Product References
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.
Cancer immunology research
Celus W,Oliveira AI,Rivis S,Van Acker HH,Landeloos E,Serneels J,Cafarello ST,Van Herck Y,Mastrantonio R,Köhler A,Garg AD,Flamand V,Tamagnone L,Marine JC,Di Matteo M,Costa BM,Bechter O,Mazzone M
250-16 was used in In vitro experiments to show that expression of the axon guidance molecule Plexin-A4 (Plxna4) in cytotoxic T cells (CTLs), especially in effector/memory CD8+ T cells, is induced upon T-cell activation, sustained in the circulation, but reduced when entering the tumor bed and that upon deletion of Plxna4, CTLs acquire improved homing capacity to the lymph nodes and to the tumor.
Sat Jan 01 00:00:00 EST 2022
Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy.
Journal of immunology (Baltimore, Md. : 1950)
Gopinath S,Lu P,Iwasaki A
Wed Apr 01 00:00:00 EDT 2020
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.
Investigative ophthalmology & visual science
Bucher F,Aguilar E,Marra KV,Rapp J,Arnold J,Diaz-Aguilar S,Lange C,Agostini H,Schlunck G,Stahl A,Friedlander M
250-16 was used in In vivo experiments to investigate the effects of of ciliary neurotrophic factor on outer retinal and choroidal angiogenesis and the mechanisms underpinning any changes in outer retinal neovascularisation following this treatment.
Mon Aug 03 00:00:00 EDT 2020
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.
Nature communications
Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T
Fri Mar 20 00:00:00 EDT 2020
Cytotoxic T cells swarm by homotypic chemokine signalling.
eLife
Galeano Niño JL,Pageon SV,Tay SS,Colakoglu F,Kempe D,Hywood J,Mazalo JK,Cremasco J,Govendir MA,Dagley LF,Hsu K,Rizzetto S,Zieba J,Rice G,Prior V,O'Neill GM,Williams RJ,Nisbet DR,Kramer B,Webb AI,Luciani F,Read MN,Biro M
Tue Oct 13 00:00:00 EDT 2020
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Cell
Benci JL,Johnson LR,Choa R,Xu Y,Qiu J,Zhou Z,Xu B,Ye D,Nathanson KL,June CH,Wherry EJ,Zhang NR,Ishwaran H,Hellmann MD,Wolchok JD,Kambayashi T,Minn AJ
Thu Aug 08 00:00:00 EDT 2019
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.
Cell
Benci JL,Johnson LR,Choa R,Xu Y,Qiu J,Zhou Z,Xu B,Ye D,Nathanson KL,June CH,Wherry EJ,Zhang NR,Ishwaran H,Hellmann MD,Wolchok JD,Kambayashi T,Minn AJ
Thu Aug 08 00:00:00 EDT 2019
Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.
The Journal of experimental medicine
Takamura S,Kato S,Motozono C,Shimaoka T,Ueha S,Matsuo K,Miyauchi K,Masumoto T,Katsushima A,Nakayama T,Tomura M,Matsushima K,Kubo M,Miyazawa M
Mon Dec 02 00:00:00 EST 2019
CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults.
Scientific reports
Joutoku Z,Onodera T,Matsuoka M,Homan K,Momma D,Baba R,Hontani K,Hamasaki M,Matsubara S,Hishimura R,Iwasaki N
Tue Mar 26 00:00:00 EDT 2019
Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Grau M,Valsesia S,Mafille J,Djebali S,Tomkowiak M,Mathieu AL,Laubreton D,de Bernard S,Jouve PE,Ventre E,Buffat L,Walzer T,Leverrier Y,Marvel J
Tue May 15 00:00:00 EDT 2018
C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10.
Journal of cellular and molecular medicine
Mödinger Y,Rapp A,Pazmandi J,Vikman A,Holzmann K,Haffner-Luntzer M,Huber-Lang M,Ignatius A
Sat Dec 01 00:00:00 EST 2018
FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression.
BioMed research international
Lv ZT,Liang S,Chen K,Zhang JM,Cheng P,Guo JC,Yang Q,Zhou CH,Liao H,Chen AM
250-16 was used in Sin vitro experiments to investigate the role and mechanisms of FNDC4 in osteoclast differentiation.
Mon Jan 14 00:00:00 EST 2019
Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.
The Journal of clinical investigation
Koyanagi N,Imai T,Shindo K,Sato A,Fujii W,Ichinohe T,Takemura N,Kakuta S,Uematsu S,Kiyono H,Maruzuru Y,Arii J,Kato A,Kawaguchi Y
Mon Oct 02 00:00:00 EDT 2017
A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A
Mon Dec 04 00:00:00 EST 2017
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Scientific reports
Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S
Tue Jun 27 00:00:00 EDT 2017
Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy.
