Gibco

Mouse IL-2 Recombinant Protein, PeproTech®

Mouse IL-2 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Mouse IL-2 Protein (212-12-20UG) in Functional

Bioassay analysis of Mouse IL-2 Recombinant Protein, PeproTech® (Product # 212-12-1MG).

Product Image Gallery

Product Details

212-12-20UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 13 publications 13 publications

Functional Assay (Functional)

Assay-dependent

View 2 publications 2 publications

In vitro Assay (IV)

View 463 publications 463 publications

Miscellaneous PubMed (Misc)

View 80 publications 80 publications

Product Specifications

Species

Mouse

Published species

Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ

Molecular weight

17.2 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Site-Specific Modification of Virus-Like Particles for Exogenous Tumor Antigen Display and Minimizing Preexisting Immunity.

Small (Weinheim an der Bergstrasse, Germany)

Cheng K,Ma N,Liang J,Ma X,Feng Q,Liu G,Xu C,Tang M,Zhang L,Gao X,Xu J,Wang C,Zhu F,Wang X,Li X,Zhao X,Nie G

212-12 was used in In vitro experiments to demonstrate the site-specific modification strategy enabled HBc VLPs behave as a potent antitumor vaccine.

Thu Jun 01 00:00:00 EDT 2023

A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion.

Advanced biology

Meng Z,Niu X,Xia L,Chen Y,Wang Z,Wang H,Ji P,Cui W,Wang Y,Lu S

212-12 was used in Cell Culture to establish that the 3D-HyGTIC system is not only inclined to mimic the early differentiation trajectories of tumor-infiltrating CD8+ T cells but also may facilitate an evaluation of the efficacy of IC blockades and guide the designing of combination immunotherapy.

Sat Jul 01 00:00:00 EDT 2023

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.

Nature biotechnology

Quijano-Rubio A,Bhuiyan AM,Yang H,Leung I,Bello E,Ali LR,Zhangxu K,Perkins J,Chun JH,Wang W,Lajoie MJ,Ravichandran R,Kuo YH,Dougan SK,Riddell SR,Spangler JB,Dougan M,Silva DA,Baker D

212-12 was used in In vivo experiments to demonstrate the approach with a previously designed mimetic of cytokines interleukin-2 and interleukin-15-Neoleukin-2/15 (Neo-2/15)-both for trans-activating immune cells surrounding targeted tumor cells and for cis-activating directly targeted immune cells.

Sat Apr 01 00:00:00 EDT 2023

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.

The Journal of experimental medicine

Evrard M,Wynne-Jones E,Peng C,Kato Y,Christo SN,Fonseca R,Park SL,Burn TN,Osman M,Devi S,Chun J,Mueller SN,Kannourakis G,Berzins SP,Pellicci DG,Heath WR,Jameson SC,Mackay LK

Mon Jan 03 00:00:00 EST 2022

Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts.

The Journal of experimental medicine

Kerdidani D,Aerakis E,Verrou KM,Angelidis I,Douka K,Maniou MA,Stamoulis P,Goudevenou K,Prados A,Tzaferis C,Ntafis V,Vamvakaris I,Kaniaris E,Vachlas K,Sepsas E,Koutsopoulos A,Potaris K,Tsoumakidou M

Mon Feb 07 00:00:00 EST 2022

Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.

Cancer immunology research

Gil Del Alcazar CR,Trinh A,Alečković M,Rojas Jimenez E,Harper NW,Oliphant MUJ,Xie S,Krop ED,Lulseged B,Murphy KC,Keenan TE,Van Allen EM,Tolaney SM,Freeman GJ,Dillon DA,Muthuswamy SK,Polyak K

212-12 was used in Tissue/organ culture to address how there are no good murine models of estrogen receptor-positive (ER+) breast cancer and demonstrate that Nitroso-N-methylurea-induced mammary tumors in outbred Sprague-Dawley rats recapitulate the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.

Fri Jun 03 00:00:00 EDT 2022

Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer.

Cancer immunology research

Celus W,Oliveira AI,Rivis S,Van Acker HH,Landeloos E,Serneels J,Cafarello ST,Van Herck Y,Mastrantonio R,Köhler A,Garg AD,Flamand V,Tamagnone L,Marine JC,Di Matteo M,Costa BM,Bechter O,Mazzone M

212-12 was used in Cell Culture to show that expression of the axon guidance molecule Plexin-A4 (Plxna4) in cytotoxic T cells (CTLs), especially in effector/memory CD8+ T cells, is induced upon T-cell activation, sustained in the circulation, but reduced when entering the tumor bed and that upon deletion of Plxna4, CTLs acquire improved homing capacity to the lymph nodes and to the tumor.

Sat Jan 01 00:00:00 EST 2022

Natural killer cells act as an extrinsic barrier for in vivo reprogramming.

Development (Cambridge, England)

Melendez E,Chondronasiou D,Mosteiro L,Martínez de Villarreal J,Fernández-Alfara M,Lynch CJ,Grimm D,Real FX,Alcamí J,Climent N,Pietrocola F,Serrano M

212-12 was used in Cell Culture to demonstrate that in vivo reprogramming of cells is significantly impeded by NK cells.

Fri Apr 15 00:00:00 EDT 2022

Control of Memory Phenotype T Lymphocyte Homeostasis: Role of Costimulation.

Journal of immunology (Baltimore, Md. : 1950)

Panda AK,Kim YH,Shevach EM

Tue Feb 15 00:00:00 EST 2022

Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro.

Journal of clinical laboratory analysis

Xu W,Li S,Li M,Zhou H,Yang X

Sat Jan 01 00:00:00 EST 2022

Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice.

Frontiers in pharmacology

Zhang R,Wang Y,Liu D,Luo Q,Du P,Zhang H,Wu W

212-12 was used in Sample Preparation (FC/FACS) to determine signaling processes in immune checkpoint blockade in colorectal cancer.

Sat Jul 16 00:00:00 EDT 2022

Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.

EMBO reports

Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A

212-12 was used in In vitro experiments to indicate that lactate is capable of reprogramming pro-inflammatory T cell phenotypes into regulatory T cells.

Tue Dec 06 00:00:00 EST 2022

GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.

Nature communications

Liu J,Pan L,Hong W,Chen S,Bai P,Luo W,Sun X,He F,Jia X,Cai J,Chen Y,Hu K,Song Z,Ge J,Sun A

212-12 was used in In vitro experiments to demonstrate that GPR174 negatively regulates angiogenesis and vascular remodeling in response to ischemic injury and that GPR174 may be a potential molecular target for therapeutic interventions of ischemic vascular diseases.

Tue Dec 06 00:00:00 EST 2022

CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy.

Oncoimmunology

Li X,Lu M,Yuan M,Ye J,Zhang W,Xu L,Wu X,Hui B,Yang Y,Wei B,Guo C,Wei M,Dong J,Wu X,Gu Y

212-12 was used in Cell Culture to construct a novel recombinant oncolytic adenovirus encoding murine CXCL10, named Adv-CXCL10.

Tue Sep 13 00:00:00 EDT 2022

Evaluation of Glutaminolysis in T Cells.

Current protocols

Tajima M,Strober W

212-12 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.

Thu Sep 01 00:00:00 EDT 2022

A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice.

JCI insight

Schmitt EG,Toth KA,Risma SI,Kolicheski A,Saucier N,Berríos RJF,Greenberg ZJ,Leiding JW,Bleesing JJ,Thatayatikom A,Schuettpelz LG,Edwards JR,Vogel TP,Cooper MA

212-12 was used in Sample Preparation (FC/FACS) to suggest that Tregs are not the primary driver of disease and highlight the importance of preclinical models in the study of disease mechanisms in rare PIRD.

Tue Nov 08 00:00:00 EST 2022

Creatine transport and creatine kinase activity is required for CD8⁺ T cell immunity.

Cell reports

Samborska B,Roy DG,Rahbani JF,Hussain MF,Ma EH,Jones RG,Kazak L

212-12 was used in Cell Culture to investigate the role of creatine kinase B on cell-intrinsic CD8+ T cell homeostasis.

Tue Mar 01 00:00:00 EST 2022

Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM.

EBioMedicine

Xiong A,Zhang J,Chen Y,Zhang Y,Yang F

212-12 was used in Cell Culture to suggest that targeting this particular GPNMB-high macrophage subset may provide a new strategy to control GBM plasticity and facilitate T cell-based immunotherapy.

Thu Sep 01 00:00:00 EDT 2022

SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4⁺ T cells.

Frontiers in immunology

Kanno T,Miyako K,Nakajima T,Yokoyama S,Sasamoto S,Asou HK,Ohara O,Nakayama T,Endo Y

212-12 was used in Sample Preparation to provide novel mechanistic insights into the process of fatty acid metabolism that is essential for the type I-IFN response and the activation of the IRF family in CD4+ T cells.

Thu Sep 08 00:00:00 EDT 2022

In Vitro Visualization of Cell-to-Cell Interactions Between Natural Killer Cells and Sensory Neurons.

Methods in molecular biology (Clifton, N.J.)

Kim HW,Davies AJ,Oh SB

212-12 was used in In vitro experiments to present methods for the morphological analysis of axon fragmentation (pruning) and dynamic cell function via live confocal calcium imaging.

Fri Apr 01 00:00:00 EDT 2022

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Nature

Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA

212-12 was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.

Thu Apr 01 00:00:00 EDT 2021

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.

Nature

Witkowski M,Tizian C,Ferreira-Gomes M,Niemeyer D,Jones TC,Heinrich F,Frischbutter S,Angermair S,Hohnstein T,Mattiola I,Nawrath P,McEwen S,Zocche S,Viviano E,Heinz GA,Maurer M,Kölsch U,Chua RL,Aschman T,Meisel C,Radke J,Sawitzki B,Roehmel J,Allers K,Moos V,Schneider T,Hanitsch L,Mall MA,Conrad C,Radbruch H,Duerr CU,Trapani JA,Marcenaro E,Kallinich T,Corman VM,Kurth F,Sander LE,Drosten C,Treskatsch S,Durek P,Kruglov A,Radbruch A,Mashreghi MF,Diefenbach A

212-12 was used in Cell Culture to investigate if a decline in viral load in COVID-19 correlates with Natural killer (NK) cell status and if NK cells can control SARS-CoV-2 replication by recognizing infected target cells.

Wed Dec 01 00:00:00 EST 2021

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

Cell

Lu SX,De Neef E,Thomas JD,Sabio E,Rousseau B,Gigoux M,Knorr DA,Greenbaum B,Elhanati Y,Hogg SJ,Chow A,Ghosh A,Xie A,Zamarin D,Cui D,Erickson C,Singer M,Cho H,Wang E,Lu B,Durham BH,Shah H,Chowell D,Gabel AM,Shen Y,Liu J,Jin J,Rhodes MC,Taylor RE,Molina H,Wolchok JD,Merghoub T,Diaz LA,Abdel-Wahab O,Bradley RK

212-12 was used in Enzyme-linked immunosorbent spot to investigate RNA splicing effects in antigen production in cancer.

Thu Jul 22 00:00:00 EDT 2021

Functional characterization of the dural sinuses as a neuroimmune interface.

Cell

Rustenhoven J,Drieu A,Mamuladze T,de Lima KA,Dykstra T,Wall M,Papadopoulos Z,Kanamori M,Salvador AF,Baker W,Lemieux M,Da Mesquita S,Cugurra A,Fitzpatrick J,Sviben S,Kossina R,Bayguinov P,Townsend RR,Zhang Q,Erdmann-Gilmore P,Smirnov I,Lopes MB,Herz J,Kipnis J

Thu Feb 18 00:00:00 EST 2021

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

Cell

Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD

Thu Jan 07 00:00:00 EST 2021

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

Cell

Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD

Thu Jan 07 00:00:00 EST 2021

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.

Cell

Koikawa K,Kibe S,Suizu F,Sekino N,Kim N,Manz TD,Pinch BJ,Akshinthala D,Verma A,Gaglia G,Nezu Y,Ke S,Qiu C,Ohuchida K,Oda Y,Lee TH,Wegiel B,Clohessy JG,London N,Santagata S,Wulf GM,Hidalgo M,Muthuswamy SK,Nakamura M,Gray NS,Zhou XZ,Lu KP

Thu Sep 02 00:00:00 EDT 2021

Transgenic mice for in vivo epigenome editing with CRISPR-based systems.

Nature methods

Gemberling MP,Siklenka K,Rodriguez E,Tonn-Eisinger KR,Barrera A,Liu F,Kantor A,Li L,Cigliola V,Hazlett MF,Williams CA,Bartelt LC,Madigan VJ,Bodle JC,Daniels H,Rouse DC,Hilton IB,Asokan A,Ciofani M,Poss KD,Reddy TE,West AE,Gersbach CA

Sun Aug 01 00:00:00 EDT 2021

Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.

Cell research

Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B

Fri Oct 01 00:00:00 EDT 2021

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.

Immunity

Onodera T,Kita S,Adachi Y,Moriyama S,Sato A,Nomura T,Sakakibara S,Inoue T,Tadokoro T,Anraku Y,Yumoto K,Tian C,Fukuhara H,Sasaki M,Orba Y,Shiwa N,Iwata N,Nagata N,Suzuki T,Sasaki J,Sekizuka T,Tonouchi K,Sun L,Fukushi S,Satofuka H,Kazuki Y,Oshimura M,Kurosaki T,Kuroda M,Matsuura Y,Suzuki T,Sawa H,Hashiguchi T,Maenaka K,Takahashi Y

Tue Oct 12 00:00:00 EDT 2021

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.

Immunity

Tue Oct 12 00:00:00 EDT 2021

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Immunity

Xu S,Chaudhary O,Rodríguez-Morales P,Sun X,Chen D,Zappasodi R,Xu Z,Pinto AFM,Williams A,Schulze I,Farsakoglu Y,Varanasi SK,Low JS,Tang W,Wang H,McDonald B,Tripple V,Downes M,Evans RM,Abumrad NA,Merghoub T,Wolchok JD,Shokhirev MN,Ho PC,Witztum JL,Emu B,Cui G,Kaech SM

212-12 was used in Cell Culture to conclude that an oxidized lipid-CD36 axis promotes intratumoral CD8+ T cell dysfunction and serves as a therapeutic avenue for immunotherapies.

Tue Jul 13 00:00:00 EDT 2021

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Immunity

212-12 was used in Cell Culture to conclude that an oxidized lipid-CD36 axis promotes intratumoral CD8+ T cell dysfunction and serves as a therapeutic avenue for immunotherapies.

Tue Jul 13 00:00:00 EDT 2021

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Immunity

212-12 was used in Cell Culture to conclude that an oxidized lipid-CD36 axis promotes intratumoral CD8+ T cell dysfunction and serves as a therapeutic avenue for immunotherapies.

Tue Jul 13 00:00:00 EDT 2021

Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.

Nature immunology

Friedrich C,Taggenbrock RLRE,Doucet-Ladevèze R,Golda G,Moenius R,Arampatzi P,Kragten NAM,Kreymborg K,Gomez de Agüero M,Kastenmüller W,Saliba AE,Grün D,van Gisbergen KPJM,Gasteiger G

Fri Oct 01 00:00:00 EDT 2021

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity.

Nature immunology

Christo SN,Evrard M,Park SL,Gandolfo LC,Burn TN,Fonseca R,Newman DM,Alexandre YO,Collins N,Zamudio NM,Souza-Fonseca-Guimaraes F,Pellicci DG,Chisanga D,Shi W,Bartholin L,Belz GT,Huntington ND,Lucas A,Lucas M,Mueller SN,Heath WR,Ginhoux F,Speed TP,Carbone FR,Kallies A,Mackay LK

Wed Sep 01 00:00:00 EDT 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Thu Sep 30 00:00:00 EDT 2021

Kidney GATA3⁺ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury.

Cellular & molecular immunology

Sakai R,Ito M,Komai K,Iizuka-Koga M,Matsuo K,Nakayama T,Yoshie O,Amano K,Nishimasu H,Nureki O,Kubo M,Yoshimura A

Sat May 01 00:00:00 EDT 2021

A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.

The Journal of clinical investigation

Veatch JR,Singhi N,Srivastava S,Szeto JL,Jesernig B,Stull SM,Fitzgibbon M,Sarvothama M,Yechan-Gunja S,James SE,Riddell SR

Mon Aug 16 00:00:00 EDT 2021

The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.

The Journal of experimental medicine

Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL

Mon Jun 07 00:00:00 EDT 2021

ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.

The Journal of experimental medicine

Nakajima T,Kanno T,Yokoyama S,Sasamoto S,Asou HK,Tumes DJ,Ohara O,Nakayama T,Endo Y

Mon Dec 06 00:00:00 EST 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Mon Jul 05 00:00:00 EDT 2021

The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.

The Journal of experimental medicine

Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE

212-12 was used in Sample Preparation (FC/FACS) to show that the histone demethylase Lsd1 (Kdm1a) performs a key role in extinguishing stem/progenitor transcriptional programs in addition to key repressive gene programs during thymocyte maturation.

Mon Dec 06 00:00:00 EST 2021

The SIRPα-CD47 immune checkpoint in NK cells.

The Journal of experimental medicine

Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S

Mon Mar 01 00:00:00 EST 2021

The SIRPα-CD47 immune checkpoint in NK cells.

The Journal of experimental medicine

Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S

Mon Mar 01 00:00:00 EST 2021

Mechanical force-driven TNFα endocytosis governs stem cell homeostasis.

