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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
9630038L21; a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 18; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif 18; ADAM metallopeptidase with thrombospondin type 1 motif, 18; ADAMs; ADAM-TS 18; ADAMTS18; ADAM-TS18; ADAMTS-18; ADAMTS21; disintegrin and metalloprotease-like protein; E130314N14Rik; KNO2; metalloendopeptidases; MMCAT; RGD1560118; sb:eu2468
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