Product References
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
The Journal of experimental medicine
Evrard M,Wynne-Jones E,Peng C,Kato Y,Christo SN,Fonseca R,Park SL,Burn TN,Osman M,Devi S,Chun J,Mueller SN,Kannourakis G,Berzins SP,Pellicci DG,Heath WR,Jameson SC,Mackay LK
Mon Jan 03 00:00:00 EST 2022
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.
Cancer immunology research
Gil Del Alcazar CR,Trinh A,Alečković M,Rojas Jimenez E,Harper NW,Oliphant MUJ,Xie S,Krop ED,Lulseged B,Murphy KC,Keenan TE,Van Allen EM,Tolaney SM,Freeman GJ,Dillon DA,Muthuswamy SK,Polyak K
210-15 was used in Tissue/organ culture to address how there are no good murine models of estrogen receptor-positive (ER+) breast cancer and demonstrate that Nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats recapitulate the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.
Fri Jun 03 00:00:00 EDT 2022
NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division.
International journal of cancer
Borst L,Sluijter M,Sturm G,Charoentong P,Santegoets SJ,van Gulijk M,van Elsas MJ,Groeneveldt C,van Montfoort N,Finotello F,Trajanoski Z,Kiełbasa SM,van der Burg SH,van Hall T
Tue Feb 15 00:00:00 EST 2022
Natural killer cells act as an extrinsic barrier for in vivo reprogramming.
Development (Cambridge, England)
Melendez E,Chondronasiou D,Mosteiro L,Martínez de Villarreal J,Fernández-Alfara M,Lynch CJ,Grimm D,Real FX,Alcamí J,Climent N,Pietrocola F,Serrano M
210-15 was used in Cell Culture to demonstrate that in vivo reprogramming of cells is significantly impeded by NK cells.
Fri Apr 15 00:00:00 EDT 2022
MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Hope JL,Zhao M,Stairiker CJ,Kiernan CH,Carey AJ,Mueller YM,van Meurs M,Brouwers-Haspels I,Otero DC,Bae EA,Faso HA,Maas A,de Looper H,Fortina PM,Rigoutsos I,Bradley LM,Erkeland SJ,Katsikis PD
Tue Feb 01 00:00:00 EST 2022
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling.
Stem cell reports
Plana-Carmona M,Stik G,Bulteau R,Segura-Morales C,Alcázar N,Wyatt CDR,Klonizakis A,de Andrés-Aguayo L,Gasnier M,Tian TV,Torcal Garcia G,Vila-Casadesús M,Plachta N,Serrano M,Francesconi M,Graf T
210-15 was used in Cell Culture to describe that IL-6 is necessary for C/EBPα-enhanced reprogramming of B cells into iPSCs.
Tue Sep 13 00:00:00 EDT 2022
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
Thu Mar 04 00:00:00 EST 2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
Thu Mar 04 00:00:00 EST 2021
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.
Cell research
Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B
Fri Oct 01 00:00:00 EDT 2021
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Mon Jun 07 00:00:00 EDT 2021
The SIRPα-CD47 immune checkpoint in NK cells.
The Journal of experimental medicine
Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S
Mon Mar 01 00:00:00 EST 2021
Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
Proceedings of the National Academy of Sciences of the United States of America
Ducimetière L,Lucchiari G,Litscher G,Nater M,Heeb L,Nuñez NG,Wyss L,Burri D,Vermeer M,Gschwend J,Moor AE,Becher B,van den Broek M,Tugues S
Tue Jul 06 00:00:00 EDT 2021
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
Proceedings of the National Academy of Sciences of the United States of America
O'Sullivan D,Stanczak MA,Villa M,Uhl FM,Corrado M,Klein Geltink RI,Sanin DE,Apostolova P,Rana N,Edwards-Hicks J,Grzes KM,Kabat AM,Kyle RL,Fabri M,Curtis JD,Buck MD,Patterson AE,Regina A,Field CS,Baixauli F,Puleston DJ,Pearce EJ,Zeiser R,Pearce EL
Tue Jun 22 00:00:00 EDT 2021
TRAM-Related TLR4 Pathway Antagonized by IRAK-M Mediates the Expression of Adhesion/Coactivating Molecules on Low-Grade Inflammatory Monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Pradhan K,Geng S,Zhang Y,Lin RC,Li L
Tue Jun 15 00:00:00 EDT 2021
Purinergic Receptor P2Y6 Is a Negative Regulator of NK Cell Maturation and Function.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Gao Y,He C,Wei H,Zhang J,Zhang H,Hu L,Jiang W
Wed Sep 15 00:00:00 EDT 2021
Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative CARD11 Allele.
Journal of immunology (Baltimore, Md. : 1950)
Hutcherson SM,Bedsaul JR,Pomerantz JL
210-15 was used in Sample Preparation (Western Blotting) to study how the heterozygous dominant negative CARD11 allele leads to the development of the CADINS-specific cluster of symptoms including espiratory and skin infections, asthma, allergies, and atopic dermatitis.
Sun Aug 15 00:00:00 EDT 2021
Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative CARD11 Allele.
Journal of immunology (Baltimore, Md. : 1950)
Hutcherson SM,Bedsaul JR,Pomerantz JL
210-15 was used in Sample Preparation (Western Blotting) to study how the heterozygous dominant negative CARD11 allele leads to the development of the CADINS-specific cluster of symptoms including espiratory and skin infections, asthma, allergies, and atopic dermatitis.
Sun Aug 15 00:00:00 EDT 2021
Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models.