Bone research

Yu W,Chen C,Kou X,Sui B,Yu T,Liu D,Wang R,Wang J,Shi S

Fri Jan 01 00:00:00 EST 2021

Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Hao F,Tian M,Zhang X,Jin X,Jiang Y,Sun X,Wang Y,Peng P,Liu J,Xia C,Feng Y,Wei M

Tue Jun 01 00:00:00 EDT 2021

Host genetic control of natural killer cell diversity revealed in the Collaborative Cross.

Proceedings of the National Academy of Sciences of the United States of America

Dupont MSJ,Guillemot V,Campagne P,Serafini N,Marie S,Montagutelli X,Di Santo JP,Vosshenrich CAJ

Tue Mar 09 00:00:00 EST 2021

Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.

Cancer immunology research

Xin G,Chen Y,Topchyan P,Kasmani MY,Burns R,Volberding PJ,Wu X,Cohn A,Chen Y,Lin CW,Ho PC,Silverstein R,Dwinell MB,Cui W

212-12 was used in Sample Preparation (FC/FACS) to investigate immune checkpoint blockade resistance mechanisms in cancer.

Thu Apr 01 00:00:00 EDT 2021

Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.

PLoS biology

Sripada A,Sirohi K,Michalec L,Guo L,McKay JT,Yadav S,Verma M,Good J,Rollins D,Gorska MM,Alam R

212-12 was used in In vitro experiments to show that knockdown of CSK or dislodgment of caveolin-1-bound CSK restored ERK1/2 activation in Spry2-/- T cells, suggesting an essential role for Spry2 in LCK activation and T cell function.

Mon Mar 01 00:00:00 EST 2021

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt⁺ T_reg generation via enhanced IL-6 induction.

Immunology

Drube S,Müller S,Weber F,Wegner P,Böttcher-Loschinski R,Gaestel M,Hutloff A,Kamradt T,Andreas N

Sat May 01 00:00:00 EDT 2021

Death-associated protein kinase 1 (DAPK1) controls CD8⁺ T cell activation, trafficking, and antitumor activity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wei Z,Du Q,Li P,Liu H,Xia M,Chen Y,Bi G,Tang ZH,Cheng X,Lu Y,He R,Laurence A,Wang J,Huang L,Li H,Yang XP

Fri Jan 01 00:00:00 EST 2021

Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.

Journal of immunology (Baltimore, Md. : 1950)

Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH

Mon Nov 15 00:00:00 EST 2021

Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus.

Journal of immunology (Baltimore, Md. : 1950)

Sonoda S,Murata S,Kato H,Zakaria F,Kyumoto-Nakamura Y,Uehara N,Yamaza H,Kukita T,Yamaza T

Tue Jun 15 00:00:00 EDT 2021

Inhibiting Glucose Metabolism Results in Herpes Simplex Encephalitis.

Journal of immunology (Baltimore, Md. : 1950)

Berber E,Sumbria D,Newkirk KM,Rouse BT

Fri Oct 01 00:00:00 EDT 2021

Assessment of Allergen-Responsive Regulatory T Cells in Experimental Asthma Induced in Different Mouse Strains.

Mediators of inflammation

Azevedo CT,Cotias AC,Arantes ACS,Ferreira TPT,Martins MA,Olsen PC

Mon Mar 28 00:00:00 EDT 2022

Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models.

BioMed research international

Miao M,Masengere H,Yu G,Shan F

Thu Jan 20 00:00:00 EST 2022

Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation.

eLife

Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS

212-12 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.

Thu Dec 02 00:00:00 EST 2021

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence.

Nature communications

Sobecki M,Krzywinska E,Nagarajan S,Audigé A,Hu¿nh K,Zacharjasz J,Debbache J,Kerdiles Y,Gotthardt D,Takeda N,Fandrey J,Sommer L,Sexl V,Stockmann C

212-12 was used in In vitro experiments to study the role of Natural Killer cells in hypoxic skin lesions and Hypoxia-inducible transcription factors.

Wed Aug 04 00:00:00 EDT 2021

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence.

Nature communications

Sobecki M,Krzywinska E,Nagarajan S,Audigé A,Hu¿nh K,Zacharjasz J,Debbache J,Kerdiles Y,Gotthardt D,Takeda N,Fandrey J,Sommer L,Sexl V,Stockmann C

212-12 was used in In vitro experiments to study the role of Natural Killer cells in hypoxic skin lesions and Hypoxia-inducible transcription factors.

Wed Aug 04 00:00:00 EDT 2021

Genetic engineering of human and mouse CD4⁺ and CD8⁺ Tregs using lentiviral vectors encoding chimeric antigen receptors.

Molecular therapy. Methods & clinical development

Vimond N,Lasselin J,Anegon I,Guillonneau C,Bézie S

Fri Mar 12 00:00:00 EST 2021

Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells' maturation and function.

Open life sciences

Guo B,Peng Y,Gu Y,Zhong Y,Su C,Liu L,Chai D,Song T,Zhao N,Yan X,Xu T

212-12 was used in In vitro experiments to indicate that resveratrol (RES) participated in protecting against the pathological process of ALI by modulating the maturation and function of cDCs.

Sat Oct 23 00:00:00 EDT 2021

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.

Nature communications

Pessoa Rodrigues C,Chatterjee A,Wiese M,Stehle T,Szymanski W,Shvedunova M,Akhtar A

Wed Oct 27 00:00:00 EDT 2021

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.

Nature communications

Pessoa Rodrigues C,Chatterjee A,Wiese M,Stehle T,Szymanski W,Shvedunova M,Akhtar A

Wed Oct 27 00:00:00 EDT 2021

Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.

Nature communications

He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J

Fri Jul 16 00:00:00 EDT 2021

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.

Nature communications

Rodriguez-Garcia A,Lynn RC,Poussin M,Eiva MA,Shaw LC,O'Connor RS,Minutolo NG,Casado-Medrano V,Lopez G,Matsuyama T,Powell DJ

Tue Feb 09 00:00:00 EST 2021

Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.

Frontiers in immunology

Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R

212-12 was used in In vitro experiments to study fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma.

Mon Dec 13 00:00:00 EST 2021

Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.

Cell reports

Nanou A,Bourbouli M,Vetrano S,Schaeper U,Ley S,Kollias G

Tue May 25 00:00:00 EDT 2021

Endothelial STING controls T cell transmigration in an IFNI-dependent manner.

JCI insight

Anastasiou M,Newton GA,Kaur K,Carrillo-Salinas FJ,Smolgovsky SA,Bayer AL,Ilyukha V,Sharma S,Poltorak A,Luscinskas FW,Alcaide P

212-12 was used in In vitro experiments to investigate IFN signalling effect on T cell transdoepithelial infiltration.

Mon Aug 09 00:00:00 EDT 2021

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.

Nature communications

Debackere K,Marcelis L,Demeyer S,Vanden Bempt M,Mentens N,Gielen O,Jacobs K,Broux M,Verhoef G,Michaux L,Graux C,Wlodarska I,Gaulard P,de Leval L,Tousseyn T,Cools J,Dierickx D

Thu Jun 17 00:00:00 EDT 2021

In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Kim GR,Kim WJ,Lim S,Lee HG,Koo JH,Nam KH,Kim SM,Park SD,Choi JM

Thu Jul 01 00:00:00 EDT 2021

Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.

Scientific reports

Akasu M,Shimada S,Kabashima A,Akiyama Y,Shimokawa M,Akahoshi K,Kudo A,Yamaoka S,Tanabe M,Tanaka S

Tue Aug 24 00:00:00 EDT 2021

Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.

Cell reports

Marks KE,Flaherty S,Patterson KM,Stratton M,Martinez GJ,Reynolds JM

Tue Jun 29 00:00:00 EDT 2021

Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy.

Nature communications

Jiang CT,Chen KG,Liu A,Huang H,Fan YN,Zhao DK,Ye QN,Zhang HB,Xu CF,Shen S,Xiong MH,Du JZ,Yang XZ,Wang J

Mon Mar 01 00:00:00 EST 2021

Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.

Nature communications

Tao H,Pan Y,Chu S,Li L,Xie J,Wang P,Zhang S,Reddy S,Sleasman JW,Zhong XP

212-12 was used in In vivo experiments to demonstrate that IL-2/IL-15 receptor β chain and inducible costimulatory (ICOS) not only serve as lineage-specific markers for IFN-γ-producing MAIT1 and IL-17A-producing MAIT17 cells, but are also important for their differentiation, respectively.

Thu Apr 01 00:00:00 EDT 2021

Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy.

Nature communications

Li Y,Cong Y,Jia M,He Q,Zhong H,Zhao Y,Li H,Yan M,You J,Liu J,Chen L,Hang H,Wang S

Thu Feb 11 00:00:00 EST 2021

Immunization with short peptide particles reveals a functional CD8⁺ T-cell neoepitope in a murine renal carcinoma model.

Journal for immunotherapy of cancer

He X,Zhou S,Dolan M,Shi Y,Wang J,Quinn B,Jahagirdar D,Huang WC,Tsuji M,Pili R,Ito F,Ortega J,Abrams SI,Ebos JML,Lovell JF

212-12 was used in In vitro experiments to study the feasibility of using short, major histocompatibility class I (MHC-I)-restricted neoepitopes for straightforward immunization with multivalent or validated neoepitopes to induce cytotoxic CD8+ T cells.

Wed Dec 01 00:00:00 EST 2021

PPAR¿ drives IL-33-dependent ILC2 pro-tumoral functions.

Nature communications

Ercolano G,Gomez-Cadena A,Dumauthioz N,Vanoni G,Kreutzfeldt M,Wyss T,Michalik L,Loyon R,Ianaro A,Ho PC,Borg C,Kopf M,Merkler D,Krebs P,Romero P,Trabanelli S,Jandus C

Wed May 05 00:00:00 EDT 2021

CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8⁺ T Cells.

Immunity

Braun M,Aguilera AR,Sundarrajan A,Corvino D,Stannard K,Krumeich S,Das I,Lima LG,Meza Guzman LG,Li K,Li R,Salim N,Jorge MV,Ham S,Kelly G,Vari F,Lepletier A,Raghavendra A,Pearson S,Madore J,Jacquelin S,Effern M,Quine B,Koufariotis LT,Casey M,Nakamura K,Seo EY,Hölzel M,Geyer M,Kristiansen G,Taheri T,Ahern E,Hughes BGM,Wilmott JS,Long GV,Scolyer RA,Batstone MD,Landsberg J,Dietrich D,Pop OT,Flatz L,Dougall WC,Veillette A,Nicholson SE,Möller A,Johnston RJ,Martinet L,Smyth MJ,Bald T

Tue Oct 13 00:00:00 EDT 2020

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.

Immunity

Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C

Tue Sep 15 00:00:00 EDT 2020

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Immunity

Śledzińska A,Vila de Mucha M,Bergerhoff K,Hotblack A,Demane DF,Ghorani E,Akarca AU,Marzolini MAV,Solomon I,Vargas FA,Pule M,Ono M,Seddon B,Kassiotis G,Ariyan CE,Korn T,Marafioti T,Lord GM,Stauss H,Jenner RG,Peggs KS,Quezada SA

Tue Jan 14 00:00:00 EST 2020

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Immunity

Tue Jan 14 00:00:00 EST 2020

Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3⁺ Regulatory T Cells via a miR-342-Dependent Mechanism.

Immunity

Kim D,Nguyen QT,Lee J,Lee SH,Janocha A,Kim S,Le HT,Dvorina N,Weiss K,Cameron MJ,Asosingh K,Erzurum SC,Baldwin WM,Lee JS,Min B

Tue Sep 15 00:00:00 EDT 2020

Developmental Relationships of Four Exhausted CD8⁺ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.

Immunity

Beltra JC,Manne S,Abdel-Hakeem MS,Kurachi M,Giles JR,Chen Z,Casella V,Ngiow SF,Khan O,Huang YJ,Yan P,Nzingha K,Xu W,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Schuchter LM,Huang AC,Wherry EJ

Tue May 19 00:00:00 EDT 2020

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.

Immunity

Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G

Tue Oct 13 00:00:00 EDT 2020

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer.

Cancer cell

Hegde S,Krisnawan VE,Herzog BH,Zuo C,Breden MA,Knolhoff BL,Hogg GD,Tang JP,Baer JM,Mpoy C,Lee KB,Alexander KA,Rogers BE,Murphy KM,Hawkins WG,Fields RC,DeSelm CJ,Schwarz JK,DeNardo DG

Mon Mar 16 00:00:00 EDT 2020

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer.

Cancer cell

Hegde S,Krisnawan VE,Herzog BH,Zuo C,Breden MA,Knolhoff BL,Hogg GD,Tang JP,Baer JM,Mpoy C,Lee KB,Alexander KA,Rogers BE,Murphy KM,Hawkins WG,Fields RC,DeSelm CJ,Schwarz JK,DeNardo DG

Mon Mar 16 00:00:00 EDT 2020

Serine Catabolism Feeds NADH when Respiration Is Impaired.

Cell metabolism

Yang L,Garcia Canaveras JC,Chen Z,Wang L,Liang L,Jang C,Mayr JA,Zhang Z,Ghergurovich JM,Zhan L,Joshi S,Hu Z,McReynolds MR,Su X,White E,Morscher RJ,Rabinowitz JD

212-12 was used in Cell Culture to show that folate-dependent serine catabolism also produces substantial NADH using deuterium-tracing studies in cultured cells and mice.

Tue Apr 07 00:00:00 EDT 2020

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.

Cell metabolism

LaMarche NM,Kane H,Kohlgruber AC,Dong H,Lynch L,Brenner MB

212-12 was used in Cell Culture to utilize non-redundant pathways to preserve metabolic integrity.

Tue Aug 04 00:00:00 EDT 2020

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.

Cell metabolism

Roy DG,Chen J,Mamane V,Ma EH,Muhire BM,Sheldon RD,Shorstova T,Koning R,Johnson RM,Esaulova E,Williams KS,Hayes S,Steadman M,Samborska B,Swain A,Daigneault A,Chubukov V,Roddy TP,Foulkes W,Pospisilik JA,Bourgeois-Daigneault MC,Artyomov MN,Witcher M,Krawczyk CM,Larochelle C,Jones RG

212-12 was used in In vitro experiments to investigate the role of methionine on CD4+ T helper cells.

Tue Feb 04 00:00:00 EST 2020

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.

Blood

Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE

Thu Aug 06 00:00:00 EDT 2020

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

The Journal of clinical investigation

Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y

Thu Oct 01 00:00:00 EDT 2020

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.

The Journal of clinical investigation

Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q

Wed Jul 01 00:00:00 EDT 2020

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.

The Journal of clinical investigation

Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q

Wed Jul 01 00:00:00 EDT 2020

S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.

The Journal of clinical investigation

Olesch C,Sirait-Fischer E,Berkefeld M,Fink AF,Susen RM,Ritter B,Michels BE,Steinhilber D,Greten FR,Savai R,Takeda K,Brüne B,Weigert A

Thu Oct 01 00:00:00 EDT 2020

BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.

The Journal of experimental medicine

Grant FM,Yang J,Nasrallah R,Clarke J,Sadiyah F,Whiteside SK,Imianowski CJ,Kuo P,Vardaka P,Todorov T,Zandhuis N,Patrascan I,Tough DF,Kometani K,Eil R,Kurosaki T,Okkenhaug K,Roychoudhuri R

Mon Sep 07 00:00:00 EDT 2020

Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.

The Journal of experimental medicine

Raynor JL,Liu C,Dhungana Y,Guy C,Chapman NM,Shi H,Neale G,Sesaki H,Chi H

Mon Jun 01 00:00:00 EDT 2020

Allergen alters IL-2/αIL-2-based Treg expansion but not tolerance induction in an allergen-specific mouse model.

Allergy

Köhler C,Smole U,Kratzer B,Trapin D,Schmetterer KG,Pickl WF

Wed Jul 01 00:00:00 EDT 2020

CCR5 deficiency impairs CD4⁺ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis.

The EMBO journal

Martín-Leal A,Blanco R,Casas J,Sáez ME,Rodríguez-Bovolenta E,de Rojas I,Drechsler C,Real LM,Fabrias G,Ruíz A,Castro M,Schamel WW,Alarcón B,van Santen HM,Mañes S

Mon Aug 03 00:00:00 EDT 2020

MNK2 governs the macrophage antiinflammatory phenotype.

Proceedings of the National Academy of Sciences of the United States of America

Bartish M,Tong D,Pan Y,Wallerius M,Liu H,Ristau J,de Souza Ferreira S,Wallmann T,van Hoef V,Masvidal L,Kerzel T,Joly AL,Goncalves C,Preston SEJ,Ebrahimian T,Seitz C,Bergh J,Pietras K,Lehoux S,Naldini L,Andersson J,Squadrito ML,Del Rincón SV,Larsson O,Rolny C

Tue Nov 03 00:00:00 EST 2020

Donor Lymphocyte-Derived Natural Killer Cells Control MHC Class I-Negative Melanoma.

Cancer immunology research

Dang N,Lin Y,Waer M,Sprangers B

212-12 was used in In vivo experiments to investigate the use of donor lymphocyte-derived natural killer cells on melanoma control.

Mon Jun 01 00:00:00 EDT 2020

Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB.

European journal of immunology

Lubrano di Ricco M,Ronin E,Collares D,Divoux J,Grégoire S,Wajant H,Gomes T,Grinberg-Bleyer Y,Baud V,Marodon G,Salomon BL

Wed Jul 01 00:00:00 EDT 2020

IL-18R-dependent and independent pathways account for IL-18-enhanced antitumor ability of CAR-T cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Huang Y,Li D,Zhang PF,Liu M,Liang X,Yang X,Jiang L,Zhang LF,Zhou WL,Su JH,Gong YL,Gou HF,Wei YQ,Wang W

Wed Jan 01 00:00:00 EST 2020

Differentiation of c-Kit⁺ CD24⁺ natural killer cells into myeloid cells in a GATA-2-dependent manner.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Song B,Lee JM,Park YJ,Kim IK,Kim BS,Shin KS,Jeon I,Koh CH,Bae EA,Seo H,Byun Y,Kang CY

Sun Mar 01 00:00:00 EST 2020

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG

Wed Jan 01 00:00:00 EST 2020

Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.

