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Product Details
PEP-0497
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 21 amino acids near the center of mouse TSLP receptor.
PEP-0497 can be used as a blocking peptide with polyclonal antibody PA5-20380.
Target Information
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRLM-2; Cytokine receptor-like factor 2; Cytokine receptor-like molecule 2; delta 1; lymphocyte antigen 114; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin, receptor; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; TSLP receptor; Type I cytokine receptor delta 1; WI2-87105E3.1
Gene Aliases: Crlf2; CRLM2; Ly114; Tpte2; Tslpr
UniProt ID: (Mouse) Q8CII9
Entrez Gene ID: (Mouse) 57914
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