BioMed research international
Miao M,Masengere H,Yu G,Shan F
Thu Jan 20 00:00:00 EST 2022
Genetic engineering of human and mouse CD4+ and CD8+ Tregs using lentiviral vectors encoding chimeric antigen receptors.
Molecular therapy. Methods & clinical development
Vimond N,Lasselin J,Anegon I,Guillonneau C,Bézie S
Fri Mar 12 00:00:00 EST 2021
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells.
Nature communications
Song H,Song J,Cheng M,Zheng M,Wang T,Tian S,Flavell RA,Zhu S,Li HB,Ding C,Wei H,Sun R,Peng H,Tian Z
Fri Sep 17 00:00:00 EDT 2021
Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Cell reports
Menzel L,Zschummel M,Crowley T,Franke V,Grau M,Ulbricht C,Hauser A,Siffrin V,Bajénoff M,Acton SE,Akalin A,Lenz G,Willimsky G,Höpken UE,Rehm A
Tue Oct 26 00:00:00 EDT 2021
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Nature communications
Bunse M,Pfeilschifter J,Bluhm J,Zschummel M,Joedicke JJ,Wirges A,Stark H,Kretschmer V,Chmielewski M,Uckert W,Abken H,Westermann J,Rehm A,Höpken UE
Mon Jan 11 00:00:00 EST 2021
Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
Nature communications
Tao H,Pan Y,Chu S,Li L,Xie J,Wang P,Zhang S,Reddy S,Sleasman JW,Zhong XP
210-15 was used in In vivo experiments to demonstrate that IL-2/IL-15 receptor β chain and inducible costimulatory (ICOS) not only serve as lineage-specific markers for IFN-γ-producing MAIT1 and IL-17A-producing MAIT17 cells, but are also important for their differentiation, respectively.
Thu Apr 01 00:00:00 EDT 2021
HIF1α is required for NK cell metabolic adaptation during virus infection.
eLife
Victorino F,Bigley TM,Park E,Yao CH,Benoit J,Yang LP,Piersma SJ,Lauron EJ,Davidson RM,Patti GJ,Yokoyama WM
210-15 was used in Cell Culture to show that NK cells require HIF1α-dependent metabolic functions to repress Bim expression and sustain cell numbers for an optimal virus response.
Mon Aug 16 00:00:00 EDT 2021
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.
Blood
Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR
Thu Dec 24 00:00:00 EST 2020
Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.
The Journal of experimental medicine
Raynor JL,Liu C,Dhungana Y,Guy C,Chapman NM,Shi H,Neale G,Sesaki H,Chi H
Mon Jun 01 00:00:00 EDT 2020
PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
The EMBO journal
Wiede F,Lu KH,Du X,Liang S,Hochheiser K,Dodd GT,Goh PK,Kearney C,Meyran D,Beavis PA,Henderson MA,Park SL,Waithman J,Zhang S,Zhang ZY,Oliaro J,Gebhardt T,Darcy PK,Tiganis T
Wed Jan 15 00:00:00 EST 2020
CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis.
The EMBO journal
Martín-Leal A,Blanco R,Casas J,Sáez ME,Rodríguez-Bovolenta E,de Rojas I,Drechsler C,Real LM,Fabrias G,Ruíz A,Castro M,Schamel WW,Alarcón B,van Santen HM,Mañes S
Mon Aug 03 00:00:00 EDT 2020
Non-apoptotic TRAIL function modulates NK cell activity during viral infection.
EMBO reports
Cardoso Alves L,Berger MD,Koutsandreas T,Kirschke N,Lauer C,Spörri R,Chatziioannou A,Corazza N,Krebs P
Tue Jan 07 00:00:00 EST 2020
Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.
PLoS pathogens
Zhao M,Kiernan CH,Stairiker CJ,Hope JL,Leon LG,van Meurs M,Brouwers-Haspels I,Boers R,Boers J,Gribnau J,van IJcken WFJ,Bindels EM,Hoogenboezem RM,Erkeland SJ,Mueller YM,Katsikis PD
210-15 was used in Cell Culture to study how repeat stimulation of purified TCR transgenic OT-I cytotoxic CD8+ T cells (CTL) with their specific peptide induces all the functional (reduced cytokine production and polyfunctionality, decreased in vivo expansion capacity) and phenotypic (increased inhibitory receptors expression and transcription factor changes) characteristics of exhaustion.
Mon Jun 01 00:00:00 EDT 2020
A TLR7 agonist strengthens T and NK cell function during BRAF-targeted therapy in a preclinical melanoma model.
International journal of cancer
Bellmann L,Cappellano G,Schachtl-Riess JF,Prokopi A,Seretis A,Ortner D,Tripp CH,Brinckerhoff CE,Mullins DW,Stoitzner P
Sun Mar 01 00:00:00 EST 2020
PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Xu X,Zhou Y,Fu B,Zhang J,Dong Z,Zhang X,Shen N,Sun R,Tian Z,Wei H
Fri May 01 00:00:00 EDT 2020
Differentiation of c-Kit+ CD24+ natural killer cells into myeloid cells in a GATA-2-dependent manner.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Song B,Lee JM,Park YJ,Kim IK,Kim BS,Shin KS,Jeon I,Koh CH,Bae EA,Seo H,Byun Y,Kang CY
Sun Mar 01 00:00:00 EST 2020
p53 Hinders CRISPR/Cas9-Mediated Targeted Gene Disruption in Memory CD8 T Cells In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Kurup SP,Moioffer SJ,Pewe LL,Harty JT
Thu Oct 15 00:00:00 EDT 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 EST 2020
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Oba T,Hoki T,Yamauchi T,Keler T,Marsh HC,Cao X,Ito F
Thu Oct 01 00:00:00 EDT 2020
DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering.