Journal of immunology (Baltimore, Md. : 1950)

Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D

Thu Oct 15 00:00:00 EDT 2020

The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Keller HR,Kim HK,Jo Y,Gress RE,Hong C,Park JH

Mon Jun 15 00:00:00 EDT 2020

P2Y₆ Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Li Z,He C,Zhang J,Zhang H,Wei H,Wu S,Jiang W

Wed Jul 15 00:00:00 EDT 2020

Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8⁺ Thymocyte Population.

Journal of immunology (Baltimore, Md. : 1950)

Daams R,Sime W,Leandersson K,Sitnicka E,Massoumi R

Thu Oct 01 00:00:00 EDT 2020

A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.

Journal of cellular and molecular medicine

Bachmann M,Lamprecht L,Gonther S,Pfeilschifter J,Mühl H

Tue Sep 01 00:00:00 EDT 2020

An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling.

The Journal of biological chemistry

Yin Y,Frank D,Zhou W,Kaur N,French JB,Carpino N

Fri Jun 19 00:00:00 EDT 2020

CD49a Regulates Cutaneous Resident Memory CD8⁺ T Cell Persistence and Response.

Cell reports

Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD

212-12 was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.

Tue Sep 01 00:00:00 EDT 2020

Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors.

Nature communications

Wang Z,Wang F,Zhong J,Zhu T,Zheng Y,Zhao T,Xie Q,Ma F,Li R,Tang Q,Xu F,Tian X,Zhu J

Fri May 01 00:00:00 EDT 2020

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.

bioRxiv : the preprint server for biology

Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD

212-12 was used in In vitro experiments to reveal that blocking the COVID-19 cytokine-mediated inflammatory cell death signaling pathway identified in this study may benefit patients with COVID-19 or other cytokine storm-driven syndromes by limiting inflammation and tissue damage.

Fri Nov 13 00:00:00 EST 2020

Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy.

Scientific reports

Chou YJ,Lin CC,Dzhagalov I,Chen NJ,Lin CH,Lin CC,Chen ST,Chen KH,Fu SL

Thu May 21 00:00:00 EDT 2020

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.

Cell death & disease

Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA

Fri Aug 14 00:00:00 EDT 2020

Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells.

Scientific reports

Kupz A,Pai S,Giacomin PR,Whan JA,Walker RA,Hammoudi PM,Smith NC,Miller CM

Tue Aug 04 00:00:00 EDT 2020

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.

Cell reports

Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB

212-12 was used in Cell Culture to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.

Tue Apr 07 00:00:00 EDT 2020

Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity.

Nature cancer

Li Y,Su Z,Zhao W,Zhang X,Momin N,Zhang C,Wittrup KD,Dong Y,Irvine DJ,Weiss R

212-12 was used in Sample Preparation (FC/FACS) to investigate novel targeting methods to stimulate. immunogenic cancer cell death.

Tue Sep 01 00:00:00 EDT 2020

Chikungunya Virus Evades Antiviral CD8⁺ T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues.

Journal of virology

Davenport BJ,Bullock C,McCarthy MK,Hawman DW,Murphy KM,Kedl RM,Diamond MS,Morrison TE

212-12 was used in Cell Culture to find that CHIKV establishes and maintains a persistent infection in joint-associated tissue in part by evading antiviral CD8+ T cell immunity.

Thu Apr 16 00:00:00 EDT 2020

In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.

Cell reports

Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM

Tue Oct 27 00:00:00 EDT 2020

In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.

Cell reports

Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM

Tue Oct 27 00:00:00 EDT 2020

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.

Nature communications

Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD

Tue Aug 11 00:00:00 EDT 2020

Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3⁺ T_reg Cells.

Cell reports

Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P

212-12 was used in In vitro experiments to establish that BMPs, a large cytokine family, are an essential link between stromal tissues and the adaptive immune system involved in sustaining tissue homeostasis by promoting immunological tolerance.

Tue Oct 06 00:00:00 EDT 2020

The induction and function of the anti-inflammatory fate of T_H17 cells.

Nature communications

Xu H,Agalioti T,Zhao J,Steglich B,Wahib R,Vesely MCA,Bielecki P,Bailis W,Jackson R,Perez D,Izbicki J,Licona-Limón P,Kaartinen V,Geginat J,Esplugues E,Tolosa E,Huber S,Flavell RA,Gagliani N

Fri Jul 03 00:00:00 EDT 2020

The induction and function of the anti-inflammatory fate of T_H17 cells.

Nature communications

Xu H,Agalioti T,Zhao J,Steglich B,Wahib R,Vesely MCA,Bielecki P,Bailis W,Jackson R,Perez D,Izbicki J,Licona-Limón P,Kaartinen V,Geginat J,Esplugues E,Tolosa E,Huber S,Flavell RA,Gagliani N

Fri Jul 03 00:00:00 EDT 2020

Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing.

Scientific reports

Shen H,Gu C,Liang T,Liu H,Guo F,Liu X

Tue Nov 10 00:00:00 EST 2020

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model.

Frontiers in immunology

Wang N,Yi H,Fang L,Jin J,Ma Q,Shen Y,Li J,Liang S,Xiong J,Li Z,Zeng H,Jiang F,Jin B,Chen L

212-12 was used in Cell Culture to investigate the importance of CD226 in immune cell activation, utilizing mouse models.

Mon Apr 19 00:00:00 EDT 2021

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury.

Cell

Davies AJ,Kim HW,Gonzalez-Cano R,Choi J,Back SK,Roh SE,Johnson E,Gabriac M,Kim MS,Lee J,Lee JE,Kim YS,Bae YC,Kim SJ,Lee KM,Na HS,Riva P,Latremoliere A,Rinaldi S,Ugolini S,Costigan M,Oh SB

Thu Feb 07 00:00:00 EST 2019

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8⁺ T Cells.

Immunity

Ma EH,Verway MJ,Johnson RM,Roy DG,Steadman M,Hayes S,Williams KS,Sheldon RD,Samborska B,Kosinski PA,Kim H,Griss T,Faubert B,Condotta SA,Krawczyk CM,DeBerardinis RJ,Stewart KM,Richer MJ,Chubukov V,Roddy TP,Jones RG

Tue Nov 19 00:00:00 EST 2019

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Immunity

Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R

Tue Sep 17 00:00:00 EDT 2019

The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses.

Immunity

Adoue V,Binet B,Malbec A,Fourquet J,Romagnoli P,van Meerwijk JPM,Amigorena S,Joffre OP

Tue Mar 19 00:00:00 EDT 2019

Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.

Immunity

Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B

212-12 was used in In vitro experiments to investigate pathogenic lymphocyte in chronic inflammatory disease.

Tue May 21 00:00:00 EDT 2019

Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb.

Immunity

Shi H,Chapman NM,Wen J,Guy C,Long L,Dhungana Y,Rankin S,Pelletier S,Vogel P,Wang H,Peng J,Guan KL,Chi H

Tue Dec 17 00:00:00 EST 2019

Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Immunity

Pai CS,Huang JT,Lu X,Simons DM,Park C,Chang A,Tamaki W,Liu E,Roybal KT,Seagal J,Chen M,Hagihara K,Wei XX,DuPage M,Kwek SS,Oh DY,Daud A,Tsai KK,Wu C,Zhang L,Fasso M,Sachidanandam R,Jayaprakash A,Lin I,Casbon AJ,Kinsbury GA,Fong L

Tue Feb 19 00:00:00 EST 2019

Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells.

Immunity

van der Veeken J,Zhong Y,Sharma R,Mazutis L,Dao P,Pe'er D,Leslie CS,Rudensky AY

Tue May 21 00:00:00 EDT 2019

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance.

Immunity

Rivadeneira DB,DePeaux K,Wang Y,Kulkarni A,Tabib T,Menk AV,Sampath P,Lafyatis R,Ferris RL,Sarkar SN,Thorne SH,Delgoffe GM

Tue Sep 17 00:00:00 EDT 2019

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.

Immunity

Xu W,Zhao X,Wang X,Feng H,Gou M,Jin W,Wang X,Liu X,Dong C

Tue Nov 19 00:00:00 EST 2019

Intratumoral Tcf1⁺PD-1⁺CD8⁺ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.

Immunity

Siddiqui I,Schaeuble K,Chennupati V,Fuertes Marraco SA,Calderon-Copete S,Pais Ferreira D,Carmona SJ,Scarpellino L,Gfeller D,Pradervand S,Luther SA,Speiser DE,Held W

Tue Jan 15 00:00:00 EST 2019

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.

Cancer cell

Srivastava S,Salter AI,Liggitt D,Yechan-Gunja S,Sarvothama M,Cooper K,Smythe KS,Dudakov JA,Pierce RH,Rader C,Riddell SR

Mon Mar 18 00:00:00 EDT 2019

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.

The Journal of clinical investigation

Kaushik DK,Bhattacharya A,Mirzaei R,Rawji KS,Ahn Y,Rho JM,Yong VW

Tue May 21 00:00:00 EDT 2019

A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity.

The Journal of clinical investigation

Rasoulouniriana D,Santana-Magal N,Gutwillig A,Farhat-Younis L,Wine Y,Saperia C,Tal L,Gutman H,Tsivian A,Brenner R,Bandora EA,Reticker-Flynn NE,Rider P,Carmi Y

Tue Oct 01 00:00:00 EDT 2019

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.

The Journal of experimental medicine

Tuncel J,Benoist C,Mathis D

Mon Jun 03 00:00:00 EDT 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B

Mon Feb 04 00:00:00 EST 2019

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

The Journal of experimental medicine

Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S

Mon Aug 05 00:00:00 EDT 2019

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.

The Journal of experimental medicine

Sun X,Cui Y,Feng H,Liu H,Liu X

Mon Dec 02 00:00:00 EST 2019

BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.

The Journal of experimental medicine

Kotov JA,Kotov DI,Linehan JL,Bardwell VJ,Gearhart MD,Jenkins MK

Mon Jun 03 00:00:00 EDT 2019

Adaptation by naïve CD4⁺ T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance.

Proceedings of the National Academy of Sciences of the United States of America

Zinzow-Kramer WM,Weiss A,Au-Yeung BB

Tue Jul 23 00:00:00 EDT 2019

Treg-mediated prolonged survival of skin allografts without immunosuppression.

Proceedings of the National Academy of Sciences of the United States of America

Pilat N,Wiletel M,Weijler AM,Steiner R,Mahr B,Warren J,Corpuz TM,Wekerle T,Webster KE,Sprent J

Tue Jul 02 00:00:00 EDT 2019

Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection.

Proceedings of the National Academy of Sciences of the United States of America

Gamache A,Cronk JM,Nash WT,Puchalski P,Gillespie A,Wei H,Gray L,Hammarskjold ML,Xu W,Brown MG

Thu Dec 26 00:00:00 EST 2019

VISTA expressed in tumour cells regulates T cell function.

British journal of cancer

Mulati K,Hamanishi J,Matsumura N,Chamoto K,Mise N,Abiko K,Baba T,Yamaguchi K,Horikawa N,Murakami R,Taki M,Budiman K,Zeng X,Hosoe Y,Azuma M,Konishi I,Mandai M

Tue Jan 01 00:00:00 EST 2019

Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.

Mucosal immunology

Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y

Fri Mar 01 00:00:00 EST 2019

JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling.

Mucosal immunology

Katagiri T,Yamazaki S,Fukui Y,Aoki K,Yagita H,Nishina T,Mikami T,Katagiri S,Shiraishi A,Kimura S,Tateda K,Sumimoto H,Endo S,Kameda H,Nakano H

Sun Sep 01 00:00:00 EDT 2019

Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models.

Cancer science

Sakai Y,Miyazawa M,Komura T,Yamada T,Nasti A,Yoshida K,Takabatake H,Yamato M,Yamashita T,Yamashita T,Mizukoshi E,Okuzono M,Ho TTB,Kawaguchi K,Wada T,Honda M,Kaneko S

Fri Mar 01 00:00:00 EST 2019

Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8⁺ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Yamada T,Nabe S,Toriyama K,Suzuki J,Inoue K,Imai Y,Shiraishi A,Takenaka K,Yasukawa M,Yamashita M

212-12 was used in Cell Culture to investigate the role of Utx histone H3K27 demethylase in the CD8+ T cell-dependent immune response.

Fri Feb 15 00:00:00 EST 2019

Proteomic Profiling of Mouse Helper T Cell Differentiation.

Proteomics

van den Ham HJ,Binai NA,Zaaraoui-Boutahar F,Heck AJR,Andeweg AC

Mon Apr 01 00:00:00 EDT 2019

Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma.

Nature communications

Tian D,Yang L,Wang S,Zhu Y,Shi W,Zhang C,Jin H,Tian Y,Xu H,Sun G,Liu K,Zhang Z,Zhang D

Wed Sep 18 00:00:00 EDT 2019

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

212-12 was used in Cell Culture to explore the lncRNAs profile in the CD4+T cells from the mouse model of acute asthma.

Fri Apr 08 00:00:00 EDT 2022

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner.

Theranostics

Li J,Yang KY,Tam RCY,Chan VW,Lan HY,Hori S,Zhou B,Lui KO

212-12 was used in Sample Preparation (FC/FACS) to investigate the role of Treg in neonatal heart regeneration in mice.

Fri Aug 14 00:00:00 EDT 2020

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.

Nature communications

Niogret C,Miah SMS,Rota G,Fonta NP,Wang H,Held W,Birchmeier W,Sexl V,Yang W,Vivier E,Ho PC,Brossay L,Guarda G

Fri Mar 29 00:00:00 EDT 2019

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.

Nature communications

Belle NM,Ji Y,Herbine K,Wei Y,Park J,Zullo K,Hung LY,Srivatsa S,Young T,Oniskey T,Pastore C,Nieves W,Somsouk M,Herbert DR

Fri Sep 27 00:00:00 EDT 2019

Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.

The Journal of biological chemistry

Yin W,Song Y,Chang X

Fri Jan 04 00:00:00 EST 2019

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.

Nature communications

Czystowska-Kuzmicz M,Sosnowska A,Nowis D,Ramji K,Szajnik M,Chlebowska-Tuz J,Wolinska E,Gaj P,Grazul M,Pilch Z,Zerrouqi A,Graczyk-Jarzynka A,Soroczynska K,Cierniak S,Koktysz R,Elishaev E,Gruca S,Stefanowicz A,Blaszczyk R,Borek B,Gzik A,Whiteside T,Golab J

Fri Jul 05 00:00:00 EDT 2019

Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yang L,Sun J,Liu Q,Zhu R,Yang Q,Hua J,Zheng L,Li K,Wang S,Li A

Wed Apr 17 00:00:00 EDT 2019

Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells.

Cell death & disease

Yang J,Yang X,Yang J,Li M

Wed Feb 13 00:00:00 EST 2019

Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

Nature communications

Miyamoto C,Kojo S,Yamashita M,Moro K,Lacaud G,Shiroguchi K,Taniuchi I,Ebihara T

Fri Jan 25 00:00:00 EST 2019

Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan Induces IL-10-Producing B Cells and Hinders CD4⁺Th1 Immunity.

iScience

Yuan C,Qu ZL,Tang XL,Liu Q,Luo W,Huang C,Pan Q,Zhang XL

212-12 was used in Cell Culture to report a new immunoregulation mechanism in which Mtb ManLAM-induced B10 cells negatively regulate host anti-TB cellular immunity.

Fri Jan 25 00:00:00 EST 2019

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Cell

Walton ZE,Patel CH,Brooks RC,Yu Y,Ibrahim-Hashim A,Riddle M,Porcu A,Jiang T,Ecker BL,Tameire F,Koumenis C,Weeraratna AT,Welsh DK,Gillies R,Alwine JC,Zhang L,Powell JD,Dang CV

Thu Jun 28 00:00:00 EDT 2018

Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.

Cell

Wroblewska A,Dhainaut M,Ben-Zvi B,Rose SA,Park ES,Amir ED,Bektesevic A,Baccarini A,Merad M,Rahman AH,Brown BD

Thu Nov 01 00:00:00 EDT 2018

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype.

Cell

Li C,DiSpirito JR,Zemmour D,Spallanzani RG,Kuswanto W,Benoist C,Mathis D

Thu Jul 12 00:00:00 EDT 2018

Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.

Immunity

Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

Tue Nov 20 00:00:00 EST 2018

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.

Immunity

Proto JD,Doran AC,Gusarova G,Yurdagul A,Sozen E,Subramanian M,Islam MN,Rymond CC,Du J,Hook J,Kuriakose G,Bhattacharya J,Tabas I

Tue Oct 16 00:00:00 EDT 2018

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.

Immunity

Gawden-Bone CM,Frazer GL,Richard AC,Ma CY,Strege K,Griffiths GM

Tue Sep 18 00:00:00 EDT 2018

PD-1 Controls Follicular T Helper Cell Positioning and Function.

Immunity

Shi J,Hou S,Fang Q,Liu X,Liu X,Qi H

Tue Aug 21 00:00:00 EDT 2018

An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis.

Immunity

Fatkhullina AR,Peshkova IO,Dzutsev A,Aghayev T,McCulloch JA,Thovarai V,Badger JH,Vats R,Sundd P,Tang HY,Kossenkov AV,Hazen SL,Trinchieri G,Grivennikov SI,Koltsova EK

Tue Nov 20 00:00:00 EST 2018

Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function.

