirrhotic human liver through transcriptomics.

Fri Nov 01 00:00:00 EDT 2019

Human blood vessel organoids as a model of diabetic vasculopathy.

Nature

Wimmer RA,Leopoldi A,Aichinger M,Wick N,Hantusch B,Novatchkova M,Taubenschmid J,Hämmerle M,Esk C,Bagley JA,Lindenhofer D,Chen G,Boehm M,Agu CA,Yang F,Fu B,Zuber J,Knoblich JA,Kerjaschki D,Penninger JM

Tue Jan 01 00:00:00 EST 2019

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

The Journal of clinical investigation

Iring A,Jin YJ,Albarrán-Juárez J,Siragusa M,Wang S,Dancs PT,Nakayama A,Tonack S,Chen M,Künne C,Sokol AM,Günther S,Martínez A,Fleming I,Wettschureck N,Graumann J,Weinstein LS,Offermanns S

Mon Jun 17 00:00:00 EDT 2019

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.

The EMBO journal

Sainz de Aja J,Menchero S,Rollan I,Barral A,Tiana M,Jawaid W,Cossio I,Alvarez A,Carreño-Tarragona G,Badia-Careaga C,Nichols J,Göttgens B,Isern J,Manzanares M

Mon Apr 01 00:00:00 EDT 2019

Restoration of FVIII expression by targeted gene insertion in the FVIII locus in hemophilia A patient-derived iPSCs.

Experimental & molecular medicine

Sung JJ,Park CY,Leem JW,Cho MS,Kim DW

Wed Apr 17 00:00:00 EDT 2019

Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering.

Experimental & molecular medicine

Jang Y,Choi J,Park N,Kang J,Kim M,Kim Y,Ju JH

Mon Jan 07 00:00:00 EST 2019

Novel human Ab against vascular endothelial growth factor receptor 2 shows therapeutic potential for leukemia and prostate cancer.

Cancer science

Lu RM,Chiu CY,Liu IJ,Chang YL,Liu YJ,Wu HC

Sun Dec 01 00:00:00 EST 2019

Novel human Ab against vascular endothelial growth factor receptor 2 shows therapeutic potential for leukemia and prostate cancer.

Cancer science

Lu RM,Chiu CY,Liu IJ,Chang YL,Liu YJ,Wu HC

Sun Dec 01 00:00:00 EST 2019

First trimester placental endothelial cells from pregnancies with abnormal uterine artery Doppler are more sensitive to apoptotic stimuli.

Laboratory investigation; a journal of technical methods and pathology

Charolidi N,Host AJ,Ashton S,Tryfonos Z,Leslie K,Thilaganathan B,Cartwright JE,Whitley GS

Fri Mar 01 00:00:00 EST 2019

Anti-angiogenic effect of quercetin and its 8-methyl pentamethyl ether derivative in human microvascular endothelial cells.

Journal of cellular and molecular medicine

Lupo G,Cambria MT,Olivieri M,Rocco C,Caporarello N,Longo A,Zanghì G,Salmeri M,Foti MC,Anfuso CD

Tue Oct 01 00:00:00 EDT 2019

Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner.

Journal of cellular and molecular medicine

Hamilton BJ,Tse D,Stan RV

Fri Feb 01 00:00:00 EST 2019

Neutrophil activation in systemic capillary leak syndrome (Clarkson disease).

Journal of cellular and molecular medicine

Xie Z,Kuhns DB,Gu X,Otu HH,Libermann TA,Gallin JI,Parikh SM,Druey KM

Thu Aug 01 00:00:00 EDT 2019

iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds.

Stem cell reports

Faley SL,Neal EH,Wang JX,Bosworth AM,Weber CM,Balotin KM,Lippmann ES,Bellan LM

Tue Mar 05 00:00:00 EST 2019

The human glomerular endothelial cells are potent pro-inflammatory contributors in an in vitro model of lupus nephritis.

Scientific reports

Dimou P,Wright RD,Budge KL,Midgley A,Satchell SC,Peak M,Beresford MW

Thu Jun 06 00:00:00 EDT 2019

Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication.

Scientific reports

Park MK,Cho H,Roh SW,Kim SJ,Myoung J

Wed Feb 20 00:00:00 EST 2019

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells.

Stem cell reports

Praça C,Rosa SC,Sevin E,Cecchelli R,Dehouck MP,Ferreira LS

Tue Oct 08 00:00:00 EDT 2019

Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.

Scientific reports

Shiga Y,Shiga A,Mesci P,Kwon H,Brifault C,Kim JH,Jeziorski JJ,Nasamran C,Ohtori S,Muotri AR,Gonias SL,Campana WM

Tue Dec 17 00:00:00 EST 2019

Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury.

Scientific reports

Shiga Y,Shiga A,Mesci P,Kwon H,Brifault C,Kim JH,Jeziorski JJ,Nasamran C,Ohtori S,Muotri AR,Gonias SL,Campana WM

Tue Dec 17 00:00:00 EST 2019

Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage.

FEBS open bio

Ha JM,Jin SY,Lee HS,Vafaeinik F,Jung YJ,Keum HJ,Song SH,Lee DH,Kim CD,Bae SS

Mon Apr 01 00:00:00 EDT 2019

Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage.

FEBS open bio

Ha JM,Jin SY,Lee HS,Vafaeinik F,Jung YJ,Keum HJ,Song SH,Lee DH,Kim CD,Bae SS

Mon Apr 01 00:00:00 EDT 2019

Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy.

Stem cell reports

Ong SB,Lee WH,Shao NY,Ismail NI,Katwadi K,Lim MM,Kwek XY,Michel NA,Li J,Newson J,Tahmasebi S,Rehman J,Kodo K,Jang HR,Ong SG

Tue Mar 05 00:00:00 EST 2019

Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF-Ang-Tie2 Signaling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Haase K,Gillrie MR,Hajal C,Kamm RD

Sun Dec 01 00:00:00 EST 2019

Generation of blood vessel organoids from human pluripotent stem cells.

Nature protocols

Wimmer RA,Leopoldi A,Aichinger M,Kerjaschki D,Penninger JM

100-20 was used in In vitro experiments to describe a protocol to generate self-organizing 3D human blood vessel organoids from hPSCs that exhibit morphological, functional and molecular features of human microvasculature.

Fri Nov 01 00:00:00 EDT 2019

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Scientific reports

Shvartsman M,Bilican S,Lancrin C

Tue Apr 23 00:00:00 EDT 2019

Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation.

Scientific reports

Randolph LN,Bao X,Oddo M,Lian XL

Wed Nov 13 00:00:00 EST 2019

A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity.

Current protocols in stem cell biology

Rosa S,Pitrez P,Fernandes H,Ferreira L

100-20 was used in In vitro experiments to describe a screening platform to identify compounds that affect human embryonic vascular development.

Sun Sep 01 00:00:00 EDT 2019

High mitogenic stimulation arrests angiogenesis.

Nature communications

Pontes-Quero S,Fernández-Chacón M,Luo W,Lunella FF,Casquero-Garcia V,Garcia-Gonzalez I,Hermoso A,Rocha SF,Bansal M,Benedito R

Wed May 01 00:00:00 EDT 2019

High mitogenic stimulation arrests angiogenesis.

Nature communications

Pontes-Quero S,Fernández-Chacón M,Luo W,Lunella FF,Casquero-Garcia V,Garcia-Gonzalez I,Hermoso A,Rocha SF,Bansal M,Benedito R

Wed May 01 00:00:00 EDT 2019

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts.

Nature communications

Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y

Mon Feb 04 00:00:00 EST 2019

Functional characterization of iPSC-derived arterial- and venous-like endothelial cells.

Scientific reports

Rosa S,Praça C,Pitrez PR,Gouveia PJ,Aranguren XL,Ricotti L,Ferreira LS

Thu Mar 07 00:00:00 EST 2019

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.

Stem cell reports

Konttinen H,Cabral-da-Silva MEC,Ohtonen S,Wojciechowski S,Shakirzyanova A,Caligola S,Giugno R,Ishchenko Y,Hernández D,Fazaludeen MF,Eamen S,Budia MG,Fagerlund I,Scoyni F,Korhonen P,Huber N,Haapasalo A,Hewitt AW,Vickers J,Smith GC,Oksanen M,Graff C,Kanninen KM,Lehtonen S,Propson N,Schwartz MP,Pébay A,Koistinaho J,Ooi L,Malm T

Tue Oct 08 00:00:00 EDT 2019

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.

Stem cell reports

Kelleher J,Dickinson A,Cain S,Hu Y,Bates N,Harvey A,Ren J,Zhang W,Moreton FC,Muir KW,Ward C,Touyz RM,Sharma P,Xu Q,Kimber SJ,Wang T

Tue Nov 12 00:00:00 EST 2019

Transplantation of human endometrial perivascular cells with elevated CYR61 expression induces angiogenesis and promotes repair of a full-thickness uterine injury in rat.

