Gibco

Mouse IL-3 Recombinant Protein, PeproTech®

Mouse IL-3 Protein in Functional Assay (Functional)

FIGURE: 1 / 2

Mouse IL-3 Protein (213-13-10UG) in Functional

Bioassay analysis of Mouse IL-3 Recombinant Protein, PeproTech® (Product # 213-13-1MG).

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Product Details

213-13-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 1 publication 1 publication

Flow Cytometry (Flow)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Neutralization (Neu)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 654 publications 654 publications

Miscellaneous PubMed (Misc)

View 52 publications 52 publications

Product Specifications

Species

Mouse

Published species

Human, Mouse, Rat, Virus

Expression System

E. coli

Amino acid sequence

MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC

Molecular weight

15.1 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Interleukin 3 (IL-3), also called Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells and eosinophils. IL-3 is a hematopoietic growth factor that stimulates colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell and monocytic lineages. Most of these functions are enhanced or dependent on co-stimulation with other cytokines. Human and mouse IL-3 share only 29% sequence identity at the amino acid level. The bioactivity of IL-3 is highly species specific. For example, human IL-3 has no activity on mouse cells. IL-3 is a potent growth promoting cytokine. IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types, and is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.

Nature

Hu C,Leche CA,Kiyatkin A,Yu Z,Stayrook SE,Ferguson KM,Lemmon MA

213-13 was used in Cell Culture to demonstrate how common extracellular glioblastoma multiforme (GBM) mutations prevent epidermal growth factor receptor (EGFR) from discriminating between its activating ligands.

Tue Feb 01 00:00:00 EST 2022

MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.

Signal transduction and targeted therapy

Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S

213-13 was used in Sample Preparation (FC/FACS) to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.

Mon Jan 24 00:00:00 EST 2022

Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.

The Journal of experimental medicine

Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T

Mon Jan 03 00:00:00 EST 2022

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.

Blood advances

Xu JJ,Chalk AM,Nikolic I,Simpson KJ,Smeets MF,Walkley CR

Tue Apr 12 00:00:00 EDT 2022

The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia.

iScience

Xu Y,Fang H,Chen Y,Tang Y,Sun H,Kong Z,Yang F,Kirschner-Schwabe R,Zhu L,Toker A,Xiao N,Zhou BS,Li H

213-13 was used in Cell Culture to investigate RAS pathway mutations in acute lymphoblastic leukaemia.

Fri Mar 18 00:00:00 EDT 2022

A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.

The Journal of biological chemistry

Koochaki SHJ,Słabicki M,Lumpkin R,Zou C,Belizaire R,Fischer ES,Ebert BL

213-13 was used in Cell Culture to identify the role and mechanisms of STUB1, an E3 ubiquitin ligase, and CHIC2 as regulators of CSF2RB ubiquitination and protein stability on IL-3, IL-5, and GM-CSF family of cytokine regulation.

Sat Oct 01 00:00:00 EDT 2022

A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.

The Journal of biological chemistry

Koochaki SHJ,Słabicki M,Lumpkin R,Zou C,Belizaire R,Fischer ES,Ebert BL

Sat Oct 01 00:00:00 EDT 2022

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

Cell

Lu SX,De Neef E,Thomas JD,Sabio E,Rousseau B,Gigoux M,Knorr DA,Greenbaum B,Elhanati Y,Hogg SJ,Chow A,Ghosh A,Xie A,Zamarin D,Cui D,Erickson C,Singer M,Cho H,Wang E,Lu B,Durham BH,Shah H,Chowell D,Gabel AM,Shen Y,Liu J,Jin J,Rhodes MC,Taylor RE,Molina H,Wolchok JD,Merghoub T,Diaz LA,Abdel-Wahab O,Bradley RK

213-13 was used in Cell Culture to investigate RNA splicing effects in antigen production in cancer.

Thu Jul 22 00:00:00 EDT 2021

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.

Cell

Zhang S,Edwards TN,Chaudhri VK,Wu J,Cohen JA,Hirai T,Rittenhouse N,Schmitz EG,Zhou PY,McNeil BD,Yang Y,Koerber HR,Sumpter TL,Poholek AC,Davis BM,Albers KM,Singh H,Kaplan DH

Thu Apr 15 00:00:00 EDT 2021

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.

Immunity

Flommersfeld S,Böttcher JP,Ersching J,Flossdorf M,Meiser P,Pachmayr LO,Leube J,Hensel I,Jarosch S,Zhang Q,Chaudhry MZ,Andrae I,Schiemann M,Busch DH,Cicin-Sain L,Sun JC,Gasteiger G,Victora GD,Höfer T,Buchholz VR,Grassmann S

Tue Oct 12 00:00:00 EDT 2021

Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.

Immunity

Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D

Tue Aug 10 00:00:00 EDT 2021

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.

Nature genetics

Yun H,Narayan N,Vohra S,Giotopoulos G,Mupo A,Madrigal P,Sasca D,Lara-Astiaso D,Horton SJ,Agrawal-Singh S,Meduri E,Basheer F,Marando L,Gozdecka M,Dovey OM,Castillo-Venzor A,Wang X,Gallipoli P,Müller-Tidow C,Osborne CS,Vassiliou GS,Huntly BJP

Fri Oct 01 00:00:00 EDT 2021

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

Cell stem cell

Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W

213-13 was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.

Thu Jul 01 00:00:00 EDT 2021

Basophils balance healing after myocardial infarction via IL-4/IL-13.

The Journal of clinical investigation

Sicklinger F,Meyer IS,Li X,Radtke D,Dicks S,Kornadt MP,Mertens C,Meier JK,Lavine KJ,Zhang Y,Kuhn TC,Terzer T,Patel J,Boerries M,Schramm G,Frey N,Katus HA,Voehringer D,Leuschner F

Thu Jul 01 00:00:00 EDT 2021

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.

Molecular cell

Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM

213-13 was used in Cell Culture to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.

Thu Jul 01 00:00:00 EDT 2021

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation.

Molecular cell

Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI

213-13 was used in Cell Culture to conclude that METTL1-mediated tRNA modification drives oncogenic transformation through a remodeling of the mRNA translatome" to increase expression of growth-promoting proteins and represents a promising anti-cancer target."

Thu Aug 19 00:00:00 EDT 2021

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

The Journal of experimental medicine

Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S

Mon Oct 04 00:00:00 EDT 2021

ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.

The Journal of experimental medicine

Nakajima T,Kanno T,Yokoyama S,Sasamoto S,Asou HK,Tumes DJ,Ohara O,Nakayama T,Endo Y

Mon Dec 06 00:00:00 EST 2021

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.

The Journal of experimental medicine

Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E

Mon Jul 05 00:00:00 EDT 2021

The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.

The Journal of experimental medicine

Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE

Mon Dec 06 00:00:00 EST 2021

Low-affinity but high-avidity interactions may offer an explanation for IgE-mediated allergen cross-reactivity.

Allergy

Chang X,Zha L,Wallimann A,Mohsen MO,Krenger P,Liu X,Vogel M,Bachmann MF

213-13 was used in In vitro experiments to suggest that the underlying mechanism of allergen cross-reactivity may be low-affinity but high-avidity binding between IgE antibodies and cross-reactive allergen.

Sun Aug 01 00:00:00 EDT 2021

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.

Leukemia

Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM

Mon Nov 01 00:00:00 EDT 2021

Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine "matalafi".

Proceedings of the National Academy of Sciences of the United States of America

Molimau-Samasoni S,Woolner VH,Foliga ST,Robichon K,Patel V,Andreassend SK,Sheridan JP,Te Kawa T,Gresham D,Miller D,Sinclair DJ,La Flamme AC,Melnik AV,Aron A,Dorrestein PC,Atkinson PH,Keyzers RA,Munkacsi AB

Tue Nov 09 00:00:00 EST 2021

Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia.

Journal of cachexia, sarcopenia and muscle

Widner DB,Liu C,Zhao Q,Sharp S,Eber MR,Park SH,Files DC,Shiozawa Y

Sun Aug 01 00:00:00 EDT 2021

Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia.

Journal of cachexia, sarcopenia and muscle

Widner DB,Liu C,Zhao Q,Sharp S,Eber MR,Park SH,Files DC,Shiozawa Y

Sun Aug 01 00:00:00 EDT 2021

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.

Blood advances

Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG

Tue Dec 14 00:00:00 EST 2021

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt⁺ T_reg generation via enhanced IL-6 induction.

Immunology

Drube S,Müller S,Weber F,Wegner P,Böttcher-Loschinski R,Gaestel M,Hutloff A,Kamradt T,Andreas N

Sat May 01 00:00:00 EDT 2021

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.

Computational and structural biotechnology journal

Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F

213-13 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.

Wed Nov 10 00:00:00 EST 2021

Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.

Journal of immunology (Baltimore, Md. : 1950)

Luo M,Lai W,He Z,Wu L

Wed Sep 15 00:00:00 EDT 2021

A Critical Role for Na⁺/H⁺ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.

Journal of immunology (Baltimore, Md. : 1950)

Kammala AK,Syed M,Yang C,Occhiuto CJ,Subramanian H

Mon Feb 01 00:00:00 EST 2021

BRD4-mediated repression of p53 is a target for combination therapy in AML.

Nature communications

Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD

Mon Jan 11 00:00:00 EST 2021

Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway.

Cell death & disease

Baba T,Yoshida T,Tanabe Y,Nishimura T,Morishita S,Gotoh N,Hirao A,Hanayama R,Mukaida N

Fri Mar 26 00:00:00 EDT 2021

NAD⁺ augmentation with nicotinamide riboside improves lymphoid potential of Atm^-/- and old mice HSCs.

NPJ aging and mechanisms of disease

Zong L,Tanaka-Yano M,Park B,Yanai H,Turhan FT,Croteau DL,Tian J,Fang EF,Bohr VA,Beerman I

Tue Sep 21 00:00:00 EDT 2021

Engineering of a bona fide light-operated calcium channel.

Nature communications

He L,Wang L,Zeng H,Tan P,Ma G,Zheng S,Li Y,Sun L,Dou F,Siwko S,Huang Y,Wang Y,Zhou Y

Mon Jan 11 00:00:00 EST 2021

Protocol to produce high-titer retrovirus for transduction of mouse bone marrow cells.

STAR protocols

Qu J,Yang Z

213-13 was used in Cell Culture to demonstrate a modified protocol to overcome challenges associated with achieving high transduction efficiency in bone marrow cells in transplantation which enables reproducible and high-efficient retroviral transduction of hematopoietic stem and progenitor cells (HSPCs) for bone marrow transplantation (BMT).

Fri Jun 18 00:00:00 EDT 2021

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.

iScience

Chatterjee S,Yabaji SM,Rukhlenko OS,Bhattacharya B,Waligurski E,Vallavoju N,Ray S,Kholodenko BN,Brown LE,Beeler AB,Ivanov AR,Kobzik L,Porco JA,Kramnik I

Fri Aug 20 00:00:00 EDT 2021

Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.

Cell reports

Dignum T,Varnum-Finney B,Srivatsan SR,Dozono S,Waltner O,Heck AM,Ishida T,Nourigat-McKay C,Jackson DL,Rafii S,Trapnell C,Bernstein ID,Hadland B

213-13 was used in In vitro experiments to suggest a revised model of developmental hematopoiesis in which the initial populations of multipotent progenitors and HSCs arise independently from HE with distinct phenotypic and transcriptional properties.

Tue Sep 14 00:00:00 EDT 2021

SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.

Journal of experimental & clinical cancer research : CR

Wang F,Li Z,Zhou J,Wang G,Zhang W,Xu J,Liang A

213-13 was used in Cell Culture to investigate SIRT1 expression and function in T-cell acute lymphoblastic leukemia.

Wed Aug 18 00:00:00 EDT 2021

MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy.

Scientific reports

Tritz R,Hudson FZ,Harris V,Ghoshal P,Singla B,Lin H,Csanyi G,Stansfield BK

Tue Dec 21 00:00:00 EST 2021

Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.

Cell reports

Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R

Tue Jun 22 00:00:00 EDT 2021

Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector.

Molecular therapy. Methods & clinical development

Dahl M,Smith EMK,Warsi S,Rothe M,Ferraz MJ,Aerts JMFG,Golipour A,Harper C,Pfeifer R,Pizzurro D,Schambach A,Mason C,Karlsson S

Fri Mar 12 00:00:00 EST 2021

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.

Nature communications

Debackere K,Marcelis L,Demeyer S,Vanden Bempt M,Mentens N,Gielen O,Jacobs K,Broux M,Verhoef G,Michaux L,Graux C,Wlodarska I,Gaulard P,de Leval L,Tousseyn T,Cools J,Dierickx D

Thu Jun 17 00:00:00 EDT 2021

Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.

STAR protocols

Liang G,Huang B,Wang F,Liu F

213-13 was used in Flow cytometry/Cell sorting to describe a protocol for isolation and characterization of the hemogenic endothelial (HE) cells from mouse placenta.

Fri Dec 17 00:00:00 EST 2021

Syngeneic leukemia models using lentiviral transgenics.

Cell death & disease

Keinan N,Scharff Y,Goldstein O,Chamo M,Ilic S,Gazit R

Thu Feb 18 00:00:00 EST 2021

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.

iScience

Nguyen GT,Xu S,Adams W,Leong JM,Bunnell SC,Mansour MK,Sykes DB,Mecsas J

Fri Aug 20 00:00:00 EDT 2021

A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival.

Cell death & disease

Massett ME,Monaghan L,Patterson S,Mannion N,Bunschoten RP,Hoose A,Marmiroli S,Liskamp RMJ,Jørgensen HG,Vetrie D,Michie AM,Huang X

Thu Jun 03 00:00:00 EDT 2021

GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis.

Cell death & disease

Hu Q,Zhang Y,Lou H,Ou Z,Liu J,Duan W,Wang H,Ge Y,Min J,Wang F,Ju Z

Thu Jul 15 00:00:00 EDT 2021

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.

Nature communications

Khateb A,Deshpande A,Feng Y,Finlay D,Lee JS,Lazar I,Fabre B,Li Y,Fujita Y,Zhang T,Yin J,Pass I,Livneh I,Jeremias I,Burian C,Mason JR,Almog R,Horesh N,Ofran Y,Brown K,Vuori K,Jackson M,Ruppin E,Deshpande AJ,Ronai ZA

Mon Sep 13 00:00:00 EDT 2021

High-resolution characterization of gene function using single-cell CRISPR tiling screen.

Nature communications

Yang L,Chan AKN,Miyashita K,Delaney CD,Wang X,Li H,Pokharel SP,Li S,Li M,Xu X,Lu W,Liu Q,Mattson N,Chen KY,Wang J,Yuan YC,Horne D,Rosen ST,Soto-Feliciano Y,Feng Z,Hoshii T,Xiao G,Müschen M,Chen J,Armstrong SA,Chen CW

Thu Jul 01 00:00:00 EDT 2021

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.

Scientific reports

Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS

Fri Mar 05 00:00:00 EST 2021

TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.

iScience

Zhao J,Xiu Y,Fu L,Dong Q,Borcherding N,Wang Y,Li Q,De Silva NS,Klein U,Boyce BF,Zhao C

213-13 was used in Cell Culture to investigate NF-kB deletion effects on MLL-AF9-AML.

Fri Dec 17 00:00:00 EST 2021

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.

eLife

Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ

213-13 was used in Cell Culture to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.

Tue Nov 02 00:00:00 EDT 2021

TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.

Cell reports

Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R

Tue Jul 13 00:00:00 EDT 2021

Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System.

Stem cell reports

Jackson M,Fidanza A,Taylor AH,Rybtsov S,Axton R,Kydonaki M,Meek S,Burdon T,Medvinsky A,Forrester LM

Tue Apr 13 00:00:00 EDT 2021

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.

Nature communications

Supper E,Rudat S,Iyer V,Droop A,Wong K,Spinella JF,Thomas P,Sauvageau G,Adams DJ,Wong CC

Fri Apr 30 00:00:00 EDT 2021

High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.

Immunity

Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM

Tue Oct 13 00:00:00 EDT 2020

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Cancer cell

Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C

Mon May 11 00:00:00 EDT 2020

Vitamin B6 Addiction in Acute Myeloid Leukemia.

Cancer cell

Chen CC,Li B,Millman SE,Chen C,Li X,Morris JP,Mayle A,Ho YJ,Loizou E,Liu H,Qin W,Shah H,Violante S,Cross JR,Lowe SW,Zhang L

Mon Jan 13 00:00:00 EST 2020

SIRT1 is downregulated by autophagy in senescence and ageing.

Nature cell biology

Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL

213-13 was used in In vitro experiments to investigate SIRT1 homeostasis in mammalian senescence and aging.

Thu Oct 01 00:00:00 EDT 2020

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.

Blood

Numata A,Kwok HS,Zhou QL,Li J,Tirado-Magallanes R,Angarica VE,Hannah R,Park J,Wang CQ,Krishnan V,Rajagopalan D,Zhang Y,Zhou S,Welner RS,Osato M,Jha S,Bohlander SK,Göttgens B,Yang H,Benoukraf T,Lough JW,Bararia D,Tenen DG

Thu Oct 08 00:00:00 EDT 2020

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell stem cell

Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

213-13 was used in In vitro experiments to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.

Thu Jul 02 00:00:00 EDT 2020

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.

Cell stem cell

Hinge A,He J,Bartram J,Javier J,Xu J,Fjellman E,Sesaki H,Li T,Yu J,Wunderlich M,Mulloy J,Kofron M,Salomonis N,Grimes HL,Filippi MD

213-13 was used in In vitro experiments to investigate the underlying role of mitochondria in hematopoietic stem cells (HSCs) to meet change of metabolic requirements during their cell cycle activity.

Thu Mar 05 00:00:00 EST 2020

Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.

The Journal of clinical investigation

Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F

213-13 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.

Mon Mar 02 00:00:00 EST 2020

Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.

The Journal of clinical investigation

Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F

213-13 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.

Mon Mar 02 00:00:00 EST 2020

Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses.

The Journal of clinical investigation

Okunishi K,Wang H,Suzukawa M,Ishizaki R,Kobayashi E,Kihara M,Abe T,Miyazaki JI,Horie M,Saito A,Saito H,Nakae S,Izumi T

Wed Jul 01 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Mon Mar 02 00:00:00 EST 2020

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.

The Journal of experimental medicine

Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z

Mon Feb 03 00:00:00 EST 2020

Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

EMBO reports

Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A

Wed Feb 05 00:00:00 EST 2020

Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.

EMBO reports

Wed Feb 05 00:00:00 EST 2020

Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Duan C,Fukuda T,Isaji T,Qi F,Yang J,Wang Y,Takahashi S,Gu J

Sat Feb 01 00:00:00 EST 2020

Differentiation of c-Kit⁺ CD24⁺ natural killer cells into myeloid cells in a GATA-2-dependent manner.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Song B,Lee JM,Park YJ,Kim IK,Kim BS,Shin KS,Jeon I,Koh CH,Bae EA,Seo H,Byun Y,Kang CY

Sun Mar 01 00:00:00 EST 2020

The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG

Wed Jan 01 00:00:00 EST 2020

Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.