Immunity

Li S,Bostick JW,Ye J,Qiu J,Zhang B,Urban JF,Avram D,Zhou L

Tue Nov 20 00:00:00 EST 2018

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.

Nature immunology

Castro W,Chelbi ST,Niogret C,Ramon-Barros C,Welten SPM,Osterheld K,Wang H,Rota G,Morgado L,Vivier E,Raeber ME,Boyman O,Delorenzi M,Barras D,Ho PC,Oxenius A,Guarda G

212-12 was used in In vivo experiments to show metabolism and homeostasis of natural killer cells can be regulated by transcription factor Rfx7.

Wed Aug 01 00:00:00 EDT 2018

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

The Journal of experimental medicine

Stier MT,Zhang J,Goleniewska K,Cephus JY,Rusznak M,Wu L,Van Kaer L,Zhou B,Newcomb DC,Peebles RS

212-12 was used in Sample Preparation (FC/FACS) to study the critical role for IL-33 which is a hallmark peripheral ILC2-activating cytokine in the process of promoting the egress of ILC2 lineage cells from the bone marrow.

Tue Jan 02 00:00:00 EST 2018

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

The Journal of experimental medicine

Stier MT,Zhang J,Goleniewska K,Cephus JY,Rusznak M,Wu L,Van Kaer L,Zhou B,Newcomb DC,Peebles RS

Tue Jan 02 00:00:00 EST 2018

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses.

The Journal of experimental medicine

Menk AV,Scharping NE,Rivadeneira DB,Calderon MJ,Watson MJ,Dunstane D,Watkins SC,Delgoffe GM

Mon Apr 02 00:00:00 EDT 2018

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin.

The Journal of experimental medicine

Lane RS,Femel J,Breazeale AP,Loo CP,Thibault G,Kaempf A,Mori M,Tsujikawa T,Chang YH,Lund AW

Mon Dec 03 00:00:00 EST 2018

ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8⁺ T cell fates.

The Journal of experimental medicine

Guan T,Dominguez CX,Amezquita RA,Laidlaw BJ,Cheng J,Henao-Mejia J,Williams A,Flavell RA,Lu J,Kaech SM

Mon Apr 02 00:00:00 EDT 2018

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

The Journal of experimental medicine

Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M

Mon Jul 02 00:00:00 EDT 2018

USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.

The Journal of experimental medicine

Chen S,Yun F,Yao Y,Cao M,Zhang Y,Wang J,Song X,Qian Y

Mon Nov 05 00:00:00 EST 2018

Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis.

Hepatology (Baltimore, Md.)

Taylor AE,Carey AN,Kudira R,Lages CS,Shi T,Lam S,Karns R,Simmons J,Shanmukhappa K,Almanan M,Chougnet CA,Miethke AG

212-12 was used in In vivo experiments to showcase IL2 countering CD8+ T cell-driven biliary injury and fibrosis via hepatic Tregs in sclerosing cholangitis suggesting Treg-directed low-dose IL2 treatment as a considerable therapeutic option for the disease..

Thu Nov 01 00:00:00 EDT 2018

CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.

Proceedings of the National Academy of Sciences of the United States of America

Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B

Tue Mar 27 00:00:00 EDT 2018

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo.

Proceedings of the National Academy of Sciences of the United States of America

DiTommaso T,Cole JM,Cassereau L,Buggé JA,Hanson JLS,Bridgen DT,Stokes BD,Loughhead SM,Beutel BA,Gilbert JB,Nussbaum K,Sorrentino A,Toggweiler J,Schmidt T,Gyuelveszi G,Bernstein H,Sharei A

Tue Nov 13 00:00:00 EST 2018

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo.

Proceedings of the National Academy of Sciences of the United States of America

DiTommaso T,Cole JM,Cassereau L,Buggé JA,Hanson JLS,Bridgen DT,Stokes BD,Loughhead SM,Beutel BA,Gilbert JB,Nussbaum K,Sorrentino A,Toggweiler J,Schmidt T,Gyuelveszi G,Bernstein H,Sharei A

Tue Nov 13 00:00:00 EST 2018

The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.

Journal of immunology (Baltimore, Md. : 1950)

Grinberg-Bleyer Y,Caron R,Seeley JJ,De Silva NS,Schindler CW,Hayden MS,Klein U,Ghosh S

Sun Apr 01 00:00:00 EDT 2018

IL-2-Anti-IL-2 Monoclonal Antibody Immune Complexes Inhibit Collagen-Induced Arthritis by Augmenting Regulatory T Cell Functions.

Journal of immunology (Baltimore, Md. : 1950)

Yokoyama Y,Iwasaki T,Kitano S,Satake A,Nomura S,Furukawa T,Matsui K,Sano H

Mon Oct 01 00:00:00 EDT 2018

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Suárez-Fueyo A,Bradley SJ,Katsuyama T,Solomon S,Katsuyama E,Kyttaris VC,Moulton VR,Tsokos GC

Tue May 01 00:00:00 EDT 2018

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.

Journal of immunology (Baltimore, Md. : 1950)

Spangler JB,Trotta E,Tomala J,Peck A,Young TA,Savvides CS,Silveria S,Votavova P,Salafsky J,Pande VS,Kovar M,Bluestone JA,Garcia KC

Mon Oct 01 00:00:00 EDT 2018

Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection.

Journal of immunology (Baltimore, Md. : 1950)

Grau M,Valsesia S,Mafille J,Djebali S,Tomkowiak M,Mathieu AL,Laubreton D,de Bernard S,Jouve PE,Ventre E,Buffat L,Walzer T,Leverrier Y,Marvel J

Tue May 15 00:00:00 EDT 2018

Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection.

Journal of immunology (Baltimore, Md. : 1950)

Grau M,Valsesia S,Mafille J,Djebali S,Tomkowiak M,Mathieu AL,Laubreton D,de Bernard S,Jouve PE,Ventre E,Buffat L,Walzer T,Leverrier Y,Marvel J

Tue May 15 00:00:00 EDT 2018

Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4⁺ T Cell Polarization.

Journal of immunology (Baltimore, Md. : 1950)

Choi SC,Xu Z,Li W,Yang H,Roopenian DC,Morse HC,Morel L

Tue May 01 00:00:00 EDT 2018

Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Bhatt B,Zeng P,Zhu H,Sivaprakasam S,Li S,Xiao H,Dong L,Shiao P,Kolhe R,Patel N,Li H,Levy-Bercowski D,Ganapathy V,Singh N

Sun Apr 15 00:00:00 EDT 2018

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3⁺ Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Sun IH,Oh MH,Zhao L,Patel CH,Arwood ML,Xu W,Tam AJ,Blosser RL,Wen J,Powell JD

Sun Jul 15 00:00:00 EDT 2018

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3⁺ Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Mathies F,Steffens N,Kleinschmidt D,Stuhlmann F,Huber FJ,Roy U,Meyer T,Luetgehetmann M,von Petersdorff M,Seiz O,Herkel J,Schramm C,Flavell RA,Gagliani N,Krebs C,Panzer U,Abdullah Z,Strowig T,Bedke T,Huber S

Sat Dec 15 00:00:00 EST 2018

A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide-Autoreactive CD4⁺ and CD8⁺ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Wan X,Pei W,Shahzad KA,Zhang L,Song S,Jin X,Wang L,Zhao C,Shen C

Wed Aug 15 00:00:00 EDT 2018

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.

Journal of immunology (Baltimore, Md. : 1950)

Hu MD,Ethridge AD,Lipstein R,Kumar S,Wang Y,Jabri B,Turner JR,Edelblum KL

Sun Jul 15 00:00:00 EDT 2018

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.

Nature communications

Chen D,Xie J,Fiskesund R,Dong W,Liang X,Lv J,Jin X,Liu J,Mo S,Zhang T,Cheng F,Zhou Y,Zhang H,Tang K,Ma J,Liu Y,Huang B

Wed Feb 28 00:00:00 EST 2018

Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.

Cell death & disease

Lv Q,Shi C,Qiao S,Cao N,Guan C,Dai Y,Wei Z

Thu Aug 30 00:00:00 EDT 2018

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.

Nature communications

Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K

Tue Oct 30 00:00:00 EDT 2018

Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.

Nature communications

Jung KB,Lee H,Son YS,Lee MO,Kim YD,Oh SJ,Kwon O,Cho S,Cho HS,Kim DS,Oh JH,Zilbauer M,Min JK,Jung CR,Kim J,Son MY

Thu Aug 02 00:00:00 EDT 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

212-12 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Protective humoral and CD4⁺ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model.

Scientific reports

Yu W,Yao D,Yu S,Wang X,Li X,Wang M,Liu S,Feng Z,Chen X,Li W,Wang L,Liu W,Ma J,Yu L,Tong C,Song B,Cui Y

Mon Feb 26 00:00:00 EST 2018

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.

Nature communications

Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM

Mon Feb 05 00:00:00 EST 2018

Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo.

Nature communications

O'Neil RT,Saha S,Veach RA,Welch RC,Woodard LE,Rooney CM,Wilson MH

Tue Apr 10 00:00:00 EDT 2018

Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells.

Cell death & disease

Sun G,Sun X,Li W,Liu K,Tian D,Dong Y,Sun X,Xu H,Zhang D

Wed May 23 00:00:00 EDT 2018

Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines.

Viruses

Sun L,Hao Y,Wang Z,Zeng Y

212-12 was used in Sample Preparation to investigate anti-tumour effects of LMP2-related vaccines.

Fri Mar 23 00:00:00 EDT 2018

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.

Nature communications

Zhang Y,Li N,Suh H,Irvine DJ

Tue Jan 02 00:00:00 EST 2018

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.

Nature communications

Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C

Thu Apr 12 00:00:00 EDT 2018

CDK4/6 inhibition triggers anti-tumour immunity.

Nature

Goel S,DeCristo MJ,Watt AC,BrinJones H,Sceneay J,Li BB,Khan N,Ubellacker JM,Xie S,Metzger-Filho O,Hoog J,Ellis MJ,Ma CX,Ramm S,Krop IE,Winer EP,Roberts TM,Kim HJ,McAllister SS,Zhao JJ

Thu Aug 24 00:00:00 EDT 2017

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.

Cell

Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z

Thu Sep 21 00:00:00 EDT 2017

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.

Immunity

Oh H,Grinberg-Bleyer Y,Liao W,Maloney D,Wang P,Wu Z,Wang J,Bhatt DM,Heise N,Schmid RM,Hayden MS,Klein U,Rabadan R,Ghosh S

Tue Sep 19 00:00:00 EDT 2017

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Immunity

Mowel WK,McCright SJ,Kotzin JJ,Collet MA,Uyar A,Chen X,DeLaney A,Spencer SP,Virtue AT,Yang E,Villarino A,Kurachi M,Dunagin MC,Pritchard GH,Stein J,Hughes C,Fonseca-Pereira D,Veiga-Fernandes H,Raj A,Kambayashi T,Brodsky IE,O'Shea JJ,Wherry EJ,Goff LA,Rinn JL,Williams A,Flavell RA,Henao-Mejia J

Tue Sep 19 00:00:00 EDT 2017

SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.

Immunity

Stephen TL,Payne KK,Chaurio RA,Allegrezza MJ,Zhu H,Perez-Sanz J,Perales-Puchalt A,Nguyen JM,Vara-Ailor AE,Eruslanov EB,Borowsky ME,Zhang R,Laufer TM,Conejo-Garcia JR

Tue Jan 17 00:00:00 EST 2017

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction.

Immunity

Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W

Tue Dec 19 00:00:00 EST 2017

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

The Journal of clinical investigation

Widjaja CE,Olvera JG,Metz PJ,Phan AT,Savas JN,de Bruin G,Leestemaker Y,Berkers CR,de Jong A,Florea BI,Fisch K,Lopez J,Kim SH,Garcia DA,Searles S,Bui JD,Chang AN,Yates JR,Goldrath AW,Overkleeft HS,Ovaa H,Chang JT

Mon Oct 02 00:00:00 EDT 2017

CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.

Molecular cell

Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K

212-12 was used in In vitro experiments to study the role of CTCF in regulating cell-to-cell variation of expression.

Thu Sep 21 00:00:00 EDT 2017

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.

The Journal of experimental medicine

Viant C,Guia S,Hennessy RJ,Rautela J,Pham K,Bernat C,Goh W,Jiao Y,Delconte R,Roger M,Simon V,Souza-Fonseca-Guimaraes F,Grabow S,Belz GT,Kile BT,Strasser A,Gray D,Hodgkin PD,Beutler B,Vivier E,Ugolini S,Huntington ND

Wed Feb 01 00:00:00 EST 2017

Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1.

The Journal of experimental medicine

Fu G,Xu Q,Qiu Y,Jin X,Xu T,Dong S,Wang J,Ke Y,Hu H,Cao X,Wang D,Cantor H,Gao X,Lu L

Mon May 01 00:00:00 EDT 2017

Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8⁺ T cells.

Proceedings of the National Academy of Sciences of the United States of America

Salerno F,Paolini NA,Stark R,von Lindern M,Wolkers MC

Tue Sep 05 00:00:00 EDT 2017

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.

Oncogene

Sochalska M,Schuler F,Weiss JG,Prchal-Murphy M,Sexl V,Villunger A

Sat Apr 01 00:00:00 EDT 2017

STAT4 Regulates the CD8⁺ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Mice.

Journal of immunology (Baltimore, Md. : 1950)

Taghavie-Moghadam PL,Waseem TC,Hattler J,Glenn LM,Dobrian AD,Kaplan MH,Yang Y,Nurieva R,Nadler JL,Galkina EV

Wed Nov 15 00:00:00 EST 2017

Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.

Journal of immunology (Baltimore, Md. : 1950)

Jin RM,Blair SJ,Warunek J,Heffner RR,Blader IJ,Wohlfert EA

Sun Jan 01 00:00:00 EST 2017

SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.

Journal of immunology (Baltimore, Md. : 1950)

Takahashi R,Nakatsukasa H,Shiozawa S,Yoshimura A

Sat Jul 01 00:00:00 EDT 2017

IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Corpuz TM,Vazquez-Lombardi R,Luong JK,Warren J,Stolp J,Christ D,King C,Brink R,Sprent J,Webster KE

Sun Oct 01 00:00:00 EDT 2017

Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells.

Journal of immunology (Baltimore, Md. : 1950)

Onodera A,Kiuchi M,Kokubo K,Kato M,Ogino T,Horiuchi S,Kanai U,Hirahara K,Nakayama T

Tue Aug 01 00:00:00 EDT 2017

Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool.

Journal of immunology (Baltimore, Md. : 1950)

Klann JE,Remedios KA,Kim SH,Metz PJ,Lopez J,Mack LA,Zheng Y,Ginsberg MH,Petrich BG,Chang JT

Thu Jun 15 00:00:00 EDT 2017

Cell penetrable-mouse forkhead box P3 suppresses type 1 T helper cell-mediated immunity in a murine model of delayed-type hypersensitivity.

Experimental and therapeutic medicine

Liu X,Wang J,Wang H,Zhou C,Yu Q,Yin L,Wu W,Xia S,Shao Q

212-12 was used in Sample Preparation (FC/FACS) to study the role and mechanism of PTD-mFOXP3, shown to alleviate experimental arthritis in mice, in type 1 T helper (Th1) cell-mediated immunity to show that PTD-mFOXP3 may attenuate delayed type hypersensitivity (DTH) reactions by suppressing the infiltration and activity of Th1 cells.

Wed Feb 01 00:00:00 EST 2017

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.

Nature communications

Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S

Wed Mar 15 00:00:00 EDT 2017

The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.

The Journal of biological chemistry

Chen J,Martindale JL,Cramer C,Gorospe M,Atasoy U,Drew PD,Yu S

Fri Sep 01 00:00:00 EDT 2017

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.

Nature communications

Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A

Wed Oct 18 00:00:00 EDT 2017

Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay.

Scientific reports

Ko JS,Koh JM,So JS,Jeon YK,Kim HY,Chung DH

Thu Nov 02 00:00:00 EDT 2017

Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.

Scientific reports

Wang Q,He J,Flies DB,Luo L,Chen L

Thu Jul 20 00:00:00 EDT 2017

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.

The Journal of biological chemistry

Van de Velde LA,Subramanian C,Smith AM,Barron L,Qualls JE,Neale G,Alfonso-Pecchio A,Jackowski S,Rock CO,Wynn TA,Murray PJ

Fri Jan 06 00:00:00 EST 2017

Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia.

Scientific reports

Kotani T,Masutani R,Suzuka T,Oda K,Makino S,Ii M

Mon Nov 06 00:00:00 EST 2017

Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production.

Scientific reports

Polesso F,Sarker M,Anderson A,Parker DC,Murray SE

Tue Nov 07 00:00:00 EST 2017

Characterization of c-Maf⁺Foxp3^- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells.

Scientific reports

Chien CH,Yu HC,Chen SY,Chiang BL

Wed Apr 12 00:00:00 EDT 2017

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

The Journal of biological chemistry

Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM

Fri Feb 03 00:00:00 EST 2017

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.

Nature communications

Schmid D,Park CG,Hartl CA,Subedi N,Cartwright AN,Puerto RB,Zheng Y,Maiarana J,Freeman GJ,Wucherpfennig KW,Irvine DJ,Goldberg MS

Thu Nov 23 00:00:00 EST 2017

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.

Nature

Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR

212-12 was used in In vitro experiments to investigate the mechanisms that sustain differential cell fates in daughter T cells after activation by an antigen-presenting cell.