Journal of immunology (Baltimore, Md. : 1950)
Mahajan VS,Demissie E,Alsufyani F,Kumari S,Yuen GJ,Viswanadham V,Huang A,Tran JQ,Moon JJ,Irvine DJ,Pillai S
Wed Jan 01 00:00:00 EST 2020
Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Sun Y,Preiss NK,Valenteros KB,Kamal Y,Usherwood YK,Frost HR,Usherwood EJ
Sun Nov 15 00:00:00 EST 2020
IFNs Drive Development of Novel IL-15-Responsive Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gordon SM,Nishiguchi MA,Chase JM,Mani S,Mainigi MA,Behrens EM
Sat Aug 15 00:00:00 EDT 2020
The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Keller HR,Kim HK,Jo Y,Gress RE,Hong C,Park JH
Mon Jun 15 00:00:00 EDT 2020
Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8+ Thymocyte Population.
Journal of immunology (Baltimore, Md. : 1950)
Daams R,Sime W,Leandersson K,Sitnicka E,Massoumi R
Thu Oct 01 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Mon May 04 00:00:00 EDT 2020
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice.
Nature communications
Bank U,Deiser K,Plaza-Sirvent C,Osbelt L,Witte A,Knop L,Labrenz R,Jänsch R,Richter F,Biswas A,Zenclussen AC,Vivier E,Romagnani C,Kühl AA,Dunay IR,Strowig T,Schmitz I,Schüler T
Wed Feb 26 00:00:00 EST 2020
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.
Nature communications
Vokali E,Yu SS,Hirosue S,Rinçon-Restrepo M,V Duraes F,Scherer S,Corthésy-Henrioud P,Kilarski WW,Mondino A,Zehn D,Hugues S,Swartz MA
Mon Jan 27 00:00:00 EST 2020
Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells.
Nature communications
Belabed M,Mauvais FX,Maschalidi S,Kurowska M,Goudin N,Huang JD,Fischer A,de Saint Basile G,van Endert P,Sepulveda FE,Ménasché G
Tue Apr 14 00:00:00 EDT 2020
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
Scientific reports
Mullins GN,Valentine KM,Al-Kuhlani M,Davini D,Jensen KDC,Hoyer KK
Tue Dec 15 00:00:00 EST 2020
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells.
Immunity
Ma EH,Verway MJ,Johnson RM,Roy DG,Steadman M,Hayes S,Williams KS,Sheldon RD,Samborska B,Kosinski PA,Kim H,Griss T,Faubert B,Condotta SA,Krawczyk CM,DeBerardinis RJ,Stewart KM,Richer MJ,Chubukov V,Roddy TP,Jones RG
Tue Nov 19 00:00:00 EST 2019
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Immunity
Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA
Tue Sep 17 00:00:00 EDT 2019
Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.
Immunity
Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR
Tue Jun 18 00:00:00 EDT 2019
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.
The Journal of experimental medicine
Vetters J,van Helden MJ,Wahlen S,Tavernier SJ,Martens A,Fayazpour F,Vergote K,Vanheerswynghels M,Deswarte K,Van Moorleghem J,De Prijck S,Takahashi N,Vandenabeele P,Boon L,van Loo G,Vivier E,Lambrecht BN,Janssens S
Mon Sep 02 00:00:00 EDT 2019
Inducible down-regulation of MHC class I results in natural killer cell tolerance.
The Journal of experimental medicine
Bern MD,Parikh BA,Yang L,Beckman DL,Poursine-Laurent J,Yokoyama WM
Mon Jan 07 00:00:00 EST 2019
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.
Nature communications
Niogret C,Miah SMS,Rota G,Fonta NP,Wang H,Held W,Birchmeier W,Sexl V,Yang W,Vivier E,Ho PC,Brossay L,Guarda G
Fri Mar 29 00:00:00 EDT 2019
Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells.
eLife
Park E,Patel S,Wang Q,Andhey P,Zaitsev K,Porter S,Hershey M,Bern M,Plougastel-Douglas B,Collins P,Colonna M,Murphy KM,Oltz E,Artyomov M,Sibley LD,Yokoyama WM
210-15 was used in In vitro experiments to explore apparently permanent transformation of NK cells into ILC1-like cells in the Toxoplasma gondii infection.
Thu Aug 08 00:00:00 EDT 2019
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
Journal for immunotherapy of cancer
Miret JJ,Kirschmeier P,Koyama S,Zhu M,Li YY,Naito Y,Wu M,Malladi VS,Huang W,Walker W,Palakurthi S,Dranoff G,Hammerman PS,Pecot CV,Wong KK,Akbay EA
210-15 was used in Cell Culture to suggest arginase as an immunomodulatory target that should further be investigated in lung tumors with high arginase activity.
Wed Feb 06 00:00:00 EST 2019
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Immunity
Herndler-Brandstetter D,Ishigame H,Shinnakasu R,Plajer V,Stecher C,Zhao J,Lietzenmayer M,Kroehling L,Takumi A,Kometani K,Inoue T,Kluger Y,Kaech SM,Kurosaki T,Okada T,Flavell RA
Tue Apr 17 00:00:00 EDT 2018
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.
Immunity
Page N,Klimek B,De Roo M,Steinbach K,Soldati H,Lemeille S,Wagner I,Kreutzfeldt M,Di Liberto G,Vincenti I,Lingner T,Salinas G,Brück W,Simons M,Murr R,Kaye J,Zehn D,Pinschewer DD,Merkler D
Tue May 15 00:00:00 EDT 2018
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.