Journal of immunology (Baltimore, Md. : 1950)

Yoshida K,Ito MA,Sato N,Obayashi K,Yamamoto K,Koizumi S,Tanaka S,Furuta K,Matsuoka I

Mon Jun 15 00:00:00 EDT 2020

Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.

Journal of immunology (Baltimore, Md. : 1950)

Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D

Thu Oct 15 00:00:00 EDT 2020

MALT1 Protease Plays a Dual Role in the Allergic Response by Acting in Both Mast Cells and Endothelial Cells.

Journal of immunology (Baltimore, Md. : 1950)

Alfano DN,Klei LR,Klei HB,Trotta M,Gough PJ,Foley KP,Bertin J,Sumpter TL,Lucas PC,McAllister-Lucas LM

Fri May 01 00:00:00 EDT 2020

Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.

Scientific reports

Olender L,Bujanover N,Sharabi O,Goldstein O,Gazit R

Tue Feb 04 00:00:00 EST 2020

GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.

Nature communications

Regan-Komito D,Swann JW,Demetriou P,Cohen ES,Horwood NJ,Sansom SN,Griseri T

Thu Jan 09 00:00:00 EST 2020

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.

Science advances

Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A

213-13 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.

Fri May 01 00:00:00 EDT 2020

Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance.

Nature communications

Yabut JM,Desjardins EM,Chan EJ,Day EA,Leroux JM,Wang B,Crane ED,Wong W,Morrison KM,Crane JD,Khan WI,Steinberg GR

213-13 was used in In vitro experiments to report that the exposure of mice to thermoneutrality promotes the infiltration of white adipose tissue with mast cells that are highly enriched with tryptophan hydroxylase 1 (Tph1), the rate limiting enzyme regulating peripheral serotonin synthesis.

Thu Jan 23 00:00:00 EST 2020

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.

Nature communications

Basilico S,Wang X,Kennedy A,Tzelepis K,Giotopoulos G,Kinston SJ,Quiros PM,Wong K,Adams DJ,Carnevalli LS,Huntly BJP,Vassiliou GS,Calero-Nieto FJ,Göttgens B

Mon Mar 16 00:00:00 EDT 2020

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.

Nature communications

Zhang Y,Guo Y,Gough SM,Zhang J,Vann KR,Li K,Cai L,Shi X,Aplan PD,Wang GG,Kutateladze TG

Fri Jul 03 00:00:00 EDT 2020

Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter.

Cell reports

Eastman AE,Chen X,Hu X,Hartman AA,Pearlman Morales AM,Yang C,Lu J,Kueh HY,Guo S

213-13 was used in Cell Culture to describe a genetically encoded fluorescent reporter that captures live-cell cycle speed using a single measurement.

Tue Jun 23 00:00:00 EDT 2020

Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.

Communications biology

AhYoung AP,Eckard SC,Gogineni A,Xi H,Lin SJ,Gerhardy S,Cox C,Phung QT,Hackney JA,Katakam AK,Reichelt M,Caplazi P,Manzanillo P,Zhang J,Roose-Girma M,Tam LW,Newman RJ,Murthy A,Weimer RM,Lill JR,Lee WP,Grimbaldeston M,Kirchhofer D,van Lookeren Campagne M

Thu Nov 19 00:00:00 EST 2020

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.

Nature communications

Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C

Wed Jan 29 00:00:00 EST 2020

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness.

Scientific reports

Mus LM,Lambertz I,Claeys S,Kumps C,Van Loocke W,Van Neste C,Umapathy G,Vaapil M,Bartenhagen C,Laureys G,De Wever O,Bexell D,Fischer M,Hallberg B,Schulte J,De Wilde B,Durinck K,Denecker G,De Preter K,Speleman F

Tue Jan 14 00:00:00 EST 2020

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.

Cell reports

Niederkorn M,Hueneman K,Choi K,Varney ME,Romano L,Pujato MA,Greis KD,Inoue JI,Meetei R,Starczynowski DT

213-13 was used in Cell Culture to study how forkhead-associated domain B (TIFAB) regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity using a combination of proteomic and genetic approaches to uncover a function of TIFAB as an effector of USP15 activity and rheostat of p53 signaling in stressed and malignant hematopoietic stem/progenitor cells (HSPCs).

Tue Feb 25 00:00:00 EST 2020

Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells.

Frontiers in immunology

Kornstädt L,Pierre S,Weigert A,Ebersberger S,Schäufele TJ,Kolbinger A,Schmid T,Cohnen J,Thomas D,Ferreirós N,Brüne B,Ebersberger I,Scholich K

213-13 was used in Cell Culture to better understand the role of mast cells during the resolution phase of a local inflammation induced with the Toll-like receptor (TLR)-2 agonist zymosan.

Mon Jun 21 00:00:00 EDT 2021

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.

Science advances

Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS

213-13 was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.

Sun Nov 01 00:00:00 EDT 2020

Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.

Nature communications

Rai S,Tanaka H,Suzuki M,Espinoza JL,Kumode T,Tanimura A,Yokota T,Oritani K,Watanabe T,Kanakura Y,Matsumura I

Tue Aug 18 00:00:00 EDT 2020

Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response.

The Journal of biological chemistry

Garg B,Mehta HM,Wang B,Kamel R,Horwitz MS,Corey SJ

Fri May 22 00:00:00 EDT 2020

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.

Nature communications

Barbier V,Erbani J,Fiveash C,Davies JM,Tay J,Tallack MR,Lowe J,Magnani JL,Pattabiraman DR,Perkins AC,Lisle J,Rasko JEJ,Levesque JP,Winkler IG

Mon Apr 27 00:00:00 EDT 2020

A Requirement for Argonaute 4 in Mammalian Antiviral Defense.

Cell reports

Adiliaghdam F,Basavappa M,Saunders TL,Harjanto D,Prior JT,Cronkite DA,Papavasiliou N,Jeffrey KL

213-13 was used in Cell Culture to study the antiviral activity of Argonautes AGO1, AGO3 or AGO4 in interferon (IFN)-competent immune cells to demonstrate an essential role for AGO4 in mammalian antiviral defense.

Tue Feb 11 00:00:00 EST 2020

The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.

Cell

Sanghvi VR,Leibold J,Mina M,Mohan P,Berishaj M,Li Z,Miele MM,Lailler N,Zhao C,de Stanchina E,Viale A,Akkari L,Lowe SW,Ciriello G,Hendrickson RC,Wendel HG

Thu Aug 08 00:00:00 EDT 2019

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.

Immunity

Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V

Tue Jul 16 00:00:00 EDT 2019

Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.

Immunity

Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E

Tue Jun 18 00:00:00 EDT 2019

MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.

Immunity

Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA

Tue Sep 17 00:00:00 EDT 2019

Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.

Immunity

Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR

Tue Jun 18 00:00:00 EDT 2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

Cancer cell

Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG

Mon Apr 15 00:00:00 EDT 2019

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.

Blood

Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS

Thu May 30 00:00:00 EDT 2019

A role for macrophages in hematopoiesis in the embryonic head.

Blood

Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E

Thu Nov 28 00:00:00 EST 2019

Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.

Blood

Abdul-Aziz AM,Sun Y,Hellmich C,Marlein CR,Mistry J,Forde E,Piddock RE,Shafat MS,Morfakis A,Mehta T,Di Palma F,Macaulay I,Ingham CJ,Haestier A,Collins A,Campisi J,Bowles KM,Rushworth SA

Thu Jan 31 00:00:00 EST 2019

Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases.

Blood

Ramasz B,Krüger A,Reinhardt J,Sinha A,Gerlach M,Gerbaulet A,Reinhardt S,Dahl A,Chavakis T,Wielockx B,Grinenko T

Thu Sep 26 00:00:00 EDT 2019

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.

Blood

Sasca D,Yun H,Giotopoulos G,Szybinski J,Evan T,Wilson NK,Gerstung M,Gallipoli P,Green AR,Hills R,Russell N,Osborne CS,Papaemmanuil E,Göttgens B,Campbell P,Huntly BJP

Thu Dec 12 00:00:00 EST 2019

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.

Blood

Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA

Thu Mar 14 00:00:00 EDT 2019

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.

Blood

Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA

Thu Mar 14 00:00:00 EDT 2019

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Cell stem cell

Yamashita M,Passegué E

213-13 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.

Thu Sep 05 00:00:00 EDT 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B

Mon Feb 04 00:00:00 EST 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

The Journal of experimental medicine

Mon Feb 04 00:00:00 EST 2019

CD97 is a critical regulator of acute myeloid leukemia stem cell function.

The Journal of experimental medicine

Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY

Mon Oct 07 00:00:00 EDT 2019

CD97 is a critical regulator of acute myeloid leukemia stem cell function.

The Journal of experimental medicine

Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY

Mon Oct 07 00:00:00 EDT 2019

Self-reactive CD4⁺ IL-3⁺ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.

The Journal of experimental medicine

Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK

Mon Feb 04 00:00:00 EST 2019

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

The Journal of experimental medicine

Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP

Mon Apr 01 00:00:00 EDT 2019

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

The Journal of experimental medicine

Mon Apr 01 00:00:00 EDT 2019

TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone.

The Journal of experimental medicine

Albright AR,Kabat J,Li M,Raso F,Reboldi A,Muppidi JR

Mon Nov 04 00:00:00 EST 2019

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity.

The Journal of allergy and clinical immunology

Klein O,Krier-Burris RA,Lazki-Hagenbach P,Gorzalczany Y,Mei Y,Ji P,Bochner BS,Sagi-Eisenberg R

213-13 was used in Cell Culture to identify mDia1 as a novel regulator of MC response that coordinates MC chemotaxis and secretion through its actin-nucleating activity.

Tue Oct 01 00:00:00 EDT 2019

Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.

Developmental cell

Li H,Natarajan A,Ezike J,Barrasa MI,Le Y,Feder ZA,Yang H,Ma C,Markoulaki S,Lodish HF

213-13 was used in In vitro experiments to demonstrate a continuum of transcriptomic states in committed transit-amplifying erythropoietic progenitors, which correlates with a continuum of proliferative potentials in these cells.

Mon Apr 08 00:00:00 EDT 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell systems

Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV

213-13 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.

Wed Oct 23 00:00:00 EDT 2019

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.

EMBO reports

Schuler F,Afreen S,Manzl C,Häcker G,Erlacher M,Villunger A

Thu Aug 01 00:00:00 EDT 2019

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications.

Stem cells translational medicine

Kwon YW,Lee SJ,Heo SC,Lee TW,Park GT,Yoon JW,Kim SC,Shin HJ,Lee SC,Kim JH

Fri Mar 01 00:00:00 EST 2019

Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.

Cancer science

Chu Y,Chen Y,Li M,Shi D,Wang B,Lian Y,Cheng X,Wang X,Xu M,Cheng T,Shi J,Yuan W

Mon Jul 01 00:00:00 EDT 2019

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

Immunology and cell biology

McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC

Tue Jan 01 00:00:00 EST 2019

Chromosome Transplantation: Correction of the Chronic Granulomatous Disease Defect in Mouse Induced Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)

Castelli A,Susani L,Menale C,Muggeo S,Caldana E,Strina D,Cassani B,Recordati C,Scanziani E,Ficara F,Villa A,Vezzoni P,Paulis M

Mon Jul 01 00:00:00 EDT 2019

Mast cell tetrahydrobiopterin contributes to itch in mice.

Journal of cellular and molecular medicine

Zschiebsch K,Fischer C,Wilken-Schmitz A,Geisslinger G,Channon K,Watschinger K,Tegeder I

Fri Feb 01 00:00:00 EST 2019

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Cell reports

Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D

213-13 was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.

Tue Jan 22 00:00:00 EST 2019

Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.

Frontiers in immunology

Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC

213-13 was used in In vitro experiments to show for the first time a role for mast cells in skin chronic graft-vs-host disease that may be targetable for preventive and therapeutic intervention in this disease.

Tue Nov 17 00:00:00 EST 2020

Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection.

FEBS open bio

Lipok M,Szlachcic A,Kindela K,Czyrek A,Otlewski J

Wed May 01 00:00:00 EDT 2019

In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.

Cell death and differentiation

Dong L,Reljic B,Cheung JG,Ng ES,Lindqvist LM,Elefanty AG,Vaux DL,Tran H

213-13 was used in Cell Culture to show that Bax-/-Bak1-/- myeloid cells deprived of growth factor consume extracellular glucose to maintain long-term viability, without a requirement for Atg5-dependent autophagy.

Tue Oct 01 00:00:00 EDT 2019

Structural and functional consequences of the STAT5B^N642H driver mutation.

Nature communications

de Araujo ED,Erdogan F,Neubauer HA,Meneksedag-Erol D,Manaswiyoungkul P,Eram MS,Seo HS,Qadree AK,Israelian J,Orlova A,Suske T,Pham HTT,Boersma A,Tangermann S,Kenner L,Rülicke T,Dong A,Ravichandran M,Brown PJ,Audette GF,Rauscher S,Dhe-Paganon S,Moriggl R,Gunning PT

Fri Jun 07 00:00:00 EDT 2019

Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells.

Scientific reports

Nishi K,Kanayama Y,Kim IH,Nakata A,Nishiwaki H,Sugahara T

Thu Nov 07 00:00:00 EST 2019

CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3.

Cell death & disease

Han X,Shi H,Sun Y,Shang C,Luan T,Wang D,Ba X,Zeng X

Thu Aug 08 00:00:00 EDT 2019

Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production.

Cell death discovery

Paivandy A,Eriksson J,Melo FR,Sellin ME,Pejler G

Thu Oct 01 00:00:00 EDT 2020

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.

Cell death & disease

Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R

Tue Dec 10 00:00:00 EST 2019

Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis.

Scientific reports

Zhang Y,Hu N,Dong F

Thu Jan 24 00:00:00 EST 2019

Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells.

Scientific reports

Dhakal H,Yang EJ,Lee S,Kim MJ,Baek MC,Lee B,Park PH,Kwon TK,Khang D,Song KS,Kim SH

Fri May 03 00:00:00 EDT 2019

Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin inflammatory diseases in NC/Nga mice.

Scientific reports

Lee MH,Lee YS,Kim HJ,Han CH,Kang SU,Kim CH

Wed Sep 18 00:00:00 EDT 2019

Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.

Scientific reports

Nakajima S,Ishimaru K,Kobayashi A,Yu G,Nakamura Y,Oh-Oka K,Suzuki-Inoue K,Kono K,Nakao A

Thu Dec 05 00:00:00 EST 2019

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.

Nature communications

Jin N,Bi A,Lan X,Xu J,Wang X,Liu Y,Wang T,Tang S,Zeng H,Chen Z,Tan M,Ai J,Xie H,Zhang T,Liu D,Huang R,Song Y,Leung EL,Yao X,Ding J,Geng M,Lin SH,Huang M

Thu Jun 20 00:00:00 EDT 2019

Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.

Nature communications

Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T

Fri Dec 06 00:00:00 EST 2019

Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells.

Scientific reports

Nakamura Y,Sasaki T,Mochizuki C,Ishimaru K,Koizumi S,Shinmori H,Suzuki-Inoue K,Nakao A

Mon Nov 04 00:00:00 EST 2019

Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation.

Nature communications

Wang N,Zheng J,Chen Z,Liu Y,Dura B,Kwak M,Xavier-Ferrucio J,Lu YC,Zhang M,Roden C,Cheng J,Krause DS,Ding Y,Fan R,Lu J

Wed Jan 09 00:00:00 EST 2019

Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.

Scientific reports

Lin CH,Wang Z,Duque-Afonso J,Wong SH,Demeter J,Loktev AV,Somervaille TCP,Jackson PK,Cleary ML

Wed Mar 20 00:00:00 EDT 2019

IL1RL1 is dynamically expressed on Cbfb-MYH11⁺ leukemia stem cells and promotes cell survival.

Scientific reports

Wang Y,Richter L,Becker M,Amador C,Hyde RK

Mon Feb 11 00:00:00 EST 2019

Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.

Stem cell research & therapy

I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I

213-13 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.

Thu Oct 17 00:00:00 EDT 2019

Population snapshots predict early haematopoietic and erythroid hierarchies.

Nature

Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M

213-13 was used in In vitro experiments to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.

Thu Mar 01 00:00:00 EST 2018

Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.

Nature

Shen Q,Zhang Q,Shi Y,Shi Q,Jiang Y,Gu Y,Li Z,Li X,Zhao K,Wang C,Li N,Cao X

Thu Feb 01 00:00:00 EST 2018

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.

Nature

Carrelha J,Meng Y,Kettyle LM,Luis TC,Norfo R,Alcolea V,Boukarabila H,Grasso F,Gambardella A,Grover A,Högstrand K,Lord AM,Sanjuan-Pla A,Woll PS,Nerlov C,Jacobsen SEW

Thu Feb 01 00:00:00 EST 2018

Clonal analysis of lineage fate in native haematopoiesis.

Nature

Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

Thu Jan 11 00:00:00 EST 2018

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.

Cell

Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH

213-13 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.

Thu Jun 28 00:00:00 EDT 2018

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting.

Cell

Cohen M,Giladi A,Gorki AD,Solodkin DG,Zada M,Hladik A,Miklosi A,Salame TM,Halpern KB,David E,Itzkovitz S,Harkany T,Knapp S,Amit I

Thu Nov 01 00:00:00 EDT 2018

Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.

Cell

Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y

Thu Sep 20 00:00:00 EDT 2018

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.

Immunity

Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W

Tue Apr 17 00:00:00 EDT 2018

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.

Immunity

Postat J,Olekhnovitch R,Lemaître F,Bousso P

Tue Oct 16 00:00:00 EDT 2018

The Majority of CD45^- Ter119^- CD31^- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.

Immunity

Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS

213-13 was used in Sample Preparation (FC/FACS) to investigate CD45, Ter119, and CD31 in hematopoietic cells.

Tue Oct 16 00:00:00 EDT 2018

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.

Immunity

Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z

Tue Apr 17 00:00:00 EDT 2018

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors.

Immunity

Li Z,Liu S,Xu J,Zhang X,Han D,Liu J,Xia M,Yi L,Shen Q,Xu S,Lu L,Cao X

Tue Oct 16 00:00:00 EDT 2018

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.

Cancer cell

Maes T,Mascaró C,Tirapu I,Estiarte A,Ciceri F,Lunardi S,Guibourt N,Perdones A,Lufino MMP,Somervaille TCP,Wiseman DH,Duy C,Melnick A,Willekens C,Ortega A,Martinell M,Valls N,Kurz G,Fyfe M,Castro-Palomino JC,Buesa C

Mon Mar 12 00:00:00 EDT 2018

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.