Stem cell research & therapy

Li Z,Yan G,Diao Q,Yu F,Li X,Sheng X,Liu Y,Dai Y,Zhou H,Zhen X,Hu Y,Péault B,Ding L,Sun H,Li H

100-20 was used in In vitro experiments to indicate that En-PSCs with elevated CYR61 expression loaded on a collagen scaffold may support uterine tissue regeneration.

Tue Jun 18 00:00:00 EDT 2019

A fully human transgene switch to regulate therapeutic protein production by cooling sensation.

Nature medicine

Bai P,Liu Y,Xue S,Hamri GC,Saxena P,Ye H,Xie M,Fussenegger M

100-20 was used in In vitro experiments to control transgene expression by harnessing signaling pathway controlled by human transient receptor potential (TRP) melastatin 8 (hTRPM8), a TRP channel family member1.

Thu Aug 01 00:00:00 EDT 2019

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Cell

Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

Thu Jan 25 00:00:00 EST 2018

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H₂S Production.

Cell

Longchamp A,Mirabella T,Arduini A,MacArthur MR,Das A,Treviño-Villarreal JH,Hine C,Ben-Sahra I,Knudsen NH,Brace LE,Reynolds J,Mejia P,Tao M,Sharma G,Wang R,Corpataux JM,Haefliger JA,Ahn KH,Lee CH,Manning BD,Sinclair DA,Chen CS,Ozaki CK,Mitchell JR

Thu Mar 22 00:00:00 EDT 2018

Generation and post-injury integration of human spinal cord neural stem cells.

Nature methods

Kumamaru H,Kadoya K,Adler AF,Takashima Y,Graham L,Coppola G,Tuszynski MH

Sat Sep 01 00:00:00 EDT 2018

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

Cell stem cell

Czerniecki SM,Cruz NM,Harder JL,Menon R,Annis J,Otto EA,Gulieva RE,Islas LV,Kim YK,Tran LM,Martins TJ,Pippin JW,Fu H,Kretzler M,Shankland SJ,Himmelfarb J,Moon RT,Paragas N,Freedman BS

100-20 was used in Cell Culture to conclude that organoids in HTS formats thus establish an attractive platform for multidimensional phenotypic screening.

Fri Jun 01 00:00:00 EDT 2018

Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration.

Proceedings of the National Academy of Sciences of the United States of America

Kim MC,Silberberg YR,Abeyaratne R,Kamm RD,Asada HH

Tue Jan 16 00:00:00 EST 2018

Human Urine-Derived Stem Cell Differentiation to Endothelial Cells with Barrier Function and Nitric Oxide Production.

Stem cells translational medicine

Liu G,Wu R,Yang B,Deng C,Lu X,Walker SJ,Ma PX,Mou S,Atala A,Zhang Y

Sat Sep 01 00:00:00 EDT 2018

Quality-Quantity Control Culture Enhances Vasculogenesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells.

Stem cells translational medicine

Tanaka R,Masuda H,Fujimura S,Ito-Hirano R,Arita K,Kakinuma Y,Hagiwara H,Kado M,Hayashi A,Mita T,Ogawa T,Watada H,Mizuno H,Sawada N,Asahara T

Tue May 01 00:00:00 EDT 2018

Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic Activities.

Journal of immunology (Baltimore, Md. : 1950)

Lavoie SS,Dumas E,Vulesevic B,Neagoe PE,White M,Sirois MG

Fri Jun 01 00:00:00 EDT 2018

Improved Left Ventricular Aneurysm Repair with Cell- and Cytokine-Seeded Collagen Patches.

Stem cells international

Qu H,Xie BD,Wu J,Lv B,Chuai JB,Li JZ,Cai J,Wu H,Jiang SL,Leng XP,Kang K

100-20 was used in In vitro experiments to determine methods of vascularising engineered heart tissue following treatment for surgical ventricular restoration.

Wed Mar 16 00:00:00 EDT 2022

Cryopreservation of canine cardiosphere-derived cells: Implications for clinical application.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Dutton LC,Church SAV,Hodgkiss-Geere H,Catchpole B,Huggins A,Dudhia J,Connolly DJ

100-20 was used in Cell Culture to show that cryopreservation of canine CDCs is feasible without altering their stem characteristics, thereby facilitating their utilization for clinical trials.

Mon Jan 01 00:00:00 EST 2018

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.

Stem cell reports

Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J

Tue Feb 13 00:00:00 EST 2018

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.

Scientific reports

Acosta MI,Urbach S,Doye A,Ng YW,Boudeau J,Mettouchi A,Debant A,Manser E,Visvikis O,Lemichez E

Tue Jan 23 00:00:00 EST 2018

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling.

Cell death & disease

Espinosa-Diez C,Wilson R,Chatterjee N,Hudson C,Ruhl R,Hipfinger C,Helms E,Khan OF,Anderson DG,Anand S

Thu May 24 00:00:00 EDT 2018

Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.

Stem cell research & therapy

Zhang W,Chu W,Liu Q,Coates D,Shang Y,Li C

100-20 was used in In vitro experiments to report the expression, functions, and molecular interactions of deer thymosin beta 10 (TMSB10) in tissue and cells in antler growth.

Tue Jun 19 00:00:00 EDT 2018

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Nature communications

Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II

Tue May 08 00:00:00 EDT 2018

A Scalable and Efficient Bioprocess for Manufacturing Human Pluripotent Stem Cell-Derived Endothelial Cells.

Stem cell reports

Lin H,Du Q,Li Q,Wang O,Wang Z,Sahu N,Elowsky C,Liu K,Zhang C,Chung S,Duan B,Lei Y

Tue Aug 14 00:00:00 EDT 2018

Soluble cMet levels in urine are a significant prognostic biomarker for diabetic nephropathy.

Scientific reports

Kim YC,An JN,Kim JH,Choi YW,Oh S,Kwon SH,Lee MY,Lee J,Jeong JG,Lim CS,Kim YS,Yang SH,Lee JP

Fri Aug 24 00:00:00 EDT 2018

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

eLife

Künzel U,Grieve AG,Meng Y,Sieber B,Cowley SA,Freeman M

100-20 was used in Cell Culture to examine the role of ADAM17 in the regulated release of multiple cytokine and growth factor signals.

Wed Jun 13 00:00:00 EDT 2018

RXRα provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells.

Cell death & disease

Zhang R,Li H,Zhang S,Zhang Y,Wang N,Zhou H,He H,Hu G,Zhang TC,Ma W

Tue May 01 00:00:00 EDT 2018

Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.

Scientific reports

Eicke D,Baigger A,Schulze K,Latham SL,Halloin C,Zweigerdt R,Guzman CA,Blasczyk R,Figueiredo C

Thu Jul 05 00:00:00 EDT 2018

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.

Stem cell reports

Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V

Tue Nov 13 00:00:00 EST 2018

Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription.

Cell discovery

Wang H,Lapek J,Fujimura K,Strnadel J,Liu B,Gonzalez DJ,Zhang W,Watson F,Yu V,Liu C,Melo CM,Miller YI,Elliott KC,Cheresh DA,Klemke RL

Thu Oct 01 00:00:00 EDT 2020

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Cell death & disease

Melguizo-Sanchis D,Xu Y,Taheem D,Yu M,Tilgner K,Barta T,Gassner K,Anyfantis G,Wan T,Elango R,Alharthi S,El-Harouni AA,Przyborski S,Adam S,Saretzki G,Samarasinghe S,Armstrong L,Lako M

Fri Jan 26 00:00:00 EST 2018

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy.

Cell death & disease

Piñol-Jurado P,Suárez-Calvet X,Fernández-Simón E,Gallardo E,de la Oliva N,Martínez-Muriana A,Gómez-Gálvez P,Escudero LM,Pérez-Peiró M,Wollin L,de Luna N,Navarro X,Illa I,Díaz-Manera J

Tue Jul 10 00:00:00 EDT 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Scientific reports

MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH

Tue May 22 00:00:00 EDT 2018

FLI1 and PKC co-activation promote highly efficient differentiation of human embryonic stem cells into endothelial-like cells.

Cell death & disease

Zhao H,Zhao Y,Li Z,Ouyang Q,Sun Y,Zhou D,Xie P,Zeng S,Dong L,Wen H,Lu G,Lin G,Hu L

Fri Jan 26 00:00:00 EST 2018

ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells.

iScience

Hofsteen P,Robitaille AM,Strash N,Palpant N,Moon RT,Pabon L,Murry CE

100-20 was used in Cell Culture to study how Alpha Protein Kinase 2 (ALPK2) is a candidate negative regulator of WNT/β-catenin signaling in cardiogenesis and that ALPK2 regulates β-catenin-dependent signaling during developmental commitment of cardiomyocytes.

Fri Apr 27 00:00:00 EDT 2018

Prostaglandin E₂ Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells.

Stem cell reports

Zhang B,He L,Liu Y,Zhang J,Zeng Q,Wang S,Fan Z,Fang F,Chen L,Lv Y,Xi J,Yue W,Li Y,Pei X

Tue Mar 13 00:00:00 EDT 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques.

