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This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
1110017C11Rik; ACAS; Acas1; Acas2; ACECS; AceCS1; acetate thiokinase; acetate-CoA ligase; acetate--CoA ligase; Acetyl-CoA synthetase; Acetyl-CoA synthetase 1; acetyl-Coenzyme A synthetase 1 (AMP forming); acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-Coenzyme A synthetase 2 (AMP forming); acetyl-coenzyme A synthetase, cytoplasmic; ACS; Acs1; ACSA; ACSS2; Acyl-activating enzyme; acyl-CoA synthetase short-chain family member 2; cytoplasmic acetyl-coenzyme A synthetase; dJ1161H23.1; Propionate--CoA ligase
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