Cancer cell

Medler TR,Murugan D,Horton W,Kumar S,Cotechini T,Forsyth AM,Leyshock P,Leitenberger JJ,Kulesz-Martin M,Margolin AA,Werb Z,Coussens LM

Mon Oct 08 00:00:00 EDT 2018

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Cancer cell

Yamauchi T,Masuda T,Canver MC,Seiler M,Semba Y,Shboul M,Al-Raqad M,Maeda M,Schoonenberg VAC,Cole MA,Macias-Trevino C,Ishikawa Y,Yao Q,Nakano M,Arai F,Orkin SH,Reversade B,Buonamici S,Pinello L,Akashi K,Bauer DE,Maeda T

Mon Mar 12 00:00:00 EDT 2018

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.

Cancer cell

Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH

Mon Jan 08 00:00:00 EST 2018

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.

Cancer cell

Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J

Mon Aug 13 00:00:00 EDT 2018

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Cancer cell

Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ

Mon Feb 12 00:00:00 EST 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer cell

Kleppe M,Koche R,Zou L,van Galen P,Hill CE,Dong L,De Groote S,Papalexi E,Hanasoge Somasundara AV,Cordner K,Keller M,Farnoud N,Medina J,McGovern E,Reyes J,Roberts J,Witkin M,Rapaport F,Teruya-Feldstein J,Qi J,Rampal R,Bernstein BE,Bradner JE,Levine RL

Mon Jan 08 00:00:00 EST 2018

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

Blood

Gallipoli P,Giotopoulos G,Tzelepis K,Costa ASH,Vohra S,Medina-Perez P,Basheer F,Marando L,Di Lisio L,Dias JML,Yun H,Sasca D,Horton SJ,Vassiliou G,Frezza C,Huntly BJP

Thu Apr 12 00:00:00 EDT 2018

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.

Blood

Dahlin JS,Hamey FK,Pijuan-Sala B,Shepherd M,Lau WWY,Nestorowa S,Weinreb C,Wolock S,Hannah R,Diamanti E,Kent DG,Göttgens B,Wilson NK

Thu May 24 00:00:00 EDT 2018

Extracellular vesicle-mediated transfer of constitutively active MyD88^L265P engages MyD88^wt and activates signaling.

Blood

Manček-Keber M,Lainšček D,Benčina M,Chen JG,Romih R,Hunter ZR,Treon SP,Jerala R

Thu Apr 12 00:00:00 EDT 2018

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.

Blood

Shima H,Takamatsu-Ichihara E,Shino M,Yamagata K,Katsumoto T,Aikawa Y,Fujita S,Koseki H,Kitabayashi I

Thu Apr 19 00:00:00 EDT 2018

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

Blood

El Ashkar S,Schwaller J,Pieters T,Goossens S,Demeulemeester J,Christ F,Van Belle S,Juge S,Boeckx N,Engelman A,Van Vlierberghe P,Debyser Z,De Rijck J

Thu Jan 04 00:00:00 EST 2018

IGF-1 facilitates thrombopoiesis primarily through Akt activation.

Blood

Chen S,Hu M,Shen M,Wang S,Wang C,Chen F,Tang Y,Wang X,Zeng H,Chen M,Gao J,Wang F,Su Y,Xu Y,Wang J

Thu Jul 12 00:00:00 EDT 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 EST 2018

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.

The Journal of clinical investigation

Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J

Tue May 01 00:00:00 EDT 2018

Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.

The Journal of clinical investigation

Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC

Mon Dec 03 00:00:00 EST 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Fri Jun 01 00:00:00 EDT 2018

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.

The Journal of experimental medicine

Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F

Mon May 07 00:00:00 EDT 2018

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.

The Journal of experimental medicine

Tober J,Maijenburg MMW,Li Y,Gao L,Hadland BK,Gao P,Minoura K,Bernstein ID,Tan K,Speck NA

Mon Feb 05 00:00:00 EST 2018

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

The Journal of experimental medicine

Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M

Mon Jul 02 00:00:00 EDT 2018

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.

Leukemia

Mingay M,Chaturvedi A,Bilenky M,Cao Q,Jackson L,Hui T,Moksa M,Heravi-Moussavi A,Humphries RK,Heuser M,Hirst M

Mon Jan 01 00:00:00 EST 2018

Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.

Proceedings of the National Academy of Sciences of the United States of America

Das P,Veazey KJ,Van HT,Kaushik S,Lin K,Lu Y,Ishii M,Kikuta J,Ge K,Nussenzweig A,Santos MA

Tue Oct 23 00:00:00 EDT 2018

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America

Sharma S,Čermáková K,De Rijck J,Demeulemeester J,Fábry M,El Ashkar S,Van Belle S,Lepšík M,Tesina P,Duchoslav V,Novák P,Hubálek M,Srb P,Christ F,Řezáčová P,Hodges HC,Debyser Z,Veverka V

Tue Jul 24 00:00:00 EDT 2018

A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Zehrer A,Pick R,Salvermoser M,Boda A,Miller M,Stark K,Weckbach LT,Walzog B,Begandt D

Sat Sep 15 00:00:00 EDT 2018

Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.

Journal of immunology (Baltimore, Md. : 1950)

Lim TJF,Su IH

Sat Dec 15 00:00:00 EST 2018

Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.

Journal of immunology (Baltimore, Md. : 1950)

Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA

Thu Feb 01 00:00:00 EST 2018

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Ocana JA,Romer E,Sahu R,Pawelzik SC,FitzGerald GA,Kaplan MH,Travers JB

Fri Jun 15 00:00:00 EDT 2018

Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.

Journal of immunology (Baltimore, Md. : 1950)

Hu MD,Ethridge AD,Lipstein R,Kumar S,Wang Y,Jabri B,Turner JR,Edelblum KL

Sun Jul 15 00:00:00 EDT 2018

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.

Nature communications

Massara M,Bonavita O,Savino B,Caronni N,Mollica Poeta V,Sironi M,Setten E,Recordati C,Crisafulli L,Ficara F,Mantovani A,Locati M,Bonecchi R

Wed Feb 14 00:00:00 EST 2018

Ecrg4 peptide is the ligand of multiple scavenger receptors.

Scientific reports

Moriguchi T,Takeda S,Iwashita S,Enomoto K,Sawamura T,Koshimizu U,Kondo T

Tue Mar 06 00:00:00 EST 2018

Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.

Scientific reports

Philp AR,Riquelme TT,Millar-Büchner P,González R,Sepúlveda FV,Cid LP,Flores CA

Mon Jun 18 00:00:00 EDT 2018

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.

Scientific reports

Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S

Tue Apr 03 00:00:00 EDT 2018

MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.

Cell death & disease

Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G

Thu Jul 26 00:00:00 EDT 2018

Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells.

The Journal of biological chemistry

Gutierrez BA,Chavez MA,Rodarte AI,Ramos MA,Dominguez A,Petrova Y,Davalos AJ,Costa RM,Elizondo R,Tuvim MJ,Dickey BF,Burns AR,Heidelberger R,Adachi R

Fri May 11 00:00:00 EDT 2018

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Nature communications

Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B

Tue May 15 00:00:00 EDT 2018

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.

Stem cell reports

Mucci A,Lopez-Rodriguez E,Hetzel M,Liu S,Suzuki T,Happle C,Ackermann M,Kempf H,Hillje R,Kunkiel J,Janosz E,Brennig S,Glage S,Bankstahl JP,Dettmer S,Rodt T,Gohring G,Trapnell B,Hansen G,Trapnell C,Knudsen L,Lachmann N,Moritz T

Tue Sep 11 00:00:00 EDT 2018

In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.

Stem cell reports

Kauts ML,Rodriguez-Seoane C,Kaimakis P,Mendes SC,Cortés-Lavaud X,Hill U,Dzierzak E

Tue Jan 09 00:00:00 EST 2018

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.

Nature communications

Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R

Wed Aug 29 00:00:00 EDT 2018

A malaria protein factor induces IL-4 production by dendritic cells via PI3K-Akt-NF-κB signaling independent of MyD88/TRIF and promotes Th2 response.

The Journal of biological chemistry

Wu X,Gowda NM,Kawasawa YI,Gowda DC

Fri Jul 06 00:00:00 EDT 2018

Honokiol is a FOXM1 antagonist.

Cell death & disease

Halasi M,Hitchinson B,Shah BN,Váraljai R,Khan I,Benevolenskaya EV,Gaponenko V,Arbiser JL,Gartel AL

Wed Jan 24 00:00:00 EST 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

213-13 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.

Cell stem cell

Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP

213-13 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.

Thu Nov 01 00:00:00 EDT 2018

Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.

Stem cell reports

Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR

Tue Nov 13 00:00:00 EST 2018

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.

Nature communications

Su H,Hu J,Huang L,Yang Y,Thenoz M,Kuchmiy A,Hu Y,Li P,Feng H,Zhou Y,Taghon T,Van Vlierberghe P,Qing G,Chen Z,Liu H

Mon Oct 15 00:00:00 EDT 2018

The effect of PU.1 knockdown on gene expression and function of mast cells.

Scientific reports

Oda Y,Kasakura K,Fujigaki I,Kageyama A,Okumura K,Ogawa H,Yashiro T,Nishiyama C

Wed Jan 31 00:00:00 EST 2018

Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.

Nature communications

Ganuza M,Chabot A,Tang X,Bi W,Natarajan S,Carter R,Gawad C,Kang G,Cheng Y,McKinney-Freeman S

Thu Dec 20 00:00:00 EST 2018

Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.

Nature communications

Xu Y,Sun Y,Shen H,Dai Y,Liu H,Li R,Zhang H,Wu L,Zhu X,Liu X

Mon Sep 24 00:00:00 EDT 2018

Effects of the Th2-dominant milieu on allergic responses in Der f 1-activated mouse basophils and mast cells.

Scientific reports

Yi MH,Kim HP,Jeong KY,Kim JY,Lee IY,Yong TS

Wed May 16 00:00:00 EDT 2018

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.

Nature communications

Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM

Tue Jan 02 00:00:00 EST 2018

IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K.

Cell death & disease

Reinhart R,Kaufmann T

Mon Jun 18 00:00:00 EDT 2018

IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils.

Cell death & disease

Zellweger F,Buschor P,Hobi G,Brigger D,Dahinden CA,Villiger PM,Eggel A

Tue May 01 00:00:00 EDT 2018

The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.

The Journal of biological chemistry

Treutlein EM,Kern K,Weigert A,Tarighi N,Schuh CD,Nüsing RM,Schreiber Y,Ferreirós N,Brüne B,Geisslinger G,Pierre S,Scholich K

Fri Jun 22 00:00:00 EDT 2018

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.

Nature communications

Numata A,Kwok HS,Kawasaki A,Li J,Zhou QL,Kerry J,Benoukraf T,Bararia D,Li F,Ballabio E,Tapia M,Deshpande AJ,Welner RS,Delwel R,Yang H,Milne TA,Taneja R,Tenen DG

Tue Apr 24 00:00:00 EDT 2018

Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.

Stem cell reports

Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A

Tue Sep 11 00:00:00 EDT 2018

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.

Nature communications

Hyrenius-Wittsten A,Pilheden M,Sturesson H,Hansson J,Walsh MP,Song G,Kazi JU,Liu J,Ramakrishan R,Garcia-Ruiz C,Nance S,Gupta P,Zhang J,Rönnstrand L,Hultquist A,Downing JR,Lindkvist-Petersson K,Paulsson K,Järås M,Gruber TA,Ma J,Hagström-Andersson AK

Wed May 02 00:00:00 EDT 2018

Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.

Cell death & disease

Schubert F,Rapp J,Brauns-Schubert P,Schlicher L,Stock K,Wissler M,Weiß M,Charvet C,Borner C,Maurer U

Tue May 01 00:00:00 EDT 2018

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports

Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E

Tue Oct 09 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Tue Dec 11 00:00:00 EST 2018

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Nature communications

Tzelepis K,De Braekeleer E,Aspris D,Barbieri I,Vijayabaskar MS,Liu WH,Gozdecka M,Metzakopian E,Toop HD,Dudek M,Robson SC,Hermida-Prado F,Yang YH,Babaei-Jadidi R,Garyfallos DA,Ponstingl H,Dias JML,Gallipoli P,Seiler M,Buonamici S,Vick B,Bannister AJ,Rad R,Prinjha RK,Marioni JC,Huntly B,Batson J,Morris JC,Pina C,Bradley A,Jeremias I,Bates DO,Yusa K,Kouzarides T,Vassiliou GS

Wed Dec 19 00:00:00 EST 2018

Promoter-bound METTL3 maintains myeloid leukaemia by m⁶A-dependent translation control.

Nature

Barbieri I,Tzelepis K,Pandolfini L,Shi J,Millán-Zambrano G,Robson SC,Aspris D,Migliori V,Bannister AJ,Han N,De Braekeleer E,Ponstingl H,Hendrick A,Vakoc CR,Vassiliou GS,Kouzarides T

Thu Dec 07 00:00:00 EST 2017

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Cell

Wang T,Yu H,Hughes NW,Liu B,Kendirli A,Klein K,Chen WW,Lander ES,Sabatini DM

Thu Feb 23 00:00:00 EST 2017

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Cell

Burgess MR,Hwang E,Mroue R,Bielski CM,Wandler AM,Huang BJ,Firestone AJ,Young A,Lacap JA,Crocker L,Asthana S,Davis EM,Xu J,Akagi K,Le Beau MM,Li Q,Haley B,Stokoe D,Sampath D,Taylor BS,Evangelista M,Shannon K

Thu Feb 23 00:00:00 EST 2017

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

Cell

Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I

Thu Sep 07 00:00:00 EDT 2017

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Cell

Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC

213-13 was used in Cell Culture to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.

Thu Mar 09 00:00:00 EST 2017

Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

Immunity

Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H

213-13 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.

Tue Dec 19 00:00:00 EST 2017

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.

Immunity

Riffelmacher T,Clarke A,Richter FC,Stranks A,Pandey S,Danielli S,Hublitz P,Yu Z,Johnson E,Schwerd T,McCullagh J,Uhlig H,Jacobsen SEW,Simon AK

Tue Sep 19 00:00:00 EDT 2017

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Cancer cell

Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P

Mon Jun 12 00:00:00 EDT 2017

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

Cancer cell

Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W

Mon Jul 10 00:00:00 EDT 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Cancer cell

Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T

Mon Apr 10 00:00:00 EDT 2017

CSF-1-induced Src signaling can instruct monocytic lineage choice.

Blood

Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T

Thu Mar 23 00:00:00 EDT 2017

Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin.

Blood

Seo A,Ben-Harosh M,Sirin M,Stein J,Dgany O,Kaplelushnik J,Hoenig M,Pannicke U,Lorenz M,Schwarz K,Stockklausner C,Walsh T,Gulsuner S,Lee MK,Sendamarai A,Sanchez-Bonilla M,King MC,Cario H,Kulozik AE,Debatin KM,Schulz A,Tamary H,Shimamura A

Thu Aug 17 00:00:00 EDT 2017

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.

Blood

Man N,Tan Y,Sun XJ,Liu F,Cheng G,Greenblatt SM,Martinez C,Karl DL,Ando K,Sun M,Hou D,Chen B,Xu M,Yang FC,Chen Z,Chen S,Nimer SD,Wang L

Thu May 18 00:00:00 EDT 2017

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.

Blood

Dovey OM,Cooper JL,Mupo A,Grove CS,Lynn C,Conte N,Andrews RM,Pacharne S,Tzelepis K,Vijayabaskar MS,Green P,Rad R,Arends M,Wright P,Yusa K,Bradley A,Varela I,Vassiliou GS

Thu Oct 26 00:00:00 EDT 2017

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.

The Journal of experimental medicine

Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A

Mon Oct 02 00:00:00 EDT 2017

Mast cells acquire MHCII from dendritic cells during skin inflammation.

The Journal of experimental medicine

Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A

Mon Dec 04 00:00:00 EST 2017

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

The Journal of experimental medicine

Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T

Mon Sep 04 00:00:00 EDT 2017

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.

The Journal of experimental medicine

McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A

Mon Dec 04 00:00:00 EST 2017

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.

Autophagy

Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y

213-13 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.

Thu May 04 00:00:00 EDT 2017

Preclinical modeling of myelodysplastic syndromes.

Leukemia

Rouault-Pierre K,Mian SA,Goulard M,Abarrategi A,Di Tulio A,Smith AE,Mohamedali A,Best S,Nloga AM,Kulasekararaj AG,Ades L,Chomienne C,Fenaux P,Dosquet C,Mufti GJ,Bonnet D

Fri Dec 01 00:00:00 EST 2017

Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.

Journal of immunology (Baltimore, Md. : 1950)

McCurdy S,Baumer Y,Toulmin E,Lee BH,Boisvert WA

Wed Nov 15 00:00:00 EST 2017

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Drube S,Grimlowski R,Deppermann C,Fröbel J,Kraft F,Andreas N,Stegner D,Dudeck J,Weber F,Rödiger M,Göpfert C,Drube J,Reich D,Nieswandt B,Dudeck A,Kamradt T

Sun Oct 15 00:00:00 EDT 2017

The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.

Journal of immunology (Baltimore, Md. : 1950)

Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI

Mon May 15 00:00:00 EDT 2017

TGF-β1 Suppresses IL-33-Induced Mast Cell Function.

Journal of immunology (Baltimore, Md. : 1950)

Ndaw VS,Abebayehu D,Spence AJ,Paez PA,Kolawole EM,Taruselli MT,Caslin HL,Chumanevich AP,Paranjape A,Baker B,Barnstein BO,Haque TT,Kiwanuka KN,Oskeritzian CA,Ryan JJ

Tue Aug 01 00:00:00 EDT 2017

The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.

Molecular and cellular biology

Peraki I,Palis J,Mavrothalassitis G

213-13 was used in In vitro experiments to study how Erf is required in all three waves of embryonic hematopoiesis to show that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs.

Sun Oct 01 00:00:00 EDT 2017

Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1).

The Journal of biological chemistry

Umezawa Y,Akiyama H,Okada K,Ishida S,Nogami A,Oshikawa G,Kurosu T,Miura O

Fri Dec 01 00:00:00 EST 2017

An unexpected protein interaction promotes drug resistance in leukemia.

Nature communications

Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD

Thu Nov 16 00:00:00 EST 2017

Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.

Molecular therapy. Methods & clinical development

Lee S,Kivimäe S,Szoka FC

213-13 was used in In vitro experiments to generate Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow cells with a constitutively expressed Hoxb8 flanked by loxP. HDPs proliferate indefinitely and differentiate into MΦ when Hoxb8 is removed by a tamoxifen-inducible Cre.

Fri Dec 15 00:00:00 EST 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Fri Sep 29 00:00:00 EDT 2017

Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling.

The Journal of biological chemistry

Chehboun S,Labrecque-Carbonneau J,Pasquin S,Meliani Y,Meddah B,Ferlin W,Sharma M,Tormo A,Masson JF,Gauchat JF

Fri Apr 21 00:00:00 EDT 2017

Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.

The Journal of biological chemistry

Ueda F,Tago K,Tamura H,Funakoshi-Tago M

Fri Feb 03 00:00:00 EST 2017

Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c.