Cancer research

Ishigaki H,Maeda T,Inoue H,Akagi T,Sasamura T,Ishida H,Inubushi T,Okahara J,Shiina T,Nakayama M,Itoh Y,Ogasawara K

100-20 was used in Cell Culture to demonstrate that autoantibodies can mitigate tumour growth in vitro and in vivo.

Wed Nov 01 00:00:00 EDT 2017

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification.

Cell death and differentiation

Vicinanza C,Aquila I,Scalise M,Cristiano F,Marino F,Cianflone E,Mancuso T,Marotta P,Sacco W,Lewis FC,Couch L,Shone V,Gritti G,Torella A,Smith AJ,Terracciano CM,Britti D,Veltri P,Indolfi C,Nadal-Ginard B,Ellison-Hughes GM,Torella D

Fri Dec 01 00:00:00 EST 2017

Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties.

mAbs

Bezabeh B,Fleming R,Fazenbaker C,Zhong H,Coffman K,Yu XQ,Leow CC,Gibson N,Wilson S,Stover CK,Wu H,Gao C,Dimasi N

100-20 was used in Enzyme-linked immunosorbent assay to characterize Bs4Ab, an innovative and generic bispecific tetravalent antibody platform.

Tue Nov 28 00:00:00 EST 2017

Angiogenic conditioning of peripheral blood mononuclear cells promotes fracture healing.

Bone & joint research

Mifuji K,Ishikawa M,Kamei N,Tanaka R,Arita K,Mizuno H,Asahara T,Adachi N,Ochi M

100-20 was used in Cell Culture to demonstrate that QQMNCs have superior potential to accelerate fracture healing compared with PBMNCs. The QQMNCs could be a promising option for fracture nonunion.

Tue Aug 01 00:00:00 EDT 2017

An Optimized 3D Coculture Assay for Preclinical Testing of Pro- and Antiangiogenic Drugs.

SLAS discovery : advancing life sciences R & D

Unterleuthner D,Kramer N,Pudelko K,Burian A,Hengstschläger M,Dolznig H

100-20 was used in In vitro experiments to investigate methods of preventing angiogenesis.

Thu Jun 01 00:00:00 EDT 2017

An Optimized 3D Coculture Assay for Preclinical Testing of Pro- and Antiangiogenic Drugs.

SLAS discovery : advancing life sciences R & D

Unterleuthner D,Kramer N,Pudelko K,Burian A,Hengstschläger M,Dolznig H

100-20 was used in In vitro experiments to investigate methods of preventing angiogenesis.

Thu Jun 01 00:00:00 EDT 2017

Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells.

Stem cell research & therapy

Li Y,Wen Y,Green M,Cabral EK,Wani P,Zhang F,Wei Y,Baer TM,Chen B

100-20 was used in Cell Culture to explore differences in stem cell differentiation between male and female human pluripotent stem cells (hPSCs) and the effect of oestrogen on hPSC-derived smooth muscle progenitor cells.

Tue Jul 04 00:00:00 EDT 2017

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.

The Journal of biological chemistry

Suh JH,Lai L,Nam D,Kim J,Jo J,Taffet GE,Kim E,Kaelber JT,Lee HK,Entman ML,Cooke JP,Reineke EL

Fri Dec 29 00:00:00 EST 2017

Bone marrow mesenchymal stem cells combine with Treated dentin matrix to build biological root.

Scientific reports

Luo S,Pei F,Zhang W,Guo W,Li R,He W,Tian W

Wed Apr 12 00:00:00 EDT 2017

Sex-specific eNOS activity and function in human endothelial cells.

Scientific reports

Cattaneo MG,Vanetti C,Decimo I,Di Chio M,Martano G,Garrone G,Bifari F,Vicentini LM

Tue Aug 29 00:00:00 EDT 2017

Modeling cadmium-induced endothelial toxicity using human pluripotent stem cell-derived endothelial cells.

Scientific reports

Tang L,Su J,Liang P

Wed Nov 01 00:00:00 EDT 2017

Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin β3 Signaling.

Scientific reports

Cai Z,Dong L,Song C,Zhang Y,Zhu C,Zhang Y,Ling Q,Hoffmann PR,Li J,Huang Z,Li W

Fri Aug 25 00:00:00 EDT 2017

Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin β3 Signaling.

Scientific reports

Cai Z,Dong L,Song C,Zhang Y,Zhu C,Zhang Y,Ling Q,Hoffmann PR,Li J,Huang Z,Li W

Fri Aug 25 00:00:00 EDT 2017

Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors.

Scientific reports

Choi WI,Sahu A,Vilos C,Kamaly N,Jo SM,Lee JH,Tae G

Mon Oct 30 00:00:00 EDT 2017

Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.

Bio-protocol

Sontag S,Förster M,Seré K,Zenke M

100-20 was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.

Sat Aug 05 00:00:00 EDT 2017

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels.

Nature communications

Zhang T,Chi S,Jiang F,Zhao Q,Xiao B

Mon Nov 27 00:00:00 EST 2017

Downregulation of LGR5 Expression Inhibits Cardiomyocyte Differentiation and Potentiates Endothelial Differentiation from Human Pluripotent Stem Cells.

Stem cell reports

Jha R,Singh M,Wu Q,Gentillon C,Preininger MK,Xu C

Tue Aug 08 00:00:00 EDT 2017

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.

Nature communications

Cho CF,Wolfe JM,Fadzen CM,Calligaris D,Hornburg K,Chiocca EA,Agar NYR,Pentelute BL,Lawler SE

100-20 was used in Cell Culture to report that self-assembling multicellular BBB spheroids display reproducible BBB features and functions.

Tue Jun 06 00:00:00 EDT 2017

SCARF-1 promotes adhesion of CD4⁺ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.

Scientific reports

Patten DA,Kamarajah SK,Rose JM,Tickle J,Shepherd EL,Adams DH,Weston CJ,Shetty S

Thu Dec 14 00:00:00 EST 2017

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Stem cell reports

Haenseler W,Sansom SN,Buchrieser J,Newey SE,Moore CS,Nicholls FJ,Chintawar S,Schnell C,Antel JP,Allen ND,Cader MZ,Wade-Martins R,James WS,Cowley SA

Tue Jun 06 00:00:00 EDT 2017

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell stem cell

Kotini AG,Chang CJ,Chow A,Yuan H,Ho TC,Wang T,Vora S,Solovyov A,Husser C,Olszewska M,Teruya-Feldstein J,Perumal D,Klimek VM,Spyridonidis A,Rampal RK,Silverman L,Reddy EP,Papaemmanuil E,Parekh S,Greenbaum BD,Leslie CS,Kharas MG,Papapetrou EP

100-20 was used in Cell Culture to provide insight into the cellular events demarcating the initiation and progression of myeloid transformation and a new platform for testing genetic and pharmacological interventions.

Thu Mar 02 00:00:00 EST 2017

Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling.

Journal of cell science

Muhl L,Folestad EB,Gladh H,Wang Y,Moessinger C,Jakobsson L,Eriksson U

100-20 was used in Cell Culture to show that NRP1 can act as a co-receptor for PDGF-D-PDGFRβ signaling and is possibly implicated in intercellular communication in the vascular wall.

Sat Apr 15 00:00:00 EDT 2017

Androgen receptor increases hematogenous metastasis yet decreases lymphatic metastasis of renal cell carcinoma.

Nature communications

Huang Q,Sun Y,Ma X,Gao Y,Li X,Niu Y,Zhang X,Chang C

Fri Oct 13 00:00:00 EDT 2017

Synthetic microparticles conjugated with VEGF₁₆₅ improve the survival of endothelial progenitor cells via microRNA-17 inhibition.

Nature communications

Aday S,Zoldan J,Besnier M,Carreto L,Saif J,Fernandes R,Santos T,Bernardino L,Langer R,Emanueli C,Ferreira L

Fri Sep 29 00:00:00 EDT 2017

Colloidal Gels with Extracellular Matrix Particles and Growth Factors for Bone Regeneration in Critical Size Rat Calvarial Defects.

The AAPS journal

Townsend JM,Dennis SC,Whitlow J,Feng Y,Wang J,Andrews B,Nudo RJ,Detamore MS,Berkland CJ

100-20 was used in In vitro experiments to study the development of a novel colloidal gel as a commercially available product for craniofacial reconstruction.

Mon May 01 00:00:00 EDT 2017

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.

The Journal of clinical investigation

Huang M,Liu T,Ma P,Mitteer RA,Zhang Z,Kim HJ,Yeo E,Zhang D,Cai P,Li C,Zhang L,Zhao B,Roccograndi L,O'Rourke DM,Dahmane N,Gong Y,Koumenis C,Fan Y

Mon May 02 00:00:00 EDT 2016

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.

The Journal of experimental medicine

Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG

Mon Nov 14 00:00:00 EST 2016

Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain.

Molecular therapy : the journal of the American Society of Gene Therapy

Jin L,Nonaka Y,Miyakawa S,Fujiwara M,Nakamura Y

Tue Nov 01 00:00:00 EDT 2016

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity.

