Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 16 amino amino terminus of human p53R2.
PEP-0095 can be used as a blocking peptide with polyclonal antibody PA5-19970.
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and -gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
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Protein Aliases: p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2 short form beta; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; Ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); TP53-inducible ribonucleotide reductase M2 B
Gene Aliases: MTDPS8A; MTDPS8B; P53R2; RRM2B
UniProt ID: (Human) Q7LG56
Entrez Gene ID: (Human) 50484
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