The Journal of experimental medicine
Guan T,Dominguez CX,Amezquita RA,Laidlaw BJ,Cheng J,Henao-Mejia J,Williams A,Flavell RA,Lu J,Kaech SM
Mon Apr 02 00:00:00 EDT 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 EDT 2018
Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.
Proceedings of the National Academy of Sciences of the United States of America
Andreani V,Ramamoorthy S,Pandey A,Lupar E,Nutt SL,Lämmermann T,Grosschedl R
Tue Oct 09 00:00:00 EDT 2018
Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production.
Journal of immunology (Baltimore, Md. : 1950)
Seshadri S,Pope RL,Zenewicz LA
Wed Aug 15 00:00:00 EDT 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
Thu Feb 15 00:00:00 EST 2018
Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.
Journal of immunology (Baltimore, Md. : 1950)
Hu MD,Ethridge AD,Lipstein R,Kumar S,Wang Y,Jabri B,Turner JR,Edelblum KL
Sun Jul 15 00:00:00 EDT 2018
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.
Nature communications
Loftus RM,Assmann N,Kedia-Mehta N,O'Brien KL,Garcia A,Gillespie C,Hukelmann JL,Oefner PJ,Lamond AI,Gardiner CM,Dettmer K,Cantrell DA,Sinclair LV,Finlay DK
Thu Jun 14 00:00:00 EDT 2018
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.
Cell stem cell
Sardina JL,Collombet S,Tian TV,Gómez A,Di Stefano B,Berenguer C,Brumbaugh J,Stadhouders R,Segura-Morales C,Gut M,Gut IG,Heath S,Aranda S,Di Croce L,Hochedlinger K,Thieffry D,Graf T
210-15 was used in Cell Culture to report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs).
Thu Nov 01 00:00:00 EDT 2018
CDK4/6 inhibition triggers anti-tumour immunity.
Nature
Goel S,DeCristo MJ,Watt AC,BrinJones H,Sceneay J,Li BB,Khan N,Ubellacker JM,Xie S,Metzger-Filho O,Hoog J,Ellis MJ,Ma CX,Ramm S,Krop IE,Winer EP,Roberts TM,Kim HJ,McAllister SS,Zhao JJ
Thu Aug 24 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
210-15 was used in Sample Preparation (FC/FACS) to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
210-15 was used in Sample Preparation (FC/FACS) to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Mitochondrial Priming by CD28.
Cell
Klein Geltink RI,O'Sullivan D,Corrado M,Bremser A,Buck MD,Buescher JM,Firat E,Zhu X,Niedermann G,Caputa G,Kelly B,Warthorst U,Rensing-Ehl A,Kyle RL,Vandersarren L,Curtis JD,Patterson AE,Lawless S,Grzes K,Qiu J,Sanin DE,Kretz O,Huber TB,Janssens S,Lambrecht BN,Rambold AS,Pearce EJ,Pearce EL
Thu Oct 05 00:00:00 EDT 2017
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
210-15 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 EST 2017
Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection.
Immunity
Man K,Gabriel SS,Liao Y,Gloury R,Preston S,Henstridge DC,Pellegrini M,Zehn D,Berberich-Siebelt F,Febbraio MA,Shi W,Kallies A
Tue Dec 19 00:00:00 EST 2017
Inflammatory Ly6Chigh Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil Activation.
Immunity
Domínguez-Andrés J,Feo-Lucas L,Minguito de la Escalera M,González L,López-Bravo M,Ardavín C
Tue Jun 20 00:00:00 EDT 2017
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Cancer cell
Spranger S,Dai D,Horton B,Gajewski TF
Mon May 08 00:00:00 EDT 2017
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.
The Journal of clinical investigation
Widjaja CE,Olvera JG,Metz PJ,Phan AT,Savas JN,de Bruin G,Leestemaker Y,Berkers CR,de Jong A,Florea BI,Fisch K,Lopez J,Kim SH,Garcia DA,Searles S,Bui JD,Chang AN,Yates JR,Goldrath AW,Overkleeft HS,Ovaa H,Chang JT
Mon Oct 02 00:00:00 EDT 2017
Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Salerno F,Paolini NA,Stark R,von Lindern M,Wolkers MC
Tue Sep 05 00:00:00 EDT 2017
Absence of Grail promotes CD8+ T cell anti-tumour activity.
Nature communications
Haymaker C,Yang Y,Wang J,Zou Q,Sahoo A,Alekseev A,Singh D,Ritthipichai K,Hailemichael Y,Hoang ON,Qin H,Schluns KS,Wang T,Overwijk WW,Sun SC,Bernatchez C,Kwak LW,Neelapu SS,Nurieva R
Thu Aug 10 00:00:00 EDT 2017
IL-15 sustains IL-7R-independent ILC2 and ILC3 development.
Nature communications
Robinette ML,Bando JK,Song W,Ulland TK,Gilfillan S,Colonna M
Fri Mar 31 00:00:00 EDT 2017
Inflammasome-Dependent Induction of Adaptive NK Cell Memory.
Immunity
van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V
Tue Jun 21 00:00:00 EDT 2016
Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.
The Journal of experimental medicine
Guo H,Cranert SA,Lu Y,Zhong MC,Zhang S,Chen J,Li R,Mahl SE,Wu N,Davidson D,Waggoner SN,Veillette A
Mon Sep 19 00:00:00 EDT 2016
The aryl hydrocarbon receptor is required for the maintenance of liver-resident natural killer cells.
The Journal of experimental medicine
Zhang LH,Shin JH,Haggadone MD,Sunwoo JB
Mon Oct 17 00:00:00 EDT 2016
Unstable FoxP3+ T regulatory cells in NZW mice.