Thu Apr 21 00:00:00 EDT 2016

NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.

Nature

Karki R,Man SM,Malireddi RKS,Kesavardhana S,Zhu Q,Burton AR,Sharma BR,Qi X,Pelletier S,Vogel P,Rosenstiel P,Kanneganti TD

212-12 was used in In vitro experiments to explore a key role for NLRC3 in mediating protection against colorectal cancer.

Thu Dec 22 00:00:00 EST 2016

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.

Immunity

Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C

Tue Jun 21 00:00:00 EDT 2016

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Immunity

Delconte RB,Shi W,Sathe P,Ushiki T,Seillet C,Minnich M,Kolesnik TB,Rankin LC,Mielke LA,Zhang JG,Busslinger M,Smyth MJ,Hutchinson DS,Nutt SL,Nicholson SE,Alexander WS,Corcoran LM,Vivier E,Belz GT,Carotta S,Huntington ND

Tue Jan 19 00:00:00 EST 2016

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Immunity

Tue Jan 19 00:00:00 EST 2016

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.

Immunity

Cortez VS,Cervantes-Barragan L,Robinette ML,Bando JK,Wang Y,Geiger TL,Gilfillan S,Fuchs A,Vivier E,Sun JC,Cella M,Colonna M

Tue May 17 00:00:00 EDT 2016

Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.

Blood

Mascarenhas MI,Bacon WA,Kapeni C,Fitch SR,Kimber G,Cheng SW,Li J,Green AR,Ottersbach K

Thu May 12 00:00:00 EDT 2016

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells.

Blood

Leclerc M,Naserian S,Pilon C,Thiolat A,Martin GH,Pouchy C,Dominique C,Belkacemi Y,Charlotte F,Maury S,Salomon BL,Cohen JL

Thu Sep 22 00:00:00 EDT 2016

FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.

The Journal of clinical investigation

Lexmond WS,Goettel JA,Lyons JJ,Jacobse J,Deken MM,Lawrence MG,DiMaggio TH,Kotlarz D,Garabedian E,Sackstein P,Nelson CC,Jones N,Stone KD,Candotti F,Rings EH,Thrasher AJ,Milner JD,Snapper SB,Fiebiger E

Mon Oct 03 00:00:00 EDT 2016

MicroRNA-29b mediates altered innate immune development in acute leukemia.

The Journal of clinical investigation

Mundy-Bosse BL,Scoville SD,Chen L,McConnell K,Mao HC,Ahmed EH,Zorko N,Harvey S,Cole J,Zhang X,Costinean S,Croce CM,Larkin K,Byrd JC,Vasu S,Blum W,Yu J,Freud AG,Caligiuri MA

Thu Dec 01 00:00:00 EST 2016

Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.

The Journal of clinical investigation

Cheng HY,Gaddis DE,Wu R,McSkimming C,Haynes LD,Taylor AM,McNamara CA,Sorci-Thomas M,Hedrick CC

Thu Sep 01 00:00:00 EDT 2016

Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.

The Journal of experimental medicine

Everts B,Tussiwand R,Dreesen L,Fairfax KC,Huang SC,Smith AM,O'Neill CM,Lam WY,Edelson BT,Urban JF,Murphy KM,Pearce EJ

Mon Jan 11 00:00:00 EST 2016

miR-23∼27∼24 clusters control effector T cell differentiation and function.

The Journal of experimental medicine

Cho S,Wu CJ,Yasuda T,Cruz LO,Khan AA,Lin LL,Nguyen DT,Miller M,Lee HM,Kuo ML,Broide DH,Rajewsky K,Rudensky AY,Lu LF

Mon Feb 08 00:00:00 EST 2016

CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America

Akane K,Kojima S,Mak TW,Shiku H,Suzuki H

Tue Mar 01 00:00:00 EST 2016

Unstable FoxP3+ T regulatory cells in NZW mice.

Proceedings of the National Academy of Sciences of the United States of America

Dépis F,Kwon HK,Mathis D,Benoist C

Tue Feb 02 00:00:00 EST 2016

Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.

Proceedings of the National Academy of Sciences of the United States of America

Rabacal W,Pabbisetty SK,Hoek KL,Cendron D,Guo Y,Maseda D,Sebzda E

Tue May 10 00:00:00 EDT 2016

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.

Proceedings of the National Academy of Sciences of the United States of America

Chu VT,Graf R,Wirtz T,Weber T,Favret J,Li X,Petsch K,Tran NT,Sieweke MH,Berek C,Kühn R,Rajewsky K

Tue Nov 01 00:00:00 EDT 2016

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.

Proceedings of the National Academy of Sciences of the United States of America

Pageon SV,Tabarin T,Yamamoto Y,Ma Y,Nicovich PR,Bridgeman JS,Cohnen A,Benzing C,Gao Y,Crowther MD,Tungatt K,Dolton G,Sewell AK,Price DA,Acuto O,Parton RG,Gooding JJ,Rossy J,Rossjohn J,Gaus K

Tue Sep 13 00:00:00 EDT 2016

Network pharmacology of JAK inhibitors.

Proceedings of the National Academy of Sciences of the United States of America

Moodley D,Yoshida H,Mostafavi S,Asinovski N,Ortiz-Lopez A,Symanowicz P,Telliez JB,Hegen M,Clark JD,Mathis D,Benoist C

Tue Aug 30 00:00:00 EDT 2016

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.

The Journal of cell biology

Hecht VC,Sullivan LB,Kimmerling RJ,Kim DH,Hosios AM,Stockslager MA,Stevens MM,Kang JH,Wirtz D,Vander Heiden MG,Manalis SR

Mon Feb 15 00:00:00 EST 2016

Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research.

Molecular therapy oncolytics

Inoo K,Inagaki R,Fujiwara K,Sasawatari S,Kamigaki T,Nakagawa S,Okada N

Wed Sep 30 00:00:00 EDT 2020

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Journal of immunology (Baltimore, Md. : 1950)

Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K

Sun May 01 00:00:00 EDT 2016

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Song Y,Kumar V,Wei HX,Qiu J,Stanley P

Fri Jan 01 00:00:00 EST 2016

Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis.

Journal of immunology (Baltimore, Md. : 1950)

Liu L,Yi H,Wang C,He H,Li P,Pan H,Sheng N,Ji M,Cai L,Ma Y

Mon Aug 15 00:00:00 EDT 2016

Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Jones LL,Alli R,Li B,Geiger TL

Fri Apr 01 00:00:00 EDT 2016

Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals.

Journal of immunology (Baltimore, Md. : 1950)

Kim MT,Kurup SP,Starbeck-Miller GR,Harty JT

Thu Sep 01 00:00:00 EDT 2016

Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration.

Journal of immunology (Baltimore, Md. : 1950)

Morillon YM,Lessey-Morillon EC,Clark M,Zhang R,Wang B,Burridge K,Tisch R

Tue Nov 01 00:00:00 EDT 2016

Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner.

Journal of immunology (Baltimore, Md. : 1950)

Sasidharan Nair V,Song MH,Oh KI

Tue Mar 01 00:00:00 EST 2016

Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells.

Journal of immunology (Baltimore, Md. : 1950)

Verrier T,Satoh-Takayama N,Serafini N,Marie S,Di Santo JP,Vosshenrich CA

Wed Jun 01 00:00:00 EDT 2016

TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.

Journal of immunology (Baltimore, Md. : 1950)

Kourepini E,Paschalidis N,Simoes DC,Aggelakopoulou M,Grogan JL,Panoutsakopoulou V

Sun May 01 00:00:00 EDT 2016

Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Radtke D,Lacher SM,Szumilas N,Sandrock L,Ackermann J,Nitschke L,Zinser E

Fri Apr 01 00:00:00 EDT 2016

A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Chen LC,Nicholson YT,Rosborough BR,Thomson AW,Raimondi G

Mon Aug 15 00:00:00 EDT 2016

ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V

Sat Oct 01 00:00:00 EDT 2016

The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Choi SC,Hutchinson TE,Titov AA,Seay HR,Li S,Brusko TM,Croker BP,Salek-Ardakani S,Morel L

Fri Jul 15 00:00:00 EDT 2016

ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Aggelakopoulou M,Kourepini E,Paschalidis N,Panoutsakopoulou V

Wed Jun 15 00:00:00 EDT 2016

Loss of immune tolerance to IL-2 in type 1 diabetes.

Nature communications

Pérol L,Lindner JM,Caudana P,Nunez NG,Baeyens A,Valle A,Sedlik C,Loirat D,Boyer O,Créange A,Cohen JL,Rogner UC,Yamanouchi J,Marchant M,Leber XC,Scharenberg M,Gagnerault MC,Mallone R,Battaglia M,Santamaria P,Hartemann A,Traggiai E,Piaggio E

Thu Oct 06 00:00:00 EDT 2016

Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers.

Scientific reports

Song KH,Lee J,Park H,Kim HM,Park J,Kwon KW,Doh J

Mon Mar 21 00:00:00 EDT 2016

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.

Nature communications

Chou TF,Chuang YT,Hsieh WC,Chang PY,Liu HY,Mo ST,Hsu TS,Miaw SC,Chen RH,Kimchi A,Lai MZ

Fri Jun 17 00:00:00 EDT 2016

Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.

Scientific reports

Lee WW,Teo TH,Lum FM,Andiappan AK,Amrun SN,Rénia L,Rötzschke O,Ng LF

Fri Nov 25 00:00:00 EST 2016

Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.

Scientific reports

Lee WW,Teo TH,Lum FM,Andiappan AK,Amrun SN,Rénia L,Rötzschke O,Ng LF

Fri Nov 25 00:00:00 EST 2016

CD45-mediated control of TCR tuning in naïve and memory CD8⁺ T cells.

Nature communications

Cho JH,Kim HO,Ju YJ,Kye YC,Lee GW,Lee SW,Yun CH,Bottini N,Webster K,Goodnow CC,Surh CD,King C,Sprent J

Mon Nov 14 00:00:00 EST 2016

CD45-mediated control of TCR tuning in naïve and memory CD8⁺ T cells.

Nature communications

Cho JH,Kim HO,Ju YJ,Kye YC,Lee GW,Lee SW,Yun CH,Bottini N,Webster K,Goodnow CC,Surh CD,King C,Sprent J

Mon Nov 14 00:00:00 EST 2016

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Scientific reports

Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ

Mon May 23 00:00:00 EDT 2016

Hybrid bright-field and hologram imaging of cell dynamics.

Scientific reports

Byeon H,Lee J,Doh J,Lee SJ

Mon Sep 19 00:00:00 EDT 2016

IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.

Scientific reports

Kritikou JS,Dahlberg CI,Baptista MA,Wagner AK,Banerjee PP,Gwalani LA,Poli C,Panda SK,Kärre K,Kaech SM,Wermeling F,Andersson J,Orange JS,Brauner H,Westerberg LS

Mon Aug 01 00:00:00 EDT 2016

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.

The Journal of biological chemistry

Pasi S,Kant R,Surolia A

Fri Jun 03 00:00:00 EDT 2016

Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.

Scientific reports

Cooley LF,El Shikh ME,Li W,Keim RC,Zhang Z,Strauss JF,Zhang Z,Conrad DH

Thu May 12 00:00:00 EDT 2016

Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice.

Scientific reports

Zhang ZQ,Ren SC,Tan Y,Li ZZ,Tang X,Wang TT,Hao DL,Zhao X,Chen HZ,Liu DP

Tue Apr 05 00:00:00 EDT 2016

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

Nature communications

Kimmerling RJ,Lee Szeto G,Li JW,Genshaft AS,Kazer SW,Payer KR,de Riba Borrajo J,Blainey PC,Irvine DJ,Shalek AK,Manalis SR

Wed Jan 06 00:00:00 EST 2016

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

Nature communications

Krausgruber T,Schiering C,Adelmann K,Harrison OJ,Chomka A,Pearson C,Ahern PP,Shale M,Oukka M,Powrie F

Thu May 19 00:00:00 EDT 2016

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

Blood

Van der Meulen J,Sanghvi V,Mavrakis K,Durinck K,Fang F,Matthijssens F,Rondou P,Rosen M,Pieters T,Vandenberghe P,Delabesse E,Lammens T,De Moerloose B,Menten B,Van Roy N,Verhasselt B,Poppe B,Benoit Y,Taghon T,Melnick AM,Speleman F,Wendel HG,Van Vlierberghe P

Thu Jan 01 00:00:00 EST 2015

Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.

The Journal of clinical investigation

McCracken MN,Vatakis DN,Dixit D,McLaughlin J,Zack JA,Witte ON

Fri May 01 00:00:00 EDT 2015

Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging.

The Journal of clinical investigation

McCracken MN,Vatakis DN,Dixit D,McLaughlin J,Zack JA,Witte ON

Fri May 01 00:00:00 EDT 2015

DNAM-1 controls NK cell activation via an ITT-like motif.

The Journal of experimental medicine

Zhang Z,Wu N,Lu Y,Davidson D,Colonna M,Veillette A

Mon Nov 16 00:00:00 EST 2015

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.

The Journal of experimental medicine

Sekiya T,Kondo T,Shichita T,Morita R,Ichinose H,Yoshimura A

Mon Sep 21 00:00:00 EDT 2015

AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway.

EMBO molecular medicine

Pérez-García A,Pérez-Durán P,Wossning T,Sernandez IV,Mur SM,Cañamero M,Real FX,Ramiro AR

Thu Oct 01 00:00:00 EDT 2015

IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.

Proceedings of the National Academy of Sciences of the United States of America

Schmaler M,Broggi MA,Lagarde N,Stöcklin BF,King CG,Finke D,Rossi SW

Tue Oct 27 00:00:00 EDT 2015

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3.

Proceedings of the National Academy of Sciences of the United States of America

Yan D,Farache J,Mingueneau M,Mathis D,Benoist C

Tue Dec 01 00:00:00 EST 2015

T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.

Proceedings of the National Academy of Sciences of the United States of America

Baumann C,Bonilla WV,Fröhlich A,Helmstetter C,Peine M,Hegazy AN,Pinschewer DD,Löhning M

Tue Mar 31 00:00:00 EDT 2015

T-cell receptor α enhancer is inactivated in αβ T lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America

del Blanco B,Angulo Ú,Krangel MS,Hernández-Munain C

Tue Apr 07 00:00:00 EDT 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America

Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X

Tue Dec 29 00:00:00 EST 2015

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.

European journal of immunology

Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S

Fri May 01 00:00:00 EDT 2015

Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.

Clinical and experimental immunology

Motozono C,Bridgeman JS,Price DA,Sewell AK,Ueno T

Mon Jun 01 00:00:00 EDT 2015

Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice.

Journal of immunology (Baltimore, Md. : 1950)

Manirarora JN,Wei CH

Tue Dec 01 00:00:00 EST 2015

Journal of immunology (Baltimore, Md. : 1950)

Manirarora JN,Wei CH

Tue Dec 01 00:00:00 EST 2015

Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Li Q,Virtuoso LP,Anderson CD,Egilmez NK

Sat Aug 01 00:00:00 EDT 2015

4-1BB ligand signaling to T cells limits T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Eun SY,Lee SW,Xu Y,Croft M

Thu Jan 01 00:00:00 EST 2015

Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells.

Journal of immunology (Baltimore, Md. : 1950)

Suzuki M,Morita R,Hirata Y,Shichita T,Yoshimura A

Sat Aug 01 00:00:00 EDT 2015

Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention.

Journal of immunology (Baltimore, Md. : 1950)

Mackay LK,Braun A,Macleod BL,Collins N,Tebartz C,Bedoui S,Carbone FR,Gebhardt T

Sun Mar 01 00:00:00 EST 2015

Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.

Journal of immunology (Baltimore, Md. : 1950)

Ebel ME,Awe O,Kaplan MH,Kansas GS

Mon Jun 15 00:00:00 EDT 2015

IL-2/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis.

Journal of immunology (Baltimore, Md. : 1950)

Gaddipati S,Estrada K,Rao P,Jerome AD,Suvas S

Thu Jan 01 00:00:00 EST 2015

Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.

Journal of immunology (Baltimore, Md. : 1950)

Kim MT,Richer MJ,Gross BP,Norian LA,Badovinac VP,Harty JT

Sun Nov 01 00:00:00 EDT 2015

TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.

Journal of immunology (Baltimore, Md. : 1950)

Vogel SZ,Schlickeiser S,Jürchott K,Akyuez L,Schumann J,Appelt C,Vogt K,Schröder M,Vaeth M,Berberich-Siebelt F,Lutz MB,Grütz G,Sawitzki B

Wed Apr 01 00:00:00 EDT 2015

Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Chan SL,Lindquist LD,Hansen MJ,Girtman MA,Pease LR,Bram RJ

Tue Dec 15 00:00:00 EST 2015

Survival of effector CD8+ T cells during influenza infection is dependent on autophagy.

Journal of immunology (Baltimore, Md. : 1950)

Schlie K,Westerback A,DeVorkin L,Hughson LR,Brandon JM,MacPherson S,Gadawski I,Townsend KN,Poon VI,Elrick MA,Côté HC,Abraham N,Wherry EJ,Mizushima N,Lum JJ

Fri May 01 00:00:00 EDT 2015

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions.

Journal of immunology (Baltimore, Md. : 1950)

Metidji A,Rieder SA,Glass DD,Cremer I,Punkosdy GA,Shevach EM

Fri May 01 00:00:00 EDT 2015

Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.

Journal of immunology (Baltimore, Md. : 1950)

Waight JD,Takai S,Marelli B,Qin G,Hance KW,Zhang D,Tighe R,Lan Y,Lo KM,Sabzevari H,Hofmeister R,Wilson NS

Sun Feb 01 00:00:00 EST 2015

Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein.