Proceedings of the National Academy of Sciences of the United States of America

Wentink MQ,Hackeng TM,Tabruyn SP,Puijk WC,Schwamborn K,Altschuh D,Meloen RH,Schuurman T,Griffioen AW,Timmerman P

Tue Nov 01 00:00:00 EDT 2016

Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity.

Proceedings of the National Academy of Sciences of the United States of America

Wentink MQ,Hackeng TM,Tabruyn SP,Puijk WC,Schwamborn K,Altschuh D,Meloen RH,Schuurman T,Griffioen AW,Timmerman P

Tue Nov 01 00:00:00 EDT 2016

Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation.

Journal of lipid research

Oh MJ,Zhang C,LeMaster E,Adamos C,Berdyshev E,Bogachkov Y,Kohler EE,Baruah J,Fang Y,Schraufnagel DE,Wary KK,Levitan I

Sun May 01 00:00:00 EDT 2016

Knockdown of DNMT1 and DNMT3a Promotes the Angiogenesis of Human Mesenchymal Stem Cells Leading to Arterial Specific Differentiation.

Stem cells (Dayton, Ohio)

Zhang R,Wang N,Zhang LN,Huang N,Song TF,Li ZZ,Li M,Luo XG,Zhou H,He HP,Zhang XY,Ma W,Zhang TC

Sun May 01 00:00:00 EDT 2016

β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs.

Stem cells (Dayton, Ohio)

Fujita A,Uchida N,Haro-Mora JJ,Winkler T,Tisdale J

Wed Jun 01 00:00:00 EDT 2016

β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs.

Stem cells (Dayton, Ohio)

Fujita A,Uchida N,Haro-Mora JJ,Winkler T,Tisdale J

Wed Jun 01 00:00:00 EDT 2016

VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation.

Journal of immunology (Baltimore, Md. : 1950)

Oussa NA,Dahmani A,Gomis M,Richaud M,Andreev E,Navab-Daneshmand AR,Taillefer J,Carli C,Boulet S,Sabbagh L,Labrecque N,Sapieha P,Delisle JS

Tue Nov 15 00:00:00 EST 2016

Recombinant adeno-associated virus-delivered anginex inhibits angiogenesis and growth of HUVECs by regulating the Akt, JNK and NF-κB signaling pathways.

Oncology reports

Ma K,Wang C,Geng Q,Fan Y,Ning J,Yang H,Dong X,Dong D,Guo Y,Wei X,Li E,Wu Y

100-20 was used in Sample Preparation to suggest that rAAV2-anginex may inhibit tumor angiogenesis and growth through regulating Akt, JNK and NF-κB signaling pathways.

Wed Jun 01 00:00:00 EDT 2016

Macrophages form functional vascular mimicry channels in vivo.

Scientific reports

Barnett FH,Rosenfeld M,Wood M,Kiosses WB,Usui Y,Marchetti V,Aguilar E,Friedlander M

Fri Nov 11 00:00:00 EST 2016

Co-delivery of VEGF and bFGF via a PLGA nanoparticle-modified BAM for effective contracture inhibition of regenerated bladder tissue in rabbits.

Scientific reports

Jiang X,Lin H,Jiang D,Xu G,Fang X,He L,Xu M,Tang B,Wang Z,Cui D,Chen F,Geng H

Mon Feb 08 00:00:00 EST 2016

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.

Cell death & disease

Di Siena S,Gimmelli R,Nori SL,Barbagallo F,Campolo F,Dolci S,Rossi P,Venneri MA,Giannetta E,Gianfrilli D,Feigenbaum L,Lenzi A,Naro F,Cianflone E,Mancuso T,Torella D,Isidori AM,Pellegrini M

Thu Jul 28 00:00:00 EDT 2016

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

Stem cell reports

D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II

Tue Feb 09 00:00:00 EST 2016

Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway.

Scientific reports

Yu Z,Zhang T,Gong C,Sheng Y,Lu B,Zhou L,Ji L,Wang Z

Wed Sep 28 00:00:00 EDT 2016

Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway.

Scientific reports

Yu Z,Zhang T,Gong C,Sheng Y,Lu B,Zhou L,Ji L,Wang Z

Wed Sep 28 00:00:00 EDT 2016

Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept.

The Journal of biological chemistry

Walker A,Chung CW,Neu M,Burman M,Batuwangala T,Jones G,Tang CM,Steward M,Mullin M,Tournier N,Lewis A,Korczynska J,Chung V,Catchpole I

Fri Mar 11 00:00:00 EST 2016

Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system.

Scientific reports

Seo HR,Jeong HE,Joo HJ,Choi SC,Park CY,Kim JH,Choi JH,Cui LH,Hong SJ,Chung S,Lim DS

Thu Jun 30 00:00:00 EDT 2016

NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase.

Scientific reports

Kuek V,Yang Z,Chim SM,Zhu S,Xu H,Chow ST,Tickner J,Rosen V,Erber W,Li X,Qin A,Qian Y,Xu J

Wed Oct 26 00:00:00 EDT 2016

The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4.

Scientific reports

Su M,Huang J,Liu S,Xiao Y,Qin X,Liu J,Pi C,Luo T,Li J,Chen X,Luo Z

Fri Jun 24 00:00:00 EDT 2016

Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.

Scientific reports

Ameku T,Taura D,Sone M,Numata T,Nakamura M,Shiota F,Toyoda T,Matsui S,Araoka T,Yasuno T,Mae S,Kobayashi H,Kondo N,Kitaoka F,Amano N,Arai S,Ichisaka T,Matsuura N,Inoue S,Yamamoto T,Takahashi K,Asaka I,Yamada Y,Ubara Y,Muso E,Fukatsu A,Watanabe A,Sato Y,Nakahata T,Mori Y,Koizumi A,Nakao K,Yamanaka S,Osafune K

Fri Jul 15 00:00:00 EDT 2016

Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans.

Blood

Massena S,Christoffersson G,Vågesjö E,Seignez C,Gustafsson K,Binet F,Herrera Hidalgo C,Giraud A,Lomei J,Weström S,Shibuya M,Claesson-Welsh L,Gerwins P,Welsh M,Kreuger J,Phillipson M

Thu Oct 22 00:00:00 EDT 2015

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.

The Journal of experimental medicine

Frye M,Dierkes M,Küppers V,Vockel M,Tomm J,Zeuschner D,Rossaint J,Zarbock A,Koh GY,Peters K,Nottebaum AF,Vestweber D

Mon Dec 14 00:00:00 EST 2015

Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.

Nature protocols

Ginsberg M,Schachterle W,Shido K,Rafii S

100-20 was used in Cell Culture to develop a method to directly convert human mid-gestation lineage-committed amniotic fluid-derived cells into vascular endothelial cells.

Tue Dec 01 00:00:00 EST 2015

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.

Proceedings of the National Academy of Sciences of the United States of America

Morita R,Suzuki M,Kasahara H,Shimizu N,Shichita T,Sekiya T,Kimura A,Sasaki K,Yasukawa H,Yoshimura A

Tue Jan 06 00:00:00 EST 2015

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation.

Proceedings of the National Academy of Sciences of the United States of America

Jeon JS,Bersini S,Gilardi M,Dubini G,Charest JL,Moretti M,Kamm RD

Tue Jan 06 00:00:00 EST 2015

Aging cell

Zolla V,Nizamutdinova IT,Scharf B,Clement CC,Maejima D,Akl T,Nagai T,Luciani P,Leroux JC,Halin C,Stukes S,Tiwari S,Casadevall A,Jacobs WR,Entenberg D,Zawieja DC,Condeelis J,Fooksman DR,Gashev AA,Santambrogio L

Sat Aug 01 00:00:00 EDT 2015

ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.

The Journal of cell biology

Tornavaca O,Chia M,Dufton N,Almagro LO,Conway DE,Randi AM,Schwartz MA,Matter K,Balda MS

Mon Mar 16 00:00:00 EDT 2015

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.

The Journal of cell biology

Grimsey NJ,Aguilar B,Smith TH,Le P,Soohoo AL,Puthenveedu MA,Nizet V,Trejo J

Mon Sep 28 00:00:00 EDT 2015

Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.

Development (Cambridge, England)

Palpant NJ,Pabon L,Roberts M,Hadland B,Jones D,Jones C,Moon RT,Ruzzo WL,Bernstein I,Zheng Y,Murry CE

100-20 was used in In vitro experiments to conclude that activin/BMP gradients specify distinct mesodermal subpopulations that generate cell derivatives with unique angiogenic, hemogenic and cardiogenic properties that should be useful for understanding embryogenesis and developing therapeutics.

Tue Sep 15 00:00:00 EDT 2015

The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Nature communications

Giampietro C,Deflorian G,Gallo S,Di Matteo A,Pradella D,Bonomi S,Belloni E,Nyqvist D,Quaranta V,Confalonieri S,Bertalot G,Orsenigo F,Pisati F,Ferrero E,Biamonti G,Fredrickx E,Taveggia C,Wyatt CD,Irimia M,Di Fiore PP,Blencowe BJ,Dejana E,Ghigna C

Thu Oct 08 00:00:00 EDT 2015

Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells.

