Gibco

Mouse CCL7 (MCP-3) Recombinant Protein, PeproTech®

Product Details

250-08-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 11 publications 11 publications

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Product Specifications

Species

Mouse

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

QPDGPNASTC CYVKKQKIPK RNLKSYRRIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTP TPKP

Molecular weight

8.5 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract BaF3 cells expressing human CCR2 receptor using a concentration range of 300-500 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine MCP-3 is an 8.5 kDa protein containing 74 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

This is a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CCL7 contributes to angiotensin II-induced abdominal aortic aneurysm by promoting macrophage infiltration and pro-inflammatory phenotype.

Journal of cellular and molecular medicine

Xie C,Ye F,Zhang N,Huang Y,Pan Y,Xie X

250-08 was used in In vitro experiments to investigate chemokine activation of inflammation in abdominal aortic aneurysm.

Sun Aug 01 00:00:00 EDT 2021

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.

Nature communications

Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q

Wed Jul 21 00:00:00 EDT 2021

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.

Nature communications

Wang W,Tang YA,Xiao Q,Lee WC,Cheng B,Niu Z,Oguz G,Feng M,Lee PL,Li B,Yang ZH,Chen YF,Lan P,Wu XJ,Yu Q

Wed Jul 21 00:00:00 EDT 2021

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response.

Immunity

Sokol CL,Camire RB,Jones MC,Luster AD

Tue Sep 18 00:00:00 EDT 2018

Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.

Scientific reports

Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW

Wed Nov 22 00:00:00 EST 2017

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.

Nature communications

Laurent V,Guérard A,Mazerolles C,Le Gonidec S,Toulet A,Nieto L,Zaidi F,Majed B,Garandeau D,Socrier Y,Golzio M,Cadoudal T,Chaoui K,Dray C,Monsarrat B,Schiltz O,Wang YY,Couderc B,Valet P,Malavaud B,Muller C

Tue Jan 12 00:00:00 EST 2016

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Bardina SV,Michlmayr D,Hoffman KW,Obara CJ,Sum J,Charo IF,Lu W,Pletnev AG,Lim JK

Sun Nov 01 00:00:00 EDT 2015

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.

Nature communications

Patel J,McNeill E,Douglas G,Hale AB,de Bono J,Lee R,Iqbal AJ,Regan-Komito D,Stylianou E,Greaves DR,Channon KM

Wed Mar 18 00:00:00 EDT 2015

Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ

Tue Jul 01 00:00:00 EDT 2014

Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.

PLoS pathogens

Lionakis MS,Fischer BG,Lim JK,Swamydas M,Wan W,Richard Lee CC,Cohen JI,Scheinberg P,Gao JL,Murphy PM

Mon Dec 17 00:00:00 EST 2012

Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection.

Journal of immunology (Baltimore, Md. : 1950)

Qiu Y,Zeltzer S,Zhang Y,Wang F,Chen GH,Dayrit J,Murdock BJ,Bhan U,Toews GB,Osterholzer JJ,Standiford TJ,Olszewski MA

Sun Apr 15 00:00:00 EDT 2012

A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Journal of immunology (Baltimore, Md. : 1950)

Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N

Wed Jul 01 00:00:00 EDT 2009

T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.

The Journal of clinical investigation

Jarmin SJ,David R,Ma L,Chai JG,Dewchand H,Takesono A,Ridley AJ,Okkenhaug K,Marelli-Berg FM

Sat Mar 01 00:00:00 EST 2008

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Michalec L,Choudhury BK,Postlethwait E,Wild JS,Alam R,Lett-Brown M,Sur S

Tue Jan 15 00:00:00 EST 2002

Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.

Cytokine

Ruth JH,Warmington KS,Shang X,Lincoln P,Evanoff H,Kunkel SL,Chensue SW

Mon May 01 00:00:00 EDT 2000

Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis.

The Journal of clinical investigation

Topham PS,Csizmadia V,Soler D,Hines D,Gerard CJ,Salant DJ,Hancock WW

Wed Dec 01 00:00:00 EST 1999

Bioinformatics

Protein Aliases: C-C motif chemokine 7; H-MCP-3; Intercrine/chemokine MARC; MCP-3; MGC138463; MGC138465; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; Protein FIC; RANTES/sis homolog; RP23-350G1.4; small inducible cytokine A7; Small-inducible cytokine A7

Mouse CCL7 (MCP-3) Recombinant Protein, PeproTech®

Product Details

250-08-10UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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