Proceedings of the National Academy of Sciences of the United States of America
Dépis F,Kwon HK,Mathis D,Benoist C
Tue Feb 02 00:00:00 EST 2016
Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.
Proceedings of the National Academy of Sciences of the United States of America
Rabacal W,Pabbisetty SK,Hoek KL,Cendron D,Guo Y,Maseda D,Sebzda E
Tue May 10 00:00:00 EDT 2016
Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.
The Journal of cell biology
Hecht VC,Sullivan LB,Kimmerling RJ,Kim DH,Hosios AM,Stockslager MA,Stevens MM,Kang JH,Wirtz D,Vander Heiden MG,Manalis SR
Mon Feb 15 00:00:00 EST 2016
IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Goplen NP,Saxena V,Knudson KM,Schrum AG,Gil D,Daniels MA,Zamoyska R,Teixeiro E
Thu Sep 15 00:00:00 EDT 2016
Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Shifrin NT,Kissiov DU,Ardolino M,Joncker NT,Raulet DH
Tue Nov 15 00:00:00 EST 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
Fri Jan 15 00:00:00 EST 2016
NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Iraolagoitia XL,Spallanzani RG,Torres NI,Araya RE,Ziblat A,Domaica CI,Sierra JM,Nuñez SY,Secchiari F,Gajewski TF,Zwirner NW,Fuertes MB
Mon Aug 01 00:00:00 EDT 2016
NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.
Journal of immunology (Baltimore, Md. : 1950)
Hamblet CE,Makowski SL,Tritapoe JM,Pomerantz JL
Tue Mar 15 00:00:00 EDT 2016
Assessment of NK Cell Metabolism.
Methods in molecular biology (Clifton, N.J.)
Keppel MP,Cooper MA
210-15 was used in In vitro experiments to present methods for using inhibitors to alter cellular metabolism, measurement of intracellular ATP in NK cells, assessment of real-time glycolysis and oxidative phosphorylation by an extracellular flux assay from Seahorse Biosciences, and some basic protocols for stimulation of NK cells via cytokines and receptors.
Mon Dec 25 00:00:00 EST 2017
A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis.
Blood
Jackson JT,Nasa C,Shi W,Huntington ND,Bogue CW,Alexander WS,McCormack MP
Thu Jan 29 00:00:00 EST 2015
Inflammatory IL-15 is required for optimal memory T cell responses.
The Journal of clinical investigation
Richer MJ,Pewe LL,Hancox LS,Hartwig SM,Varga SM,Harty JT
Tue Sep 01 00:00:00 EDT 2015
Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.
The EMBO journal
Preston GC,Sinclair LV,Kaskar A,Hukelmann JL,Navarro MN,Ferrero I,MacDonald HR,Cowling VH,Cantrell DA
Tue Aug 04 00:00:00 EDT 2015
PTEN regulates natural killer cell trafficking in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Leong JW,Schneider SE,Sullivan RP,Parikh BA,Anthony BA,Singh A,Jewell BA,Schappe T,Wagner JA,Link DC,Yokoyama WM,Fehniger TA
Tue Feb 17 00:00:00 EST 2015
IL-18-induced expression of high-affinity IL-2R on murine NK cells is essential for NK-cell IFN-γ production during murine Plasmodium yoelii infection.
European journal of immunology
Stegmann KA,De Souza JB,Riley EM
Tue Dec 01 00:00:00 EST 2015
Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity.
Stem cells (Dayton, Ohio)
Carrillo-Galvez AB,Cobo M,Cuevas-Ocaña S,Gutiérrez-Guerrero A,Sánchez-Gilabert A,Bongarzone P,García-Pérez A,Muñoz P,Benabdellah K,Toscano MG,Martín F,Anderson P
Thu Jan 01 00:00:00 EST 2015
Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.
Clinical and experimental immunology
Motozono C,Bridgeman JS,Price DA,Sewell AK,Ueno T
Mon Jun 01 00:00:00 EDT 2015
Activation-specific metabolic requirements for NK Cell IFN-γ production.
Journal of immunology (Baltimore, Md. : 1950)
Keppel MP,Saucier N,Mah AY,Vogel TP,Cooper MA
Sun Feb 15 00:00:00 EST 2015
Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
Salmond RJ,Brownlie RJ,Meyuhas O,Zamoyska R
Sun Nov 15 00:00:00 EST 2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Ebel ME,Awe O,Kaplan MH,Kansas GS
Mon Jun 15 00:00:00 EDT 2015
Cardif (MAVS) Regulates the Maturation of NK Cells.
Journal of immunology (Baltimore, Md. : 1950)
Haynes LD,Verma S,McDonald B,Wu R,Tacke R,Nowyhed HN,Ekstein J,Feuvrier A,Benedict CA,Hedrick CC
Tue Sep 01 00:00:00 EDT 2015
Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus.
Journal of immunology (Baltimore, Md. : 1950)
Barra MM,Richards DM,Hansson J,Hofer AC,Delacher M,Hettinger J,Krijgsveld J,Feuerer M
Thu Oct 01 00:00:00 EDT 2015
Composition, Development, and Function of Uterine Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Balmas E,Boulenouar S,Gaynor LM,Kieckbusch J,Gardner L,Hawkes DA,Barbara CF,Sharkey AM,Brady HJ,Brosens JJ,Moffett A,Colucci F
Thu Oct 15 00:00:00 EDT 2015
CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs.
