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Product Details
PMC1081
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Expression System
E. coli
Molecular weight
8.7 kDa
Class
Recombinant
Type
Protein
Purity
>95% by SDS-PAGE
Endotoxin concentration
<0.1 ng/µg
Activity
ED50 < 100 ng/mL; determined by the dose-dependent chemotaxis of human lymphocytes cultured in the presence of IL-2.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Wet ice (domestic); Wet or Dry ice (international)
Product Specific Information
Carrier-Free
Reconstitution: We recommend that the vial be briefly centrifuged prior to opening to bring the contents to the bottom. Mouse IP-10 should be dissolved in sterile, distilled water to a concentration of 0.1-1.0 mg/mL. Mouse IP-10 is also soluble in most buffered solutions. Stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilutions should be made in low endotoxin medium or buffered solution with FBS or tissue culture grade BSA. Storage: Lyophilized mouse IP-10 should be stored at 2-8°C preferably desiccated. Following reconstitution, apportion into working aliquots and store at ≤-20⪚C. Avoid repeated freeze-thaw cycles.
Target Information
IP-10 (interferon-gamma induced protein 10 kD; in mouse, also called cytokine responsive gene 2, Crg-2, or mob-1) is a highly inducible, primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 1985. The biological functions of IP-10 are still unclear. Like Mig, IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor, CXCR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 10 kDa interferon gamma-induced protein; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 10; C7; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; Gamma-IP10; H-IP-10; interferon activated gene 10; Interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; M-IP-10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; Small-inducible cytokine B10
Gene Aliases: C7; CRG-2; Crg2; Cxcl10; gIP-10; Ifi10; INP10; IP-10; IP10; mob-1; Scyb10
UniProt ID: (Mouse) P17515
Entrez Gene ID: (Mouse) 15945
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