The Journal of biological chemistry

Aki S,Yoshioka K,Okamoto Y,Takuwa N,Takuwa Y

Fri Mar 06 00:00:00 EST 2015

Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells.

The Journal of biological chemistry

Aki S,Yoshioka K,Okamoto Y,Takuwa N,Takuwa Y

Fri Mar 06 00:00:00 EST 2015

A method to tune the shape of protein-encapsulated polymeric microspheres.

Scientific reports

de Alteriis R,Vecchione R,Attanasio C,De Gregorio M,Porzio M,Battista E,Netti PA

Thu Jul 30 00:00:00 EDT 2015

A method to tune the shape of protein-encapsulated polymeric microspheres.

Scientific reports

de Alteriis R,Vecchione R,Attanasio C,De Gregorio M,Porzio M,Battista E,Netti PA

Thu Jul 30 00:00:00 EDT 2015

Reinforcing endothelial junctions prevents microvessel permeability increase and tumor cell adhesion in microvessels in vivo.

Scientific reports

Fu BM,Yang J,Cai B,Fan J,Zhang L,Zeng M

Wed Oct 28 00:00:00 EDT 2015

Reinforcing endothelial junctions prevents microvessel permeability increase and tumor cell adhesion in microvessels in vivo.

Scientific reports

Fu BM,Yang J,Cai B,Fan J,Zhang L,Zeng M

Wed Oct 28 00:00:00 EDT 2015

Neurons limit angiogenesis by titrating VEGF in retina.

Cell

Okabe K,Kobayashi S,Yamada T,Kurihara T,Tai-Nagara I,Miyamoto T,Mukouyama YS,Sato TN,Suda T,Ema M,Kubota Y

Thu Oct 23 00:00:00 EDT 2014

Sensitizing protective tumor microenvironments to antibody-mediated therapy.

Cell

Pallasch CP,Leskov I,Braun CJ,Vorholt D,Drake A,Soto-Feliciano YM,Bent EH,Schwamb J,Iliopoulou B,Kutsch N,van Rooijen N,Frenzel LP,Wendtner CM,Heukamp L,Kreuzer KA,Hallek M,Chen J,Hemann MT

Thu Jan 30 00:00:00 EST 2014

Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.

Cell research

Sahara M,Hansson EM,Wernet O,Lui KO,Später D,Chien KR

Tue Jul 01 00:00:00 EDT 2014

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Immunity

Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR

Thu Sep 18 00:00:00 EDT 2014

Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk.

The Journal of clinical investigation

Dejda A,Mawambo G,Cerani A,Miloudi K,Shao Z,Daudelin JF,Boulet S,Oubaha M,Beaudoin F,Akla N,Henriques S,Menard C,Stahl A,Delisle JS,Rezende FA,Labrecque N,Sapieha P

Sat Nov 01 00:00:00 EDT 2014

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.

The Journal of clinical investigation

Okon IS,Coughlan KA,Zhang C,Moriasi C,Ding Y,Song P,Zhang W,Li G,Zou MH

Wed Oct 01 00:00:00 EDT 2014

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.

The Journal of clinical investigation

Shen J,Frye M,Lee BL,Reinardy JL,McClung JM,Ding K,Kojima M,Xia H,Seidel C,Lima e Silva R,Dong A,Hackett SF,Wang J,Howard BW,Vestweber D,Kontos CD,Peters KG,Campochiaro PA

Wed Oct 01 00:00:00 EDT 2014

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.

Proceedings of the National Academy of Sciences of the United States of America

Favia A,Desideri M,Gambara G,D'Alessio A,Ruas M,Esposito B,Del Bufalo D,Parrington J,Ziparo E,Palombi F,Galione A,Filippini A

Tue Nov 04 00:00:00 EST 2014

Adaptive immune contexture at the tumour site and downmodulation of circulating myeloid-derived suppressor cells in the response of solitary fibrous tumour patients to anti-angiogenic therapy.

British journal of cancer

Tazzari M,Negri T,Rini F,Vergani B,Huber V,Villa A,Dagrada P,Colombo C,Fiore M,Gronchi A,Stacchiotti S,Casali PG,Pilotti S,Rivoltini L,Castelli C

Tue Sep 23 00:00:00 EDT 2014

Suprabasin as a novel tumor endothelial cell marker.

Cancer science

Alam MT,Nagao-Kitamoto H,Ohga N,Akiyama K,Maishi N,Kawamoto T,Shinohara N,Taketomi A,Shindoh M,Hida Y,Hida K

Mon Dec 01 00:00:00 EST 2014

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

Stem cells (Dayton, Ohio)

Langlois T,da Costa Reis Monte-Mor B,Lenglet G,Droin N,Marty C,Le Couédic JP,Almire C,Auger N,Mercher T,Delhommeau F,Christensen J,Helin K,Debili N,Fuks F,Bernard OA,Solary E,Vainchenker W,Plo I

Fri Aug 01 00:00:00 EDT 2014

Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy.

Stem cells (Dayton, Ohio)

Navarro S,Moleiro V,Molina-Estevez FJ,Lozano ML,Chinchon R,Almarza E,Quintana-Bustamante O,Mostoslavsky G,Maetzig T,Galla M,Heinz N,Schiedlmeier B,Torres Y,Modlich U,Samper E,Río P,Segovia JC,Raya A,Güenechea G,Izpisua-Belmonte JC,Bueren JA

Sat Feb 01 00:00:00 EST 2014

Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model.

Journal of vascular and interventional radiology : JVIR

Fuchs K,Bize PE,Dormond O,Denys A,Doelker E,Borchard G,Jordan O

100-20 was used in In vitro experiments to indicate the potential of sunitinib-eluting beads for use in embolization.

Sat Mar 01 00:00:00 EST 2014

Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models.

Scientific reports

Chwalek K,Tsurkan MV,Freudenberg U,Werner C

Wed Mar 19 00:00:00 EDT 2014

YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical models.

Scientific reports

Xia Y,Song X,Li D,Ye T,Xu Y,Lin H,Meng N,Li G,Deng S,Zhang S,Liu L,Zhu Y,Zeng J,Lei Q,Pan Y,Wei Y,Zhao Y,Yu L

Tue Aug 12 00:00:00 EDT 2014

Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.

The Journal of biological chemistry

Ohashi K,Enomoto T,Joki Y,Shibata R,Ogura Y,Kataoka Y,Shimizu Y,Kambara T,Uemura Y,Yuasa D,Matsuo K,Hayakawa S,Hiramatsu-Ito M,Murohara T,Ouchi N

Fri May 16 00:00:00 EDT 2014

VEGF modulates synaptic activity in the developing spinal cord.

Developmental neurobiology

Guérit S,Allain AE,Léon C,Cazenave W,Ferrara N,Branchereau P,Bikfalvi A

100-20 was used in In vitro experiments to identify VEGF as a modulator of the neuronal activity during synapse formation and highlight a new ontogenic role for this angiogenic factor in the nervous system.

Sat Nov 01 00:00:00 EDT 2014

Testing an unusual in vivo vessel network model: a method to study angiogenesis in the colonial tunicate Botryllus schlosseri.

Scientific reports

Gasparini F,Caicci F,Rigon F,Zaniolo G,Manni L

Wed Sep 24 00:00:00 EDT 2014

Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA.

Cell research

Lui KO,Zangi L,Silva EA,Bu L,Sahara M,Li RA,Mooney DJ,Chien KR

Tue Oct 01 00:00:00 EDT 2013

Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity.

Blood

Singh N,Tiem M,Watkins R,Cho YK,Wang Y,Olsen T,Uehara H,Mamalis C,Luo L,Oakey Z,Ambati BK

Thu May 16 00:00:00 EDT 2013

Role of SOX17 in hematopoietic development from human embryonic stem cells.

Blood

Nakajima-Takagi Y,Osawa M,Oshima M,Takagi H,Miyagi S,Endoh M,Endo TA,Takayama N,Eto K,Toyoda T,Koseki H,Nakauchi H,Iwama A

Thu Jan 17 00:00:00 EST 2013

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

The Journal of experimental medicine

Soler A,Serra H,Pearce W,Angulo A,Guillermet-Guibert J,Friedman LS,Viñals F,Gerhardt H,Casanovas O,Graupera M,Vanhaesebroeck B

Mon Sep 23 00:00:00 EDT 2013

Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Castriconi R,Dondero A,Bellora F,Moretta L,Castellano A,Locatelli F,Corrias MV,Moretta A,Bottino C

Wed May 15 00:00:00 EDT 2013

Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry

Cossette É,Cloutier I,Tardif K,DonPierre G,Tanguay JF

Tue Jan 01 00:00:00 EST 2013

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.

PloS one

Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG

Thu Aug 08 00:00:00 EDT 2013

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.

PloS one

Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG

Thu Aug 08 00:00:00 EDT 2013

Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.

The Journal of biological chemistry

Kilari S,Remadevi I,Zhao B,Pan J,Miao R,Ramchandran R,North PE,You M,Rahimi N,Wilkinson GA

Fri Apr 12 00:00:00 EDT 2013

The Journal of biological chemistry

Kilari S,Remadevi I,Zhao B,Pan J,Miao R,Ramchandran R,North PE,You M,Rahimi N,Wilkinson GA

Fri Apr 12 00:00:00 EDT 2013

Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.