Scientific reports
Wang C,Liu X,Li Z,Chai Y,Jiang Y,Wang Q,Ji Y,Zhu Z,Wan Y,Yuan Z,Chang Z,Zhang M
Tue Sep 15 00:00:00 EDT 2015
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Nature
Paolino M,Choidas A,Wallner S,Pranjic B,Uribesalgo I,Loeser S,Jamieson AM,Langdon WY,Ikeda F,Fededa JP,Cronin SJ,Nitsch R,Schultz-Fademrecht C,Eickhoff J,Menninger S,Unger A,Torka R,Gruber T,Hinterleitner R,Baier G,Wolf D,Ullrich A,Klebl BM,Penninger JM
Thu Mar 27 00:00:00 EDT 2014
In vivo discovery of immunotherapy targets in the tumour microenvironment.
Nature
Zhou P,Shaffer DR,Alvarez Arias DA,Nakazaki Y,Pos W,Torres AJ,Cremasco V,Dougan SK,Cowley GS,Elpek K,Brogdon J,Lamb J,Turley SJ,Ploegh HL,Root DE,Love JC,Dranoff G,Hacohen N,Cantor H,Wucherpfennig KW
Thu Feb 06 00:00:00 EST 2014
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Cell
Klose CSN,Flach M,Möhle L,Rogell L,Hoyler T,Ebert K,Fabiunke C,Pfeifer D,Sexl V,Fonseca-Pereira D,Domingues RG,Veiga-Fernandes H,Arnold SJ,Busslinger M,Dunay IR,Tanriver Y,Diefenbach A
Thu Apr 10 00:00:00 EDT 2014
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance.
Blood
Gotthardt D,Putz EM,Straka E,Kudweis P,Biaggio M,Poli V,Strobl B,Müller M,Sexl V
Thu Oct 09 00:00:00 EDT 2014
IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking.
The Journal of clinical investigation
Nolz JC,Harty JT
Sat Mar 01 00:00:00 EST 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
Mon Apr 07 00:00:00 EDT 2014
Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis.
Mucosal immunology
Pichavant M,Rémy G,Bekaert S,Le Rouzic O,Kervoaze G,Vilain E,Just N,Tillie-Leblond I,Trottein F,Cataldo D,Gosset P
Thu May 01 00:00:00 EDT 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
Sat Mar 15 00:00:00 EDT 2014
The absence or overexpression of IL-15 drastically alters breast cancer metastasis via effects on NK cells, CD4 T cells, and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gillgrass A,Gill N,Babian A,Ashkar AA
Mon Dec 15 00:00:00 EST 2014
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.
Journal of immunology (Baltimore, Md. : 1950)
Donnelly RP,Loftus RM,Keating SE,Liou KT,Biron CA,Gardiner CM,Finlay DK
Sat Nov 01 00:00:00 EDT 2014
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.
Journal of immunology (Baltimore, Md. : 1950)
Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
Fri Aug 01 00:00:00 EDT 2014
The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development.
Journal of immunology (Baltimore, Md. : 1950)
Crotta S,Gkioka A,Male V,Duarte JH,Davidson S,Nisoli I,Brady HJ,Wack A
Sat Mar 15 00:00:00 EDT 2014
CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Stojanovic A,Fiegler N,Brunner-Weinzierl M,Cerwenka A
Thu May 01 00:00:00 EDT 2014
Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength.
Journal of immunology (Baltimore, Md. : 1950)
Knudson KM,Hamilton SE,Daniels MA,Jameson SC,Teixeiro E
Sun Dec 15 00:00:00 EST 2013
CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.
Journal of immunology (Baltimore, Md. : 1950)
Sosinowski T,White JT,Cross EW,Haluszczak C,Marrack P,Gapin L,Kedl RM
Fri Mar 01 00:00:00 EST 2013
Unique features of naive CD8+ T cell activation by IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J
Sun Dec 01 00:00:00 EST 2013
Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Keppel MP,Yang L,Cooper MA
Wed May 01 00:00:00 EDT 2013
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM
Sat Jun 01 00:00:00 EDT 2013
MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan RP,Fogel LA,Leong JW,Schneider SE,Wong R,Romee R,Thai TH,Sexl V,Matkovich SJ,Dorn GW,French AR,Fehniger TA
Sun Dec 15 00:00:00 EST 2013
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Guo Z,Khattar M,Schroder PM,Miyahara Y,Wang G,He X,Chen W,Stepkowski SM
Mon Apr 01 00:00:00 EDT 2013
Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Borger JG,Filby A,Zamoyska R
Mon Apr 01 00:00:00 EDT 2013
Markers of nonselective and specific NK cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Fogel LA,Sun MM,Geurs TL,Carayannopoulos LN,French AR
Sat Jun 15 00:00:00 EDT 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 EDT 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 EST 2013
Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
The Journal of biological chemistry
Souza-Fonseca-Guimaraes F,Parlato M,de Oliveira RB,Golenbock D,Fitzgerald K,Shalova IN,Biswas SK,Cavaillon JM,Adib-Conquy M
Fri Apr 12 00:00:00 EDT 2013
Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.
Blood
Tang Y,Peitzsch C,Charoudeh HN,Cheng M,Chaves P,Jacobsen SE,Sitnicka E
Thu Jul 05 00:00:00 EDT 2012
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
The Journal of experimental medicine
Ni J,Miller M,Stojanovic A,Garbi N,Cerwenka A
Mon Dec 17 00:00:00 EST 2012
Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Zandi S,Ahsberg J,Tsapogas P,Stjernberg J,Qian H,Sigvardsson M
Tue Sep 25 00:00:00 EDT 2012
Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.