The Journal of biological chemistry

Schultz V,Suflita M,Liu X,Zhang X,Yu Y,Li L,Green DE,Xu Y,Zhang F,DeAngelis PL,Liu J,Linhardt RJ

Fri Feb 10 00:00:00 EST 2017

Murine Retrovirally-Transduced Bone Marrow Engraftment Models of MLL-Fusion-Driven Acute Myelogenous Leukemias (AML).

Current protocols in pharmacology

Stubbs MC,Krivtsov AV

213-13 was used in In vitro experiments to define protocols which focus on bone marrow-derived models only, using one particular MLL fusion, MLL-AF9.

Mon Sep 11 00:00:00 EDT 2017

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

Nature communications

Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,Kähne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schnöder TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B

Mon Aug 21 00:00:00 EDT 2017

Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.

Scientific reports

MacNicol MC,Cragle CE,McDaniel FK,Hardy LL,Wang Y,Arumugam K,Rahmatallah Y,Glazko GV,Wilczynska A,Childs GV,Zhou D,MacNicol AM

Thu Sep 14 00:00:00 EDT 2017

Hematopoietic pannexin 1 function is critical for neuropathic pain.

Scientific reports

Weaver JL,Arandjelovic S,Brown G,K Mendu S,S Schappe M,Buckley MW,Chiu YH,Shu S,Kim JK,Chung J,Krupa J,Jevtovic-Todorovic V,Desai BN,Ravichandran KS,Bayliss DA

Tue Feb 14 00:00:00 EST 2017

Role of Mast Cells in clearance of Leishmania through extracellular trap formation.

Scientific reports

Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N

Mon Oct 16 00:00:00 EDT 2017

Role of Mast Cells in clearance of Leishmania through extracellular trap formation.

Scientific reports

Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N

Mon Oct 16 00:00:00 EDT 2017

TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.

Scientific reports

Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML

Mon Oct 16 00:00:00 EDT 2017

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.

Nature biotechnology

Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR

213-13 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.

Tue Nov 01 00:00:00 EDT 2016

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell

Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL

Thu Apr 07 00:00:00 EDT 2016

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.

Cell

Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I

Thu Dec 15 00:00:00 EST 2016

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Cell

Sykes DB,Kfoury YS,Mercier FE,Wawer MJ,Law JM,Haynes MK,Lewis TA,Schajnovitz A,Jain E,Lee D,Meyer H,Pierce KA,Tolliday NJ,Waller A,Ferrara SJ,Eheim AL,Stoeckigt D,Maxcy KL,Cobert JM,Bachand J,Szekely BA,Mukherjee S,Sklar LA,Kotz JD,Clish CB,Sadreyev RI,Clemons PA,Janzer A,Schreiber SL,Scadden DT

Thu Sep 22 00:00:00 EDT 2016

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.

Immunity

Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J

Tue Aug 16 00:00:00 EDT 2016

Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis.

Immunity

Matthews SP,McMillan SJ,Colbert JD,Lawrence RA,Watts C

Tue Apr 19 00:00:00 EDT 2016

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Cell metabolism

Kishton RJ,Barnes CE,Nichols AG,Cohen S,Gerriets VA,Siska PJ,Macintyre AN,Goraksha-Hicks P,de Cubas AA,Liu T,Warmoes MO,Abel ED,Yeoh AE,Gershon TR,Rathmell WK,Richards KL,Locasale JW,Rathmell JC

213-13 was used in Cell Culture to study to what extent the leukemic T cell populations are metabolically similar and if differences reveal T cell acute lymphoblastic leukemia (T-ALL) vulnerabilities.

Tue Apr 12 00:00:00 EDT 2016

Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.

Blood

Schulze I,Rohde C,Scheller-Wendorff M,Bäumer N,Krause A,Herbst F,Riemke P,Hebestreit K,Tschanter P,Lin Q,Linhart H,Godley LA,Glimm H,Dugas M,Wagner W,Berdel WE,Rosenbauer F,Müller-Tidow C

Thu Mar 24 00:00:00 EDT 2016

Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.

Blood

Mascarenhas MI,Bacon WA,Kapeni C,Fitch SR,Kimber G,Cheng SW,Li J,Green AR,Ottersbach K

Thu May 12 00:00:00 EDT 2016

Developing HSCs become Notch independent by the end of maturation in the AGM region.

Blood

Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A

Thu Sep 22 00:00:00 EDT 2016

MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.

Blood

Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH

Thu Oct 27 00:00:00 EDT 2016

MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.

Blood

Baba T,Tanabe Y,Yoshikawa S,Yamanishi Y,Morishita S,Komatsu N,Karasuyama H,Hirao A,Mukaida N

Thu May 26 00:00:00 EDT 2016

Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.

The Journal of clinical investigation

Sanges D,Simonte G,Di Vicino U,Romo N,Pinilla I,Nicolás M,Cosma MP

Mon Aug 01 00:00:00 EDT 2016

FGF23 signaling impairs neutrophil recruitment and host defense during CKD.

The Journal of clinical investigation

Rossaint J,Oehmichen J,Van Aken H,Reuter S,Pavenstädt HJ,Meersch M,Unruh M,Zarbock A

Tue Mar 01 00:00:00 EST 2016

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.

The Journal of clinical investigation

Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ

Fri Jan 01 00:00:00 EST 2016

Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.

The Journal of clinical investigation

Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J

Thu Dec 01 00:00:00 EST 2016

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

The Journal of experimental medicine

Hatlen MA,Arora K,Vacic V,Grabowska EA,Liao W,Riley-Gillis B,Oschwald DM,Wang L,Joergens JE,Shih AH,Rapaport F,Gu S,Voza F,Asai T,Neel BG,Kharas MG,Gonen M,Levine RL,Nimer SD

Mon Jan 11 00:00:00 EST 2016

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.

The Journal of experimental medicine

Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ

Mon Oct 17 00:00:00 EDT 2016

Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.

The Journal of experimental medicine

Bannard O,McGowan SJ,Ersching J,Ishido S,Victora GD,Shin JS,Cyster JG

Mon May 30 00:00:00 EDT 2016

Targeting MTHFD2 in acute myeloid leukemia.

The Journal of experimental medicine

Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K

Mon Jun 27 00:00:00 EDT 2016

TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Weaver LK,Chu N,Behrens EM

Tue Sep 27 00:00:00 EDT 2016

Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life.

Mucosal immunology

Patel KR,Aven L,Shao F,Krishnamoorthy N,Duvall MG,Levy BD,Ai X

Tue Nov 01 00:00:00 EDT 2016

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.

Stem cells translational medicine

Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM

213-13 was used in Cell Culture to investigate whether activation of exogenous HOXB4 promotes the production of more mature, definitive red blood cells.

Mon Aug 01 00:00:00 EDT 2016

Rel B-modified dendritic cells possess tolerogenic phenotype and functions on lupus splenic lymphocytes in vitro.

Immunology

Wu H,Lo Y,Chan A,Law KS,Mok MY

Thu Sep 01 00:00:00 EDT 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.

Stem cells (Dayton, Ohio)

Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA

Tue Mar 01 00:00:00 EST 2016

AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.

Stem cells (Dayton, Ohio)

Singh S,Moirangthem RD,Vaidya A,Jalnapurkar S,Limaye L,Kale V

Thu Sep 01 00:00:00 EDT 2016

CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential.

Stem cells (Dayton, Ohio)

Ahmed T,Tsuji-Tamura K,Ogawa M

Thu Dec 01 00:00:00 EST 2016

TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.

Journal of immunology (Baltimore, Md. : 1950)

Nagashima H,Okuyama Y,Hayashi T,Ishii N,So T

Sun May 15 00:00:00 EDT 2016

Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex.

Journal of immunology (Baltimore, Md. : 1950)

Efergan A,Azouz NP,Klein O,Noguchi K,Rothenberg ME,Fukuda M,Sagi-Eisenberg R

Mon Feb 01 00:00:00 EST 2016

Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.

Journal of immunology (Baltimore, Md. : 1950)

Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P

Mon Aug 01 00:00:00 EDT 2016

IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10-Deficient Mice.

Journal of immunology (Baltimore, Md. : 1950)

Polukort SH,Rovatti J,Carlson L,Thompson C,Ser-Dolansky J,Kinney SR,Schneider SS,Mathias CB

Wed Jun 15 00:00:00 EDT 2016

Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion.

Journal of immunology (Baltimore, Md. : 1950)

Martín-Ávila A,Medina-Tamayo J,Ibarra-Sánchez A,Vázquez-Victorio G,Castillo-Arellano JI,Hernández-Mondragón AC,Rivera J,Madera-Salcedo IK,Blank U,Macías-Silva M,González-Espinosa C

Wed Jun 15 00:00:00 EDT 2016

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.

Journal of pharmaceutical sciences

Xia X,Kumru OS,Blaber SI,Middaugh CR,Li L,Ornitz DM,Sutherland MA,Tenorio CA,Blaber M

Fri Apr 01 00:00:00 EDT 2016

An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.

Journal of pharmaceutical sciences

Xia X,Kumru OS,Blaber SI,Middaugh CR,Li L,Ornitz DM,Suh JM,Atkins AR,Downes M,Evans RM,Tenorio CA,Bienkiewicz E,Blaber M

Thu Dec 01 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Tue Aug 09 00:00:00 EDT 2016

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.

Nature communications

Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A

Tue Mar 08 00:00:00 EST 2016

RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.

Blood cancer journal

Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M

Fri Jan 08 00:00:00 EST 2016

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.

Cell death & disease

Liu Q,Chen L,Atkinson JM,Claxton DF,Wang HG

Thu Sep 08 00:00:00 EDT 2016

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.

Nature communications

George J,Uyar A,Young K,Kuffler L,Waldron-Francis K,Marquez E,Ucar D,Trowbridge JJ

Mon Jul 11 00:00:00 EDT 2016

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.

Nature communications

Grover A,Sanjuan-Pla A,Thongjuea S,Carrelha J,Giustacchini A,Gambardella A,Macaulay I,Mancini E,Luis TC,Mead A,Jacobsen SE,Nerlov C

Thu Mar 24 00:00:00 EDT 2016

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

Nature communications

Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK

Mon Aug 08 00:00:00 EDT 2016

Acetylation of C/EBPα inhibits its granulopoietic function.

Nature communications

Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG

Wed Mar 23 00:00:00 EDT 2016

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.

Molecular & cellular proteomics : MCP

Bigenzahn JW,Fauster A,Rebsamen M,Kandasamy RK,Scorzoni S,Vladimer GI,Müller AC,Gstaiger M,Zuber J,Bennett KL,Superti-Furga G

Tue Mar 01 00:00:00 EST 2016

A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions.

Nature communications

Cheng J,Roden CA,Pan W,Zhu S,Baccei A,Pan X,Jiang T,Kluger Y,Weissman SM,Guo S,Flavell RA,Ding Y,Lu J

Wed Mar 30 00:00:00 EDT 2016

Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.

Cell death & disease

Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H

Thu Oct 06 00:00:00 EDT 2016

Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.

Cell death & disease

Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H

Thu Oct 06 00:00:00 EDT 2016

Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research.

Methods in molecular biology (Clifton, N.J.)

Peng C,Li S

213-13 was used in Cell Culture to describe how we utilize this triple gene system to prove the function of Pten as a tumor suppressor in leukemogenesis.

Mon Dec 18 00:00:00 EST 2017

Activated mast cells promote differentiation of B cells into effector cells.

Scientific reports

Palm AK,Garcia-Faroldi G,Lundberg M,Pejler G,Kleinau S

Fri Feb 05 00:00:00 EST 2016

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Cell discovery

Yuzugullu H,Von T,Thorpe LM,Walker SR,Roberts TM,Frank DA,Zhao JJ

Tue Sep 27 00:00:00 EDT 2016

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.

Nature communications

Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG

Tue Nov 08 00:00:00 EST 2016

Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.

Nature communications

Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC

Mon Oct 10 00:00:00 EDT 2016

USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.

Stem cell reports

Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M

Tue Dec 13 00:00:00 EST 2016

KRAS insertion mutations are oncogenic and exhibit distinct functional properties.

Nature communications

White Y,Bagchi A,Van Ziffle J,Inguva A,Bollag G,Zhang C,Carias H,Dickens D,Loh M,Shannon K,Firestone AJ

Mon Feb 08 00:00:00 EST 2016

Induction of Chronic Myeloid Leukemia in Mice.

Methods in molecular biology (Clifton, N.J.)

Zhang H,Li S

213-13 was used in In vitro experiments to describe methods for induction of CML in mice with BCR-ABL.

Fri Jan 26 00:00:00 EST 2018

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Nature

Chen Z,Shojaee S,Buchner M,Geng H,Lee JW,Klemm L,Titz B,Graeber TG,Park E,Tan YX,Satterthwaite A,Paietta E,Hunger SP,Willman CL,Melnick A,Loh ML,Jung JU,Coligan JE,Bolland S,Mak TW,Limnander A,Jumaa H,Reth M,Weiss A,Lowell CA,Müschen M

Thu May 21 00:00:00 EDT 2015

T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.

Blood

Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y

Thu Jan 08 00:00:00 EST 2015

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

Blood

Di Savino A,Panuzzo C,Rocca S,Familiari U,Piazza R,Crivellaro S,Carrà G,Ferretti R,Fusella F,Giugliano E,Camporeale A,Franco I,Miniscalco B,Cutrin JC,Turco E,Silengo L,Hirsch E,Rege-Cambrin G,Gambacorti-Passerini C,Pandolfi PP,Papotti M,Saglio G,Tarone G,Morotti A,Brancaccio M

Thu Apr 02 00:00:00 EDT 2015

Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN.

Blood

Grisouard J,Shimizu T,Duek A,Kubovcakova L,Hao-Shen H,Dirnhofer S,Skoda RC

Thu Mar 26 00:00:00 EDT 2015

MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.

Blood

Roychoudhury J,Clark JP,Gracia-Maldonado G,Unnisa Z,Wunderlich M,Link KA,Dasgupta N,Aronow B,Huang G,Mulloy JC,Kumar AR

Thu Apr 16 00:00:00 EDT 2015

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Blood

Kosoff RE,Aslan JE,Kostyak JC,Dulaimi E,Chow HY,Prudnikova TY,Radu M,Kunapuli SP,McCarty OJ,Chernoff J

Thu May 07 00:00:00 EDT 2015

Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.

Blood

Xiao N,Laha S,Das SP,Morlock K,Jesneck JL,Raffel GD

Thu Feb 05 00:00:00 EST 2015

IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.

Blood

Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS

Thu Feb 26 00:00:00 EST 2015

Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.

The Journal of clinical investigation

Millet A,Martin KR,Bonnefoy F,Saas P,Mocek J,Alkan M,Terrier B,Kerstein A,Tamassia N,Satyanarayanan SK,Ariel A,Ribeil JA,Guillevin L,Cassatella MA,Mueller A,Thieblemont N,Lamprecht P,Mouthon L,Perruche S,Witko-Sarsat V

Mon Nov 02 00:00:00 EST 2015

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

The Journal of clinical investigation

Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG

Mon Mar 02 00:00:00 EST 2015

Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

The Journal of clinical investigation

Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG

Mon Mar 02 00:00:00 EST 2015

Coordinate expression of heme and globin is essential for effective erythropoiesis.

The Journal of clinical investigation

Doty RT,Phelps SR,Shadle C,Sanchez-Bonilla M,Keel SB,Abkowitz JL

Tue Dec 01 00:00:00 EST 2015

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

The Journal of clinical investigation

Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID

Fri May 01 00:00:00 EDT 2015

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.

The Journal of clinical investigation

Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML

Tue Sep 01 00:00:00 EDT 2015

Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.

The Journal of experimental medicine

Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z

Mon Dec 14 00:00:00 EST 2015

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.

The Journal of experimental medicine

Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I

213-13 was used in Sample Preparation (FC/FACS) to represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.

Mon Oct 19 00:00:00 EDT 2015

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.

The Journal of experimental medicine

Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I

Mon Oct 19 00:00:00 EDT 2015

Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.

Proceedings of the National Academy of Sciences of the United States of America

Smith DJ,Liu S,Ji S,Li B,McLaughlin J,Cheng D,Witte ON,Yang L

Tue Feb 03 00:00:00 EST 2015

MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.

Oncogenesis

Wenge DV,Felipe-Fumero E,Angenendt L,Schliemann C,Schmidt E,Schmidt LH,Thiede C,Ehninger G,Berdel WE,Arteaga MF,Mikesch JH

Mon Dec 21 00:00:00 EST 2015

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Stem cells (Dayton, Ohio)

Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW

Fri May 01 00:00:00 EDT 2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Stem cells (Dayton, Ohio)

Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y

Sun Mar 01 00:00:00 EST 2015

IL-4-Producing Dendritic Cells Induced during Schistosoma japonica Infection Promote Th2 Cells via IL-4-Dependent Pathway.

Journal of immunology (Baltimore, Md. : 1950)

Ma YL,Huang FJ,Cong L,Gong WC,Bai HM,Li J,Chen CX,Zhou NY,Jiang XL,Yin L,Chen XP

Thu Oct 15 00:00:00 EDT 2015

Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.

Journal of immunology (Baltimore, Md. : 1950)

Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS

Wed Jul 01 00:00:00 EDT 2015

Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.

Journal of immunology (Baltimore, Md. : 1950)

Xiao Y,Qiao G,Tang J,Tang R,Guo H,Warwar S,Langdon WY,Tao L,Zhang J

Sun Nov 01 00:00:00 EDT 2015

Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.

Journal of immunology (Baltimore, Md. : 1950)

Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT

Sun Mar 15 00:00:00 EDT 2015

The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.

Journal of immunology (Baltimore, Md. : 1950)

Viret C,Mahiddine K,Baker RL,Haskins K,Guerder S

Tue Sep 01 00:00:00 EDT 2015

Heme exporter FLVCR is required for T cell development and peripheral survival.

Journal of immunology (Baltimore, Md. : 1950)

Philip M,Funkhouser SA,Chiu EY,Phelps SR,Delrow JJ,Cox J,Fink PJ,Abkowitz JL

Sun Feb 15 00:00:00 EST 2015

Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.

Journal of immunology (Baltimore, Md. : 1950)

Ottina E,Lyberg K,Sochalska M,Villunger A,Nilsson GP

Sun Feb 01 00:00:00 EST 2015

Microtubule nucleation in mouse bone marrow-derived mast cells is regulated by the concerted action of GIT1/βPIX proteins and calcium.

Journal of immunology (Baltimore, Md. : 1950)

Sulimenko V,Hájková Z,Černohorská M,Sulimenko T,Sládková V,Dráberová L,Vinopal S,Dráberová E,Dráber P

Fri May 01 00:00:00 EDT 2015

Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells.

Journal of immunology (Baltimore, Md. : 1950)

Balseiro-Gomez S,Flores JA,Acosta J,Ramirez-Ponce MP,Ales E

Tue Sep 01 00:00:00 EDT 2015

IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals.

Journal of immunology (Baltimore, Md. : 1950)

Stoycheva D,Deiser K,Stärck L,Nishanth G,Schlüter D,Uckert W,Schüler T

Thu Jan 15 00:00:00 EST 2015

Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation.

