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Product Details
250-29-20UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Published species
Bacteria,
Human,
Mouse,
Non-human primate
Expression System
E. coli
Amino acid sequence
FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM
Molecular weight
9 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to chemoattract murine CXCR3-transfected HEK293 cells using a concentration range of 10.0-100.0 ng/ml.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Murine I-TAC is a 9.0 kDa protein containing 79 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
Interferon-inducible T-cell alpha chemoattractant ( I-TAC), belonging to the CXC chemokine family, is expressed in peripheral blood leukocytes, pancreas and liver, thymus, spleen, lung, small intestine, placenta and prostate. Its molecular weight is 8-11 kD. I-TAC is also known as CXCL-11 and IP-9. The cytokine is involved in regulating calcium release and inducing a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. It is upregulated in patients with AIDS, dementia and in patients with multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 11; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; I-TAC; Interferon-inducible T-cell alpha chemoattractant; MGC102770; small inducible cytokine subfamily B (Cys-X-Cys), member 11; Small-inducible cytokine B11
Gene Aliases: b-R1; betaR1; Cxc11; Cxcl11; H174; I-tac; Ip9; Itac; Scyb11; Scyb9b
UniProt ID: (Mouse) Q9JHH5
Entrez Gene ID: (Mouse) 56066
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