Proceedings of the National Academy of Sciences of the United States of America
Nolz JC,Rai D,Badovinac VP,Harty JT
Tue Apr 17 00:00:00 EDT 2012
Two-compartment model of NK cell proliferation: insights from population response to IL-15 stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Zhao YM,French AR
Sun Apr 01 00:00:00 EDT 2012
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Chenoweth MJ,Mian MF,Barra NG,Alain T,Sonenberg N,Bramson J,Lichty BD,Richards CD,Ma A,Ashkar AA
Tue May 01 00:00:00 EDT 2012
NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Souza-Fonseca-Guimaraes F,Parlato M,Fitting C,Cavaillon JM,Adib-Conquy M
Fri Jun 15 00:00:00 EDT 2012
MicroRNA-deficient NK cells exhibit decreased survival but enhanced function.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan RP,Leong JW,Schneider SE,Keppel CR,Germino E,French AR,Fehniger TA
Sun Apr 01 00:00:00 EDT 2012
A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Fiorenza S,Kenna TJ,Comerford I,McColl S,Steptoe RJ,Leggatt GR,Frazer IH
Sat Dec 15 00:00:00 EST 2012
Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Zhang M,Ju W,Yao Z,Yu P,Wei BR,Simpson RM,Waitz R,Fassò M,Allison JP,Waldmann TA
Fri Jun 15 00:00:00 EDT 2012
TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.
PloS one
Zhang L,Zhang H,Li L,Xiao Y,Rao E,Miao Z,Chen H,Sun L,Li H,Liu G,Zhao Y
Fri Jun 29 00:00:00 EDT 2012
Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice.
PloS one
Chow KP,Qiu JT,Lee JM,Hsu SL,Yang SC,Wu NN,Huang W,Wu TS
Mon Aug 20 00:00:00 EDT 2012
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.
Immunity
Li Q,Rao RR,Araki K,Pollizzi K,Odunsi K,Powell JD,Shrikant PA
Fri Apr 22 00:00:00 EDT 2011
CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice.
Blood
Noda M,Omatsu Y,Sugiyama T,Oishi S,Fujii N,Nagasawa T
Thu Jan 13 00:00:00 EST 2011
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.
Blood
Tsapogas P,Zandi S,Åhsberg J,Zetterblad J,Welinder E,Jönsson JI,Månsson R,Qian H,Sigvardsson M
Thu Aug 04 00:00:00 EDT 2011
Development of thymic NK cells from double negative 1 thymocyte precursors.
Blood
Vargas CL,Poursine-Laurent J,Yang L,Yokoyama WM
Thu Sep 29 00:00:00 EDT 2011
TCR-dependent transformation of mature memory phenotype T cells in mice.
The Journal of clinical investigation
Wang X,Werneck MB,Wilson BG,Kim HJ,Kluk MJ,Thom CS,Wischhusen JW,Evans JA,Jesneck JL,Nguyen P,Sansam CG,Cantor H,Roberts CW
Sat Oct 01 00:00:00 EDT 2011
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
The Journal of experimental medicine
Lai D,Zhu J,Wang T,Hu-Li J,Terabe M,Berzofsky JA,Clayberger C,Krensky AM
Mon May 09 00:00:00 EDT 2011
Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells.
Immunology and cell biology
Palmer MJ,Mahajan VS,Chen J,Irvine DJ,Lauffenburger DA
Fri Jul 01 00:00:00 EDT 2011
Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.
Journal of immunology (Baltimore, Md. : 1950)
Kmieciak M,Basu D,Payne KK,Toor A,Yacoub A,Wang XY,Smith L,Bear HD,Manjili MH
Fri Jul 15 00:00:00 EDT 2011
Functional CD8 T cell memory responding to persistent latent infection is maintained for life.
Journal of immunology (Baltimore, Md. : 1950)
Lang A,Nikolich-Zugich J
Sat Oct 01 00:00:00 EDT 2011
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950)
Terawaki S,Chikuma S,Shibayama S,Hayashi T,Yoshida T,Okazaki T,Honjo T
Tue Mar 01 00:00:00 EST 2011
IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Yoshizawa K,Nakajima S,Notake T,Miyagawa S,Hida S,Taki S
Tue Nov 15 00:00:00 EST 2011
Ex vivo expansion of tumor-reactive T cells by means of bryostatin 1/ionomycin and the common gamma chain cytokines formulation.
Journal of visualized experiments : JoVE
Kmieciak M,Toor A,Graham L,Bear HD,Manjili MH
Fri Jan 14 00:00:00 EST 2011
Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes.
Cell death & disease
Dunkle A,Dzhagalov I,He YW
Thu Oct 06 00:00:00 EDT 2011
Co-administration of IL-1+IL-6+TNF-α with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG.
PloS one
Singh V,Jain S,Gowthaman U,Parihar P,Gupta P,Gupta UD,Agrewala JN
Wed Jan 19 00:00:00 EST 2011
Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus.
PloS one
Goldstein JD,Balderas RS,Marodon G
Tue Apr 26 00:00:00 EDT 2011
c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.
PloS one
Grigoriadis G,Vasanthakumar A,Banerjee A,Grumont R,Overall S,Gleeson P,Shannon F,Gerondakis S
Thu Mar 15 00:00:00 EDT 2012
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 EST 2010
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.
Immunity
Vonarbourg C,Mortha A,Bui VL,Hernandez PP,Kiss EA,Hoyler T,Flach M,Bengsch B,Thimme R,Hölscher C,Hönig M,Pannicke U,Schwarz K,Ware CF,Finke D,Diefenbach A
Wed Nov 24 00:00:00 EST 2010
Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation.
Blood
Castillo EF,Acero LF,Stonier SW,Zhou D,Schluns KS
Thu Oct 07 00:00:00 EDT 2010
Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.