Journal of immunology (Baltimore, Md. : 1950)

Orlowski GM,Colbert JD,Sharma S,Bogyo M,Robertson SA,Rock KL

Sat Aug 15 00:00:00 EDT 2015

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.

Molecular therapy. Methods & clinical development

Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A

Wed Oct 28 00:00:00 EDT 2015

Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.

Molecular therapy. Methods & clinical development

Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW

213-13 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.

Mon Jun 08 00:00:00 EDT 2015

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Nature communications

Buchner M,Park E,Geng H,Klemm L,Flach J,Passegué E,Schjerven H,Melnick A,Paietta E,Kopanja D,Raychaudhuri P,Müschen M

Tue Mar 10 00:00:00 EDT 2015

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.

Nature communications

Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A

Mon Jun 22 00:00:00 EDT 2015

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.

Stem cell reports

Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F

Tue Oct 13 00:00:00 EDT 2015

Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Scientific reports

Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y

Fri Dec 18 00:00:00 EST 2015

Fancb deficiency impairs hematopoietic stem cell function.

Scientific reports

Du W,Amarachintha S,Erden O,Wilson A,Meetei AR,Andreassen PR,Namekawa SH,Pang Q

Fri Dec 11 00:00:00 EST 2015

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Nature communications

Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J

Mon Oct 12 00:00:00 EDT 2015

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

Stem cell reports

Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH

Tue Oct 13 00:00:00 EDT 2015

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.

Nature communications

Haetscher N,Feuermann Y,Wingert S,Rehage M,Thalheimer FB,Weiser C,Bohnenberger H,Jung K,Schroeder T,Serve H,Oellerich T,Hennighausen L,Rieger MA

Wed Nov 25 00:00:00 EST 2015

Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.

The Journal of biological chemistry

Zhang J,Ranheim EA,Du J,Liu Y,Wang J,Kong G,Zhang J

Fri Jul 31 00:00:00 EDT 2015

Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.

The Journal of biological chemistry

Hu N,Qiu Y,Dong F

Fri Oct 02 00:00:00 EDT 2015

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.

Cell

Cunningham JT,Moreno MV,Lodi A,Ronen SM,Ruggero D

Thu May 22 00:00:00 EDT 2014

Dissecting engineered cell types and enhancing cell fate conversion via CellNet.

Cell

Morris SA,Cahan P,Li H,Zhao AM,San Roman AK,Shivdasani RA,Collins JJ,Daley GQ

Thu Aug 14 00:00:00 EDT 2014

Nonstochastic reprogramming from a privileged somatic cell state.

Cell

Guo S,Zi X,Schulz VP,Cheng J,Zhong M,Koochaki SH,Megyola CM,Pan X,Heydari K,Weissman SM,Gallagher PG,Krause DS,Fan R,Lu J

Thu Feb 13 00:00:00 EST 2014

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.

Immunity

Nabekura T,Kanaya M,Shibuya A,Fu G,Gascoigne NR,Lanier LL

Thu Feb 20 00:00:00 EST 2014

Blood

Komeno Y,Yan M,Matsuura S,Lam K,Lo MC,Huang YJ,Tenen DG,Downing JR,Zhang DE

Thu Jun 12 00:00:00 EDT 2014

The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells.

Blood

Kobayashi CI,Takubo K,Kobayashi H,Nakamura-Ishizu A,Honda H,Kataoka K,Kumano K,Akiyama H,Sudo T,Kurokawa M,Suda T

Thu Apr 17 00:00:00 EDT 2014

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.

Blood

Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA

Thu Dec 18 00:00:00 EST 2014

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Blood

Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J

Thu Nov 13 00:00:00 EST 2014

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.

Blood

de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F

Thu Jan 23 00:00:00 EST 2014

Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.

Blood

Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X

Thu Apr 03 00:00:00 EDT 2014

Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.

Blood

Pawlikowska P,Fouchet P,Vainchenker W,Rosselli F,Naim V

Thu Dec 04 00:00:00 EST 2014

Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.

The Journal of clinical investigation

Wegiel B,Larsen R,Gallo D,Chin BY,Harris C,Mannam P,Kaczmarek E,Lee PJ,Zuckerbraun BS,Flavell R,Soares MP,Otterbein LE

Sat Nov 01 00:00:00 EDT 2014

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

The Journal of clinical investigation

Dahdah A,Gautier G,Attout T,Fiore F,Lebourdais E,Msallam R,Daëron M,Monteiro RC,Benhamou M,Charles N,Davoust J,Blank U,Malissen B,Launay P

Wed Oct 01 00:00:00 EDT 2014

Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.

The Journal of clinical investigation

Jones M,Osawa G,Regal JA,Weinberg DN,Taggart J,Kocak H,Friedman A,Ferguson DO,Keegan CE,Maillard I

Wed Jan 01 00:00:00 EST 2014

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

The Journal of clinical investigation

Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP

Tue Apr 01 00:00:00 EDT 2014

iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

The Journal of clinical investigation

Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP

Tue Apr 01 00:00:00 EDT 2014

Serum IgE clearance is facilitated by human FcεRI internalization.

The Journal of clinical investigation

Greer AM,Wu N,Putnam AL,Woodruff PG,Wolters P,Kinet JP,Shin JS

Sat Mar 01 00:00:00 EST 2014

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.

The Journal of clinical investigation

Smeets MF,DeLuca E,Wall M,Quach JM,Chalk AM,Deans AJ,Heierhorst J,Purton LE,Izon DJ,Walkley CR

Fri Aug 01 00:00:00 EDT 2014

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

The Journal of experimental medicine

Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E

Mon Aug 25 00:00:00 EDT 2014

CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.

The Journal of experimental medicine

Beck TC,Gomes AC,Cyster JG,Pereira JP

Mon Dec 15 00:00:00 EST 2014

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

The Journal of experimental medicine

Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E

Mon Feb 10 00:00:00 EST 2014

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.

The Journal of experimental medicine

Ogawa K,Tanaka Y,Uruno T,Duan X,Harada Y,Sanematsu F,Yamamura K,Terasawa M,Nishikimi A,Côté JF,Fukui Y

Mon Jun 30 00:00:00 EDT 2014

Initiation of MLL-rearranged AML is dependent on C/EBPα.

The Journal of experimental medicine

Ohlsson E,Hasemann MS,Willer A,Lauridsen FK,Rapin N,Jendholm J,Porse BT

Mon Jan 13 00:00:00 EST 2014

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

The Journal of experimental medicine

Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL

Mon Apr 07 00:00:00 EDT 2014

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.

The Journal of experimental medicine

Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z

Mon Sep 22 00:00:00 EDT 2014

Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.

The Journal of experimental medicine

Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L

Mon Dec 15 00:00:00 EST 2014

Fgd5 identifies hematopoietic stem cells in the murine bone marrow.

The Journal of experimental medicine

Gazit R,Mandal PK,Ebina W,Ben-Zvi A,Nombela-Arrieta C,Silberstein LE,Rossi DJ

Mon Jun 30 00:00:00 EDT 2014

High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.

The Journal of experimental medicine

Shin JY,Hu W,Naramura M,Park CY

Mon Feb 10 00:00:00 EST 2014

IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.

EMBO molecular medicine

Wang J,Lindholt JS,Sukhova GK,Shi MA,Xia M,Chen H,Xiang M,He A,Wang Y,Xiong N,Libby P,Wang JA,Shi GP

Tue Jul 01 00:00:00 EDT 2014

Key regulators control distinct transcriptional programmes in blood progenitor and mast cells.

The EMBO journal

Calero-Nieto FJ,Ng FS,Wilson NK,Hannah R,Moignard V,Leal-Cervantes AI,Jimenez-Madrid I,Diamanti E,Wernisch L,Göttgens B

Mon Jun 02 00:00:00 EDT 2014

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

Proceedings of the National Academy of Sciences of the United States of America

Shi J,Kundrat L,Pishesha N,Bilate A,Theile C,Maruyama T,Dougan SK,Ploegh HL,Lodish HF

Tue Jul 15 00:00:00 EDT 2014

IL-33/ST2 axis promotes mast cell survival via BCLXL.

Proceedings of the National Academy of Sciences of the United States of America

Wang JX,Kaieda S,Ameri S,Fishgal N,Dwyer D,Dellinger A,Kepley CL,Gurish MF,Nigrovic PA

Tue Jul 15 00:00:00 EDT 2014

JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms.

Proceedings of the National Academy of Sciences of the United States of America

Etheridge SL,Roh ME,Cosgrove ME,Sangkhae V,Fox NE,Chen J,López JA,Kaushansky K,Hitchcock IS

Tue Feb 11 00:00:00 EST 2014

K-RasV14I recapitulates Noonan syndrome in mice.

Proceedings of the National Academy of Sciences of the United States of America

Hernández-Porras I,Fabbiano S,Schuhmacher AJ,Aicher A,Cañamero M,Cámara JA,Cussó L,Desco M,Heeschen C,Mulero F,Bustelo XR,Guerra C,Barbacid M

Tue Nov 18 00:00:00 EST 2014

Signaling pathways activated by a protease allergen in basophils.

Proceedings of the National Academy of Sciences of the United States of America

Rosenstein RK,Bezbradica JS,Yu S,Medzhitov R

Tue Nov 18 00:00:00 EST 2014

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.

Blood cancer journal

Sprissler C,Belenki D,Maurer H,Aumann K,Pfeifer D,Klein C,Müller TA,Kissel S,Hülsdünker J,Alexandrovski J,Brummer T,Jumaa H,Duyster J,Dierks C

Fri Aug 22 00:00:00 EDT 2014

Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.

Blood cancer journal

Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K

Fri Jan 10 00:00:00 EST 2014

Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.

Stem cells (Dayton, Ohio)

Dong CY,Liu XY,Wang N,Wang LN,Yang BX,Ren Q,Liang HY,Ma XT

Mon Dec 01 00:00:00 EST 2014

Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities.

Journal of immunology (Baltimore, Md. : 1950)

Deho' L,Leoni C,Brodie TM,Montagner S,De Simone M,Polletti S,Barozzi I,Natoli G,Monticelli S

Mon Sep 01 00:00:00 EDT 2014

Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Journal of immunology (Baltimore, Md. : 1950)

Azouz NP,Zur N,Efergan A,Ohbayashi N,Fukuda M,Amihai D,Hammel I,Rothenberg ME,Sagi-Eisenberg R

Thu May 01 00:00:00 EDT 2014

Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y

Sun Jun 15 00:00:00 EDT 2014

Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.

Journal of immunology (Baltimore, Md. : 1950)

Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ

Sat Nov 15 00:00:00 EST 2014

SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.

Journal of immunology (Baltimore, Md. : 1950)

Chu C,Wang Y,Zhang X,Ni X,Cao J,Xu W,Dong Z,Yuan P,Wei W,Ma Y,Zhang L,Wu L,Qi H

Wed Oct 15 00:00:00 EDT 2014

Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.

Journal of immunology (Baltimore, Md. : 1950)

Brochetta C,Suzuki R,Vita F,Soranzo MR,Claver J,Madjene LC,Attout T,Vitte J,Varin-Blank N,Zabucchi G,Rivera J,Blank U

Wed Jan 01 00:00:00 EST 2014

Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.

Journal of immunology (Baltimore, Md. : 1950)

Stärck L,Popp K,Pircher H,Uckert W

Wed Jan 01 00:00:00 EST 2014

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage.

Cell death & disease

Nugues AL,El Bouazzati H,Hétuin D,Berthon C,Loyens A,Bertrand E,Jouy N,Idziorek T,Quesnel B

Thu Aug 21 00:00:00 EDT 2014

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.

Nature communications

Piunti A,Rossi A,Cerutti A,Albert M,Jammula S,Scelfo A,Cedrone L,Fragola G,Olsson L,Koseki H,Testa G,Casola S,Helin K,d'Adda di Fagagna F,Pasini D

Mon Apr 14 00:00:00 EDT 2014

The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

Oncotarget

Saurabh K,Scherzer MT,Shah PP,Mims AS,Lockwood WW,Kraft AS,Beverly LJ

213-13 was used in Cell Culture to assess the comparative signalling and oncogenic potential of three PIM kinases.

Tue Sep 30 00:00:00 EDT 2014

Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.

The Journal of biological chemistry

Subramanian H,Gupta K,Parameswaran N,Ali H

Fri Jul 25 00:00:00 EDT 2014

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

Nature

Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E

Thu Feb 21 00:00:00 EST 2013

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.

Cancer cell

Arteaga MF,Mikesch JH,Qiu J,Christensen J,Helin K,Kogan SC,Dong S,So CW

Mon Mar 18 00:00:00 EDT 2013

Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.

Blood

Chen Y,Aardema J,Kale S,Whichard ZL,Awomolo A,Blanchard E,Chang B,Myers DR,Ju L,Tran R,Reece D,Christensen H,Boukour S,Debili N,Strom TS,Rawlings D,Vázquez FX,Voth GA,Zhu C,Kahr WH,Lam WA,Corey SJ

Thu Sep 05 00:00:00 EDT 2013

A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.

Blood

Conway AE,Scotland PB,Lavau CP,Wechsler DS

Thu Jun 06 00:00:00 EDT 2013

Interferon-γ impairs proliferation of hematopoietic stem cells in mice.

Blood

de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA

Thu May 02 00:00:00 EDT 2013

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

Blood

May RM,Okumura M,Hsu CJ,Bassiri H,Yang E,Rak G,Mace EM,Philip NH,Zhang W,Baumgart T,Orange JS,Nichols KE,Kambayashi T

Thu Apr 18 00:00:00 EDT 2013

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Blood

Santoro F,Botrugno OA,Dal Zuffo R,Pallavicini I,Matthews GM,Cluse L,Barozzi I,Senese S,Fornasari L,Moretti S,Altucci L,Pelicci PG,Chiocca S,Johnstone RW,Minucci S

Thu Apr 25 00:00:00 EDT 2013

Ikaros limits basophil development by suppressing C/EBP-α expression.

Blood

Rao KN,Smuda C,Gregory GD,Min B,Brown MA

Thu Oct 10 00:00:00 EDT 2013

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.

Blood

Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM

Thu Jun 13 00:00:00 EDT 2013

Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.

Blood

Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A

Thu Oct 03 00:00:00 EDT 2013

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.

Blood

Sportoletti P,Varasano E,Rossi R,Bereshchenko O,Cecchini D,Gionfriddo I,Bolli N,Tiacci E,Intermesoli T,Zanghì P,Masciulli A,Martelli MP,Falzetti F,Martelli MF,Falini B

Thu Apr 25 00:00:00 EDT 2013

The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.

Blood

Sakai Y,Tanaka Y,Yanagihara T,Watanabe M,Duan X,Terasawa M,Nishikimi A,Sanematsu F,Fukui Y

Thu Jul 18 00:00:00 EDT 2013

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

Blood

Wahlestedt M,Norddahl GL,Sten G,Ugale A,Frisk MA,Mattsson R,Deierborg T,Sigvardsson M,Bryder D

Thu May 23 00:00:00 EDT 2013

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.

The Journal of clinical investigation

Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW

Tue Jan 01 00:00:00 EST 2013

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.

The Journal of clinical investigation

Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R

Tue Oct 01 00:00:00 EDT 2013

TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.

The Journal of experimental medicine

Yi Z,Stunz LL,Bishop GA

Mon Jun 03 00:00:00 EDT 2013

Notch pathway activation targets AML-initiating cell homeostasis and differentiation.

The Journal of experimental medicine

Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I

Mon Feb 11 00:00:00 EST 2013

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Leukemia

Hansen N,Ågerstam H,Wahlestedt M,Landberg N,Askmyr M,Ehinger M,Rissler M,Lilljebjörn H,Johnels P,Ishiko J,Melo JV,Alexander WS,Bryder D,Järås M,Fioretos T

Tue Jan 01 00:00:00 EST 2013

Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling.

Proceedings of the National Academy of Sciences of the United States of America

Jin HS,Liao L,Park Y,Liu YC

Tue Jan 08 00:00:00 EST 2013

CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Arndt K,Grinenko T,Mende N,Reichert D,Portz M,Ripich T,Carmeliet P,Corbeil D,Waskow C

Tue Apr 02 00:00:00 EDT 2013

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.

Proceedings of the National Academy of Sciences of the United States of America

Kurokawa M,Ito T,Yang CS,Zhao C,Macintyre AN,Rizzieri DA,Rathmell JC,Deininger MW,Reya T,Kornbluth S

Tue Feb 05 00:00:00 EST 2013

Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.

Stem cells (Dayton, Ohio)

Porter RL,Georger MA,Bromberg O,McGrath KE,Frisch BJ,Becker MW,Calvi LM

Fri Feb 01 00:00:00 EST 2013

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.

Stem cells (Dayton, Ohio)

Pfaff N,Lachmann N,Ackermann M,Kohlscheen S,Brendel C,Maetzig T,Niemann H,Antoniou MN,Grez M,Schambach A,Cantz T,Moritz T

Fri Mar 01 00:00:00 EST 2013

The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.

Journal of immunology (Baltimore, Md. : 1950)

Sesti-Costa R,Silva GK,Proença-Módena JL,Carlos D,Silva ML,Alves-Filho JC,Arruda E,Liew FY,Silva JS

Mon Jul 01 00:00:00 EDT 2013

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ

Fri Nov 01 00:00:00 EDT 2013

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Journal of immunology (Baltimore, Md. : 1950)

Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ

Fri Nov 01 00:00:00 EDT 2013

TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis.

Journal of immunology (Baltimore, Md. : 1950)

Oh MH,Oh SY,Lu J,Lou H,Myers AC,Zhu Z,Zheng T

Sun Dec 01 00:00:00 EST 2013

β-Defensins activate human mast cells via Mas-related gene X2.

Journal of immunology (Baltimore, Md. : 1950)

Subramanian H,Gupta K,Lee D,Bayir AK,Ahn H,Ali H

Mon Jul 01 00:00:00 EDT 2013

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Kamijo S,Takeda H,Tokura T,Suzuki M,Inui K,Hara M,Matsuda H,Matsuda A,Oboki K,Ohno T,Saito H,Nakae S,Sudo K,Suto H,Ichikawa S,Ogawa H,Okumura K,Takai T

Wed May 01 00:00:00 EDT 2013

Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.

Journal of immunology (Baltimore, Md. : 1950)

Graham AC,Hilmer KM,Zickovich JM,Obar JJ

Wed May 01 00:00:00 EDT 2013

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

Journal of immunology (Baltimore, Md. : 1950)

Paster W,Brockmeyer C,Fu G,Simister PC,de Wet B,Martinez-Riaño A,Hoerter JA,Feller SM,Wülfing C,Gascoigne NR,Acuto O

Mon Apr 01 00:00:00 EDT 2013

Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex.

Journal of immunology (Baltimore, Md. : 1950)

Madera-Salcedo IK,Cruz SL,Gonzalez-Espinosa C

Sun Sep 15 00:00:00 EDT 2013

Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.

