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Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. [UniProt]
2-phosphoxylose phosphatase 1; 9430094M07Rik; acid phosphatase-like 2; acid phosphatase-like protein 2; ACPL2; BB177120; C130099A20Rik; epididymis luminal protein 124; HEL124; PXYLP1; PXYLP1 (HGNC:26303); UNQ370/PRO706; Xylosyl phosphatase; XYLP
100 µL
100 µL
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