The Journal of biological chemistry

Zheng Y,Zou F,Wang J,Yin G,Le V,Fei Z,Liu J

Fri Apr 03 00:00:00 EDT 2015

Immunodominant epitope-specific Th1 but not Th17 responses mediate protection against Helicobacter pylori infection following UreB vaccination of BALB/c mice.

Scientific reports

Li B,Chen L,Sun H,Yang W,Hu J,He Y,Wei S,Zhao Z,Zhang J,Li H,Zou Q,Wu C

Mon Oct 05 00:00:00 EDT 2015

CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs.

Scientific reports

Wang C,Liu X,Li Z,Chai Y,Jiang Y,Wang Q,Ji Y,Zhu Z,Wan Y,Yuan Z,Chang Z,Zhang M

Tue Sep 15 00:00:00 EDT 2015

AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.

Nature communications

Herter JM,Grabie N,Cullere X,Azcutia V,Rosetti F,Bennett P,Herter-Sprie GS,Elyaman W,Luscinskas FW,Lichtman AH,Mayadas TN

Fri Dec 18 00:00:00 EST 2015

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.

Cell

Klose CSN,Flach M,Möhle L,Rogell L,Hoyler T,Ebert K,Fabiunke C,Pfeifer D,Sexl V,Fonseca-Pereira D,Domingues RG,Veiga-Fernandes H,Arnold SJ,Busslinger M,Dunay IR,Tanriver Y,Diefenbach A

Thu Apr 10 00:00:00 EDT 2014

Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes.

Nature methods

Thestrup T,Litzlbauer J,Bartholomäus I,Mues M,Russo L,Dana H,Kovalchuk Y,Liang Y,Kalamakis G,Laukat Y,Becker S,Witte G,Geiger A,Allen T,Rome LC,Chen TW,Kim DS,Garaschuk O,Griesinger C,Griesbeck O

Sat Feb 01 00:00:00 EST 2014

The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.

Immunity

Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U

Thu Oct 16 00:00:00 EDT 2014

The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells.

Blood

Kobayashi CI,Takubo K,Kobayashi H,Nakamura-Ishizu A,Honda H,Kataoka K,Kumano K,Akiyama H,Sudo T,Kurokawa M,Suda T

Thu Apr 17 00:00:00 EDT 2014

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Blood

Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J

Thu Nov 13 00:00:00 EST 2014

Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.

The Journal of experimental medicine

Madireddi S,Eun SY,Lee SW,Nemčovičová I,Mehta AK,Zajonc DM,Nishi N,Niki T,Hirashima M,Croft M

Mon Jun 30 00:00:00 EDT 2014

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

The Journal of experimental medicine

Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ

Mon Apr 07 00:00:00 EDT 2014

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection.

The Journal of experimental medicine

Srivastava S,Koch MA,Pepper M,Campbell DJ

Mon May 05 00:00:00 EDT 2014

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

The Journal of experimental medicine

Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR

Mon Jul 28 00:00:00 EDT 2014

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.

The Journal of experimental medicine

Vaeth M,Müller G,Stauss D,Dietz L,Klein-Hessling S,Serfling E,Lipp M,Berberich I,Berberich-Siebelt F

Mon Mar 10 00:00:00 EDT 2014

IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo.

The Journal of experimental medicine

Starbeck-Miller GR,Xue HH,Harty JT

Mon Jan 13 00:00:00 EST 2014

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

The Journal of experimental medicine

Kumar L,Chou J,Yee CS,Borzutzky A,Vollmann EH,von Andrian UH,Park SY,Hollander G,Manis JP,Poliani PL,Geha RS

Mon May 05 00:00:00 EDT 2014

Nfil3 is required for the development of all innate lymphoid cell subsets.

The Journal of experimental medicine

Seillet C,Rankin LC,Groom JR,Mielke LA,Tellier J,Chopin M,Huntington ND,Belz GT,Carotta S

Mon Aug 25 00:00:00 EDT 2014

CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.

The Journal of experimental medicine

Cortez VS,Cervantes-Barragan L,Song C,Gilfillan S,McDonald KG,Tussiwand R,Edelson BT,Murakami Y,Murphy KM,Newberry RD,Sibley LD,Colonna M

Mon Apr 07 00:00:00 EDT 2014

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.

The Journal of experimental medicine

Gomez-Rodriguez J,Wohlfert EA,Handon R,Meylan F,Wu JZ,Anderson SM,Kirby MR,Belkaid Y,Schwartzberg PL

Mon Mar 10 00:00:00 EDT 2014

Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.

Proceedings of the National Academy of Sciences of the United States of America

Zarin P,Wong GW,Mohtashami M,Wiest DL,Zúñiga-Pflücker JC

Tue Apr 15 00:00:00 EDT 2014

Effector and central memory T helper 2 cells respond differently to peptide immunotherapy.

Proceedings of the National Academy of Sciences of the United States of America

Mackenzie KJ,Nowakowska DJ,Leech MD,McFarlane AJ,Wilson C,Fitch PM,O'Connor RA,Howie SE,Schwarze J,Anderton SM

Tue Feb 25 00:00:00 EST 2014

Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B

Tue Aug 26 00:00:00 EDT 2014

Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.

Proceedings of the National Academy of Sciences of the United States of America

Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS

Tue Jul 29 00:00:00 EDT 2014

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Kissick HT,Sanda MG,Dunn LK,Pellegrini KL,On ST,Noel JK,Arredouani MS

Tue Jul 08 00:00:00 EDT 2014

MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Li C,Jiang S,Liu SQ,Lykken E,Zhao LT,Sevilla J,Zhu B,Li QJ

Tue Jul 08 00:00:00 EDT 2014

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.

Proceedings of the National Academy of Sciences of the United States of America

Brennan PJ,Tatituri RV,Heiss C,Watts GF,Hsu FF,Veerapen N,Cox LR,Azadi P,Besra GS,Brenner MB

Tue Sep 16 00:00:00 EDT 2014

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America

Sundberg TB,Choi HG,Song JH,Russell CN,Hussain MM,Graham DB,Khor B,Gagnon J,O'Connell DJ,Narayan K,Dančík V,Perez JR,Reinecker HC,Gray NS,Schreiber SL,Xavier RJ,Shamji AF

Tue Aug 26 00:00:00 EDT 2014

Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib.

The Journal of investigative dermatology

Okiyama N,Furumoto Y,Villarroel VA,Linton JT,Tsai WL,Gutermuth J,Ghoreschi K,Gadina M,O'Shea JJ,Katz SI

Tue Apr 01 00:00:00 EDT 2014

Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.

Stem cells (Dayton, Ohio)

Glenn JD,Smith MD,Calabresi PA,Whartenby KA

Wed Oct 01 00:00:00 EDT 2014

CCR7 guides migration of mesenchymal stem cell to secondary lymphoid organs: a novel approach to separate GvHD from GvL effect.

Stem cells (Dayton, Ohio)

Li H,Jiang Y,Jiang X,Guo X,Ning H,Li Y,Liao L,Yao H,Wang X,Liu Y,Zhang Y,Chen H,Mao N

Tue Jul 01 00:00:00 EDT 2014

TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction.

Journal of immunology (Baltimore, Md. : 1950)

Crites TJ,Padhan K,Muller J,Krogsgaard M,Gudla PR,Lockett SJ,Varma R

Tue Jul 01 00:00:00 EDT 2014

Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities.

Journal of immunology (Baltimore, Md. : 1950)

Deho' L,Leoni C,Brodie TM,Montagner S,De Simone M,Polletti S,Barozzi I,Natoli G,Monticelli S

Mon Sep 01 00:00:00 EDT 2014

The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.

Journal of immunology (Baltimore, Md. : 1950)

Ehrlich A,Castilho TM,Goldsmith-Pestana K,Chae WJ,Bothwell AL,Sparwasser T,McMahon-Pratt D

Mon Sep 15 00:00:00 EDT 2014

Eliminating encephalitogenic T cells without undermining protective immunity.

Journal of immunology (Baltimore, Md. : 1950)

McNally JP,Elfers EE,Terrell CE,Grunblatt E,Hildeman DA,Jordan MB,Katz JD

Wed Jan 01 00:00:00 EST 2014

Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.

Journal of immunology (Baltimore, Md. : 1950)

O'Brien S,Thomas RM,Wertheim GB,Zhang F,Shen H,Wells AD

Sun Jun 01 00:00:00 EDT 2014

IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.

Journal of immunology (Baltimore, Md. : 1950)

Huang W,Jeong AR,Kannan AK,Huang L,August A

Mon Sep 01 00:00:00 EDT 2014

Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion.

Journal of immunology (Baltimore, Md. : 1950)

Chevalier N,Thorburn AN,Macia L,Tan J,Juglair L,Yagita H,Yu D,Hansbro PM,Mackay CR

Sat Nov 15 00:00:00 EST 2014

SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.

Journal of immunology (Baltimore, Md. : 1950)

Chu C,Wang Y,Zhang X,Ni X,Cao J,Xu W,Dong Z,Yuan P,Wei W,Ma Y,Zhang L,Wu L,Qi H

Wed Oct 15 00:00:00 EDT 2014

The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.

Journal of immunology (Baltimore, Md. : 1950)

Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD

Wed Jan 01 00:00:00 EST 2014

Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Tilahun AY,Chowdhary VR,David CS,Rajagopalan G

Mon Sep 15 00:00:00 EDT 2014

TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.

Journal of immunology (Baltimore, Md. : 1950)

Ogawa C,Tone Y,Tsuda M,Peter C,Waldmann H,Tone M

Wed Jan 01 00:00:00 EST 2014

Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.

American journal of reproductive immunology (New York, N.Y. : 1989)

Qin X,Liu X,Shan B,Shi L,Sharma S,Wu J,Lin Y

212-12 was used in Cell Culture to investigate the effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of eukaryotic initiation factor 5A, on natural killer cells in vitro.

Sat Mar 01 00:00:00 EST 2014

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.

Nature communications

Ling GS,Bennett J,Woollard KJ,Szajna M,Fossati-Jimack L,Taylor PR,Scott D,Franzoso G,Cook HT,Botto M

Tue Nov 24 00:00:00 EST 2015

High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.

Scientific reports

Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

Wed Apr 23 00:00:00 EDT 2014

Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes.

Blood

Rafei M,Rouette A,Brochu S,Vanegas JR,Perreault C

Thu Jan 03 00:00:00 EST 2013

The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.

Blood

Sakai Y,Tanaka Y,Yanagihara T,Watanabe M,Duan X,Terasawa M,Nishikimi A,Sanematsu F,Fukui Y

Thu Jul 18 00:00:00 EDT 2013

IL-2-dependent adaptive control of NK cell homeostasis.

The Journal of experimental medicine

Gasteiger G,Hemmers S,Bos PD,Sun JC,Rudensky AY

Mon Jun 03 00:00:00 EDT 2013

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.

The Journal of experimental medicine

Holmgaard RB,Zamarin D,Munn DH,Wolchok JD,Allison JP

Mon Jul 01 00:00:00 EDT 2013

IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.

The Journal of experimental medicine

Gasteiger G,Hemmers S,Firth MA,Le Floc'h A,Huse M,Sun JC,Rudensky AY

Mon Jun 03 00:00:00 EDT 2013

Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells.

Proceedings of the National Academy of Sciences of the United States of America

Loebbermann J,Durant L,Thornton H,Johansson C,Openshaw PJ

Tue Feb 19 00:00:00 EST 2013

Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy.

Cancer gene therapy

Kanagawa N,Yanagawa T,Nakagawa T,Okada N,Nakagawa S

Tue Jan 01 00:00:00 EST 2013

Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.

Journal of immunology (Baltimore, Md. : 1950)

Tamiya T,Ichiyama K,Kotani H,Fukaya T,Sekiya T,Shichita T,Honma K,Yui K,Matsuyama T,Nakao T,Fukuyama S,Inoue H,Nomura M,Yoshimura A

Sun Sep 01 00:00:00 EDT 2013

Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T

Mon Jul 15 00:00:00 EDT 2013

Reduced CD18 levels drive regulatory T cell conversion into Th17 cells in the CD18hypo PL/J mouse model of psoriasis.

Journal of immunology (Baltimore, Md. : 1950)

Singh K,Gatzka M,Peters T,Borkner L,Hainzl A,Wang H,Sindrilaru A,Scharffetter-Kochanek K

Fri Mar 15 00:00:00 EDT 2013

Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Jia Y,Takeda K,Han J,Joetham A,Marcus RA,Lucas JJ,O'Connor BP,Gelfand EW

Mon Apr 15 00:00:00 EDT 2013

Unique features of naive CD8+ T cell activation by IL-2.

Journal of immunology (Baltimore, Md. : 1950)

Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J

Sun Dec 01 00:00:00 EST 2013

Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Edwards JP,Fujii H,Zhou AX,Creemers J,Unutmaz D,Shevach EM

Sat Jun 01 00:00:00 EDT 2013

Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice.

Journal of immunology (Baltimore, Md. : 1950)

Li J,Heinrichs J,Leconte J,Haarberg K,Semple K,Liu C,Gigoux M,Kornete M,Piccirillo CA,Suh WK,Yu XZ

Mon Jul 01 00:00:00 EDT 2013

Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles.

Journal of immunology (Baltimore, Md. : 1950)

Lo YC,Edidin MA,Powell JD

Fri Nov 15 00:00:00 EST 2013

CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.

Journal of immunology (Baltimore, Md. : 1950)

Frazer LC,Sullivan JE,Zurenski MA,Mintus M,Tomasak TE,Prantner D,Nagarajan UM,Darville T

Tue Oct 15 00:00:00 EDT 2013

Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.

Journal of immunology (Baltimore, Md. : 1950)

Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M

Tue Oct 01 00:00:00 EDT 2013

A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Guo Z,Khattar M,Schroder PM,Miyahara Y,Wang G,He X,Chen W,Stepkowski SM

Mon Apr 01 00:00:00 EDT 2013

ASC controls IFN-γ levels in an IL-18-dependent manner in caspase-1-deficient mice infected with Francisella novicida.

Journal of immunology (Baltimore, Md. : 1950)

Pierini R,Perret M,Djebali S,Juruj C,Michallet MC,Förster I,Marvel J,Walzer T,Henry T

Tue Oct 01 00:00:00 EDT 2013

Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Borger JG,Filby A,Zamoyska R

Mon Apr 01 00:00:00 EDT 2013

Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.

Journal of immunology (Baltimore, Md. : 1950)

Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y

Wed May 01 00:00:00 EDT 2013

IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection.

PloS one

Behrends J,Renauld JC,Ehlers S,Hölscher C

Tue Sep 03 00:00:00 EDT 2013

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

The Journal of biological chemistry

Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M

Fri Nov 15 00:00:00 EST 2013

Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).

The Journal of biological chemistry

Souza-Fonseca-Guimaraes F,Parlato M,de Oliveira RB,Golenbock D,Fitzgerald K,Shalova IN,Biswas SK,Cavaillon JM,Adib-Conquy M

Fri Apr 12 00:00:00 EDT 2013

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Cell

Hu J,Hwang SS,Liesa M,Gan B,Sahin E,Jaskelioff M,Ding Z,Ying H,Boutin AT,Zhang H,Johnson S,Ivanova E,Kost-Alimova M,Protopopov A,Wang YA,Shirihai OS,Chin L,DePinho RA

Fri Feb 17 00:00:00 EST 2012

Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.

Cell

Zhang B,Kracker S,Yasuda T,Casola S,Vanneman M,Hömig-Hölzel C,Wang Z,Derudder E,Li S,Chakraborty T,Cotter SE,Koyama S,Currie T,Freeman GJ,Kutok JL,Rodig SJ,Dranoff G,Rajewsky K

Fri Feb 17 00:00:00 EST 2012

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.

Blood

Tang Y,Peitzsch C,Charoudeh HN,Cheng M,Chaves P,Jacobsen SE,Sitnicka E

Thu Jul 05 00:00:00 EDT 2012

IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.

Blood

Vigne S,Palmer G,Martin P,Lamacchia C,Strebel D,Rodriguez E,Olleros ML,Vesin D,Garcia I,Ronchi F,Sallusto F,Sims JE,Gabay C

Thu Oct 25 00:00:00 EDT 2012

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.

Blood

Attridge K,Wang CJ,Wardzinski L,Kenefeck R,Chamberlain JL,Manzotti C,Kopf M,Walker LS

Thu May 17 00:00:00 EDT 2012

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.

Blood

Attridge K,Wang CJ,Wardzinski L,Kenefeck R,Chamberlain JL,Manzotti C,Kopf M,Walker LS

Thu May 17 00:00:00 EDT 2012

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.

Blood

Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ

Thu Jun 21 00:00:00 EDT 2012

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.

The Journal of clinical investigation

Gupta S,Thornley TB,Gao W,Larocca R,Turka LA,Kuchroo VK,Strom TB

Sun Jul 01 00:00:00 EDT 2012

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.

The Journal of experimental medicine

Schlenner SM,Weigmann B,Ruan Q,Chen Y,von Boehmer H

Mon Aug 27 00:00:00 EDT 2012

Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.

Journal of autoimmunity

Tischner D,Gaggl I,Peschel I,Kaufmann M,Tuzlak S,Drach M,Thuille N,Villunger A,Jan Wiegers G

Wed Feb 01 00:00:00 EST 2012

MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination.

Proceedings of the National Academy of Sciences of the United States of America

Mycko MP,Cichalewska M,Machlanska A,Cwiklinska H,Mariasiewicz M,Selmaj KW

Tue May 15 00:00:00 EDT 2012

Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.