Journal of immunology (Baltimore, Md. : 1950)

Dillahunt SE,Sargent JL,Suzuki R,Proia RL,Gilfillan A,Rivera J,Olivera A

Fri Mar 01 00:00:00 EST 2013

The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.

Journal of immunology (Baltimore, Md. : 1950)

Kraft S,Jouvin MH,Kulkarni N,Kissing S,Morgan ES,Dvorak AM,Schröder B,Saftig P,Kinet JP

Sun Sep 15 00:00:00 EDT 2013

Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

The Journal of biological chemistry

Kosoff R,Chow HY,Radu M,Chernoff J

Fri Jan 11 00:00:00 EST 2013

Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation.

PloS one

Coutinho AE,Brown JK,Yang F,Brownstein DG,Gray M,Seckl JR,Savill JS,Chapman KE

Fri Jul 19 00:00:00 EDT 2013

Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.

PloS one

Funakoshi-Tago M,Sumi K,Kasahara T,Tago K

Tue Aug 20 00:00:00 EDT 2013

Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.

PloS one

Funakoshi-Tago M,Sumi K,Kasahara T,Tago K

Tue Aug 20 00:00:00 EDT 2013

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

The Journal of biological chemistry

Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M

Fri Nov 15 00:00:00 EST 2013

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.

Cell

Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA

Fri Jun 08 00:00:00 EDT 2012

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.

Cancer cell

Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,Ma J,Radtke I,Ding L,Cazzaniga G,Biondi A,Kornblau SM,Ravandi F,Kantarjian H,Nimer SD,Döhner K,Döhner H,Ley TJ,Ballerini P,Shurtleff S,Tomizawa D,Adachi S,Hayashi Y,Tawa A,Shih LY,Liang DC,Rubnitz JE,Pui CH,Mardis ER,Wilson RK,Downing JR

Tue Nov 13 00:00:00 EST 2012

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.

Blood

Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J

Thu Sep 20 00:00:00 EDT 2012

The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.

Blood

Fares J,Koller R,Humeniuk R,Wolff L,Bies J

Thu May 24 00:00:00 EDT 2012

Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.

Blood

Matsuura S,Yan M,Lo MC,Ahn EY,Weng S,Dangoor D,Matin M,Higashi T,Feng GS,Zhang DE

Thu Mar 29 00:00:00 EDT 2012

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.

Blood

Yuan H,Wang Z,Li L,Zhang H,Modi H,Horne D,Bhatia R,Chen W

Thu Feb 23 00:00:00 EST 2012

Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.

Blood

Lu H,Zhu S,Qian L,Xiang D,Zhang W,Nie A,Gao J,Wu M,Gao J,Lu B,Yu Y,Han W,Moldenhauer A

Thu May 24 00:00:00 EDT 2012

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.

Blood

Reddy PN,Sargin B,Choudhary C,Stein S,Grez M,Müller-Tidow C,Berdel WE,Serve H,Brandts CH

Thu Aug 23 00:00:00 EDT 2012

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.

Blood

Mérino D,Khaw SL,Glaser SP,Anderson DJ,Belmont LD,Wong C,Yue P,Robati M,Phipson B,Fairlie WD,Lee EF,Campbell KJ,Vandenberg CJ,Cory S,Roberts AW,Ludlam MJ,Huang DC,Bouillet P

Thu Jun 14 00:00:00 EDT 2012

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.

Blood

Godfrey R,Arora D,Bauer R,Stopp S,Müller JP,Heinrich T,Böhmer SA,Dagnell M,Schnetzke U,Scholl S,Östman A,Böhmer FD

Thu May 10 00:00:00 EDT 2012

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.

Blood

Zhang Y,Yan X,Sashida G,Zhao X,Rao Y,Goyama S,Whitman SP,Zorko N,Bernot K,Conway RM,Witte D,Wang QF,Tenen DG,Xiao Z,Marcucci G,Mulloy JC,Grimes HL,Caligiuri MA,Huang G

Thu Aug 02 00:00:00 EDT 2012

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.

Blood

Krishnan S,Mali RS,Ramdas B,Sims E,Ma P,Ghosh J,Munugalavadla V,Hanneman P,Beane JD,Kapur R

Thu Apr 26 00:00:00 EDT 2012

Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration.

Blood

Kostyak JC,Naik MU,Naik UP

Thu Jan 19 00:00:00 EST 2012

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

Blood

Spranger S,Jeremias I,Wilde S,Leisegang M,Stärck L,Mosetter B,Uckert W,Heemskerk MH,Schendel DJ,Frankenberger B

Thu Apr 12 00:00:00 EDT 2012

IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors.

Blood

Becker AM,Michael DG,Satpathy AT,Sciammas R,Singh H,Bhattacharya D

Thu Mar 01 00:00:00 EST 2012

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.

Blood

Cai M,Langer EM,Gill JG,Satpathy AT,Albring JC,KC W,Murphy TL,Murphy KM

Thu Jul 12 00:00:00 EDT 2012

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.

Blood

Guo H,Ma O,Speck NA,Friedman AD

Thu May 10 00:00:00 EDT 2012

Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.

Blood

Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E

Thu Oct 25 00:00:00 EDT 2012

Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.

Blood

Sun K,Alvarez M,Ames E,Barao I,Chen M,Longo DL,Redelman D,Murphy WJ

Thu Feb 09 00:00:00 EST 2012

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.

Blood

Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ

Thu Jun 21 00:00:00 EDT 2012

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.

Blood

Greenblatt S,Li L,Slape C,Nguyen B,Novak R,Duffield A,Huso D,Desiderio S,Borowitz MJ,Aplan P,Small D

Thu Mar 22 00:00:00 EDT 2012

Critical role of P1-Runx1 in mouse basophil development.

Blood

Mukai K,BenBarak MJ,Tachibana M,Nishida K,Karasuyama H,Taniuchi I,Galli SJ

Thu Jul 05 00:00:00 EDT 2012

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.

Blood

Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC

Thu Oct 11 00:00:00 EDT 2012

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.

Blood

Asai T,Liu Y,Di Giandomenico S,Bae N,Ndiaye-Lobry D,Deblasio A,Menendez S,Antipin Y,Reva B,Wevrick R,Nimer SD

Thu Aug 23 00:00:00 EDT 2012

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.

The Journal of clinical investigation

Jiang J,Balcerek J,Rozenova K,Cheng Y,Bersenev A,Wu C,Song Y,Tong W

Fri Jun 01 00:00:00 EDT 2012

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

The Journal of clinical investigation

Schoppy DW,Ragland RL,Gilad O,Shastri N,Peters AA,Murga M,Fernandez-Capetillo O,Diehl JA,Brown EJ

Sun Jan 01 00:00:00 EST 2012

Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.

Nucleic acids research

Rodríguez-Ubreva J,Ciudad L,Gómez-Cabrero D,Parra M,Bussmann LH,di Tullio A,Kallin EM,Tegnér J,Graf T,Ballestar E

Thu Mar 01 00:00:00 EST 2012

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

The Journal of experimental medicine

Kaufmann KB,Gründer A,Hadlich T,Wehrle J,Gothwal M,Bogeska R,Seeger TS,Kayser S,Pham KB,Jutzi JS,Ganzenmüller L,Steinemann D,Schlegelberger B,Wagner JM,Jung M,Will B,Steidl U,Aumann K,Werner M,Günther T,Schüle R,Rambaldi A,Pahl HL

Mon Jan 16 00:00:00 EST 2012

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.

The Journal of experimental medicine

Block H,Herter JM,Rossaint J,Stadtmann A,Kliche S,Lowell CA,Zarbock A

Mon Feb 13 00:00:00 EST 2012

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.

The Journal of experimental medicine

Oguro H,Yuan J,Tanaka S,Miyagi S,Mochizuki-Kashio M,Ichikawa H,Yamazaki S,Koseki H,Nakauchi H,Iwama A

Mon Mar 12 00:00:00 EDT 2012

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.

The Journal of experimental medicine

Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ

Mon Oct 22 00:00:00 EDT 2012

Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.

The Journal of experimental medicine

Fang TC,Schaefer U,Mecklenbrauker I,Stienen A,Dewell S,Chen MS,Rioja I,Parravicini V,Prinjha RK,Chandwani R,MacDonald MR,Lee K,Rice CM,Tarakhovsky A

Mon Apr 09 00:00:00 EDT 2012

ZBTB1 is a determinant of lymphoid development.

The Journal of experimental medicine

Siggs OM,Li X,Xia Y,Beutler B

Mon Jan 16 00:00:00 EST 2012

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.

Proceedings of the National Academy of Sciences of the United States of America

Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J

Tue Oct 09 00:00:00 EDT 2012

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.

Proceedings of the National Academy of Sciences of the United States of America

Wang Y,Roche O,Xu C,Moriyama EH,Heir P,Chung J,Roos FC,Chen Y,Finak G,Milosevic M,Wilson BC,Teh BT,Park M,Irwin MS,Ohh M

Tue Mar 27 00:00:00 EDT 2012

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.

Proceedings of the National Academy of Sciences of the United States of America

Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P

Tue Sep 04 00:00:00 EDT 2012

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.

Oncogene

Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T

Thu Mar 15 00:00:00 EDT 2012

Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.

Cancer gene therapy

Noyan F,Díez IA,Hapke M,Klein C,Dewey RA

Tue May 01 00:00:00 EDT 2012

Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53.

Stem cells (Dayton, Ohio)

Hegde S,Hankey P,Paulson RF

Wed Feb 01 00:00:00 EST 2012

The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L.

Journal of immunology (Baltimore, Md. : 1950)

Nunomura S,Kawakami Y,Kawakami T,Ra C

Sun Apr 15 00:00:00 EDT 2012

NLRP3 inflammasome activity is negatively controlled by miR-223.

Journal of immunology (Baltimore, Md. : 1950)

Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V

Mon Oct 15 00:00:00 EDT 2012

Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP

Mon Oct 01 00:00:00 EDT 2012

The SWI/SNF-like BAF complex is essential for early B cell development.

Journal of immunology (Baltimore, Md. : 1950)

Choi J,Ko M,Jeon S,Jeon Y,Park K,Lee C,Lee H,Seong RH

Sun Apr 15 00:00:00 EDT 2012

The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C.

Journal of immunology (Baltimore, Md. : 1950)

Kono H,Orlowski GM,Patel Z,Rock KL

Mon Oct 01 00:00:00 EDT 2012

Stem cell factor programs the mast cell activation phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Ito T,Smrž D,Jung MY,Bandara G,Desai A,Smržová Š,Kuehn HS,Beaven MA,Metcalfe DD,Gilfillan AM

Fri Jun 01 00:00:00 EDT 2012

Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy.

Journal of immunology (Baltimore, Md. : 1950)

Hershko AY,Charles N,Olivera A,Alvarez-Errico D,Rivera J

Sun Jan 15 00:00:00 EST 2012

Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.

Journal of immunology (Baltimore, Md. : 1950)

Shen S,Manser T

Sun Jan 01 00:00:00 EST 2012

Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.

Journal of immunology (Baltimore, Md. : 1950)

Falanga YT,Chaimowitz NS,Charles N,Finkelman FD,Pullen NA,Barbour S,Dholaria K,Faber T,Kolawole M,Huang B,Odom S,Rivera J,Carlyon J,Conrad DH,Spiegel S,Oskeritzian CA,Ryan JJ

Tue May 01 00:00:00 EDT 2012

Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.

Evidence-based complementary and alternative medicine : eCAM

Wang X,Kageyama-Yahara N,Hayashi S,Yamamoto T,Kadowaki M

Thu Aug 23 00:00:00 EDT 2012

Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

The Journal of biological chemistry

Khanna-Gupta A,Abayasekara N,Levine M,Sun H,Virgilio M,Nia N,Halene S,Sportoletti P,Jeong JY,Pandolfi PP,Berliner N

Fri Sep 21 00:00:00 EDT 2012

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.

Cell communication and signaling : CCS

Arora D,Köthe S,van den Eijnden M,Hooft van Huijsduijnen R,Heidel F,Fischer T,Scholl S,Tölle B,Böhmer SA,Lennartsson J,Isken F,Müller-Tidow C,Böhmer FD

Wed Jul 11 00:00:00 EDT 2012

Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?

The Journal of biological chemistry

Vogel S,Raulf N,Bregenhorn S,Biniossek ML,Maurer U,Czabotar P,Borner C

Fri Mar 16 00:00:00 EDT 2012

Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.

The Journal of biological chemistry

Pullen NA,Barnstein BO,Falanga YT,Wang Z,Suzuki R,Tamang TD,Khurana MC,Harry EA,Draber P,Bunting KD,Mizuno K,Wilson BS,Ryan JJ

Fri Jan 13 00:00:00 EST 2012

γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.

PloS one

Vinopal S,Cernohorská M,Sulimenko V,Sulimenko T,Vosecká V,Flemr M,Dráberová E,Dráber P

Mon May 14 00:00:00 EDT 2012

Type II-activated murine macrophages produce IL-4.

PloS one

La Flamme AC,Kharkrang M,Stone S,Mirmoeini S,Chuluundorj D,Kyle R

Wed May 01 00:00:00 EDT 2013

Evidence that formation of vimentin mitogen-activated protein kinase (MAPK) complex mediates mast cell activation following FcεRI/CC chemokine receptor 1 cross-talk.

The Journal of biological chemistry

Toda M,Kuo CH,Borman SK,Richardson RM,Inoko A,Inagaki M,Collins A,Schneider K,Ono SJ

Fri Jul 13 00:00:00 EDT 2012

Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.

PloS one

Nakamura S,Oshima M,Yuan J,Saraya A,Miyagi S,Konuma T,Yamazaki S,Osawa M,Nakauchi H,Koseki H,Iwama A

Tue Oct 16 00:00:00 EDT 2012

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.

The Journal of biological chemistry

Hu P,Carlesso N,Xu M,Liu Y,Nebreda AR,Takemoto C,Kapur R

Fri Jun 08 00:00:00 EDT 2012

Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.

PloS one

Drechsler J,Grötzinger J,Hermanns HM

Thu Apr 25 00:00:00 EDT 2013

The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.

PloS one

Yamada T,Park CS,Burns A,Nakada D,Lacorazza HD

Mon Oct 22 00:00:00 EDT 2012

A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.

PloS one

Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A

Wed May 22 00:00:00 EDT 2013

Induction of histiocytic sarcoma in mouse skeletal muscle.

PloS one

Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ

Thu Feb 07 00:00:00 EST 2013

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PloS one

Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H

Wed Jan 16 00:00:00 EST 2013

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PloS one

Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H

Wed Jan 16 00:00:00 EST 2013

Burn injury triggered dysfunction in dendritic cell response to TLR9 activation and resulted in skewed T cell functions.

PloS one

Shen H,de Almeida PE,Kang KH,Yao P,Chan CW

Thu May 16 00:00:00 EDT 2013

Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

Nature

Anthony RM,Kobayashi T,Wermeling F,Ravetch JV

Sun Jun 19 00:00:00 EDT 2011

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

Cancer cell

Mazzieri R,Pucci F,Moi D,Zonari E,Ranghetti A,Berti A,Politi LS,Gentner B,Brown JL,Naldini L,De Palma M

Tue Apr 12 00:00:00 EDT 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

Cancer cell

Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R

Tue Sep 13 00:00:00 EDT 2011

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.

Blood

Singbrant S,Russell MR,Jovic T,Liddicoat B,Izon DJ,Purton LE,Sims NA,Martin TJ,Sankaran VG,Walkley CR

Thu May 26 00:00:00 EDT 2011

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.

Blood

Nelson EA,Walker SR,Weisberg E,Bar-Natan M,Barrett R,Gashin LB,Terrell S,Klitgaard JL,Santo L,Addorio MR,Ebert BL,Griffin JD,Frank DA

Thu Mar 24 00:00:00 EDT 2011

HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.

Blood

Flygare J,Rayon Estrada V,Shin C,Gupta S,Lodish HF

Thu Mar 24 00:00:00 EDT 2011

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.

Blood

Nguyen AT,Taranova O,He J,Zhang Y

Thu Jun 23 00:00:00 EDT 2011

PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.

Blood

Furumoto Y,Charles N,Olivera A,Leung WH,Dillahunt S,Sargent JL,Tinsley K,Odom S,Scott E,Wilson TM,Ghoreschi K,Kneilling M,Chen M,Lee DM,Bolland S,Rivera J

Thu Nov 17 00:00:00 EST 2011

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Blood

Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C

Thu Mar 17 00:00:00 EDT 2011

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Blood

Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ

Thu Feb 24 00:00:00 EST 2011

Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination.

Blood

Pospori C,Xue SA,Holler A,Voisine C,Perro M,King J,Fallah-Arani F,Flutter B,Chakraverty R,Stauss HJ,Morris EC

Thu Jun 23 00:00:00 EDT 2011

C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes.

Blood

Paz-Priel I,Houng S,Dooher J,Friedman AD

Thu Apr 14 00:00:00 EDT 2011

Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.

Blood

Chi AW,Chavez A,Xu L,Weber BN,Shestova O,Schaffer A,Wertheim G,Pear WS,Izon D,Bhandoola A

Thu Sep 08 00:00:00 EDT 2011

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

Blood

Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ

Thu Mar 17 00:00:00 EDT 2011

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.

Blood

Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ

Thu Feb 03 00:00:00 EST 2011

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.

Blood

Aue G,Du Y,Cleveland SM,Smith SB,Davé UP,Liu D,Weniger MA,Metais JY,Jenkins NA,Copeland NG,Dunbar CE

Thu Oct 27 00:00:00 EDT 2011

E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.

Blood

Yang Q,Esplin B,Borghesi L

Thu Mar 31 00:00:00 EDT 2011

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.

Blood

Ma P,Mali RS,Munugalavadla V,Krishnan S,Ramdas B,Sims E,Martin H,Ghosh J,Li S,Chan RJ,Krystal G,Craig AW,Takemoto C,Kapur R

Thu Sep 29 00:00:00 EDT 2011

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

Blood

Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S

Thu Dec 01 00:00:00 EST 2011

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

Blood

Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE

Thu Sep 29 00:00:00 EDT 2011

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.

Blood

Steffen B,Knop M,Bergholz U,Vakhrusheva O,Rode M,Köhler G,Henrichs MP,Bulk E,Hehn S,Stehling M,Dugas M,Bäumer N,Tschanter P,Brandts C,Koschmieder S,Berdel WE,Serve H,Stocking C,Müller-Tidow C

Thu Apr 21 00:00:00 EDT 2011

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.

Blood

Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW

Thu Dec 08 00:00:00 EST 2011

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.

Blood

Zhang L,Friedman AD

Thu Aug 25 00:00:00 EDT 2011

In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.

Blood

Richie Ehrlich LI,Serwold T,Weissman IL

Thu Mar 03 00:00:00 EST 2011

Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.

Blood

Sakata-Yanagimoto M,Sakai T,Miyake Y,Saito TI,Maruyama H,Morishita Y,Nakagami-Yamaguchi E,Kumano K,Yagita H,Fukayama M,Ogawa S,Kurokawa M,Yasutomo K,Chiba S

Thu Jan 06 00:00:00 EST 2011

Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.

