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Product Details
315-38-20UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Published species
Mouse
Expression System
E. coli
Amino acid sequence
MAVITGACDK DSQCGGGMCC AVSIWVKSIR ICTPMGQVGD SCHPLTRKSH VANGRQERRR AKRRKRKKEV PFWGRRMHHT CPCLPGLACL RTSFNRFICL ARK
Molecular weight
11.6 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Murine Prokineticin-2 is an 11.6 kDa protein consisting of 103 amino acid residues, including ten cysteine residues that can potentially form five pairs of intra-molecular disulfide bonds.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bombina variegata 8 kD protein; Bombina variegata 8kDa protein; Bv 8 homolog (Bombina variegata); PK2; prokineticin 1; Prokineticin-2; Protein Bv8 homolog
Gene Aliases: Bv8; PK2; Prok1; Prok2
UniProt ID: (Mouse) Q9QXU7
Entrez Gene ID: (Mouse) 50501
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