Proceedings of the National Academy of Sciences of the United States of America

Perona-Wright G,Kohlmeier JE,Bassity E,Freitas TC,Mohrs K,Cookenham T,Situ H,Pearce EJ,Woodland DL,Mohrs M

Tue Nov 06 00:00:00 EST 2012

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Zandi S,Ahsberg J,Tsapogas P,Stjernberg J,Qian H,Sigvardsson M

Tue Sep 25 00:00:00 EDT 2012

A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Link JM,Ota S,Zhou ZQ,Daniel CJ,Sears RC,Hurlin PJ

Tue Nov 27 00:00:00 EST 2012

Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.

Mucosal immunology

Loebbermann J,Thornton H,Durant L,Sparwasser T,Webster KE,Sprent J,Culley FJ,Johansson C,Openshaw PJ

Thu Mar 01 00:00:00 EST 2012

Effective adoptive transfer of haploidentical tumor-specific T cells in B16-melanoma bearing mice.

Chinese medical journal

Cui NP,Xie SJ,Han JS,Ma ZF,Chen BP,Cai JH

Thu Mar 01 00:00:00 EST 2012

Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction.

Immune network

Kim SH,Youn J

Mon Oct 01 00:00:00 EDT 2012

Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Ma J,Ding Y,Fang X,Wang R,Sun Z

Fri Jun 01 00:00:00 EDT 2012

Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.

Journal of immunology (Baltimore, Md. : 1950)

Cedeno-Laurent F,Opperman M,Barthel SR,Kuchroo VK,Dimitroff CJ

Sun Apr 01 00:00:00 EDT 2012

RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.

Journal of immunology (Baltimore, Md. : 1950)

Shankar SP,Wilson MS,DiVietro JA,Mentink-Kane MM,Xie Z,Wynn TA,Druey KM

Fri Jun 15 00:00:00 EDT 2012

Foxp3 expression is required for the induction of therapeutic tissue tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Regateiro FS,Chen Y,Kendal AR,Hilbrands R,Adams E,Cobbold SP,Ma J,Andersen KG,Betz AG,Zhang M,Madhiwalla S,Roberts B,Waldmann H,Nolan KF,Howie D

Mon Oct 15 00:00:00 EDT 2012

Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Ramalingam R,Larmonier CB,Thurston RD,Midura-Kiela MT,Zheng SG,Ghishan FK,Kiela PR

Mon Oct 15 00:00:00 EDT 2012

Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.

Journal of immunology (Baltimore, Md. : 1950)

Cuda CM,Li S,Liang S,Yin Y,Potula HH,Xu Z,Sengupta M,Chen Y,Butfiloski E,Baker H,Chang LJ,Dozmorov I,Sobel ES,Morel L

Sun Jan 15 00:00:00 EST 2012

Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Lin YY,Jones-Mason ME,Inoue M,Lasorella A,Iavarone A,Li QJ,Shinohara ML,Zhuang Y

Wed Aug 01 00:00:00 EDT 2012

STAT6-dependent regulation of Th9 development.

Journal of immunology (Baltimore, Md. : 1950)

Goswami R,Jabeen R,Yagi R,Pham D,Zhu J,Goenka S,Kaplan MH

Wed Feb 01 00:00:00 EST 2012

IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T cell compartments during peripheral T cell reconstitution.

Journal of immunology (Baltimore, Md. : 1950)

Le Campion A,Pommier A,Delpoux A,Stouvenel L,Auffray C,Martin B,Lucas B

Mon Oct 01 00:00:00 EDT 2012

Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Poovassery JS,Bishop GA

Wed Aug 15 00:00:00 EDT 2012

NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.

Journal of immunology (Baltimore, Md. : 1950)

Souza-Fonseca-Guimaraes F,Parlato M,Fitting C,Cavaillon JM,Adib-Conquy M

Fri Jun 15 00:00:00 EDT 2012

Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Dervovic DD,Ciofani M,Kianizad K,Zúñiga-Pflücker JC

Mon Oct 01 00:00:00 EDT 2012

Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?

Journal of immunology (Baltimore, Md. : 1950)

Abdi K,Singh NJ,Matzinger P

Fri Jun 15 00:00:00 EDT 2012

The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.

Journal of immunology (Baltimore, Md. : 1950)

Yamaji O,Nagaishi T,Totsuka T,Onizawa M,Suzuki M,Tsuge N,Hasegawa A,Okamoto R,Tsuchiya K,Nakamura T,Arase H,Kanai T,Watanabe M

Thu Mar 15 00:00:00 EDT 2012

Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.

Journal of immunology (Baltimore, Md. : 1950)

Kinoshita M,Kayama H,Kusu T,Yamaguchi T,Kunisawa J,Kiyono H,Sakaguchi S,Takeda K

Sat Sep 15 00:00:00 EDT 2012

A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin.

Journal of immunology (Baltimore, Md. : 1950)

Fiorenza S,Kenna TJ,Comerford I,McColl S,Steptoe RJ,Leggatt GR,Frazer IH

Sat Dec 15 00:00:00 EST 2012

NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.

Journal of immunology (Baltimore, Md. : 1950)

Wortham BW,Eppert BL,Motz GT,Flury JL,Orozco-Levi M,Hoebe K,Panos RJ,Maxfield M,Glasser SW,Senft AP,Raulet DH,Borchers MT

Tue May 01 00:00:00 EDT 2012

Nanotopography-guided migration of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Kwon KW,Park H,Song KH,Choi JC,Ahn H,Park MJ,Suh KY,Doh J

Sat Sep 01 00:00:00 EDT 2012

Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.

Journal of immunology (Baltimore, Md. : 1950)

Gallo RM,Khan MA,Shi J,Kapur R,Wei L,Bailey JC,Liu J,Brutkiewicz RR

Wed Aug 15 00:00:00 EDT 2012

Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.

Journal of immunology (Baltimore, Md. : 1950)

Chen Y,Shen S,Gorentla BK,Gao J,Zhong XP

Wed Feb 15 00:00:00 EST 2012

Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice.

Evidence-based complementary and alternative medicine : eCAM

Jin X,Uchiyama M,Zhang Q,Hirai T,Niimi M

Thu Aug 23 00:00:00 EDT 2012

Ischemic preconditioning in the liver is independent of regulatory T cell activity.

PloS one

Devey LR,Richards JA,O'Connor RA,Borthwick G,Clay S,Howie AF,Wigmore SJ,Anderton SM,Howie SE

Wed May 22 00:00:00 EDT 2013

Ischemic preconditioning in the liver is independent of regulatory T cell activity.

PloS one

Devey LR,Richards JA,O'Connor RA,Borthwick G,Clay S,Howie AF,Wigmore SJ,Anderton SM,Howie SE

Wed May 22 00:00:00 EDT 2013

β-defensin 2 as an adjuvant promotes anti-melanoma immune responses and inhibits the growth of implanted murine melanoma in vivo.

PloS one

Mei HF,Jin XB,Zhu JY,Zeng AH,Wu Q,Lu XM,Li XB,Shen J

Tue Jul 31 00:00:00 EDT 2012

p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.

The Journal of biological chemistry

Hu P,Nebreda AR,Liu Y,Carlesso N,Kaplan M,Kapur R

Fri Sep 28 00:00:00 EDT 2012

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk.

Oncoimmunology

Chinnery F,King CA,Elliott T,Bateman AR,James E

Sat Sep 01 00:00:00 EDT 2012

Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution.

Frontiers in immunology

Andersen KG,Nissen JK,Betz AG

Thu Aug 23 00:00:00 EDT 2012

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection.

Journal of neuroinflammation

Friedman-Levi Y,Hoftberger R,Budka H,Mayer-Sonnenfeld T,Abramsky O,Ovadia H,Gabizon R

Wed Mar 21 00:00:00 EDT 2012

Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.

PloS one

Collins S,Waickman A,Basson A,Kupfer A,Licht JD,Horton MR,Powell JD

Thu Jun 20 00:00:00 EDT 2013

Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells.

Journal of cardiothoracic surgery

Uchiyama M,Jin X,Zhang Q,Hirai T,Amano A,Bashuda H,Niimi M

Fri Mar 23 00:00:00 EDT 2012

MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.

PloS one

Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH

Thu Mar 28 00:00:00 EDT 2013

De novo DNA methylation is required to restrict T helper lineage plasticity.

The Journal of biological chemistry

Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD

Fri Jun 29 00:00:00 EDT 2012

Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.

Blood

Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E

Thu Feb 03 00:00:00 EST 2011

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.

Blood

Jiang S,Li C,Olive V,Lykken E,Feng F,Sevilla J,Wan Y,He L,Li QJ

Thu Nov 17 00:00:00 EST 2011

IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.

Blood

Tsapogas P,Zandi S,Åhsberg J,Zetterblad J,Welinder E,Jönsson JI,Månsson R,Qian H,Sigvardsson M

Thu Aug 04 00:00:00 EDT 2011

SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.

Blood

Giroux M,Delisle JS,Gauthier SD,Heinonen KM,Hinsinger J,Houde B,Gaboury L,Brochu S,Wu J,Hébert MJ,Perreault C

Thu Feb 03 00:00:00 EST 2011

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.

The Journal of clinical investigation

Lv H,Havari E,Pinto S,Gottumukkala RV,Cornivelli L,Raddassi K,Matsui T,Rosenzweig A,Bronson RT,Smith R,Fletcher AL,Turley SJ,Wucherpfennig K,Kyewski B,Lipes MA

Fri Apr 01 00:00:00 EDT 2011

GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.

The Journal of clinical investigation

Wohlfert EA,Grainger JR,Bouladoux N,Konkel JE,Oldenhove G,Ribeiro CH,Hall JA,Yagi R,Naik S,Bhairavabhotla R,Paul WE,Bosselut R,Wei G,Zhao K,Oukka M,Zhu J,Belkaid Y

Tue Nov 01 00:00:00 EDT 2011

Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.

The Journal of clinical investigation

Ma H,Lu C,Ziegler J,Liu A,Sepulveda A,Okada H,Lentzsch S,Mapara MY

Fri Jul 01 00:00:00 EDT 2011

Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice.

The Journal of experimental medicine

Sela U,Olds P,Park A,Schlesinger SJ,Steinman RM

Mon Nov 21 00:00:00 EST 2011

Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.

The Journal of experimental medicine

Kurachi M,Kurachi J,Suenaga F,Tsukui T,Abe J,Ueha S,Tomura M,Sugihara K,Takamura S,Kakimi K,Matsushima K

Mon Aug 01 00:00:00 EDT 2011

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.

The Journal of experimental medicine

Purtha WE,Tedder TF,Johnson S,Bhattacharya D,Diamond MS

Mon Dec 19 00:00:00 EST 2011

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.

The Journal of experimental medicine

Brigl M,Tatituri RV,Watts GF,Bhowruth V,Leadbetter EA,Barton N,Cohen NR,Hsu FF,Besra GS,Brenner MB

Mon Jun 06 00:00:00 EDT 2011

Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells.

Cancer immunology, immunotherapy : CII

Warncke M,Buchner M,Thaller G,Dodero A,Bulashevska A,Pfeifer D,Timmer J,Veelken H

Sat Jan 01 00:00:00 EST 2011

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells.

Immunology and cell biology

Palmer MJ,Mahajan VS,Chen J,Irvine DJ,Lauffenburger DA

Fri Jul 01 00:00:00 EDT 2011

An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection.

Journal of immunology (Baltimore, Md. : 1950)

Kroetz DN,Deepe GS

Sun May 15 00:00:00 EDT 2011

MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.

Journal of immunology (Baltimore, Md. : 1950)

Wang X,Zhang F,Chen F,Liu D,Zheng Y,Zhang Y,Dong C,Su B

Sun May 15 00:00:00 EDT 2011

Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles.

Journal of immunology (Baltimore, Md. : 1950)

Mukai Y,Yoshinaga T,Yoshikawa M,Matsuo K,Yoshikawa T,Matsuo K,Niki K,Yoshioka Y,Okada N,Nakagawa S

Thu Dec 15 00:00:00 EST 2011

Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex.

Journal of immunology (Baltimore, Md. : 1950)

Ohoka Y,Yokota A,Takeuchi H,Maeda N,Iwata M

Sat Jan 15 00:00:00 EST 2011

Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes.

Journal of immunology (Baltimore, Md. : 1950)

Rafei M,Hardy MP,Williams P,Vanegas JR,Forner KA,Dulude G,Labrecque N,Galipeau J,Perreault C

Thu Sep 15 00:00:00 EDT 2011

Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N

Thu Dec 15 00:00:00 EST 2011

The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.

Journal of immunology (Baltimore, Md. : 1950)

MacIver NJ,Blagih J,Saucillo DC,Tonelli L,Griss T,Rathmell JC,Jones RG

Sat Oct 15 00:00:00 EDT 2011

Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Yu S,Zhao J,Cantorna MT

Tue Nov 01 00:00:00 EDT 2011

Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse.

Journal of immunology (Baltimore, Md. : 1950)

Kmieciak M,Basu D,Payne KK,Toor A,Yacoub A,Wang XY,Smith L,Bear HD,Manjili MH

Fri Jul 15 00:00:00 EDT 2011

IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Chen Q,Kim YC,Laurence A,Punkosdy GA,Shevach EM

Wed Jun 01 00:00:00 EDT 2011

Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.

Journal of immunology (Baltimore, Md. : 1950)

Kastenmuller W,Gasteiger G,Subramanian N,Sparwasser T,Busch DH,Belkaid Y,Drexler I,Germain RN

Thu Sep 15 00:00:00 EDT 2011

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Wang L,Du C,Lv J,Wei W,Cui Y,Xie X

Thu Sep 01 00:00:00 EDT 2011

Chemokine-containing exosomes are released from heat-stressed tumor cells via lipid raft-dependent pathway and act as efficient tumor vaccine.

Journal of immunology (Baltimore, Md. : 1950)

Chen T,Guo J,Yang M,Zhu X,Cao X

Tue Feb 15 00:00:00 EST 2011

TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling.

Journal of immunology (Baltimore, Md. : 1950)

Xie P,Kraus ZJ,Stunz LL,Liu Y,Bishop GA

Sat Jan 01 00:00:00 EST 2011

Role of SLAM in NKT cell development revealed by transgenic complementation in NOD mice.

Journal of immunology (Baltimore, Md. : 1950)

Jordan MA,Fletcher JM,Jose R,Chowdhury S,Gerlach N,Allison J,Baxter AG

Fri Apr 01 00:00:00 EDT 2011

Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy.

Human molecular genetics

Cui CH,Miyoshi S,Tsuji H,Makino H,Kanzaki S,Kami D,Terai M,Suzuki H,Umezawa A

Sat Jan 15 00:00:00 EST 2011

Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy.

Human molecular genetics

Cui CH,Miyoshi S,Tsuji H,Makino H,Kanzaki S,Kami D,Terai M,Suzuki H,Umezawa A

Sat Jan 15 00:00:00 EST 2011

Polysaccharides isolated from Açaí fruit induce innate immune responses.

PloS one

Holderness J,Schepetkin IA,Freedman B,Kirpotina LN,Quinn MT,Hedges JF,Jutila MA

Mon Feb 28 00:00:00 EST 2011

Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production.

The Journal of biological chemistry

Wong WF,Kurokawa M,Satake M,Kohu K

Fri Apr 01 00:00:00 EDT 2011

Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.

PloS one

Takeuchi H,Yokota A,Ohoka Y,Iwata M

Fri Jan 07 00:00:00 EST 2011

Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice.

PloS one

Kaminitz A,Yolcu ES,Askenasy EM,Stein J,Yaniv I,Shirwan H,Askenasy N

Thu Dec 01 00:00:00 EST 2011

Enhanced transduction and replication of RGD-fiber modified adenovirus in primary T cells.

PloS one

Sengupta S,Ulasov IV,Thaci B,Ahmed AU,Lesniak MS

Mon Mar 28 00:00:00 EDT 2011

Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus.

PloS one

Goldstein JD,Balderas RS,Marodon G

Tue Apr 26 00:00:00 EDT 2011

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.

PloS one

Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I

Thu Sep 29 00:00:00 EDT 2011

c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

PloS one

Grigoriadis G,Vasanthakumar A,Banerjee A,Grumont R,Overall S,Gleeson P,Shannon F,Gerondakis S

Thu Mar 15 00:00:00 EDT 2012

DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice.

BMC immunology

Werner JM,Busl E,Farkas SA,Schlitt HJ,Geissler EK,Hornung M

Fri Apr 29 00:00:00 EDT 2011

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.

Nature communications

Sekiya T,Kashiwagi I,Inoue N,Morita R,Hori S,Waldmann H,Rudensky AY,Ichinose H,Metzger D,Chambon P,Yoshimura A

Fri Jul 22 00:00:00 EDT 2011

Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.

PloS one

Grespi F,Ottina E,Yannoutsos N,Geley S,Villunger A

Mon Mar 21 00:00:00 EDT 2011

Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.

The Journal of biological chemistry

Coloff JL,Mason EF,Altman BJ,Gerriets VA,Liu T,Nichols AN,Zhao Y,Wofford JA,Jacobs SR,Ilkayeva O,Garrison SP,Zambetti GP,Rathmell JC

Fri Feb 18 00:00:00 EST 2011

Regulation of T cell priming by lymphoid stroma.

PloS one

Khan O,Headley M,Gerard A,Wei W,Liu L,Krummel MF

Mon Mar 26 00:00:00 EDT 2012

Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.

The Journal of biological chemistry

Zhu Y,Gumlaw N,Karman J,Zhao H,Zhang J,Jiang JL,Maniatis P,Edling A,Chuang WL,Siegel C,Shayman JA,Kaplan J,Jiang C,Cheng SH

Fri Apr 29 00:00:00 EDT 2011

IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.