Blood

Negre O,Fusil F,Colomb C,Roth S,Gillet-Legrand B,Henri A,Beuzard Y,Bushman F,Leboulch P,Payen E

Thu May 19 00:00:00 EDT 2011

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.

Blood

Futami M,Zhu QS,Whichard ZL,Xia L,Ke Y,Neel BG,Feng GS,Corey SJ

Thu Jul 28 00:00:00 EDT 2011

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.

Blood

Kleppe M,Soulier J,Asnafi V,Mentens N,Hornakova T,Knoops L,Constantinescu S,Sigaux F,Meijerink JP,Vandenberghe P,Tartaglia M,Foa R,Macintyre E,Haferlach T,Cools J

Thu Jun 30 00:00:00 EDT 2011

Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.

Blood

Li N,Matte-Martone C,Zheng H,Cui W,Venkatesan S,Tan HS,McNiff J,Demetris AJ,Roopenian D,Kaech S,Shlomchik WD

Thu Nov 24 00:00:00 EST 2011

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.

The Journal of clinical investigation

Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE

Sat Jan 01 00:00:00 EST 2011

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.

The Journal of experimental medicine

Hurtz C,Hatzi K,Cerchietti L,Braig M,Park E,Kim YM,Herzog S,Ramezani-Rad P,Jumaa H,Müller MC,Hofmann WK,Hochhaus A,Ye BH,Agarwal A,Druker BJ,Shah NP,Melnick AM,Müschen M

Mon Oct 24 00:00:00 EDT 2011

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

The Journal of experimental medicine

Pronk CJ,Veiby OP,Bryder D,Jacobsen SE

Mon Aug 01 00:00:00 EDT 2011

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.

The Journal of experimental medicine

Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A

Mon Jun 06 00:00:00 EDT 2011

Complex interactions in EML cell stimulation by stem cell factor and IL-3.

Proceedings of the National Academy of Sciences of the United States of America

Ye ZJ,Gulcicek E,Stone K,Lam T,Schulz V,Weissman SM

Tue Mar 22 00:00:00 EDT 2011

Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression.

Cell death and differentiation

Guitart AV,Debeissat C,Hermitte F,Villacreces A,Ivanovic Z,Boeuf H,Praloran V

213-13 was used in In vitro experiments to show that culture of the murine hematopoietic nonleukemic factor-dependent cell Paterson (FDCP)-Mix cell line under hypoxic conditions induced hypophosphorylation of pRb and increased the expression of p27(KIP1).

Sat Jan 01 00:00:00 EST 2011

IL-21 reduces immediate hypersensitivity reactions in mouse skin by suppressing mast cell activation or IgE production.

The Journal of investigative dermatology

Tamagawa-Mineoka R,Kishida T,Mazda O,Katoh N

Fri Jul 01 00:00:00 EDT 2011

Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.

Stem cells (Dayton, Ohio)

Heffner GC,Clutter MR,Nolan GP,Weissman IL

Tue Nov 01 00:00:00 EDT 2011

Ets-1 maintains IL-7 receptor expression in peripheral T cells.

Journal of immunology (Baltimore, Md. : 1950)

Grenningloh R,Tai TS,Frahm N,Hongo TC,Chicoine AT,Brander C,Kaufmann DE,Ho IC

Sat Jan 15 00:00:00 EST 2011

Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.

Journal of immunology (Baltimore, Md. : 1950)

Bonnefoy F,Perruche S,Couturier M,Sedrati A,Sun Y,Tiberghien P,Gaugler B,Saas P

Sun May 15 00:00:00 EDT 2011

Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.

Journal of immunology (Baltimore, Md. : 1950)

Maxwell MJ,Duan M,Armes JE,Anderson GP,Tarlinton DM,Hibbs ML

Wed Jun 15 00:00:00 EDT 2011

STIM1-directed reorganization of microtubules in activated mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Hájková Z,Bugajev V,Dráberová E,Vinopal S,Dráberová L,Janáček J,Dráber P,Dráber P

Sat Jan 15 00:00:00 EST 2011

Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Cantor J,Slepak M,Ege N,Chang JT,Ginsberg MH

Fri Jul 15 00:00:00 EDT 2011

Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.

Journal of immunology (Baltimore, Md. : 1950)

Li H,Nourbakhsh B,Safavi F,Li K,Xu H,Cullimore M,Zhou F,Zhang G,Rostami A

Fri Jul 01 00:00:00 EDT 2011

Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function.

Journal of immunology (Baltimore, Md. : 1950)

Chacón-Salinas R,Limón-Flores AY,Chávez-Blanco AD,Gonzalez-Estrada A,Ullrich SE

Sat Jan 01 00:00:00 EST 2011

TGF-beta-exposed plasmacytoid dendritic cells participate in Th17 commitment.

Journal of immunology (Baltimore, Md. : 1950)

Bonnefoy F,Couturier M,Clauzon A,Rémy-Martin JP,Gaugler B,Tiberghien P,Chen W,Saas P,Perruche S

Wed Jun 01 00:00:00 EDT 2011

Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.

Journal of immunology (Baltimore, Md. : 1950)

Matte-Martone C,Venkatesan S,Tan HS,Athanasiadis I,Chang J,Pavisic J,Shlomchik WD

Mon Aug 15 00:00:00 EDT 2011

Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.

Journal of immunology (Baltimore, Md. : 1950)

Pascual-García M,Carbó JM,León T,Matalonga J,Out R,Van Berkel T,Sarrias MR,Lozano F,Celada A,Valledor AF

Fri Apr 15 00:00:00 EDT 2011

Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice.

PloS one

Sutherland RE,Xu X,Kim SS,Seeley EJ,Caughey GH,Wolters PJ

Mon Mar 26 00:00:00 EDT 2012

Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells.

The Journal of biological chemistry

Matsushita H,Endo S,Kobayashi E,Sakamoto Y,Kobayashi K,Kitaguchi K,Kuroki K,Söderhäll A,Maenaka K,Nakamura A,Strittmatter SM,Takai T

Fri Jul 22 00:00:00 EDT 2011

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.

The Journal of biological chemistry

Guo H,Friedman AD

Fri Jan 07 00:00:00 EST 2011

Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release.

The Journal of biological chemistry

Kuehn HS,Jung MY,Beaven MA,Metcalfe DD,Gilfillan AM

Fri Jan 07 00:00:00 EST 2011

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.

PloS one

Reichel CA,Lerchenberger M,Uhl B,Rehberg M,Berberich N,Zahler S,Wymann MP,Krombach F

Tue Feb 22 00:00:00 EST 2011

R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.

The Journal of biological chemistry

Shang X,Cancelas JA,Li L,Guo F,Liu W,Johnson JF,Ficker A,Daria D,Geiger H,Ratner N,Zheng Y

Fri Jul 08 00:00:00 EDT 2011

Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.

The Journal of biological chemistry

Liu Z,Yang A,Wang Z,Bunting KD,Davuluri G,Green MR,Devireddy LR

Fri Jun 10 00:00:00 EDT 2011

Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.

PloS one

Otsuka A,Kubo M,Honda T,Egawa G,Nakajima S,Tanizaki H,Kim B,Matsuoka S,Watanabe T,Nakae S,Miyachi Y,Kabashima K

Thu Jan 26 00:00:00 EST 2012

Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

The Journal of biological chemistry

Dagälv A,Holmborn K,Kjellén L,Abrink M

Fri Dec 30 00:00:00 EST 2011

Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.

BMC immunology

Arumugam M,Ahrens R,Osterfeld H,Kottyan LC,Shang X,Maclennan JA,Zimmermann N,Zheng Y,Finkelman FD,Hogan SP

Thu Feb 03 00:00:00 EST 2011

Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.

PloS one

Zhang J,Alcaide P,Liu L,Sun J,He A,Luscinskas FW,Shi GP

Fri Jan 14 00:00:00 EST 2011

Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.

PloS one

Ohno T,Oboki K,Morita H,Kajiwara N,Arae K,Tanaka S,Ikeda M,Iikura M,Akiyama T,Inoue J,Matsumoto K,Sudo K,Azuma M,Okumura K,Kamradt T,Saito H,Nakae S

Mon Apr 11 00:00:00 EDT 2011

Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.

The Journal of biological chemistry

Coloff JL,Mason EF,Altman BJ,Gerriets VA,Liu T,Nichols AN,Zhao Y,Wofford JA,Jacobs SR,Ilkayeva O,Garrison SP,Zambetti GP,Rathmell JC

Fri Feb 18 00:00:00 EST 2011

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

The Journal of biological chemistry

Arora D,Stopp S,Böhmer SA,Schons J,Godfrey R,Masson K,Razumovskaya E,Rönnstrand L,Tänzer S,Bauer R,Böhmer FD,Müller JP

Fri Apr 01 00:00:00 EDT 2011

Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.

PloS one

Heinonen KM,Vanegas JR,Lew D,Krosl J,Perreault C

Tue Apr 26 00:00:00 EDT 2011

Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.

The Journal of biological chemistry

Nörenberg W,Hempel C,Urban N,Sobottka H,Illes P,Schaefer M

Fri Apr 01 00:00:00 EDT 2011

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

Nature

Nakada D,Saunders TL,Morrison SJ

Thu Dec 02 00:00:00 EST 2010

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Nature

Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP

Thu Sep 16 00:00:00 EDT 2010

β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.

Cancer cell

Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW

Tue Dec 14 00:00:00 EST 2010

Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.

Blood

van der Poel CE,Karssemeijer RA,Boross P,van der Linden JA,Blokland M,van de Winkel JG,Leusen JH

Thu Dec 09 00:00:00 EST 2010

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood

Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS

Thu Dec 02 00:00:00 EST 2010

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.

Blood

Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS

Thu Dec 02 00:00:00 EST 2010

Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.

Blood

Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S

Thu Jan 21 00:00:00 EST 2010

Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development.

Blood

Li H,Ji M,Klarmann KD,Keller JR

Thu Aug 19 00:00:00 EDT 2010

Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Blood

Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS

Thu Aug 26 00:00:00 EDT 2010

Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.

Blood

Singbrant S,Karlsson G,Ehinger M,Olsson K,Jaako P,Miharada K,Stadtfeld M,Graf T,Karlsson S

Thu Jun 10 00:00:00 EDT 2010

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.

Blood

Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT

Thu Dec 23 00:00:00 EST 2010

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.

Blood

Drube S,Heink S,Walter S,Löhn T,Grusser M,Gerbaulet A,Berod L,Schons J,Dudeck A,Freitag J,Grotha S,Reich D,Rudeschko O,Norgauer J,Hartmann K,Roers A,Kamradt T

Thu May 13 00:00:00 EDT 2010

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

Blood

Juntilla MM,Patil VD,Calamito M,Joshi RP,Birnbaum MJ,Koretzky GA

Thu May 20 00:00:00 EDT 2010

Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells.

Blood

Lee HM,Zhang H,Schulz V,Tuck DP,Forget BG

Thu Aug 05 00:00:00 EDT 2010

Essential role for focal adhesion kinase in regulating stress hematopoiesis.

Blood

Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R

Thu Nov 18 00:00:00 EST 2010

The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.

Blood

de la Luz Sierra M,Sakakibara S,Gasperini P,Salvucci O,Jiang K,McCormick PJ,Segarra M,Stone J,Maric D,Zhu J,Qian X,Lowy DR,Tosato G

Thu May 13 00:00:00 EDT 2010

Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.

Blood

Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H

Thu Jun 03 00:00:00 EDT 2010

Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.

Blood

Heaney NB,Pellicano F,Zhang B,Crawford L,Chu S,Kazmi SM,Allan EK,Jorgensen HG,Irvine AE,Bhatia R,Holyoake TL

Thu Mar 18 00:00:00 EDT 2010

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Blood

Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE

Thu Jun 17 00:00:00 EDT 2010

A key role for ATF3 in regulating mast cell survival and mediator release.

Blood

Gilchrist M,Henderson WR,Morotti A,Johnson CD,Nachman A,Schmitz F,Smith KD,Aderem A

Thu Jun 10 00:00:00 EDT 2010

The transcription factor Srf regulates hematopoietic stem cell adhesion.

Blood

Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V

Thu Nov 25 00:00:00 EST 2010

The transcription factor Srf regulates hematopoietic stem cell adhesion.

Blood

Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V

Thu Nov 25 00:00:00 EST 2010

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.

Blood

Vemula S,Shi J,Hanneman P,Wei L,Kapur R

Thu Mar 04 00:00:00 EST 2010

Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.

Blood

Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F

Thu Dec 02 00:00:00 EST 2010

Serum response factor is an essential transcription factor in megakaryocytic maturation.

Blood

Halene S,Gao Y,Hahn K,Massaro S,Italiano JE,Schulz V,Lin S,Kupfer GM,Krause DS

Thu Sep 16 00:00:00 EDT 2010

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.

Blood

Pulliam-Leath AC,Ciccone SL,Nalepa G,Li X,Si Y,Miravalle L,Smith D,Yuan J,Li J,Anur P,Orazi A,Vance GH,Yang FC,Hanenberg H,Bagby GC,Clapp DW

Thu Oct 21 00:00:00 EDT 2010

Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.

Blood

de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA

Thu Oct 07 00:00:00 EDT 2010

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

Blood

Li G,Miskimen KL,Wang Z,Xie XY,Brenzovich J,Ryan JJ,Tse W,Moriggl R,Bunting KD

Thu Feb 18 00:00:00 EST 2010

Leukemogenic transformation by HOXA cluster genes.

Blood

Bach C,Buhl S,Mueller D,García-Cuéllar MP,Maethner E,Slany RK

Thu Apr 08 00:00:00 EDT 2010

Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts.

The Journal of clinical investigation

Liao CH,Akazawa H,Tamagawa M,Ito K,Yasuda N,Kudo Y,Yamamoto R,Ozasa Y,Fujimoto M,Wang P,Nakauchi H,Nakaya H,Komuro I

Fri Jan 01 00:00:00 EST 2010

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.

The Journal of clinical investigation

Si Y,Tsou CL,Croft K,Charo IF

Thu Apr 01 00:00:00 EDT 2010

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

The Journal of experimental medicine

Morita Y,Ema H,Nakauchi H

Mon Jun 07 00:00:00 EDT 2010

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.

The Journal of experimental medicine

Yu L,Ji W,Zhang H,Renda MJ,He Y,Lin S,Cheng EC,Chen H,Krause DS,Min W

Mon Jun 07 00:00:00 EDT 2010

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

The Journal of experimental medicine

Henderson RB,Grys K,Vehlow A,de Bettignies C,Zachacz A,Henley T,Turner M,Batista F,Tybulewicz VL

Mon Apr 12 00:00:00 EDT 2010

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

The Journal of experimental medicine

Lauterbach H,Bathke B,Gilles S,Traidl-Hoffmann C,Luber CA,Fejer G,Freudenberg MA,Davey GM,Vremec D,Kallies A,Wu L,Shortman K,Chaplin P,Suter M,O'Keeffe M,Hochrein H

Mon Nov 22 00:00:00 EST 2010

Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.

The Journal of experimental medicine

Buono M,Visigalli I,Bergamasco R,Biffi A,Cosma MP

Mon Aug 02 00:00:00 EDT 2010

NIP45 controls the magnitude of the type 2 T helper cell response.

Proceedings of the National Academy of Sciences of the United States of America

Fathman JW,Gurish MF,Hemmers S,Bonham K,Friend DS,Grusby MJ,Glimcher LH,Mowen KA

Tue Feb 23 00:00:00 EST 2010

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

Proceedings of the National Academy of Sciences of the United States of America

Foukas LC,Berenjeno IM,Gray A,Khwaja A,Vanhaesebroeck B

Tue Jun 22 00:00:00 EDT 2010

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Naramura M,Nandwani N,Gu H,Band V,Band H

Tue Sep 14 00:00:00 EDT 2010

Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.

Haematologica

Kalfa TA,Pushkaran S,Zhang X,Johnson JF,Pan D,Daria D,Geiger H,Cancelas JA,Williams DA,Zheng Y

Fri Jan 01 00:00:00 EST 2010

A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.

PLoS biology

Pop R,Shearstone JR,Shen Q,Liu Y,Hallstrom K,Koulnis M,Gribnau J,Socolovsky M

Tue Sep 21 00:00:00 EDT 2010

The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis.

PLoS pathogens

Garrison SP,Thornton JA,Häcker H,Webby R,Rehg JE,Parganas E,Zambetti GP,Tuomanen EI

Thu Dec 23 00:00:00 EST 2010

Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway.

Stem cells (Dayton, Ohio)

Xynos A,Corbella P,Belmonte N,Zini R,Manfredini R,Ferrari G

Sat May 01 00:00:00 EDT 2010

Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY

Wed Mar 31 00:00:00 EDT 2010

Basophils support the survival of plasma cells in mice.

Journal of immunology (Baltimore, Md. : 1950)

Rodriguez Gomez M,Talke Y,Goebel N,Hermann F,Reich B,Mack M

Wed Dec 15 00:00:00 EST 2010

Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.

Journal of immunology (Baltimore, Md. : 1950)

Scandiuzzi L,Beghdadi W,Daugas E,Abrink M,Tiwari N,Brochetta C,Claver J,Arouche N,Zang X,Pretolani M,Monteiro RC,Pejler G,Blank U

Thu Jul 01 00:00:00 EDT 2010

Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Alvarez-Errico D,Yamashita Y,Suzuki R,Odom S,Furumoto Y,Yamashita T,Rivera J

Sat May 01 00:00:00 EDT 2010

A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth.

Journal of immunology (Baltimore, Md. : 1950)

Oldford SA,Haidl ID,Howatt MA,Leiva CA,Johnston B,Marshall JS

Wed Dec 01 00:00:00 EST 2010

"Default" generation of neonatal regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W

Thu Jul 01 00:00:00 EDT 2010

PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.

Journal of immunology (Baltimore, Md. : 1950)

Samayawardhena LA,Pallen CJ

Mon Nov 15 00:00:00 EST 2010

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Wrzesinski C,Paulos CM,Kaiser A,Muranski P,Palmer DC,Gattinoni L,Yu Z,Rosenberg SA,Restifo NP

Fri Jan 01 00:00:00 EST 2010

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.

Gene therapy

Maetzig T,Galla M,Brugman MH,Loew R,Baum C,Schambach A

Mon Mar 01 00:00:00 EST 2010

Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model.

PloS one

Yang Z,Zhang B,Li D,Lv M,Huang C,Shen GX,Huang B

Wed Jan 27 00:00:00 EST 2010

Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.

The Journal of biological chemistry

Zhang Y,Tang W,Jones MC,Xu W,Halene S,Wu D

Fri Aug 06 00:00:00 EDT 2010

Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector.

Virology journal

Fratini P,Strauss BE

Fri Jan 22 00:00:00 EST 2010

STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.

