Product References
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.
Mucosal immunology
Nagatake T,Kishino S,Urano E,Murakami H,Kitamura N,Konishi K,Ohno H,Tiwari P,Morimoto S,Node E,Adachi J,Abe Y,Isoyama J,Sawane K,Honda T,Inoue A,Uwamizu A,Matsuzaka T,Miyamoto Y,Hirata SI,Saika A,Shibata Y,Hosomi K,Matsunaga A,Shimano H,Arita M,Aoki J,Oka M,Matsutani A,Tomonaga T,Kabashima K,Miyachi M,Yasutomi Y,Ogawa J,Kunisawa J
Tue Feb 01 00:00:00 EST 2022
Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway.
Journal of neuroinflammation
Fang Y,Ding X,Zhang Y,Cai L,Ge Y,Ma K,Xu R,Li S,Song M,Zhu H,Liu J,Ding J,Lu M,Hu G
211-11A was used in Cell Culture to investigate the precise interactions between fluoxetine and 5-HT2B receptor.
Sat Jan 29 00:00:00 EST 2022
Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop.
The EMBO journal
Draberova H,Janusova S,Knizkova D,Semberova T,Pribikova M,Ujevic A,Harant K,Knapkova S,Hrdinka M,Fanfani V,Stracquadanio G,Drobek A,Ruppova K,Stepanek O,Draber P
Tue Sep 01 00:00:00 EDT 2020
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α.
Journal of immunology (Baltimore, Md. : 1950)
Martin P,Palmer G,Rodriguez E,Palomo J,Lemeille S,Goldstein J,Gabay C
Sat Feb 15 00:00:00 EST 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.
Nature communications
Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T
Fri Mar 20 00:00:00 EDT 2020
Type I interferon induces CXCL13 to support ectopic germinal center formation.
The Journal of experimental medicine
Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA
Mon Mar 04 00:00:00 EST 2019
IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners.
Nature communications
Wang P,Gamero AM,Jensen LE
Wed Oct 16 00:00:00 EDT 2019
CNS-resident classical DCs play a critical role in CNS autoimmune disease.
The Journal of clinical investigation
Giles DA,Duncker PC,Wilkinson NM,Washnock-Schmid JM,Segal BM
Mon Dec 03 00:00:00 EST 2018
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
PLoS biology
Zhao J,Zhang L,Mu X,Doebelin C,Nguyen W,Wallace C,Reay DP,McGowan SJ,Corbo L,Clemens PR,Wilson GM,Watkins SC,Solt LA,Cameron MD,Huard J,Niedernhofer LJ,Kamenecka TM,Robbins PD
211-11A was used in Cell Culture to demonstrate that chronic treatment of a mouse model of Duchenne muscular dystrophy with two optimized lead NBD mimetics, attenuated inflammatory infiltration, necrosis and muscle degeneration, suggesting they are potential therapeutics for inflammatory and degenerative diseases.
Fri Jun 01 00:00:00 EDT 2018
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
211-11A was used in Cell Culture to genetically investigate the role of the interleukin-1 receptor 1 pathway in breast cancer tumourigenesis and metastasis using a mouse model.
Tue Jan 12 00:00:00 EST 2021
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
Wed Apr 01 00:00:00 EDT 2015
Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Bourdeaux C,Lurquin C,Jacquemart I,Lethé B,Brasseur F,van Baren N,Baurain JF,Dyson J,Van Snick J,Uyttenhove C,Boon T
Tue Mar 04 00:00:00 EST 2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M
Tue Dec 30 00:00:00 EST 2014
Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ikeda S,Saijo S,Murayama MA,Shimizu K,Akitsu A,Iwakura Y
Sat Feb 15 00:00:00 EST 2014
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
Wed Mar 06 00:00:00 EST 2013
O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release.
The EMBO journal
Pathak S,Borodkin VS,Albarbarawi O,Campbell DG,Ibrahim A,van Aalten DM
Wed Mar 21 00:00:00 EDT 2012
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Ramon HE,Beal AM,Liu Y,Worthen GS,Oliver PM
Sun Apr 15 00:00:00 EDT 2012
Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Matzinger P
Fri Jun 15 00:00:00 EDT 2012
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K
Sat Jan 15 00:00:00 EST 2011
Co-administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG.
PloS one
Singh V,Jain S,Gowthaman U,Parihar P,Gupta P,Gupta UD,Agrewala JN
Wed Jan 19 00:00:00 EST 2011
The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.
BMC immunology
Sprague L,Muccioli M,Pate M,Meles E,McGinty J,Nandigam H,Venkatesh AK,Gu MY,Mansfield K,Rutowski A,Omosebi O,Courreges MC,Benencia F
Mon Jun 06 00:00:00 EDT 2011
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Nature
Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H
Thu Apr 29 00:00:00 EDT 2010
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Journal of immunology (Baltimore, Md. : 1950)
Tan C,Aziz MK,Lovaas JD,Vistica BP,Shi G,Wawrousek EF,Gery I
Wed Dec 01 00:00:00 EST 2010
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Journal of immunology (Baltimore, Md. : 1950)
Tan C,Aziz MK,Lovaas JD,Vistica BP,Shi G,Wawrousek EF,Gery I
Wed Dec 01 00:00:00 EST 2010
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Immunity
Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL
Fri Oct 16 00:00:00 EDT 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 EDT 2009
Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Maue AC,Eaton SM,Lanthier PA,Sweet KB,Blumerman SL,Haynes L
Fri May 15 00:00:00 EDT 2009
Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Li Z,Mao K,Zou J,Wang Y,Tao Z,Lin G,Tian L,Ji Y,Wu X,Zhu X,Sun S,Chen W,Xiang C,Sun B
Sun Nov 15 00:00:00 EST 2009
Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death.
Journal of immunology (Baltimore, Md. : 1950)
Shi G,Ramaswamy M,Vistica BP,Cox CA,Tan C,Wawrousek EF,Siegel RM,Gery I
Tue Dec 01 00:00:00 EST 2009
Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.
The Journal of biological chemistry
Lee JH,Kim HN,Yang D,Jung K,Kim HM,Kim HH,Ha H,Lee ZH
Fri May 15 00:00:00 EDT 2009
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation.
The Journal of biological chemistry
Martinez GJ,Zhang Z,Chung Y,Reynolds JM,Lin X,Jetten AM,Feng XH,Dong C
Fri Dec 18 00:00:00 EST 2009
Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells.
Journal of immunology (Baltimore, Md. : 1950)
Shi G,Cox CA,Vistica BP,Tan C,Wawrousek EF,Gery I
Sat Nov 15 00:00:00 EST 2008