The Journal of biological chemistry

Mazor R,Alsaigh T,Shaked H,Altshuler AE,Pocock ES,Kistler EB,Karin M,Schmid-Schönbein GW

Fri Jan 04 00:00:00 EST 2013

The effect of Heparin-VEGF multilayer on the biocompatibility of decellularized aortic valve with platelet and endothelial progenitor cells.

PloS one

Ye X,Wang H,Zhou J,Li H,Liu J,Wang Z,Chen A,Zhao Q

Fri Sep 06 00:00:00 EDT 2013

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors.

PloS one

Schwenke M,Knöfler M,Velicky P,Weimar CH,Kruse M,Samalecos A,Wolf A,Macklon NS,Bamberger AM,Gellersen B

Wed Jul 24 00:00:00 EDT 2013

MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA).

The Journal of biological chemistry

Kasza Z,Fredlund Fuchs P,Tamm C,Eriksson AS,O'Callaghan P,Heindryckx F,Spillmann D,Larsson E,Le Jan S,Eriksson I,Gerwins P,Kjellén L,Kreuger J

Fri Sep 06 00:00:00 EDT 2013

A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.

PloS one

Curtis VF,Wang H,Yang P,McLendon RE,Li X,Zhou QY,Wang XF

Fri Jul 26 00:00:00 EDT 2013

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.

Nature

Benedito R,Rocha SF,Woeste M,Zamykal M,Radtke F,Casanovas O,Duarte A,Pytowski B,Adams RH

Sun Mar 18 00:00:00 EDT 2012

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.

Nature

Benedito R,Rocha SF,Woeste M,Zamykal M,Radtke F,Casanovas O,Duarte A,Pytowski B,Adams RH

Sun Mar 18 00:00:00 EDT 2012

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth.

Blood

Abéngozar MA,de Frutos S,Ferreiro S,Soriano J,Perez-Martinez M,Olmeda D,Marenchino M,Cañamero M,Ortega S,Megias D,Rodriguez A,Martínez-Torrecuadrada JL

Thu May 10 00:00:00 EDT 2012

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth.

Blood

Abéngozar MA,de Frutos S,Ferreiro S,Soriano J,Perez-Martinez M,Olmeda D,Marenchino M,Cañamero M,Ortega S,Megias D,Rodriguez A,Martínez-Torrecuadrada JL

Thu May 10 00:00:00 EDT 2012

ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells.

Blood

Joo HJ,Choi DK,Lim JS,Park JS,Lee SH,Song S,Shin JH,Lim DS,Kim I,Hwang KC,Koh GY

Thu Sep 27 00:00:00 EDT 2012

APELIN promotes hematopoiesis from human embryonic stem cells.

Blood

Yu QC,Hirst CE,Costa M,Ng ES,Schiesser JV,Gertow K,Stanley EG,Elefanty AG

Thu Jun 28 00:00:00 EDT 2012

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.

The Journal of cell biology

Huveneers S,Oldenburg J,Spanjaard E,van der Krogt G,Grigoriev I,Akhmanova A,Rehmann H,de Rooij J

Mon Mar 05 00:00:00 EST 2012

p120-catenin binding masks an endocytic signal conserved in classical cadherins.

The Journal of cell biology

Nanes BA,Chiasson-MacKenzie C,Lowery AM,Ishiyama N,Faundez V,Ikura M,Vincent PA,Kowalczyk AP

Mon Oct 15 00:00:00 EDT 2012

Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Swanson CD,Akama-Garren EH,Stein EA,Petralia JD,Ruiz PJ,Edalati A,Lindstrom TM,Robinson WH

Sun Apr 01 00:00:00 EDT 2012

Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.

Gene therapy

Silk KM,Silk JD,Ichiryu N,Davies TJ,Nolan KF,Leishman AJ,Carpenter L,Watt SM,Cerundolo V,Fairchild PJ

Mon Oct 01 00:00:00 EDT 2012

Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods.

Cell and tissue research

Szczepkowska A,Wąsowska B,Gilun PD,Lagaraine C,Robert V,Dufourny L,Thiéry JC,Skipor J

Mon Oct 01 00:00:00 EDT 2012

Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.

PloS one

Sachdeva R,Bhardwaj N,Huhtaniemi I,Aggrawal U,Jain SK,Zaidi R,Singh O,Pal R

Tue May 28 00:00:00 EDT 2013

The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling.

PloS one

Singh H,Hansen TM,Patel N,Brindle NP

Mon May 14 00:00:00 EDT 2012

Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.

PloS one

Ferro F,Spelat R,D'Aurizio F,Puppato E,Pandolfi M,Beltrami AP,Cesselli D,Falini G,Beltrami CA,Curcio F

Wed Nov 28 00:00:00 EST 2012

A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation.

Cell death & disease

Zhang YM,Dai BL,Zheng L,Zhan YZ,Zhang J,Smith WW,Wang XL,Chen YN,He LC

Thu Oct 11 00:00:00 EDT 2012

Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells.

The Journal of biological chemistry

Zhao N,Liu H,Lilly B

Fri May 11 00:00:00 EDT 2012

Leukocyte inflammatory responses provoked by pneumococcal sialidase.

mBio

Chang YC,Uchiyama S,Varki A,Nizet V

Thu Apr 19 00:00:00 EDT 2012

Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting.

PloS one

Chan JM,Zervantonakis IK,Rimchala T,Polacheck WJ,Whisler J,Kamm RD

Tue Jun 11 00:00:00 EDT 2013

Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2.

PloS one

Dwyer J,Hebda JK,Le Guelte A,Galan-Moya EM,Smith SS,Azzi S,Bidere N,Gavard J

Wed Mar 06 00:00:00 EST 2013

Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway.

PloS one

Xu W,Huang JJ,Cheung PC

Fri Aug 03 00:00:00 EDT 2012

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Cell

Bock C,Kiskinis E,Verstappen G,Gu H,Boulting G,Smith ZD,Ziller M,Croft GF,Amoroso MW,Oakley DH,Gnirke A,Eggan K,Meissner A

Fri Feb 04 00:00:00 EST 2011

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

Nature methods

Elliott DA,Braam SR,Koutsis K,Ng ES,Jenny R,Lagerqvist EL,Biben C,Hatzistavrou T,Hirst CE,Yu QC,Skelton RJ,Ward-van Oostwaard D,Lim SM,Khammy O,Li X,Hawes SM,Davis RP,Goulburn AL,Passier R,Prall OW,Haynes JM,Pouton CW,Kaye DM,Mummery CL,Elefanty AG,Stanley EG

Sun Oct 23 00:00:00 EDT 2011

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.

Cell research

Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R

Tue Mar 01 00:00:00 EST 2011

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.

Blood

Dai Y,Chen S,Shah R,Pei XY,Wang L,Almenara JA,Kramer LB,Dent P,Grant S

Thu Feb 10 00:00:00 EST 2011

NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.

Blood

Urso K,Alfranca A,Martínez-Martínez S,Escolano A,Ortega I,Rodríguez A,Redondo JM

Thu Jul 21 00:00:00 EDT 2011

Endothelial von Willebrand factor regulates angiogenesis.

Blood

Starke RD,Ferraro F,Paschalaki KE,Dryden NH,McKinnon TA,Sutton RE,Payne EM,Haskard DO,Hughes AD,Cutler DF,Laffan MA,Randi AM

Thu Jan 20 00:00:00 EST 2011

Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae.

Blood

Margheri F,Chillà A,Laurenzana A,Serratì S,Mazzanti B,Saccardi R,Santosuosso M,Danza G,Sturli N,Rosati F,Magnelli L,Papucci L,Calorini L,Bianchini F,Del Rosso M,Fibbi G

Thu Sep 29 00:00:00 EDT 2011

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.

Blood

Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F

Thu Mar 17 00:00:00 EDT 2011

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo.

The Journal of experimental medicine

Broermann A,Winderlich M,Block H,Frye M,Rossaint J,Zarbock A,Cagna G,Linnepe R,Schulte D,Nottebaum AF,Vestweber D

Mon Nov 21 00:00:00 EST 2011

E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models.

Cancer research

Bello E,Colella G,Scarlato V,Oliva P,Berndt A,Valbusa G,Serra SC,D'Incalci M,Cavalletti E,Giavazzi R,Damia G,Camboni G

Tue Feb 15 00:00:00 EST 2011

E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models.

Cancer research

Bello E,Colella G,Scarlato V,Oliva P,Berndt A,Valbusa G,Serra SC,D'Incalci M,Cavalletti E,Giavazzi R,Damia G,Camboni G

Tue Feb 15 00:00:00 EST 2011

Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair.

Proceedings of the National Academy of Sciences of the United States of America

Webber MJ,Tongers J,Newcomb CJ,Marquardt KT,Bauersachs J,Losordo DW,Stupp SI

Tue Aug 16 00:00:00 EDT 2011

Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair.