Scientific reports
Yagawa Y,Robertson-Tessi M,Zhou SL,Anderson ARA,Mulé JJ,Mailloux AW
Wed Nov 22 00:00:00 EST 2017
C-X-C motif chemokine ligand 10 produced by mouse Sertoli cells in response to mumps virus infection induces male germ cell apoptosis.
Cell death & disease
Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D
Thu Oct 26 00:00:00 EDT 2017
pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.
The Journal of experimental medicine
Ozga AJ,Moalli F,Abe J,Swoger J,Sharpe J,Zehn D,Kreutzfeldt M,Merkler D,Ripoll J,Stein JV
Mon Nov 14 00:00:00 EST 2016
Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.
Journal of immunology (Baltimore, Md. : 1950)
Chheda ZS,Sharma RK,Jala VR,Luster AD,Haribabu B
Thu Sep 01 00:00:00 EDT 2016
CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.
Nature communications
Shin H,Kumamoto Y,Gopinath S,Iwasaki A
Wed Nov 09 00:00:00 EST 2016
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release.
Immunity
Komarowska I,Coe D,Wang G,Haas R,Mauro C,Kishore M,Cooper D,Nadkarni S,Fu H,Steinbruchel DA,Pitzalis C,Anderson G,Bucy P,Lombardi G,Breckenridge R,Marelli-Berg FM
Tue Jun 16 00:00:00 EDT 2015
PTEN regulates natural killer cell trafficking in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Leong JW,Schneider SE,Sullivan RP,Parikh BA,Anthony BA,Singh A,Jewell BA,Schappe T,Wagner JA,Link DC,Yokoyama WM,Fehniger TA
Tue Feb 17 00:00:00 EST 2015
CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.
Journal of immunology (Baltimore, Md. : 1950)
Elgueta R,Marks E,Nowak E,Menezes S,Benson M,Raman VS,Ortiz C,O'Connell S,Hess H,Lord GM,Noelle R
Thu Jan 15 00:00:00 EST 2015
Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma.
Cell death & disease
Ha Y,Liu H,Xu Z,Yokota H,Narayanan SP,Lemtalsi T,Smith SB,Caldwell RW,Caldwell RB,Zhang W
Thu Oct 08 00:00:00 EDT 2015
The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages.
Journal of immunology (Baltimore, Md. : 1950)
Drennan MB,Govindarajan S,De Wilde K,Schlenner SM,Ware C,Nedospasov S,Rodewald HR,Elewaut D
Mon Dec 15 00:00:00 EST 2014
IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation.
Journal of immunology (Baltimore, Md. : 1950)
Fulkerson PC,Schollaert KL,Bouffi C,Rothenberg ME
Wed Oct 15 00:00:00 EDT 2014
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
Fri Mar 14 00:00:00 EDT 2014
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.
The Journal of cell biology
Liou GY,Döppler H,Necela B,Krishna M,Crawford HC,Raimondo M,Storz P
Mon Aug 05 00:00:00 EDT 2013
CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool.
Journal of immunology (Baltimore, Md. : 1950)
Peperzak V,Veraar EA,Xiao Y,Babala N,Thiadens K,Brugmans M,Borst J
Sun Sep 15 00:00:00 EDT 2013
IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection.
Journal of immunology (Baltimore, Md. : 1950)
Gwyer Findlay E,Villegas-Mendez A,de Souza JB,Inkson CA,Shaw TN,Saris CJ,Hunter CA,Riley EM,Couper KN
Wed May 01 00:00:00 EDT 2013
Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Wei J,Xia S,Sun H,Zhang S,Wang J,Zhao H,Wu X,Chen X,Hao J,Zhou X,Zhu Z,Gao X,Gao JX,Wang P,Wu Z,Zhao L,Yin Z
Mon Jul 01 00:00:00 EDT 2013
A vaccine strategy that protects against genital herpes by establishing local memory T cells.
Nature
Shin H,Iwasaki A
Thu Nov 15 00:00:00 EST 2012
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.
The Journal of experimental medicine
Hyun YM,Sumagin R,Sarangi PP,Lomakina E,Overstreet MG,Baker CM,Fowell DJ,Waugh RE,Sarelius IH,Kim M
Mon Jul 02 00:00:00 EDT 2012
A novel NKR-P1B(bright) NK cell subset expresses an activated CD25(+)CX(3)CR1(+)CD62L(-)CD11b(-)CD27(-) phenotype and is prevalent in blood, liver, and gut-associated lymphoid organs of rats.
Journal of immunology (Baltimore, Md. : 1950)
Inngjerdingen M,Kveberg L,Vaage JT
Thu Mar 15 00:00:00 EDT 2012
Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.
PloS one
Kishore M,Ma L,Cornish G,Nourshargh S,Marelli-Berg FM
Wed Dec 12 00:00:00 EST 2012
Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells.