Blood
Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E
Thu Jul 15 00:00:00 EDT 2010
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.
Blood
Mansson R,Zandi S,Welinder E,Tsapogas P,Sakaguchi N,Bryder D,Sigvardsson M
Thu Apr 01 00:00:00 EDT 2010
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice.
The Journal of experimental medicine
Schallenberg S,Tsai PY,Riewaldt J,Kretschmer K
Mon Jul 05 00:00:00 EDT 2010
Dicer controls CD8+ T-cell activation, migration, and survival.
Proceedings of the National Academy of Sciences of the United States of America
Zhang N,Bevan MJ
Tue Dec 14 00:00:00 EST 2010
Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950)
Lee HH,Meyer EH,Goya S,Pichavant M,Kim HY,Bu X,Umetsu SE,Jones JC,Savage PB,Iwakura Y,Casasnovas JM,Kaplan G,Freeman GJ,DeKruyff RH,Umetsu DT
Mon Nov 01 00:00:00 EDT 2010
Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function.
Journal of immunology (Baltimore, Md. : 1950)
Kenna TJ,Waldie T,McNally A,Thomson M,Yagita H,Thomas R,Steptoe RJ
Fri Jan 15 00:00:00 EST 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 EDT 2010
Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes.
Autoimmune diseases
Linkes S,Fry C,Quinn A
Wed Sep 29 00:00:00 EDT 2010
RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.
Nature immunology
Sanos SL,Bui VL,Mortha A,Oberle K,Heners C,Johner C,Diefenbach A
Thu Jan 01 00:00:00 EST 2009
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib.
Blood
Yong AS,Keyvanfar K,Hensel N,Eniafe R,Savani BN,Berg M,Lundqvist A,Adams S,Sloand EM,Goldman JM,Childs R,Barrett AJ
Thu Jan 22 00:00:00 EST 2009
IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo.
Blood
Do JS,Min B
Thu Jun 18 00:00:00 EDT 2009
An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.
The Journal of clinical investigation
Hou Y,DeVoss J,Dao V,Kwek S,Simko JP,McNeel DG,Anderson MS,Fong L
Wed Jul 01 00:00:00 EDT 2009
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.
The Journal of experimental medicine
Takatori H,Kanno Y,Watford WT,Tato CM,Weiss G,Ivanov II,Littman DR,O'Shea JJ
Fri Jan 16 00:00:00 EST 2009
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
The Journal of experimental medicine
Huntington ND,Legrand N,Alves NL,Jaron B,Weijer K,Plet A,Corcuff E,Mortier E,Jacques Y,Spits H,Di Santo JP
Fri Jan 16 00:00:00 EST 2009
Cytokine-induced memory-like natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
Cooper MA,Elliott JM,Keyel PA,Yang L,Carrero JA,Yokoyama WM
Tue Feb 10 00:00:00 EST 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 EDT 2009
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America
Zhang M,Yao Z,Dubois S,Ju W,Müller JR,Waldmann TA
Tue May 05 00:00:00 EDT 2009
The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Wolf AM,Eller K,Zeiser R,Dürr C,Gerlach UV,Sixt M,Markut L,Gastl G,Rosenkranz AR,Wolf D
Tue Sep 15 00:00:00 EDT 2009
IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sharma R,Sung SS,Abaya CE,Ju AC,Fu SM,Ju ST
Wed Jul 15 00:00:00 EDT 2009
Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.
PloS one
Hale MB,Krutzik PO,Samra SS,Crane JM,Nolan GP
Tue Aug 25 00:00:00 EDT 2009
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.
Immunity
Zenewicz LA,Yancopoulos GD,Valenzuela DM,Murphy AJ,Stevens S,Flavell RA
Fri Dec 19 00:00:00 EST 2008
A two-step process for thymic regulatory T cell development.
Immunity
Lio CW,Hsieh CS
Tue Jan 01 00:00:00 EST 2008
Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury.
Glia
Gómez-Nicola D,Valle-Argos B,Pita-Thomas DW,Nieto-Sampedro M
Tue Apr 01 00:00:00 EDT 2008
Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
Journal of immunology (Baltimore, Md. : 1950)
Hara H,Ishihara C,Takeuchi A,Xue L,Morris SW,Penninger JM,Yoshida H,Saito T
Tue Jul 15 00:00:00 EDT 2008
In vitro generation of T lymphocytes from embryonic stem cells.
Methods in molecular biology (Clifton, N.J.)
de Pooter RF,Schmitt TM,Zúñiga-Pflücker JC
210-15 was used in Cell Culture to describe a protocol for the generation of T lymphocytes from embryonic stem cells in vitro, within a two-dimensional microenvironment, provided by OP9 bone marrow stromal cells.
Tue Aug 22 00:00:00 EDT 2006
Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation.
Journal of immunology (Baltimore, Md. : 1950)
Suto A,Nakajima H,Tokumasa N,Takatori H,Kagami S,Suzuki K,Iwamoto I
Tue Nov 01 00:00:00 EST 2005
Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity.
Immunity
Wildbaum G,Nahir MA,Karin N
Sat Nov 01 00:00:00 EST 2003
Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.
The Journal of biological chemistry
Cornish AL,Chong MM,Davey GM,Darwiche R,Nicola NA,Hilton DJ,Kay TW,Starr R,Alexander WS
Fri Jun 20 00:00:00 EDT 2003
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
Proceedings of the National Academy of Sciences of the United States of America
Ge Q,Palliser D,Eisen HN,Chen J
Tue Mar 05 00:00:00 EST 2002