The Journal of biological chemistry

Funakoshi-Tago M,Tago K,Abe M,Sonoda Y,Kasahara T

Fri Feb 19 00:00:00 EST 2010

Hepatocyte nuclear factor-4alpha induces transdifferentiation of hematopoietic cells into hepatocytes.

The Journal of biological chemistry

Khurana S,Jaiswal AK,Mukhopadhyay A

Fri Feb 12 00:00:00 EST 2010

Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.

The Journal of biological chemistry

Ohtake-Niimi S,Kondo S,Ito T,Kakehi S,Ohta T,Habuchi H,Kimata K,Habuchi O

Fri Jul 02 00:00:00 EDT 2010

Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts.

The Journal of biological chemistry

Heneberg P,Dráberová L,Bambousková M,Pompach P,Dráber P

Fri Apr 23 00:00:00 EDT 2010

Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).

The Journal of biological chemistry

Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM

Fri Jul 09 00:00:00 EDT 2010

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

Nature

Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T

Thu Nov 05 00:00:00 EST 2009

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

Nature

Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG

Thu Jan 01 00:00:00 EST 2009

MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.

Cell

Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH

Thu Jul 23 00:00:00 EDT 2009

Intraclonal competition limits the fate determination of regulatory T cells in the thymus.

Nature immunology

Bautista JL,Lio CW,Lathrop SK,Forbush K,Liang Y,Luo J,Rudensky AY,Hsieh CS

Mon Jun 01 00:00:00 EDT 2009

Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression.

Blood

Fromm G,de Vries C,Byron R,Fields J,Fiering S,Groudine M,Bender MA,Palis J,Bulger M

Thu Oct 15 00:00:00 EDT 2009

Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation.

Blood

Piconese S,Gri G,Tripodo C,Musio S,Gorzanelli A,Frossi B,Pedotti R,Pucillo CE,Colombo MP

Thu Sep 24 00:00:00 EDT 2009

HOXA9 is required for survival in human MLL-rearranged acute leukemias.

Blood

Faber J,Krivtsov AV,Stubbs MC,Wright R,Davis TN,van den Heuvel-Eibrink M,Zwaan CM,Kung AL,Armstrong SA

Thu Mar 12 00:00:00 EDT 2009

BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.

Blood

Nordigården A,Kraft M,Eliasson P,Labi V,Lam EW,Villunger A,Jönsson JI

Thu Mar 05 00:00:00 EST 2009

Gfi1 integrates progenitor versus granulocytic transcriptional programming.

Blood

Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL

Thu May 28 00:00:00 EDT 2009

Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.

Blood

Praetor A,McBride JM,Chiu H,Rangell L,Cabote L,Lee WP,Cupp J,Danilenko DM,Fong S

Thu Feb 26 00:00:00 EST 2009

Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.

Blood

Cochrane SW,Zhao Y,Welner RS,Sun XH

Thu Jan 29 00:00:00 EST 2009

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.

Blood

Li Y,Chen S,Yuan J,Yang Y,Li J,Ma J,Wu X,Freund M,Pollok K,Hanenberg H,Goebel WS,Yang FC

Thu Mar 05 00:00:00 EST 2009

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.

Blood

Rice KL,Hormaeche I,Doulatov S,Flatow JM,Grimwade D,Mills KI,Leiva M,Ablain J,Ambardekar C,McConnell MJ,Dick JE,Licht JD

Thu Dec 24 00:00:00 EST 2009

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

Blood

Bandi SR,Brandts C,Rensinghoff M,Grundler R,Tickenbrock L,Köhler G,Duyster J,Berdel WE,Müller-Tidow C,Serve H,Sargin B

Thu Nov 05 00:00:00 EST 2009

Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.

Blood

Blue R,Kowalska MA,Hirsch J,Murcia M,Janczak CA,Harrington A,Jirouskova M,Li J,Fuentes R,Thornton MA,Filizola M,Poncz M,Coller BS

Thu Jul 02 00:00:00 EDT 2009

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.

Blood

Schmidt-Arras D,Böhmer SA,Koch S,Müller JP,Blei L,Cornils H,Bauer R,Korasikha S,Thiede C,Böhmer FD

Thu Apr 09 00:00:00 EDT 2009

Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.

Blood

Lannutti BJ,Epp A,Roy J,Chen J,Josephson NC

Thu Feb 19 00:00:00 EST 2009

Role for MKL1 in megakaryocytic maturation.

Blood

Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

Thu Mar 19 00:00:00 EDT 2009

Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.

Blood

Kuo YH,Zaidi SK,Gornostaeva S,Komori T,Stein GS,Castilla LH

Thu Apr 02 00:00:00 EDT 2009

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.

Blood

Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK

Thu Apr 09 00:00:00 EDT 2009

Negative regulation of activated alpha-2 integrins during thrombopoiesis.

Blood

Zou Z,Schmaier AA,Cheng L,Mericko P,Dickeson SK,Stricker TP,Santoro SA,Kahn ML

Thu Jun 18 00:00:00 EDT 2009

Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model.

Blood

Hu X,Shen H,Tian C,Yu H,Zheng G,XuFeng R,Ju Z,Xu J,Wang J,Cheng T

Thu Oct 29 00:00:00 EDT 2009

Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.

Blood

Velu CS,Baktula AM,Grimes HL

Thu May 07 00:00:00 EDT 2009

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Blood

Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW

Thu Mar 19 00:00:00 EDT 2009

Critical role of class IA PI3K for c-Rel expression in B lymphocytes.

Blood

Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S

Thu Jan 29 00:00:00 EST 2009

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

Blood

Xu H,Eleswarapu S,Geiger H,Szczur K,Daria D,Zheng Y,Settleman J,Srour EF,Williams DA,Filippi MD

Thu Oct 22 00:00:00 EDT 2009

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

Blood

Milsom MD,Schiedlmeier B,Bailey J,Kim MO,Li D,Jansen M,Ali AM,Kirby M,Baum C,Fairbairn LJ,Williams DA

Thu May 21 00:00:00 EDT 2009

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.

Blood

Horton SJ,Walf-Vorderwülbecke V,Chatters SJ,Sebire NJ,de Boer J,Williams O

Thu May 14 00:00:00 EDT 2009

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

The Journal of clinical investigation

Montini E,Cesana D,Schmidt M,Sanvito F,Bartholomae CC,Ranzani M,Benedicenti F,Sergi LS,Ambrosi A,Ponzoni M,Doglioni C,Di Serio C,von Kalle C,Naldini L

Wed Apr 01 00:00:00 EDT 2009

Niche recycling through division-independent egress of hematopoietic stem cells.

The Journal of experimental medicine

Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL

Mon Nov 23 00:00:00 EST 2009

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.

The Journal of experimental medicine

Fukui R,Saitoh S,Matsumoto F,Kozuka-Hata H,Oyama M,Tabeta K,Beutler B,Miyake K

Mon Jun 08 00:00:00 EDT 2009

Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.

The EMBO journal

Sheng Z,Wang SZ,Green MR

Wed Apr 08 00:00:00 EDT 2009

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

Modlich U,Navarro S,Zychlinski D,Maetzig T,Knoess S,Brugman MH,Schambach A,Charrier S,Galy A,Thrasher AJ,Bueren J,Baum C

Sun Nov 01 00:00:00 EDT 2009

Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes.

Leukemia

Kozuma Y,Yuki S,Ninomiya H,Nagasawa T,Kojima H

Mon Jun 01 00:00:00 EDT 2009

CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients.

Leukemia

Pardanani A,Lasho T,Smith G,Burns CJ,Fantino E,Tefferi A

Sat Aug 01 00:00:00 EDT 2009

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism.

Proceedings of the National Academy of Sciences of the United States of America

Groschwitz KR,Ahrens R,Osterfeld H,Gurish MF,Han X,Abrink M,Finkelman FD,Pejler G,Hogan SP

Tue Dec 29 00:00:00 EST 2009

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Proceedings of the National Academy of Sciences of the United States of America

Schmaier AA,Zou Z,Kazlauskas A,Emert-Sedlak L,Fong KP,Neeves KB,Maloney SF,Diamond SL,Kunapuli SP,Ware J,Brass LF,Smithgall TE,Saksela K,Kahn ML

Tue Dec 15 00:00:00 EST 2009

Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America

Mathas S,Kreher S,Meaburn KJ,Jöhrens K,Lamprecht B,Assaf C,Sterry W,Kadin ME,Daibata M,Joos S,Hummel M,Stein H,Janz M,Anagnostopoulos I,Schrock E,Misteli T,Dörken B

Tue Apr 07 00:00:00 EDT 2009

Misguided transcriptional elongation causes mixed lineage leukemia.

PLoS biology

Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK

Sun Nov 01 00:00:00 EDT 2009

The adhesion molecule esam1 is a novel hematopoietic stem cell marker.

Stem cells (Dayton, Ohio)

Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC

Sun Mar 01 00:00:00 EST 2009

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Ogaeri T,Eto K,Otsu M,Ema H,Nakauchi H

Fri May 01 00:00:00 EDT 2009

Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Ohno T,Oboki K,Kajiwara N,Morii E,Aozasa K,Flavell RA,Okumura K,Saito H,Nakae S

Tue Dec 15 00:00:00 EST 2009

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.

Journal of immunology (Baltimore, Md. : 1950)

Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R

Sun Feb 15 00:00:00 EST 2009

Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA

Wed Apr 15 00:00:00 EDT 2009

Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties.

Journal of immunology (Baltimore, Md. : 1950)

Smith TR,Tang X,Maricic I,Garcia Z,Fanchiang S,Kumar V

Mon Jun 01 00:00:00 EDT 2009

14-3-3 gamma is stimulated by IL-3 and promotes cell proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Ajjappala BS,Kim YS,Kim MS,Lee MY,Lee KY,Ki HY,Cha DH,Baek KH

Thu Jan 15 00:00:00 EST 2009

Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.

Journal of immunology (Baltimore, Md. : 1950)

Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A

Sat Aug 01 00:00:00 EDT 2009

Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Zheng H,Matte-Martone C,Jain D,McNiff J,Shlomchik WD

Fri May 15 00:00:00 EDT 2009

Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes.

Journal of immunology (Baltimore, Md. : 1950)

Kim S,Shen T,Min B

Tue Sep 01 00:00:00 EDT 2009

Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.

Journal of immunology (Baltimore, Md. : 1950)

Duelli A,Rönnberg E,Waern I,Ringvall M,Kolset SO,Pejler G

Tue Dec 01 00:00:00 EST 2009

Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.

Journal of immunology (Baltimore, Md. : 1950)

Carlens J,Wahl B,Ballmaier M,Bulfone-Paus S,Förster R,Pabst O

Sun Nov 01 00:00:00 EDT 2009

Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content.

Journal of immunology (Baltimore, Md. : 1950)

Tagen M,Elorza A,Kempuraj D,Boucher W,Kepley CL,Shirihai OS,Theoharides TC

Sun Nov 15 00:00:00 EST 2009

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.

The Journal of biological chemistry

Zhao L,Dong H,Zhang CC,Kinch L,Osawa M,Iacovino M,Grishin NV,Kyba M,Huang LJ

Fri Sep 25 00:00:00 EDT 2009

IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability.

PloS one

Ernst J,Ghanem L,Bar-Joseph Z,McNamara M,Brown J,Steinman RA

Thu Oct 15 00:00:00 EDT 2009

Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells.

The Journal of biological chemistry

Gao Y,Howard A,Ban K,Chandra J

Fri Mar 13 00:00:00 EDT 2009

Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity.

The Journal of biological chemistry

Marty C,Chaligné R,Lacout C,Constantinescu SN,Vainchenker W,Villeval JL

Fri May 01 00:00:00 EDT 2009

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

PloS one

Miletic AV,Graham DB,Sakata-Sogawa K,Hiroshima M,Hamann MJ,Cemerski S,Kloeppel T,Billadeau DD,Kanagawa O,Tokunaga M,Swat W

Wed Aug 12 00:00:00 EDT 2009

A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.

PloS one

Johnson KJ,Griswold IJ,O'Hare T,Corbin AS,Loriaux M,Deininger MW,Druker BJ

Tue Oct 13 00:00:00 EDT 2009

Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.

The Journal of biological chemistry

Lin IJ,Zhou Z,Crusselle-Davis VJ,Moghimi B,Gandhi K,Anantharaman A,Pantic D,Huang S,Jayandharan G,Zhong L,Srivastava A,Bungert J

Fri Jul 24 00:00:00 EDT 2009

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

Cancer cell

Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA

Tue Nov 04 00:00:00 EST 2008

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

Blood

Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T

Fri Feb 15 00:00:00 EST 2008

Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes.

Blood

Crist SA,Sprague DL,Ratliff TL

Tue Apr 01 00:00:00 EDT 2008

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Proceedings of the National Academy of Sciences of the United States of America

Gan B,Sahin E,Jiang S,Sanchez-Aguilera A,Scott KL,Chin L,Williams DA,Kwiatkowski DJ,DePinho RA

Tue Dec 09 00:00:00 EST 2008

Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo.

Stem cells (Dayton, Ohio)

Kobune M,Kato J,Kawano Y,Sasaki K,Uchida H,Takada K,Takahashi S,Takimoto R,Niitsu Y

Fri Feb 01 00:00:00 EST 2008

Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.

Stem cells (Dayton, Ohio)

Schenke-Layland K,Rhodes KE,Angelis E,Butylkova Y,Heydarkhan-Hagvall S,Gekas C,Zhang R,Goldhaber JI,Mikkola HK,Plath K,MacLellan WR

Sun Jun 01 00:00:00 EDT 2008

Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils.

Journal of immunology (Baltimore, Md. : 1950)

Watanabe M,Satoh T,Yamamoto Y,Kanai Y,Karasuyama H,Yokozeki H

Wed Oct 15 00:00:00 EDT 2008

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Kuehn HS,Swindle EJ,Kim MS,Beaven MA,Metcalfe DD,Gilfillan AM

Mon Dec 01 00:00:00 EST 2008

IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.

Journal of immunology (Baltimore, Md. : 1950)

Song C,Luo L,Lei Z,Li B,Liang Z,Liu G,Li D,Zhang G,Huang B,Feng ZH

Sat Nov 01 00:00:00 EDT 2008

Instant conditional transgenesis in the mouse hematopoietic compartment.

Journal of immunological methods

Csikós T,Reijmers RM,Uren AG,Spaargaren M,Pals ST

Wed Dec 31 00:00:00 EST 2008

Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.

PloS one

Kalaitzidis D,Neel BG

Tue Feb 10 00:00:00 EST 2009

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.

BMC immunology

Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD

Thu Aug 07 00:00:00 EDT 2008

Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.

Blood

Khanna-Gupta A,Sun H,Zibello T,Lee HM,Dahl R,Boxer LA,Berliner N

Tue May 15 00:00:00 EDT 2007

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.

Blood

Yang L,Wang L,Kalfa TA,Cancelas JA,Shang X,Pushkaran S,Mo J,Williams DA,Zheng Y

Sat Dec 01 00:00:00 EST 2007

PECAM-1: a multifaceted regulator of megakaryocytopoiesis.

Blood

Wu Y,Welte T,Michaud M,Madri JA

Wed Aug 01 00:00:00 EDT 2007

TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.

The Journal of clinical investigation

Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q

Thu Nov 01 00:00:00 EDT 2007

Mast cells are essential intermediaries in regulatory T-cell tolerance.

Nature

Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ

Thu Aug 31 00:00:00 EDT 2006

The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells.

Blood

Trudel S,Stewart AK,Rom E,Wei E,Li ZH,Kotzer S,Chumakov I,Singer Y,Chang H,Liang SB,Yayon A

Mon May 15 00:00:00 EDT 2006

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

The Journal of biological chemistry

Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM

Fri Jun 09 00:00:00 EDT 2006

Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.

The Journal of biological chemistry

McDowell LM,Frazier BA,Studelska DR,Giljum K,Chen J,Liu J,Yu K,Ornitz DM,Zhang L

Fri Mar 17 00:00:00 EST 2006

Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.

The Journal of experimental medicine

Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ

Mon Jun 20 00:00:00 EDT 2005

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.

Endocrinology

Yu X,Ibrahimi OA,Goetz R,Zhang F,Davis SI,Garringer HJ,Linhardt RJ,Ornitz DM,Mohammadi M,White KE

Tue Nov 01 00:00:00 EST 2005

Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain.

The Journal of biological chemistry

Yamauchi A,Marchal CC,Molitoris J,Pech N,Knaus U,Towe J,Atkinson SJ,Dinauer MC

Fri Jan 14 00:00:00 EST 2005

Basophils initiate IL-4 production during a memory T-dependent response.

The Journal of experimental medicine

Khodoun MV,Orekhova T,Potter C,Morris S,Finkelman FD

Mon Oct 04 00:00:00 EDT 2004

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.

Blood

Xie X,Chan RJ,Johnson SA,Starr M,McCarthy J,Kapur R,Yoder MC

Sat Feb 15 00:00:00 EST 2003

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.

Blood

Chandra S,Kapur R,Chuzhanova N,Summey V,Prentice D,Barker J,Cooper DN,Williams DA

Sat Nov 15 00:00:00 EST 2003

Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.

Stem cells (Dayton, Ohio)

Metcalf D,Mifsud S,Di Rago L

Wed Mar 12 00:00:00 EST 2003

Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.

Cancer research

Kobune M,Xu Y,Baum C,Kelley MR,Williams DA

Sun Jul 01 00:00:00 EDT 2001

TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation.

Journal of immunology (Baltimore, Md. : 1950)

Rovida E,Paccagnini A,Del Rosso M,Peschon J,Dello Sbarba P

213-13 was used in Cell Culture to study how M-CSFR is shed from macrophage surface and identify the protease responsible for M-CSFR cleavage and down-modulation and demonstrate how the proTNF-converting enzyme (TACE) protease is responsible for M-CSFR shedding and down-modulation in mononuclear phagocytes undergoing activation.

Thu Feb 01 00:00:00 EST 2001

The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation.

Blood

Peled A,Gonzalo JA,Lloyd C,Gutierrez-Ramos JC

Sun Mar 15 00:00:00 EST 1998

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA

Tue Sep 15 00:00:00 EDT 1998

Studies of thiamine metabolism in man; thiamine and pyrimidine excretion with special reference to the relationship between injected and excreted thiamine in normal and abnormal subjects.

The Journal of clinical investigation

ALEXANDER B,LANDWEHR G,MITCHELL F

Wed May 01 00:00:00 EDT 1946

Bioinformatics

Protein Aliases: BP/BPA; Colony stimulating factor multiple; Eo-CSF; Hematopoietic growth factor; IL-3; ILN; Interleukin; Interleukin 3 (colony stimulating factor; Interleukin-3; Interleukin3; Mast cell growth factor; MCGF; MGC79398; MGC79399; Multi CSF; Multilineage colony stimulating factor; multiple); Multipotential colony-stimulating factor; P cell stimulating factor; P-cell-stimulating factor; PCSA

Mouse IL-3 Recombinant Protein, PeproTech®

Mouse IL-3 Protein (213-13-10UG) in Functional

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213-13-10UG

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