Proceedings of the National Academy of Sciences of the United States of America

Webber MJ,Tongers J,Newcomb CJ,Marquardt KT,Bauersachs J,Losordo DW,Stupp SI

Tue Aug 16 00:00:00 EDT 2011

High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells.

Journal of biomedical science

Yang XF,He X,He J,Zhang LH,Su XJ,Dong ZY,Xu YJ,Li Y,Li YL

Fri Aug 19 00:00:00 EDT 2011

Decrease in VEGF expression induces intussusceptive vascular pruning.

Arteriosclerosis, thrombosis, and vascular biology

Hlushchuk R,Ehrbar M,Reichmuth P,Heinimann N,Styp-Rekowska B,Escher R,Baum O,Lienemann P,Makanya A,Keshet E,Djonov V

Thu Dec 01 00:00:00 EST 2011

Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib.

Oncogene

Welti JC,Gourlaouen M,Powles T,Kudahetti SC,Wilson P,Berney DM,Reynolds AR

Thu Mar 10 00:00:00 EST 2011

Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration.

Stem cells (Dayton, Ohio)

Dragoni S,Laforenza U,Bonetti E,Lodola F,Bottino C,Berra-Romani R,Carlo Bongio G,Cinelli MP,Guerra G,Pedrazzoli P,Rosti V,Tanzi F,Moccia F

Tue Nov 01 00:00:00 EDT 2011

Dissection of the biphasic nature of hypoxia-induced motogenic action in bone marrow-derived human mesenchymal stem cells.

Stem cells (Dayton, Ohio)

Busletta C,Novo E,Valfrè Di Bonzo L,Povero D,Paternostro C,Ievolella M,Mareschi K,Ferrero I,Cannito S,Compagnone A,Bandino A,Colombatto S,Fagioli F,Parola M

Wed Jun 01 00:00:00 EDT 2011

Debrided skin as a source of autologous stem cells for wound repair.

Stem cells (Dayton, Ohio)

Natesan S,Wrice NL,Baer DG,Christy RJ

Mon Aug 01 00:00:00 EDT 2011

Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.

Journal of immunology (Baltimore, Md. : 1950)

Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH

Fri Apr 01 00:00:00 EDT 2011

Differential adhesion molecule expression during murine embryonic stem cell commitment to the hematopoietic and endothelial lineages.

PloS one

Stankovich BL,Aguayo E,Barragan F,Sharma A,Pallavicini MG

Thu Jan 05 00:00:00 EST 2012

Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src.

PloS one

Lee M,Choy WC,Abid MR

Thu May 03 00:00:00 EDT 2012

Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes.

Stem cell reviews and reports

Lee YK,Ng KM,Lai WH,Chan YC,Lau YM,Lian Q,Tse HF,Siu CW

Tue Nov 01 00:00:00 EDT 2011

Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2.

Aging

Bogomazova AN,Lagarkova MA,Tskhovrebova LV,Shutova MV,Kiselev SL

Wed Jun 01 00:00:00 EDT 2011

Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.

The Journal of biological chemistry

Fang JD,Chou HC,Tung HH,Huang PY,Lee SL

Fri Feb 18 00:00:00 EST 2011

Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.

PLoS neglected tropical diseases

Castro de Moura M,Miro F,Han JM,Kim S,Celada A,Ribas de Pouplana L

Tue Nov 01 00:00:00 EDT 2011

Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.

PloS one

Garrido-Urbani S,Jemelin S,Deffert C,Carnesecchi S,Basset O,Szyndralewiez C,Heitz F,Page P,Montet X,Michalik L,Arbiser J,Rüegg C,Krause KH,Imhof BA

Mon Feb 07 00:00:00 EST 2011

Physical passaging of embryoid bodies generated from human pluripotent stem cells.

PloS one

Son MY,Kim HJ,Kim MJ,Cho YS

Tue May 03 00:00:00 EDT 2011

Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

PloS one

Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S

Fri Apr 29 00:00:00 EDT 2011

Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo.

PloS one

Mohan RR,Tovey JC,Sharma A,Schultz GS,Cowden JW,Tandon A

Tue Feb 28 00:00:00 EST 2012

SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration.

Molecular vision

Thill M,Berna MJ,Kunst F,Wege H,Strunnikova NV,Gordiyenko N,Grierson R,Richard G,Csaky KG

Mon Jan 10 00:00:00 EST 2011

Efficacious and safe tissue-selective controlled gene therapy approaches for the cornea.

PloS one

Mohan RR,Sinha S,Tandon A,Gupta R,Tovey JC,Sharma A

Tue Apr 12 00:00:00 EDT 2011

Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.

The Journal of biological chemistry

Bouillot S,Tillet E,Carmona G,Prandini MH,Gauchez AS,Hoffmann P,Alfaidy N,Cand F,Huber P

Fri Apr 29 00:00:00 EDT 2011

Regulation of tumor angiogenesis by EZH2.

Cancer cell

Lu C,Han HD,Mangala LS,Ali-Fehmi R,Newton CS,Ozbun L,Armaiz-Pena GN,Hu W,Stone RL,Munkarah A,Ravoori MK,Shahzad MM,Lee JW,Mora E,Langley RR,Carroll AR,Matsuo K,Spannuth WA,Schmandt R,Jennings NB,Goodman BW,Jaffe RB,Nick AM,Kim HS,Guven EO,Chen YH,Li LY,Hsu MC,Coleman RL,Calin GA,Denkbas EB,Lim JY,Lee JS,Kundra V,Birrer MJ,Hung MC,Lopez-Berestein G,Sood AK

Mon Aug 09 00:00:00 EDT 2010

VEGF/VEGFR2 interaction down-regulates matrix metalloproteinase-9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration.

Blood

Ugarte-Berzal E,Redondo-Muñoz J,Eroles P,Del Cerro MH,García-Marco JA,Terol MJ,García-Pardo A

Thu Jan 28 00:00:00 EST 2010

Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels.

Blood

Taylor SM,Nevis KR,Park HL,Rogers GC,Rogers SL,Cook JG,Bautch VL

Thu Oct 21 00:00:00 EDT 2010

Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration.

Blood

Grote K,Schuett H,Salguero G,Grothusen C,Jagielska J,Drexler H,Mühlradt PF,Schieffer B

Thu Mar 25 00:00:00 EDT 2010

Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity.

Blood

Verma A,Bhattacharya R,Remadevi I,Li K,Pramanik K,Samant GV,Horswill M,Chun CZ,Zhao B,Wang E,Miao RQ,Mukhopadhyay D,Ramchandran R,Wilkinson GA

Thu Jun 03 00:00:00 EDT 2010

Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.

Blood

Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H

Thu Dec 02 00:00:00 EST 2010

Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture.

Angiogenesis

Trapp V,Parmakhtiar B,Papazian V,Willmott L,Fruehauf JP

Wed Dec 01 00:00:00 EST 2010

Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

Oncogene

Cantelmo AR,Cammarota R,Noonan DM,Focaccetti C,Comoglio PM,Prat M,Albini A

Thu Sep 23 00:00:00 EDT 2010

The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development.

Stem cells (Dayton, Ohio)

Szatmari I,Iacovino M,Kyba M

Wed Sep 01 00:00:00 EDT 2010

Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.

Journal of immunology (Baltimore, Md. : 1950)

Oo YH,Weston CJ,Lalor PF,Curbishley SM,Withers DR,Reynolds GM,Shetty S,Harki J,Shaw JC,Eksteen B,Hubscher SG,Walker LS,Adams DH

Mon Mar 15 00:00:00 EDT 2010

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer.

Journal of cellular biochemistry

Bussard KM,Venzon DJ,Mastro AM

Wed Dec 01 00:00:00 EST 2010

VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.

PloS one

Holmes K,Chapman E,See V,Cross MJ

Tue Jul 06 00:00:00 EDT 2010

Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate.

PloS one

Nishiguchi KM,Kataoka K,Kachi S,Komeima K,Terasaki H

Wed Oct 20 00:00:00 EDT 2010

Generic approach for the generation of stable humanized single-chain Fv fragments from rabbit monoclonal antibodies.

The Journal of biological chemistry

Borras L,Gunde T,Tietz J,Bauer U,Hulmann-Cottier V,Grimshaw JP,Urech DM

Fri Mar 19 00:00:00 EDT 2010

Dynamic interaction networks in a hierarchically organized tissue.

Molecular systems biology

Kirouac DC,Ito C,Csaszar E,Roch A,Yu M,Sykes EA,Bader GD,Zandstra PW

Tue Oct 05 00:00:00 EDT 2010

Localization of angiotensin converting enzyme in rabbit cornea and its role in controlling corneal angiogenesis in vivo.

Molecular vision

Sharma A,Bettis DI,Cowden JW,Mohan RR

Fri Apr 23 00:00:00 EDT 2010

Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.

Blood

McKinney-Freeman SL,Naveiras O,Yates F,Loewer S,Philitas M,Curran M,Park PJ,Daley GQ

Thu Jul 09 00:00:00 EDT 2009

Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin.

Blood

Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC

Thu Feb 12 00:00:00 EST 2009

The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization.