PloS one
Liang YJ,Luo J,Lu Q,Zhou Y,Wu HW,Zheng D,Ren YY,Sun KY,Wang Y,Zhang ZS
Mon Feb 11 00:00:00 EST 2013
Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.
The Journal of experimental medicine
Kurachi M,Kurachi J,Suenaga F,Tsukui T,Abe J,Ueha S,Tomura M,Sugihara K,Takamura S,Kakimi K,Matsushima K
Mon Aug 01 00:00:00 EDT 2011
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.
The Journal of clinical investigation
Jiang D,Liang J,Campanella GS,Guo R,Yu S,Xie T,Liu N,Jung Y,Homer R,Meltzer EB,Li Y,Tager AM,Goetinck PF,Luster AD,Noble PW
Tue Jun 01 00:00:00 EDT 2010
CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.
The Journal of experimental medicine
Zhou J,Tang PC,Qin L,Gayed PM,Li W,Skokos EA,Kyriakides TR,Pober JS,Tellides G
Mon Aug 30 00:00:00 EDT 2010
Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection.
PLoS pathogens
Crawford MA,Burdick MD,Glomski IJ,Boyer AE,Barr JR,Mehrad B,Strieter RM,Hughes MA
Thu Nov 18 00:00:00 EST 2010
Resistance to dengue virus infection in mice is potentiated by CXCL10 and is independent of CXCL10-mediated leukocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Ip PP,Liao F
Sat May 15 00:00:00 EDT 2010
Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Buatois V,Fagète S,Magistrelli G,Chatel L,Fischer N,Kosco-Vilbois MH,Ferlin WG
Sun Aug 15 00:00:00 EDT 2010
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
Blood
David R,Ma L,Ivetic A,Takesono A,Ridley AJ,Chai JG,Tybulewicz VL,Marelli-Berg FM
Thu Apr 16 00:00:00 EDT 2009
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.
Proceedings of the National Academy of Sciences of the United States of America
Saudemont A,Garçon F,Yadi H,Roche-Molina M,Kim N,Segonds-Pichon A,Martín-Fontecha A,Okkenhaug K,Colucci F
Tue Apr 07 00:00:00 EDT 2009
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.
Journal of immunology (Baltimore, Md. : 1950)
Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N
Wed Jul 01 00:00:00 EDT 2009
The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections.
Immunity
Kohlmeier JE,Miller SC,Smith J,Lu B,Gerard C,Cookenham T,Roberts AD,Woodland DL
Fri Jul 18 00:00:00 EDT 2008
T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.
The Journal of clinical investigation
Jarmin SJ,David R,Ma L,Chai JG,Dewchand H,Takesono A,Ridley AJ,Okkenhaug K,Marelli-Berg FM
Sat Mar 01 00:00:00 EST 2008
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
Proceedings of the National Academy of Sciences of the United States of America
Zhu Q,Egelston C,Vivekanandhan A,Uematsu S,Akira S,Klinman DM,Belyakov IM,Berzofsky JA
Tue Oct 21 00:00:00 EDT 2008
Structure and function of A41, a vaccinia virus chemokine binding protein.
PLoS pathogens
Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM
Tue Jan 01 00:00:00 EST 2008
Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.
Cancer biology & therapy
Benencia F,Courrèges MC,Fraser NW,Coukos G
250-16 was used in Enzyme-linked immunosorbent assay to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.
Fri Aug 01 00:00:00 EDT 2008
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.
Journal of immune based therapies and vaccines
Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW
Tue Oct 28 00:00:00 EDT 2008
NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria.
Journal of immunology (Baltimore, Md. : 1950)
Hansen DS,Bernard NJ,Nie CQ,Schofield L
Tue May 01 00:00:00 EDT 2007
Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
The Journal of biological chemistry
Thompson BD,Jin Y,Wu KH,Colvin RA,Luster AD,Birnbaumer L,Wu MX
Fri Mar 30 00:00:00 EDT 2007
Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate.
Journal of immunology (Baltimore, Md. : 1950)
Chen JP,Lu HL,Lai SL,Campanella GS,Sung JM,Lu MY,Wu-Hsieh BA,Lin YL,Lane TE,Luster AD,Liao F
Fri Sep 01 00:00:00 EDT 2006
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine
Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ
Mon Jun 20 00:00:00 EDT 2005
Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes.
Cancer research
Kawada K,Sonoshita M,Sakashita H,Takabayashi A,Yamaoka Y,Manabe T,Inaba K,Minato N,Oshima M,Taketo MM
Tue Jun 01 00:00:00 EDT 2004
Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity.
Immunity
Wildbaum G,Nahir MA,Karin N
Sat Nov 01 00:00:00 EST 2003
CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Michalec L,Choudhury BK,Postlethwait E,Wild JS,Alam R,Lett-Brown M,Sur S
Tue Jan 15 00:00:00 EST 2002