Nature

Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H

Thu Apr 29 00:00:00 EDT 2010

A reprogrammable mouse strain from gene-targeted embryonic stem cells.

Nature methods

Stadtfeld M,Maherali N,Borkent M,Hochedlinger K

Fri Jan 01 00:00:00 EST 2010

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

Immunity

Durant L,Watford WT,Ramos HL,Laurence A,Vahedi G,Wei L,Takahashi H,Sun HW,Kanno Y,Powrie F,O'Shea JJ

Fri May 28 00:00:00 EDT 2010

Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

Blood

Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E

Thu Jul 15 00:00:00 EDT 2010

Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.

Blood

Mansson R,Zandi S,Welinder E,Tsapogas P,Sakaguchi N,Bryder D,Sigvardsson M

Thu Apr 01 00:00:00 EDT 2010

Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells.

Blood

Mace EM,Zhang J,Siminovitch KA,Takei F

Thu Aug 26 00:00:00 EDT 2010

Lnk constrains myeloproliferative diseases in mice.

The Journal of clinical investigation

Bersenev A,Wu C,Balcerek J,Jing J,Kundu M,Blobel GA,Chikwava KR,Tong W

Tue Jun 01 00:00:00 EDT 2010

A new fractionation assay, based on the size of formaldehyde-crosslinked, mildly sheared chromatin, delineates the chromatin structure at promoter regions.

Nucleic acids research

Ishihara S,Varma R,Schwartz RH

Tue Jun 01 00:00:00 EDT 2010

CD11c depletion severely disrupts Th2 induction and development in vivo.

The Journal of experimental medicine

Phythian-Adams AT,Cook PC,Lundie RJ,Jones LH,Smith KA,Barr TA,Hochweller K,Anderton SM,Hämmerling GJ,Maizels RM,MacDonald AS

Mon Sep 27 00:00:00 EDT 2010

Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells.

Proceedings of the National Academy of Sciences of the United States of America

Alvarez Arias DA,McCarty N,Lu L,Maldonado RA,Shinohara ML,Cantor H

Tue Feb 09 00:00:00 EST 2010

FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950)

Tartar DM,VanMorlan AM,Wan X,Guloglu FB,Jain R,Haymaker CL,Ellis JS,Hoeman CM,Cascio JA,Dhakal M,Oukka M,Zaghouani H

Thu Apr 01 00:00:00 EDT 2010

Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity.

Journal of immunology (Baltimore, Md. : 1950)

Prokopowicz ZM,Arce F,Biedroń R,Chiang CL,Ciszek M,Katz DR,Nowakowska M,Zapotoczny S,Marcinkiewicz J,Chain BM

Fri Jan 15 00:00:00 EST 2010

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.

Journal of immunology (Baltimore, Md. : 1950)

Rolf J,Bell SE,Kovesdi D,Janas ML,Soond DR,Webb LM,Santinelli S,Saunders T,Hebeis B,Killeen N,Okkenhaug K,Turner M

Fri Oct 01 00:00:00 EDT 2010

Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.

Journal of immunology (Baltimore, Md. : 1950)

Johannsen A,Genolet R,Legler DF,Luther SA,Luescher IF

Wed Sep 15 00:00:00 EDT 2010

Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.

Journal of immunology (Baltimore, Md. : 1950)

Motz GT,Eppert BL,Wortham BW,Amos-Kroohs RM,Flury JL,Wesselkamper SC,Borchers MT

Thu Apr 15 00:00:00 EDT 2010

Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function.

Journal of immunology (Baltimore, Md. : 1950)

Kenna TJ,Waldie T,McNally A,Thomson M,Yagita H,Thomas R,Steptoe RJ

Fri Jan 15 00:00:00 EST 2010

Differential suppression of tumor-specific CD8+ T cells by regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

James E,Yeh A,King C,Korangy F,Bailey I,Boulanger DS,Van den Eynde BJ,Murray N,Elliott TJ

Mon Nov 01 00:00:00 EDT 2010

Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins.

Journal of immunology (Baltimore, Md. : 1950)

Takeuchi H,Yokota A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M

Mon Nov 01 00:00:00 EDT 2010

"Default" generation of neonatal regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W

Thu Jul 01 00:00:00 EDT 2010

Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.

The Journal of biological chemistry

Humphrey RK,Newcomb CJ,Yu SM,Hao E,Yu D,Krajewski S,Du K,Jhala US

Fri Jul 16 00:00:00 EDT 2010

Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice.

PloS one

Kaminitz A,Askenasy EM,Yaniv I,Stein J,Askenasy N

Fri Dec 31 00:00:00 EST 2010

RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.

PloS one

Chae HD,Siefring JE,Hildeman DA,Gu Y,Williams DA

Fri Nov 12 00:00:00 EST 2010

Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes.

Autoimmune diseases

Linkes S,Fry C,Quinn A

Wed Sep 29 00:00:00 EDT 2010

IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions.

PloS one

Le Saout C,Villard M,Cabasse C,Jacquet C,Taylor N,Hernandez J

Fri Sep 10 00:00:00 EDT 2010

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.

Nature medicine

Feuerer M,Herrero L,Cipolletta D,Naaz A,Wong J,Nayer A,Lee J,Goldfine AB,Benoist C,Shoelson S,Mathis D

Sat Aug 01 00:00:00 EDT 2009

Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

Immunity

Lauritsen JP,Wong GW,Lee SY,Lefebvre JM,Ciofani M,Rhodes M,Kappes DJ,Zúñiga-Pflücker JC,Wiest DL

Fri Oct 16 00:00:00 EDT 2009

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.

Immunity

Yu A,Zhu L,Altman NH,Malek TR

Fri Feb 20 00:00:00 EST 2009

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.

Blood

Gérard A,van der Kammen RA,Janssen H,Ellenbroek SI,Collard JG

Thu Jun 11 00:00:00 EDT 2009

An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans.

The Journal of clinical investigation

Hou Y,DeVoss J,Dao V,Kwek S,Simko JP,McNeel DG,Anderson MS,Fong L

Wed Jul 01 00:00:00 EDT 2009

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.

The Journal of experimental medicine

Takatori H,Kanno Y,Watford WT,Tato CM,Weiss G,Ivanov II,Littman DR,O'Shea JJ

Fri Jan 16 00:00:00 EST 2009

Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.

The Journal of experimental medicine

Nolting J,Daniel C,Reuter S,Stuelten C,Li P,Sucov H,Kim BG,Letterio JJ,Kretschmer K,Kim HJ,von Boehmer H

Mon Sep 28 00:00:00 EDT 2009

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.

The Journal of experimental medicine

Isomura I,Palmer S,Grumont RJ,Bunting K,Hoyne G,Wilkinson N,Banerjee A,Proietto A,Gugasyan R,Wu L,McNally A,Steptoe RJ,Thomas R,Shannon MF,Gerondakis S

Mon Dec 21 00:00:00 EST 2009

Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease.

The Journal of experimental medicine

Semitekolou M,Alissafi T,Aggelakopoulou M,Kourepini E,Kariyawasam HH,Kay AB,Robinson DS,Lloyd CM,Panoutsakopoulou V,Xanthou G

Mon Aug 03 00:00:00 EDT 2009

Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.

The Journal of experimental medicine

Maldonado RA,Soriano MA,Perdomo LC,Sigrist K,Irvine DJ,Decker T,Glimcher LH

Mon Apr 13 00:00:00 EDT 2009

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.

The Journal of experimental medicine

Werninghaus K,Babiak A,Gross O,Hölscher C,Dietrich H,Agger EM,Mages J,Mocsai A,Schoenen H,Finger K,Nimmerjahn F,Brown GD,Kirschning C,Heit A,Andersen P,Wagner H,Ruland J,Lang R

Fri Jan 16 00:00:00 EST 2009

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.

The Journal of experimental medicine

Werninghaus K,Babiak A,Gross O,Hölscher C,Dietrich H,Agger EM,Mages J,Mocsai A,Schoenen H,Finger K,Nimmerjahn F,Brown GD,Kirschning C,Heit A,Andersen P,Wagner H,Ruland J,Lang R

Fri Jan 16 00:00:00 EST 2009

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

The Journal of experimental medicine

Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J

Mon Apr 13 00:00:00 EDT 2009

CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes.

Proceedings of the National Academy of Sciences of the United States of America

Niedermeier M,Reich B,Rodriguez Gomez M,Denzel A,Schmidbauer K,Göbel N,Talke Y,Schweda F,Mack M

Tue Oct 20 00:00:00 EDT 2009

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.

Proceedings of the National Academy of Sciences of the United States of America

Ranatunga D,Hedrich CM,Wang F,McVicar DW,Nowak N,Joshi T,Feigenbaum L,Grant LR,Stäger S,Bream JH

Tue Oct 06 00:00:00 EDT 2009

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE

Tue Apr 28 00:00:00 EDT 2009

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.

Proceedings of the National Academy of Sciences of the United States of America

McGuire HM,Vogelzang A,Hill N,Flodström-Tullberg M,Sprent J,King C

Tue Nov 17 00:00:00 EST 2009

T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control.

Proceedings of the National Academy of Sciences of the United States of America

Chaudhri G,Quah BJ,Wang Y,Tan AH,Zhou J,Karupiah G,Parish CR

Tue Sep 01 00:00:00 EDT 2009

The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.

Journal of immunology (Baltimore, Md. : 1950)

Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M

Tue Dec 15 00:00:00 EST 2009

Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation.

Journal of immunology (Baltimore, Md. : 1950)

Khan MA,Gallo RM,Renukaradhya GJ,Du W,Gervay-Hague J,Brutkiewicz RR

Wed Apr 15 00:00:00 EDT 2009

Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Mikhak Z,Farsidjani A,Luster AD

Mon Jun 15 00:00:00 EDT 2009

Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.

Journal of immunology (Baltimore, Md. : 1950)

Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK

Sat Aug 15 00:00:00 EDT 2009

Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1.

Journal of immunology (Baltimore, Md. : 1950)

Aoki K,Sato N,Yamaguchi A,Kaminuma O,Hosozawa T,Miyatake S

Mon Jun 15 00:00:00 EDT 2009

The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Wolf AM,Eller K,Zeiser R,Dürr C,Gerlach UV,Sixt M,Markut L,Gastl G,Rosenkranz AR,Wolf D

Tue Sep 15 00:00:00 EDT 2009

Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A

Sat Aug 01 00:00:00 EDT 2009

MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.

Journal of immunology (Baltimore, Md. : 1950)

Wang X,Chang X,Facchinetti V,Zhuang Y,Su B

Sun Mar 15 00:00:00 EDT 2009

Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.

Journal of immunology (Baltimore, Md. : 1950)

Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K

Mon Jun 15 00:00:00 EDT 2009

SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis.

Journal of immunology (Baltimore, Md. : 1950)

Nakaya M,Hashimoto M,Nakagawa R,Wakabayashi Y,Ishizaki T,Takada I,Komai K,Yoshida H,Yoshimura A

Tue Dec 01 00:00:00 EST 2009

Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Chen T,Guo J,Han C,Yang M,Cao X

Sun Feb 01 00:00:00 EST 2009

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Journal of immunology (Baltimore, Md. : 1950)

Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW

Sun Mar 15 00:00:00 EDT 2009

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Oyamada A,Ikebe H,Itsumi M,Saiwai H,Okada S,Shimoda K,Iwakura Y,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H

Tue Dec 01 00:00:00 EST 2009

A dual role for talin in NK cell cytotoxicity: activation of LFA-1-mediated cell adhesion and polarization of NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Mace EM,Monkley SJ,Critchley DR,Takei F

Thu Jan 15 00:00:00 EST 2009

Mucosally delivered Salmonella typhi expressing the Yersinia pestis F1 antigen elicits mucosal and systemic immunity early in life and primes the neonatal immune system for a vigorous anamnestic response to parenteral F1 boost.

Journal of immunology (Baltimore, Md. : 1950)

Ramirez K,Capozzo AV,Lloyd SA,Sztein MB,Nataro JP,Pasetti MF

Thu Jan 15 00:00:00 EST 2009

JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.

Journal of immunology (Baltimore, Md. : 1950)

Chang BY,Zhao F,He X,Ren H,Braselmann S,Taylor V,Wicks J,Payan DG,Grossbard EB,Pine PR,Bullard DC

Sat Aug 01 00:00:00 EDT 2009

Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation.

Journal of immunology (Baltimore, Md. : 1950)

Gutermuth J,Nograles KE,Miyagawa F,Nelson E,Cho YH,Katz SI

Tue Sep 01 00:00:00 EDT 2009

SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Canonigo-Balancio AJ,Fos C,Prod'homme T,Bécart S,Altman A

Tue Dec 01 00:00:00 EST 2009

IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Sharma R,Sung SS,Abaya CE,Ju AC,Fu SM,Ju ST

Wed Jul 15 00:00:00 EDT 2009

PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.

Molecular and cellular biology

Peacock JW,Palmer J,Fink D,Ip S,Pietras EM,Mui AL,Chung SW,Gleave ME,Cox ME,Parsons R,Peter ME,Ong CJ

Sun Mar 01 00:00:00 EST 2009

Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model.

PloS one

Liao D,Luo Y,Markowitz D,Xiang R,Reisfeld RA

Mon Nov 23 00:00:00 EST 2009

A two-step process for thymic regulatory T cell development.

Immunity

Lio CW,Hsieh CS

Tue Jan 01 00:00:00 EST 2008

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.

The Journal of experimental medicine

Chong MM,Rasmussen JP,Rudensky AY,Littman DR

Mon Sep 01 00:00:00 EDT 2008

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Proceedings of the National Academy of Sciences of the United States of America

Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J

Tue Dec 23 00:00:00 EST 2008

Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.

PLoS biology

Andersen KG,Butcher T,Betz AG

Tue Nov 11 00:00:00 EST 2008

A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus.

PLoS pathogens

Marques S,Alenquer M,Stevenson PG,Simas JP

Wed Oct 01 00:00:00 EDT 2008

Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.

Journal of immunology (Baltimore, Md. : 1950)

Hara H,Ishihara C,Takeuchi A,Xue L,Morris SW,Penninger JM,Yoshida H,Saito T

Tue Jul 15 00:00:00 EDT 2008

Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Tonkin DR,He J,Barbour G,Haskins K

Wed Oct 01 00:00:00 EDT 2008

Regulated movement of CD4 in and out of the immunological synapse.

Journal of immunology (Baltimore, Md. : 1950)

Kao H,Lin J,Littman DR,Shaw AS,Allen PM

Mon Dec 15 00:00:00 EST 2008

Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery.

Journal of immunology (Baltimore, Md. : 1950)

Kawamura K,Yao K,Shukaliak-Quandt JA,Huh J,Baig M,Quigley L,Ito N,Necker A,McFarland HF,Muraro PA,Martin R,Ito K

Wed Oct 15 00:00:00 EDT 2008

Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.

Journal of immunology (Baltimore, Md. : 1950)

Kamimura D,Bevan MJ

Wed Oct 15 00:00:00 EDT 2008

Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

Journal of immunology (Baltimore, Md. : 1950)

Nagahara K,Arikawa T,Oomizu S,Kontani K,Nobumoto A,Tateno H,Watanabe K,Niki T,Katoh S,Miyake M,Nagahata S,Hirabayashi J,Kuchroo VK,Yamauchi A,Hirashima M

Mon Dec 01 00:00:00 EST 2008

Galectin-1 promotes immunoglobulin production during plasma cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Tsai CM,Chiu YK,Hsu TL,Lin IY,Hsieh SL,Lin KI

Wed Oct 01 00:00:00 EDT 2008

Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.

The Journal of biological chemistry

Zhao Y,Coloff JL,Ferguson EC,Jacobs SR,Cui K,Rathmell JC

Fri Dec 26 00:00:00 EST 2008

CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.

Journal of immune based therapies and vaccines

Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW

Tue Oct 28 00:00:00 EDT 2008

Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device.

Journal of controlled release : official journal of the Controlled Release Society

Gu F,Neufeld R,Amsden B

Mon Jan 22 00:00:00 EST 2007

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B

Sat Dec 15 00:00:00 EST 2007

Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

Shimaoka T,Seino K,Kume N,Minami M,Nishime C,Suematsu M,Kita T,Taniguchi M,Matsushima K,Yonehara S

Sat Dec 15 00:00:00 EST 2007

Runx3 regulates dendritic epidermal T cell development.

Developmental biology

Woolf E,Brenner O,Goldenberg D,Levanon D,Groner Y

Thu Mar 15 00:00:00 EDT 2007

Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation.

Journal of immunology (Baltimore, Md. : 1950)

Suto A,Nakajima H,Tokumasa N,Takatori H,Kagami S,Suzuki K,Iwamoto I

Tue Nov 01 00:00:00 EST 2005

Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis.

Journal of immunology (Baltimore, Md. : 1950)

Park H,Jung YK,Park OJ,Lee YJ,Choi JY,Choi Y

Thu Dec 01 00:00:00 EST 2005

Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells.

The Journal of biological chemistry

Cornish AL,Chong MM,Davey GM,Darwiche R,Nicola NA,Hilton DJ,Kay TW,Starr R,Alexander WS

Fri Jun 20 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: H-IL-2; il 2; IL-2; ILN; Interleukin; Interleukin-2; Interleukin2; Involved in regulation of T cell clonal expansion; M-IL-2; T-cell growth factor; T-cell growth factor (TCGF); TCGF

Mouse IL-2 Recombinant Protein, PeproTech®

Mouse IL-2 Protein (212-12-20UG) in Functional

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212-12-20UG

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