Biomaterials

Freeman I,Cohen S

Wed Apr 01 00:00:00 EDT 2009

Erlotinib and bevacizumab have synergistic activity against melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schicher N,Paulitschke V,Swoboda A,Kunstfeld R,Loewe R,Pilarski P,Pehamberger H,Hoeller C

Fri May 15 00:00:00 EDT 2009

Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Tsukamoto N,Okada S,Onami Y,Sasaki Y,Umezawa K,Kawakami Y

Tue Sep 15 00:00:00 EDT 2009

Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma.

Cancer research

Hu J,Dong A,Fernandez-Ruiz V,Shan J,Kawa M,Martínez-Ansó E,Prieto J,Qian C

Tue Sep 01 00:00:00 EDT 2009

Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis.

Oncogene

Ayada T,Taniguchi K,Okamoto F,Kato R,Komune S,Takaesu G,Yoshimura A

Thu Feb 26 00:00:00 EST 2009

TGFbeta1 antagonistic peptides inhibit TGFbeta1-dependent angiogenesis.

Biochemical pharmacology

Serratì S,Margheri F,Pucci M,Cantelmo AR,Cammarota R,Dotor J,Borràs-Cuesta F,Fibbi G,Albini A,Del Rosso M

100-20 was used in In vitro experiments to show that TGFbeta up-regulates expression not only of plasminogen activator inhibitor type-1 (PAI-1), but also of the urokinase-type plasminogen activator receptor (uPAR), whose inhibition by specific antibodies blunted the TGFbeta angiogenic response in vitro.

Sun Mar 01 00:00:00 EST 2009

A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.

Stem cells (Dayton, Ohio)

Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A

Thu Jan 01 00:00:00 EST 2009

Hematopoietic and endothelial differentiation of human induced pluripotent stem cells.

Stem cells (Dayton, Ohio)

Choi KD,Yu J,Smuga-Otto K,Salvagiotto G,Rehrauer W,Vodyanik M,Thomson J,Slukvin I

Sun Mar 01 00:00:00 EST 2009

Differential gene expression in a coculture model of angiogenesis reveals modulation of select pathways and a role for Notch signaling.

Physiological genomics

Lilly B,Kennard S

Thu Jan 08 00:00:00 EST 2009

Contribution of rat endothelial progenitor cells on three-dimensional network formation in vitro.

Tissue engineering. Part A

Koga M,Sudo R,Abe Y,Yamamoto K,Ando J,Ikeda M,Tanishita K

Tue Sep 01 00:00:00 EDT 2009

Dose effect of dual delivery of vascular endothelial growth factor and bone morphogenetic protein-2 on bone regeneration in a rat critical-size defect model.

Tissue engineering. Part A

Young S,Patel ZS,Kretlow JD,Murphy MB,Mountziaris PM,Baggett LS,Ueda H,Tabata Y,Jansen JA,Wong M,Mikos AG

Tue Sep 01 00:00:00 EDT 2009

Evidence for in vivo growth potential and vascular remodeling of tissue-engineered artery.

Tissue engineering. Part A

Cho SW,Kim IK,Kang JM,Song KW,Kim HS,Park CH,Yoo KJ,Kim BS

Wed Apr 01 00:00:00 EDT 2009

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1.

Genome medicine

Larsson E,Fredlund Fuchs P,Heldin J,Barkefors I,Bondjers C,Genové G,Arrondel C,Gerwins P,Kurschat C,Schermer B,Benzing T,Harvey SJ,Kreuger J,Lindahl P

Mon Nov 16 00:00:00 EST 2009

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.

The Journal of biological chemistry

Robinson SD,Reynolds LE,Kostourou V,Reynolds AR,da Silva RG,Tavora B,Baker M,Marshall JF,Hodivala-Dilke KM

Fri Dec 04 00:00:00 EST 2009

Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.

The Journal of biological chemistry

Ardi VC,Van den Steen PE,Opdenakker G,Schweighofer B,Deryugina EI,Quigley JP

Fri Sep 18 00:00:00 EDT 2009

Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.

The Journal of biological chemistry

Ardi VC,Van den Steen PE,Opdenakker G,Schweighofer B,Deryugina EI,Quigley JP

Fri Sep 18 00:00:00 EDT 2009

Sox18 induces development of the lymphatic vasculature in mice.

Nature

François M,Caprini A,Hosking B,Orsenigo F,Wilhelm D,Browne C,Paavonen K,Karnezis T,Shayan R,Downes M,Davidson T,Tutt D,Cheah KS,Stacker SA,Muscat GE,Achen MG,Dejana E,Koopman P

Thu Dec 04 00:00:00 EST 2008

Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models.

Clinical cancer research : an official journal of the American Association for Cancer Research

Lee FY,Covello KL,Castaneda S,Hawken DR,Kan D,Lewin A,Wen ML,Ryseck RP,Fairchild CR,Fargnoli J,Kramer R

Mon Dec 15 00:00:00 EST 2008

Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice.

Journal of translational medicine

Oyamada N,Itoh H,Sone M,Yamahara K,Miyashita K,Park K,Taura D,Inuzuka M,Sonoyama T,Tsujimoto H,Fukunaga Y,Tamura N,Nakao K

Tue Sep 30 00:00:00 EDT 2008

Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice.

Journal of translational medicine

Oyamada N,Itoh H,Sone M,Yamahara K,Miyashita K,Park K,Taura D,Inuzuka M,Sonoyama T,Tsujimoto H,Fukunaga Y,Tamura N,Nakao K

Tue Sep 30 00:00:00 EDT 2008

Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor.

Blood

Fischer S,Gerriets T,Wessels C,Walberer M,Kostin S,Stolz E,Zheleva K,Hocke A,Hippenstiel S,Preissner KT

Mon Oct 01 00:00:00 EDT 2007

Dual GPCR and GAG mimicry by the M3 chemokine decoy receptor.

The Journal of experimental medicine

Alexander-Brett JM,Fremont DH

Mon Dec 24 00:00:00 EST 2007

Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device.

Journal of controlled release : official journal of the Controlled Release Society

Gu F,Neufeld R,Amsden B

Mon Jan 22 00:00:00 EST 2007

The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.

Stem cells (Dayton, Ohio)

Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J

Sun Jul 01 00:00:00 EDT 2007

Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone.

The Journal of clinical endocrinology and metabolism

Engel JB,Keller G,Schally AV,Toller GL,Groot K,Havt A,Armatis P,Zarandi M,Varga JL,Halmos G

Wed Jun 01 00:00:00 EDT 2005

Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP

Thu Jan 15 00:00:00 EST 2004

Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers.

British journal of cancer

Bajo AM,Schally AV,Groot K,Szepeshazi K

Mon Jan 12 00:00:00 EST 2004

Direct regulation of prostate blood flow by vascular endothelial growth factor and its participation in the androgenic regulation of prostate blood flow in vivo.

Endocrinology

Shibata Y,Kashiwagi B,Arai S,Fukabori Y,Suzuki K,Honma S,Yamanaka H

Fri Oct 01 00:00:00 EDT 2004

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

The Journal of biological chemistry

Dixelius J,Makinen T,Wirzenius M,Karkkainen MJ,Wernstedt C,Alitalo K,Claesson-Welsh L

100-20 was used in Cell Culture to study five tyrosyl phosphorylation sites in the vascular endothelial growth factor receptor-3 (VEGFR-3) carboxyl-terminal tail and suggest that it provides important regulatory tyrosine phosphorylation sites with potential signal transduction capacity and that these sites are differentially used in ligand-induced homo- and heterodimeric receptor complexes.

Fri Oct 17 00:00:00 EDT 2003

Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1.

Blood

Salvucci O,Yao L,Villalba S,Sajewicz A,Pittaluga S,Tosato G

Mon Apr 15 00:00:00 EDT 2002

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells.

Blood

Burger PE,Coetzee S,McKeehan WL,Kan M,Cook P,Fan Y,Suda T,Hebbel RP,Novitzky N,Muller WA,Wilson EL

Fri Nov 15 00:00:00 EST 2002

Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.

Laboratory investigation; a journal of technical methods and pathology

Feraud O,Cao Y,Vittet D

Sat Dec 01 00:00:00 EST 2001

Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.

Laboratory investigation; a journal of technical methods and pathology

Feraud O,Cao Y,Vittet D

Sat Dec 01 00:00:00 EST 2001

In vitro differentiation of endothelial cells from AC133-positive progenitor cells.

Blood

Gehling UM,Ergün S,Schumacher U,Wagener C,Pantel K,Otte M,Schuch G,Schafhausen P,Mende T,Kilic N,Kluge K,Schäfer B,Hossfeld DK,Fiedler W

Mon May 15 00:00:00 EDT 2000

Bioinformatics

Protein Aliases: H-VEGF-165; L-VEGF; M-VEGF-165; Vascular endothelial growth factor A, long form; vascular endothelial growth factor A121; vascular endothelial growth factor A165; Vascular permeability factor; VEGF165; VPF

Human VEGF-165 Recombinant Protein, PeproTech®

Human VEGF-165 Protein (100-20-10UG) in Functional

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100-20-10UG

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